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Treatment of severe steroid refractory ulcerative colitis

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World Journal of Gastroenterology 2008年第36期14卷 5508-5511页

作者： Gert Van Assche séverine Vermeire Paul Rutgeerts Division of Gastroen-terology University of Leuven Hospitals Herestraat 49 B-3000 Leuven Belgium Division of Gastroenterology University of Leuven Hospitals Herestraat 49 B-3000 Leuven Belgium

Although systemic steroids are highly efficacious in ulcerative colitis (UC), failure to respond to steroids still poses an important challenge to the surgeon and physician alike. Even if the life time risk of a fulminant UC flare is only 20%, this condition is potentially life threatening and should be managed in hospital. If patients fail 3 to 5 d of intravenous corticosteroids and optimal supportive care, they should be considered for any of three options: intravenous cyclosporine (2 mg/kg for 7 d, and serum level controlled), infliximab (5 mg/kg Ⅳ, 0-2-6 wk) or total colectomy. The choice between these three options is a medical- surgical decision based on clinical signs, radiological and endoscopic findings and blood analysis (CRP, serum albumin). Between 65 and 85% of patients will initially respond to cyclosporine and avoid colectomy on the short term. Over 5 years only 50% of initial responders avoid colectomy and outcomes are better in patients naive to azathioprine (bridging strategy). The data on infliximab as a medical rescue in fulminant colitis are more limited although the efficacy of this anti tumor necrosis factor (TNF) monoclonal antibody has been demonstrated in a controlled trial. Controlled data on the comparative efficacy of cyclosporine and infliximab are not available at this moment. Both drugs are immunosuppressants and are used in combination with steroids and azathioprine, which infers a risk of serious, even fatal, opportunistic infections. Therefore, patients not responding to these agents within 5-7 d should be considered for colectomy and responders should be closely monitored for infections.

关键词： Ulcerative colitis steroids Corticosteroids Azathioprine Cyclosporine Infliximab Imrnunosuppressants

A Note on Hermitian-Einstein Metrics on Parabolic stable Bundles

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Acta Mathematica sinica,English series 2001年第1期17卷 77-80页

作者： Jia Yu LI M. s. NARAsIMHAN Institute of Mathematics Academy of Mathematics and System Sciences Academia Sinica Institute of Mathematics Fudan University Mathematics section International Centre for Theoretic Physics

Let M be a compact complex manifold of complex dimension two with a smooth K hler metric and D a smooth divisor on . If E is a rank 2 holomorphic vector bundle on M with a stable parabolic structure along D, we prove that there exists a Hermitian-Einstein metric on E’=E|sub> \Dsub> compatible with the parabolic structure, whose curvature is square integrable.

关键词： Hermitian-Einstein metric Parabolic stable bundle Kahler manifold

GIs-Practical Experience in the Boundaries Definition of the Platform Deep Crustal Blocks on the studying of the Earth＇s surface Fractal Divisibility： Example of the White sea-Kuloi Plateau

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Journal of Geodesy and Geomatics Engineering 2016年第1期3卷 19-24页

作者： I. s. sergeev st. Petersburg state University Institute of Earth Sciences Russia

This study examines the use of the geographic information systems （GIs） in structural geomorphology to build the model of the crust based on fractal analysis of relief. Fractal theory, developed by B. Mandelbrot, used to determination morpho-bloc divisibility of the Earth＇s surface. There is the traceable statistically recurring relief structure indicate the appropriate tiered hierarchy of crustal blocks forming the tectonic and kinematic layers. This hypothesis tested on a digital elevation model （DEM） of the White sea-Kuloi Plateau -- an area of tectonic and magmatic activity of the Paleozoic era. Found the correlation of position the kimberlite magmatic bodies with the tectonic blocks certain depth according to a flactal analysis.

关键词： structural relief tectonic blocs geographic information systems digital elevation model fractal dimension.

