检索结果-南通市图书馆

World Journal of Gastroenterology 2007年第7期13卷 993-996页

作者： N Thirumoorthy KT Manisenthil Kumar A Shyam Sundar L Panayappan malay chatterjee College of Pharmacy Kovai Estate Kalapatti Road Tamilnadu India Department of Pharmaceutical Technology Jadavpur University Kolkata India

Metallothioneins （MTs） were discovered in 1957 by Margoshes and Vallee and identified as low-molecular weight and sulphydryl rich proteins. It is not surprising that most mammalian tissues contain age related basal levels of MTs since they are involved in metalloregulatory processes that include cell growth and multiplication. In an effort to understand the biology of this intriguing tumor, various biomarkers such as oncogenes, p53 tumor suppressor gene, war 1 protein, proliferating cell nuclear antigen, telomerase, microsatellite markers and cytogenetic changes have been examined. One biomarker which has recently shown to be expressed in various human tumors but still less reported in carcinoma is MT. Immunohistochemical detection of MT proteins in cold acetone-fixed paraffin embedded liver sections was performed by the streptavidin-avidin-biotin immunoperoxidase complex method.

关键词： Metallothioneins Protective function Immuno-histochemical detection Anti-oxidant character Metal regulatory gene Oncogene Apoptosis Genotoxic Non-genotoxic environment Detoxification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model

引用

World Journal of Gastroenterology 2007年第48期13卷 6538-6548页

作者： Tridib Chakraborty Dipak Bhuniya Mary chatterjee Mosiur Rahaman Dipak Singha Baidya Nath chatterjee Subrata Datta Ajay Rana Kartick Samanta Sunil Srivastawa Sankar K Maitra malay chatterjee Chemical Carcinogenesis and Chemoprevention Laboratory Division of Biochemistry Department of Pharmaceutical Technology Jadavpur University Division of Medicinal Chemistry Indian Institute of Chemical Biology Jadavpur East Calcutta Girls' College Lake Town Cell Signaling Laboratory Cardiovascular and Cancer Research Institute College of Medicine The Texas A&M University System HSC Temple TX 76504 United States

AIM： To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma （EAC）- bearing murine model.METHODS： Male Swiss albino mice were divided into four groups： Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal （ip） inoculations of rapidly proliferating 2 × 10^5 viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract （ALE） of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation （ALE control）; and Group D was the EAC ＋ ALE- treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein （MT） protein, sister-chromatid exchanges （SCEs）, and DNA alterations.RESULTS： Treatment of the EAC-bearing mice with the ALE significantly （P 〈 0.001） reduced viable tumour cell count by 68.34% （228.7 × 10^6 ± 0.53） when compared to EAC control mice （72.4 × 10^6 ± 0.49）, and restored body and organ weights almost to the normal values. ALE administration also increased （P 〈 0.001） mean survival of the hosts from 35 ± 3.46 d in EAC control mice to 83 ± 2.69 d in EAC ＋ ALE-treated mice. Haematological indices also showed marked improvement with administration of ALE in EAC-bearing animals. There was a significant increase in RBC count （P 〈 0.001）, hemoglobin percent （P 〈 0.001）, and haematocrit value （P 〈 0.001） from 4.3 ± 0.12, 6.4 ± 0.93, and 17.63 ± 0.72 respectively in EAC control mice to 7.1 ± 0.13, 12.1 ± 0.77, and 30.23 ± 0.57 respectively in EAC ＋ ALE-treated group, along with concurrent de

关键词： Acanthus ilicifolius Chemoprevention DNA strand-breaks Ehrlich ascites carcinoma Haematological indices Medicinal plants Metallothionein Sister- chromatid exchange Transplantable tumour

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

1α,25-dihydroxyvitamin D_(3) prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital

引用

World Journal of Gastroenterology 2004年第9期10卷 1268-1275页

作者： Mahendrakumar Chandrasekharappa Banakar Suresh Kanna Paramasivan Mitali Basu Chattopadhyay Subrata Datta Prabir Chakraborty malay chatterjee Kalaiselvi Kannan Elayaraja Thygarajan Division of Biochemistry Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Environmental Science PSG College of Arts and ScienceCoimbatore 641014TamilnaduIndia

AIM:To investigate the chemopreventive iffects of 1α,25-dihydroxyvitamin D3 in diethylnitrosamine induced,phenobarbital promoted rat ***:The rats were randomly divided into 6 different groups(A-F).Group A,C and E rats received a single intraperitoneal (i.p) injection of diethylnitrosamine (DEN) at a dose of 200 mg/kg body mass in 9 g/L NaCl solution at 4 wk of age ,while group B served as normal vehicle control received normal saline *** a brief recovery of 2 WK, all the DEN treated rats were given phenobarbital (PB) at 0.5g/L daily in the basal diet till WK *** C was started 4 wk prior to DEN injection and continued thereafter till wk 20 at a dose (os) twice a *** E received the treatment of 1α,25-(OH)2D3 at the same dose mentioned as above for 15 *** rats in group D and F received 1α,25-(OH)2D3 alone as in group C without DEN ***:The comet assay showed statistically higher mean values for length to width ratios (L:W) of DNA mass and tailed cells (p<0.01;p<0.01 respectively) in DEN treated rats as compared to their normal *** supplementation of 1α,25-dihydroxyvitaminD3 showed a significant (p<0.01) decrease in L:W ratio of DNA mass tailed ***,1α,25-(OH)2D3 supplementations elevated the super oxide dismutase (SOD) activety,hepatic malondialdehyde(MDA) levle,reduced glutathione (GSH) and glutathione S-transferase (GST) activety (p<0.01,p<0.01,p<0.05 and p<0.05 respectively).As an endpoint marker histological changes were observed to establish the chemopreventive effects of 1α,***:Supplementations of 1α,25-(OH)2D3 has a marked protection against hepatic nodelogenesis,antioxidant enzymes and DNA damages in DEN induced rat hepatocarcinogenesis promoted by phenobarbital.

