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Relationship between hepatitis C virus infection and type 2 diabetes mellitus:Meta-analysis

World Journal of Gastroenterology 2012年第14期18卷 1642-1651页

作者： Cho Naing Joon Wah Mak Syed Imran Ahmed mala maung Faculty of Medicine and Health International Medical UniversityKuala Lumpur 57000Malaysia

AIM:To investigate the association between hepatitis C infection and type 2 diabetes ***:Observational studies assessing the relationship between hepatitis C infection and type 2 diabetes mellitus were identified via electronic and hand *** published between 1988 to March 2011 were screened,according to the inclusion criteria set for the present *** performed separate analyses for the comparisons between hepatitis C virus(HCV) infected and not infected,and HCV infected and hepatitis B virus *** included studies were further subgrouped according to the study *** was assessed using I2 *** summary odds ratios with their corresponding 95% CIs were calculated based on a random-effects *** included studies were subgrouped according to the study *** assess any factor that could potentially affect the outcome,results were further stratified by age group(proportion of ≥ 40 years),gender(proportion of male gender),body mass index(BMI)(pro-portion of BMI ≥ 27),and family history of diabetes(i.e.,self reported).For stability of results,a sensitivity analysis was conducted including only prospective ***:Combining the electronic database and hand searches,a total of 35 observational studies(in 31 articles) were identified for the final *** on random-effects model,17 studies(n = 286 084) compared hepatitis C-infected patients with those who were uninfected [summary odds ratio(OR):1.68,95% CI:1.15-2.45].Of these 17 studies,7 were both a cross-sectional design(41.2%) and cohort design(41.2%),while 3 were case-control studies(17.6%).Nineteen studies(n = 51 156) compared hepatitis C-infected participants with hepatitis B-infected(summary OR:1.92,95% CI:1.41-2.62).Of these 19 studies,4(21.1%),6(31.6%) and 9(47.4%) were cross-sectional,cohort and case-control studies,respectively.A sensitivity analysis with 3 prospective studies indicated that hepatitis C-infected patients had a

关键词： Hepatitis C Type 2 diabetes mellitus Observational studies Meta-analysis

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