Resolution of Hardy’s Paradox within spacetime Physics and the Ithaca Interpretation of Quantum Mechanics

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World Journal of Condensed Matter Physics 2018年第2期8卷 23-29页

作者： Mohamed s. El Naschie Dept. of Physics Faculty of Science University of Alexandria Alexandria Egypt

By religiously adhering to physics in spacetime and taking the final verdict of N.D. Mermin’s Ithaca interpretation of quantum mechanics seriously, Hardy’s paradox is completely resolved. It is then concluded that logical and mathematically consistent physical theories must be put in spacetime related formalism such as noncommutative geometry and E-infinity theory to avoid quantum paradoxes. At a minimum, we should employ the philosophy behind consistent quantum interpretation such as that of the famous Ithaca interpretation of D. Mermin.

关键词： Hardy’s Paradox Mermin’s Ithaca Interpretation Hardy’s Quantum Entanglement Noncommutative Geometry E-Infinity Fractal-Cantorian spacetime Golden Mean Number system

From Nikolay Umov E=kmc^(2) via Albert Einstein’s E=γmc^(2) to the Dark Energy Density of the Cosmos E=(21 22)mc^(2)

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World Journal of Mechanics 2018年第4期8卷 73-81页

作者： Mohamed s.El Naschie Department of Physics Faculty of ScienceUniversity of AlexandriaAlexandriaEgypt

The paper starts from the remarkable classical equation of the great nineteenth century Russian physicist Nikolay Umov E=kmc2 where 1/2≤k≤1, m is the mass, c is the speed of light and E is the equivalent energy of m. After a short but deep discussion of the derivation of Umov we move to Einstein’s formula E=γmc2?where γis the Lorentz factor of special relativity and point out the interesting difference and similarity between Umov’s k and Lorentz-Einstein γ. This is particularly considered in depth for the special case which leads to the famous equation?E=mc2?that is interpreted here to be the maximal cosmic energy density possible. subsequently we discuss the dissection of E=mc2 into two components, namely the cosmic dark energy density E(D)=(21/22)MC2 and the ordinary energy density E(O)=MC2/22? where?E(D)+E(O)=MC2. Finally we move from this to the three-part dissection where we show that E is simply the sum of pure dark energy E(PD) plus dark matter energy E(DM) as well as ordinary energy E(O).

关键词： N.Umov Energy A.Einstein Energy El Naschie Energy Ordinary Cosmic Energy Cosmic Dark Energy F.Hasenohrl’s Electromagnetic Energy H.Poincaré History of special Relativity

Quantum chemical study on the thermal Diels-Alder reaction of cyclohexadiene and methyl crotonate

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Chinese Journal of Chemistry 1997年第1期15卷 21-24页

作者： Li, YH Hong, sG Wang, s Peng, YY Department of Chemistry Jiangxi Normal University Nanchang Jiangxi 330027 China

AM1 molecular orbital method using the unrestricted Hartree-Fock(UHF) calculations has been applied to investigate the thermal reaction of cyclohexadiene and methyl crotonate. The calculated results indicate that the ... 详细信息

关键词： thermal Diels-Alder reaction concerted and radical pathways transition state UHF/AM1 method

COVID-19 associated diabetes mellitus: A review

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World Journal of Diabetes 2022年第9期13卷 729-737页

作者： Ajay M Gavkare Neeta Nanaware Abhijit s Rayate sachin Mumbre Basavraj s Nagoba Physiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531MaharashtraIndia Physiology Vilasrao Deshmukh Government Medical CollegeLatur 413512MaharashtraIndia surgery Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531MaharashtraIndia Community Medicine Ashwini Rural Medical CollegeSolapur 413006MaharashtraIndia Microbiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531MaharashtraIndia