关键词： COMET ASSAY VITAMIN-D SUPEROXIDE-DISMUTASE LIPID-PEROXIDATION REPAIR CAPACITY S-TRANSFERASES BETA-CAROTENE CANCER CELLS LIVER GLUTATHIONE

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

multi-solitons interaction multicomponent plasma extended Poincare–Lighthill–Kuo method head-on collision

引用

Communications in Theoretical Physics 2016年第2期65卷 237-246页

作者： Kaushik Roy malay Kumar Ghorui Prasanta chatterjee Mouloud Tribeche Beluti M.K.M. High School P.O. -Beluti Dist. Birbhum West Bengal-731301 India Department of Mathematics Siksha Bhavana Visva Bharati University Santiniketan-731235 India plasma Physics Group Theoretical Physics Laboratory Faculty of Physics University of Bab-Ezzouar USTHB B.P. 32 E1 Alia Algiers 16111 Algeria

The propagation and interaction between ion acoustic multi-solitons in an unmagnetized multicomponent plasma consisting of fluid hot ions, positrons and both hot and cold electrons, are investigated by employing the extended Poincare–Lighthill–Kuo（PLK） method. Two different Kortewege-de Vries（K-dV） equations are derived. The Hirota＇s method is applied to get the K-dV multi-solitons solution. The phase shift due to the overtaking and head- on collision of the multi-solitons is obtained.

关键词： Head-on Collision of Ion-acoustic Multi-Solitons in e-p-i Plasma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia

引用

Chinese Journal of Cancer 2010年第12期29卷 969-979页

作者： Pratima Basak Sumanta chatterjee Prosun Das Madhurima Das Jacintha Archana Pereira Ranjan Kumar Dutta malay Chaklader Samaresh Chaudhuri Sujata Law Department of Biochemistry and Medical Biotechnology Stem Cell Research and Application Unit Calcutta School of Tropical Medicine

Background and Objective: Leukemic microenvironment has a major role in the progression of leukemia. Leukemic cells can induce reversible changes in microenvironmental components, especially the stromal function which results in improved growth conditions for maintaining the malignant leukemic cells. This study aimed to investigate the survival advantage of leukemic cells over normal hematopoietic cells in stromal microenvironment in long term. Methods: The mice were injected intraperitoneally with N-N’ ethylnitrosourea (ENU) to induce leukemia; the mice received injection of normal saline were used as control. At 180 days after ENU induction, the mice were killed and the bone marrows were cultured for 19 days. Colony-forming assays were used to analyze the formation of various cell colonies. The expression of Sca-1, CD146, VEGFR2, CD95, pStat3, pStat5, and Bcl-xL in marrow cells were detected by flow cytometry. Results: Long-term leukemic bone marrow culture showed abnormal elongated stromal fibroblasts with almost absence of normal hematopoietic cells. Adherent cell colonies were increased, but CFU-F and other hematopoietic cell colonies were significantly decreased in leukemia group (P< 0.001). Primitive progenitor-specific Sca-1 receptor expression was decreased with subsequent increased expression of CD146 and VEGFR-2 in leukemic bone marrow cells. Decreased Fas antigen expression with increased intracellular pStat3, pStat5 and Bcl-xL proteins were observed in leukemic bone marrow cells. Conclusions: Stromal microenvironment shows altered morphology and decreased maturation in leukemia. Effective progenitor cells are decreased in leukemia with increased leukemia-specific cell population. Leukemic microenvironment plays a role in promoting and maintaining the leukemic cell proliferation and survivability in long term.

关键词：白血病细胞环境基质造血功能小鼠负调控造血微环境骨髓细胞集落形成

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development and Characterization of Al_2O_3 Dispersed Al/Mg/Cu/Ti Matrix Composite

引用

Journal of Materials Science & Technology 2013年第11期29卷 1085-1090页

作者： Sumit Chabri Subhranshu chatterjee Santanu Pattanayak Himel Chakraborty Nandagopal Bhowmik Arijit Sinha Department of Metallurgy and Materials Engineering Bengal Engineering and Science University School of Materials Science and Engineering Bengal Engineering and Science University

The effect of dispersion with different weight fractions of Al2O3 particles in metallic matrices （AI/Mg/Ti/Cu） fabricated by powder metallurgy was investigated. In the case of 15 wt% Al2O3 reinforced composites, peak hardness was attained which subsequently decreased with increasing the content of Al2O3. A correlation between the microhardness and nanomechanical properties at submicron scale was examined for all the composites. Specific strength and specific modulus were measured in order to figure out the performance of the composites.

关键词： Metal matrix composites Powder metallurgy Hardening Coarsening Hardness Nanoindentation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：