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Attenuated retinoic acid signaling is among the early responses in mouse uterus approaching embryo attachment

Reproductive and Developmental Medicine 2024年第1期8卷 61-65页

作者： Honglu Diao Shuo Xiao Tong Zhou Taylor E.Martin Wendy T.watford Xiaoqin Ye Department of Physiology and Pharmacology College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Toxicology Program University of GeorgiaAthensGA 30602USA Department of Physiology and Cell Biology University of NevadaReno School of MedicineRenoNV 89557USA Department of Infectious Diseases College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA

The uterus is transiently receptive for embryo *** remains to be understood why the uterus does not reject a semi-allogeneic embryo(to the biological mother)or an allogeneic embryo(to a surrogate)for *** gain insights,we examined uterine early response genes approaching embryo attachment on day 3 post coitum(D3)at 22 hours when blue dye reaction,an indication of embryo attachment,had not manifested in mice.C57BL/6 pseudo-pregnant(control)and pregnant mouse uteri were collected on D3 at 22 hours for microarray *** self-assembling-manifold(SAM)algorithm identified 21,858 unique *** component analysis indicated a clear separation between the pseudo-pregnant and pregnant *** were 106 upregulated and five downregulated protein-coding genes in the pregnant uterus with fold change(fc)>1.5 andq value<5%.Gene ontology(GO)analysis of the 106 upregulated genes revealed 38 significant GO biological process(GOBP)terms(P<0.05),and 32(84%)of them were associated with immune responses,with a dominant natural killer(NK)cell activation *** the top eight upregulated protein-coding genes,Cyp26a1 inactivates retinoic acid(RA)whileLrat promotes vitamin A storage,both of which are expected to attenuate RA bioavailability;Atp6v0d2 andGjb2 play roles in ion transport and transmembrane transport;Gzmb,Gzmc,andIl2rb are involved in immune responses;andTdo2 is important for kynurenine *** of these genes or their related pathways have functions in immune *** signaling has been implicated in immune tolerance and immune homeostasis,and uterine NK cells have been implicated in immunotolerance at the maternal-fetal interface in the *** mechanisms of immune responses approaching embryo attachment remain to be *** coordinated effects of the early response genes may hold the keys to the question of why the uterus does not reject an implanting embryo.

关键词： Embryo attachment Pseudo-pregnant uterus Pregnant uterus Natural killer cell activation signature Retinoic acid bioavailability Transmembrane transport and ion transport

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Glutamine and glutamate: Nonessential or essential amino acids?

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Animal Nutrition 2015年第3期1卷 119-122页

作者： malc.lm watford Department of Nutritional Sciences Rutgers The State University

Glutamine and glutamate are not considered essential amino acids but they play important roles in maintaining growth and health in both neonates and adults. Although glutamine and glutamate are highly abundant in most feedstuffs there is increasing evidence that they may be limiting during pregnancy, lactation and neonatal growth, particularly when relatively low protein diets are fed. Supplementation of diets with glutamine, glutamate or both at 0.5 to 1.0% to both suckling and recently weaned piglets improves intestinal and immune function and results in better growth. In addition such supplementation to the sow prevents some of the loss of lean body mass during lactation, and increases milk glutamine content. However, a number of important questions related to physiological condition,species under study and the form and amount of the supplements need to be addressed before the full benefits of glutamine and glutamate supplementation in domestic animal production can be realized.

关键词： Amino acid Glutamate Glutamine Lactation Pregnancy Growth

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Subtropical urban turfs： Carbon and nitrogen pools and the role of enzyme activity

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Journal of Environmental Sciences 2018年第3期30卷 18-28页

作者： Ling Kong lm Chu School of Life Sciences The Chinese University of Hong Kong Shatin NT Hong Kong SAR China department of orthopaedics & traumatology faculty of medicine the chinese university of hong kong