A significantly higher rate of new-onset diabetes in many coronavirus disease 2019(COVID-19)patients is a frequently observed *** resultant hyperglycemia is known to influence the clinical outcome,thereby increasing the cost of treatment and stay in *** will also affect the post-hospitalization *** has been observed that new-onset diabetes in COVID-19 patients is associated with considerable increase in morbidity and may be associated with increased mortality in some *** mini-review focuses on the possible causes to understand how COVID-19-related diabetes develops,various associated risk factors,and possible mechanism to understand the natural history of the disease process,clinical outcome,associated morbidities and various treatment options in the mana-gement of post COVID-19 diabetes.A literature search was performed in PubMed and other online database using appropriate keywords.A total of 80 articles were found,among which,53 of the most relevant were evaluated/analyzed and relevant data were *** studies show that patients who have had severe acute respiratory syndrome coronavirus 2 infection leading to development of COVID-19 may manifest not only with new-onset diabetes but also worsening of pre-existing *** effect and autoimmune destruction of insulin-secreting pancreatic beta cells,cytokine storm during the active phase of infection causing impaired insulin secretion and resistance,druginduced hyperglycemia,undetected pre-existing hyperglycemia/diabetic condition,and stress-induced impairment of glucose metabolism are some of the possible potential mechanisms of COVID-19-associated new-onset diabetes *** studies published in recent times have found a significantly higher rate of new-onset diabetes mellitus in many COVID-19 *** it is an inflammatory or immune-mediated response,direct effect of virus or combination of these is *** resultant hyperglycemia is known t

关键词： Coronavirus disease 2019 Coronavirus disease 2019 associated diabetes Coronavirus disease 2019 related diabetes Hyperglycemia in coronavirus disease 2019 patients New-onset diabetes Postcoronavirus disease 2019 diabetes

Hybrid Isothermal Model for the Ferrohydrodynamic Chemically Reactive species

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Communications in Theoretical Physics 2019年第4期71卷 384-392页

作者： Noor Muhammad s.Nadeem M.T.Mustafa Department of Mathematics Quaid-I-Azam University 45320 Department of Mathematics Statistics & Physics Qatar University

A hybrid isothermal model for the homogeneous-heterogeneous reactions in ferrohydrodynamic boundary layer ?ow is established. The characteristics of Newtonian heating and magnetic dipole in a ferro?uid due to a stretchable surface is analyzed for three chemical species. It is presumed that the isothermal cubic autocatalator kinetic gives the homogeneous reaction and the ?rst order kinetics gives the heterogeneous(surface) reaction. The analysis is carried out for equal diffusion coe?cients of all autocatalyst and reactions. Heat ?ux is examined by incorporating Fourier's law of heat conduction. Characteristics of materialized parameters on the magneto-thermomechanical coupling in the ?ow of a chemically reactive species are investigated. Further, the heat transfer rate and friction drag are depicted for the ferrohydrodynamic chemically reactive species. It is evident that the schmidt number has increasing behavior on the rate of heat transfer in the boundary layer. Comparison with available results for speci?c cases is found an excellent agreement.

关键词： ferromagnetic fluid hybrid chemically reactive species Newtonian heating heat transfer friction drag

Inference by exclusion in the red-tailed black cockatoo(Calyptorhynchus banksii)

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Integrative Zoology 2019年第2期14卷 193-203页

作者： Lorraine sUBIAs. Andrea s.GRIFFIN David GUEZ school of Psychology James Cook UniversityCairnsAustralia school of Psychology University of NewcastleCallaghanAustralia

Inference by exclusion is the ability to select a given option by excluding the *** designed appropriately,tests of this ability can reveal choices that cannot be explained by associative *** the past decade,exclusion reasoning has been explored in several non-human taxonomic groups,including birds,mainly in Corvids and *** increase our understanding of the taxonomic distribution of exclusion reasoning and,therefore,its evolution,we investigated exclusion performances in red-tailed black cockatoos(Calyptorhynchus banksii),an Australian relative of the Goffin cockatoo(Cacatua goffini),using a food-finding ***atoos were required to find a food item hidden in 1 of the 2 experimenter’s *** training sessions in which they reliably selected the closed baited hand they had just been shown open,each individual was tested on 4 different *** to demonstrating exclusion reasoning was the condition in which they were shown the empty hand and then offered a choice of both closed *** performance of all birds was above chance on all experimental conditions but not on an olfactory and/or cuing control *** results suggest that the birds might be able to infer by exclusion,although an explanation based on rule learning cannot be *** first experiment in red-tailed black cockatoo highlights the potential of this species as a model to study avian cognition and paves the pathway for future investigations.

关键词： cognition comparative cognition inferential reasoning parrot cognition Psittaciforms