Urban grasslands not only provide a recreational venue for urban residents, but also sequester organic carbon in vegetation and soils through photosynthesis, and release carbon dioxide through respiration, which largely contribute to carbon storage and fluxes at regional and global scales. We investigated organic carbon and nitrogen pools in subtropical turfs and found that dissolved organic carbon（DOC） and dissolved organic nitrogen（DON）were regulated by several factors including microbial activity which is indicated by soil enzymatic activity. We observed a vertical variation and different temporal patterns in both soil DOC, DON and enzyme activities, which decreased significantly with increasing soil depths. We further found that concentration of soil DON was linked with turf age. There were correlations between grass biomass and soil properties, and soil enzyme activities. In particular, soil bulk density was significantly correlated with soil moisture and soil organic carbon（SOC）. In addition, DOC correlated significantly with DON. Significant negative correlations were also observed between soil total dissolved nitrogen（TDN） and grass biomass of Axonopus compressus and Zoysia matrella. Specifically, grass biomass was significantly correlated with the soil activity of urease and β-glucosidase. Soil NO3-N concentration also showed negative correlations with the activity of both β-glucosidase and protease but there were no significant correlations between cellulase and soil properties or grass biomass. Our study demonstrated a relationship between soil C and N dynamics and soil enzymes that could be modulated to enhance SOC pools through management and maintenance practices.

关键词： Dissolved organic carbon (DOC)lDissolved organic nitrogen (DON)lSoil enzymelTurfgrass

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Comparison study of several numerical integration schemes used in calculations of density functional theory

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Chinese Journal of Chemistry 1996年第4期14卷 289-296页

作者： Hong, GY Li, lm BEIJING UNIV COLL CHEM & MOL ENGNSTATE KEY LAB RARE EARTH MAT CHEM & APPLICATBEIJING 100871PEOPLES R CHINA

Several numerical integration schemes for the evaluation of matrix elements in density functional theory calculations have been studied and compared by computational practice. The best scheme was found to be the combination of the atomic partition function proposed by Becke with the scaled generalized Gauss-Laguerre quadrature formula for radial integration suggested by Yang, which achieve the highest convergence rate to the numerical integration. With the same number of integration points, the accuracy of the calculated results by this scheme is higher by 1 to 2 orders of magnitudes than that by other schemes. The reason for achieving higher accuracy by this scheme has been proposed preliminarily.

关键词： density functional theory partition function numerical integration Gaussian quadrature numerical error

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X-RAY POWDER DIFFRACTION DATA AND STRUCTURE REFINEMENT OF COMPOUND ErNi_2Si_2

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中国有色金属学会会刊：英文版 1998年第4期8卷 91-94页

作者： Yan, JL Ou, XL Zeng, lm Guangxi Univ Inst Mat Sci Nanning 530004 Peoples R China Tianjin Elect Mat Res Inst Tianjin 300192 Peoples R China

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｒａｒｅｅａｒｔｈｃｏｍｐｏｕｎｄｓＲＥＴ２Ｓｉ２，ｗｈｅｒｅＲＥｉｓａｒａｒｅｅａｒｔｈｅｌｅｍｅｎｔａｎｄＴｉｓａｔｒａｎｓｉｔｉｏｎｍｅｔａｌｅｌｅｍｅｎｔ，ｈａｖｅｂｅｅｎｓｔ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｒａｒｅｅａｒｔｈｃｏｍｐｏｕｎｄｓＲＥＴ２Ｓｉ２，ｗｈｅｒｅＲＥｉｓａｒａｒｅｅａｒｔｈｅｌｅｍｅｎｔａｎｄＴｉｓａｔｒａｎｓｉｔｉｏｎｍｅｔａｌｅｌｅｍｅｎｔ，ｈａｖｅｂｅｅｎｓｔｕｄｉｅｄｗｉｔｈｇｒｅａｔｉｎ?..

关键词： ErNi 2Si 2 X ray powder diffraction Rietveld structure refinement

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Time-Dependent Reliability Analysis of Offshore Structures

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China Ocean Engineering 1997年第2期12卷 151-160页

作者： Tang, lm Xi, X Department of Naval Architecture and Ocean Engineering Shanghai Jiaotong University Shanghai 200030 China

During the life of an offshore structure, its structural strength declines due to various kinds of damages related to the time factor. In this paper, four major kinds of damages, including damages caused by fatigue, dent, corrosion and marine life, are discussed. Based on these analyses, formulas for the evaluation of the damaged structure reliability are derived. Furthermore the computer program ISM for the analysis of structural reliability is developed by the use of Advanced First Order Second Moment method and Monte-Carlo Importance Sampling method. The reliability of a turbular joint and a beam are studied as numerical examples. The results show that the theory and the analysis method given in this paper are reasonable and effective.

关键词： structural reliability analysis fatigue damage dent damage corrosion damage Monte-Carlo importance sampling method

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Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts

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Journal of Animal Science and Biotechnology 2012年第1期3卷 25-31页

作者： Helena Emilia CCC Manso Helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira malc.lm watford Department of Animal Sciences Rural Federal University of PernambucoRecifePE52171-900Brazil Departament of Animal Sciences Federal University of CearáFortalezaCE60020-181Brazil Ajinomoto do Brazil S oPauloSP04015-001Brazil Department of Nutritional Sciences Rutgers UniversityNew BrunswickNJ08901USA.

Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut （2.5% by weight mixed into daily feed） provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased （P 〈 0.05） in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose （P 〈 0.05） during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend （P = 0.053）. Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development.

关键词： glutamate glutamine lactation milk pig skeletal muscle

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DIFFUSION WELDING FOR 6061 Al REINFORCED WITH SiCw WHISKER

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Journal of Wuhan University of Technology(Materials Science) 1999年第1期14卷 1-5页

作者： Niu, JT Liu, lm Han, LH Harbin Inst Technol Sch Mat Sci & Engn Harbin 150001 Peoples R China

The weldability of SiCw/6061Al -was investigated. From the results of experiments, it is found that the strength of joint is mainly influenced by welding temperature, and high strength of joint is obtained under melding temperature between liquidus and solidus of matrix alloy. Diffusion welding of SiCw/6061Al was successfully realized with appropriate ivelding parameters.

关键词： SiCw/6061Al composite diffusion welding welding temperature

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1,3-Dipolar Cycloaddition Reaction between Vinyl Acetate and N-Alkyl Hydroxypyridinium Halide

引用

Chinese Chemical Letters 2001年第12期12卷 1053-1054页

作者： Zhou, SF Su, JY Zeng, lm Zhongshan Univ Sch Chem & Engn Guangzhou 510275 Peoples R China

1, 3 Dipolar cycloaddition reaction between vinyl acetate and 3-hydroxypyridiniun betaine was performed under solid-liquid phase transfer catalytic condition, This reaction has been successfully used on the synthesis ... 详细信息

关键词： 1,3-dipolar cycloaddition 3-hydroxypyridiniun betaines dipolarphiles

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Densification of the Tungsten Heavy Alloys at 1473 K and Fabrication of W-Mo System FGM with Density Gradient

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Journal of Materials Science & Technology 1999年第3期15卷 229-232页

作者： Xiong, HP Zhang, lm Li, JG Yuan, RZ Wuhan Univ Technol State Key Lab Adv Technol Mat Synthesis & Proc Wuhan 430070 Peoples R China

The tungsten heavy alloys with Hi-Al and Fe-Al additives were sintered by hot-press method at 1473 K for 1 h. It was found that the relative density of the W-Fe alloy could be increased evidently by addition of Al. However, the relative density of W-Ni-Al alloy with low content of Al was conversely decreased considerably compared with that of W-Ni alloy. The causes have been studied. The sintering experiments of Mo alloy and W-Mo alloys with 3 wt pet Fe-1.5 wt pet Al additives were also carried out under the same sintering condition of low temperature. Finally, W-Mo system FGM with density gradient was successfully fabricated. Its density changed gradually from 17.0x10(3) kg/m(3) to 9.5x10(3) kg/m(3) within the middle 1.1 mm thickness range.

关键词： Tungsten alloys

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