检索结果-南通市图书馆

Neural Regeneration Research 2012年第22期7卷 1715-1721页

作者： Sung Eun Kim ll Gyu Ko mal soon shin Chang Ju Kim Young Gwan Ko Hanjin Cho Department of Physiology College of Medicine Kyung Hee University Department of Emergency Medicine College of Medicine Kyung Hee University Department of Emergency Medicine Korea University Ansan Hospital

Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyI-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.

关键词： wintracerebral hemorrhage organotypic hippocampal slice culture bovine colostrum apoptotic celldeath N-methyI-D-aspartic acid caspase-3 hippocampus memory

Neuroprotective effects of tamsulosin on intracerebral hemorrhage

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2011年第32期6卷 2505-2510页

作者： Hong-Jin Suh Sung-Min So Young-Gil Na Il-Gyu Ko Sung-Eun Kim Yun-Hee Sung mal-soon shin Chang-Ju Kim Young-Sam Cho Khae-Hawn Kim Department of Urology Incheon St. Mary's Hospital the Catholic University of Korea School of Medicine Department of Urology Chungnam National University School of Medicine Department of Physiology Kyung Hee University School of Medicine Department of Urology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Urology Gachon University Gil Hospital Gachon University of Medicine and Science

The alpha1 adrenoreceptor antagonist tamsulosin is primarily used to treat benign prostatic hypertrophy. In this study, we intragastrically administered rats with 0.01,0.1 and 1 mg/kg tamsulosin to investigate the effects of tamsulosin on memory function, and hippocampal cell apoptosis and proliferation following intracerebral hemorrhage. Step-down avoidance task results showed that tamsulosin treatment markedly alleviated intracerebral hemorrhage- induced short-term memory impairment. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling results showed that tamsulosin treatment markedly suppressed intracerebral hemorrhage-induced caspase-3 expression in the hippocampal CA1 region and cell proliferation in the hippocampal dentate gyrus. Tamsulosin treatment at a dose of 0.01 mg/kg exhibited the most potent inhibitory effects on cell apoptosis and proliferation. These findings suggest that tamsulosin treatment facilitates the recovery of rat memory function by inhibiting hippocampal cell apoptosis and proliferation followincl intracerebral hemorrhaQe.

关键词： tamsulosin, intracerebral hemorrhage short-term memory apoptosis cellproliferation hippocampus neural regeneration

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin shin Sun-Young Kwon Sojin shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Optimal rotor wear design in hypotrochoidal gear pump using genetic algorithm

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第3期18卷 718-725页

作者： KWON soon-man KIM Chang-Hyun shin Joong-ho Department of Mechanical Design and Manufacturing Engineering Changwon National University

The wear rate between the rotors of a hypotrochoidal gear pump is *** the knowledge of shape design on the rotors,the contact stresses without hydrodynamic effect between the rotor teeth were evaluated through the calculation of the Hertzian contact *** on the above results and the sliding velocity between the rotors,a genetic algorithm (GA) was used as an optimization technique forminimizing the wear rate proportional factor (WRPF).The result shows that the wear rate or the WRPF can be reduced considerably,*** 12.8%,throughout the optimization using GA.

关键词： gerotor hypotrochoidal gear pump Hertzian contact stress wear rate proportional factor genetic algorithm

Kinematical system of breadth cam profile design

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第2期18卷 451-457页

作者： shin Joong-ho 李琳 YANG Hyun-dai KWON soon-man Department of Mechanical Design & Manufacturing Changwon National University

The design solutions for breadth cam mechanism was presented. The main topics of the shape design for breadth cam was to calculate the coordinate at each contact point to determine the cam profile. The proposed method according to velocity and geometric relationships of instant velocity centers can easily determine each contact point at any instant moment. The cam profile was defined by contouring of the contact points. And also a program was developed by using Microsoft Visual C++ program,which can quickly and easily draw a 2D cam profile through the displacement diagram. Finally,the program was used to confirm the accuracy on the breadth cam profile design by computer animation graphically.

关键词： cam profile breadth cam reciprocating follower oscillating follower instant velocity center

Structural identification of active moiety in anti-tumor metastatic polysaccharide purified from fermented barley by sequential enzymatic hydrolysis

在线全文

学校读者我要写书评

暂无评论

Food Bioscience 2022年第6期50卷 139-149页

作者： Seung-U Son Han Wool Kim Kwang-soon shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea

The potent anti-cancer metastatic effects induced by the immunostimulatory activities of intravenously administered BF–I,an active polysaccharide purified from fermented barley,were previously *** study aimed to evaluate the anti-cancer metastatic effect of orally administered BF–I and elucidated the microstructure and active moiety of BF–I using sequential enzymatic *** experiments using Colon26-M3.1 carcinoma,prophylactic oral administration of BF–I potently suppressed lung cancer ***,gas chromatography-mass spectrometry analysis of partially methylated alditol acetate showed that BF–I comprised 15 different glycosyl linkages,including 4-linked Xylp(16.1%),terminal Araf(12.4%),4-linked Glcp(32.8%),3-linked Glcp(13.5%),3,6-linked Glcp(1.5%),and 3,6-linked Galp(5.3%).These glycosyl linkage combinations are typical for arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II *** clarify the microstructure,BF–I was sequentially degraded via linkage-specific enzymatic hydrolysis using five ***,the sugar composition,glycosyl linkage,and reactivity with theβ-glucosyl Yariv reagent were analyzed,along with sequencing based on tandem mass spectra of partially degraded fragment *** results confirmed that BF–I comprises a mixture of four different types of polysaccharides(arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II arabinogalactan)with similar molecular ***,different polysaccharides contribute significantly to cytokine(interleukin-6,-12,and tumor necrosis factor-α)secretion by peritoneal ***,the potent anti-cancer metastatic activity of BF–I is proposed to be related to the immunostimulatory activities of the four different types of polysaccharides.

关键词： Barley Polysaccharide structure Anti-cancer Enzymatic hydrolysis

Moving Personal-Cell Network: Characteristics and Performance Evaluation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2018年第12期15卷 159-173页

作者： Syed Tariq Shah Minsu shin Young Min Kwon JaeSheung shin Ae-soon Park Min Young Chung Department of Electrical and Computer Engineering Sungkyunkwan University Department of Telecommunication Engineering FICT Balochistan University of Information Technology Engineering and Management Sciences Mobile Access Research Division Electronics and Telecommunications Research Institute

Recent years have witnessed a huge demand for ubiquitous communications services from continuously moving users. In order to provide seamless network services to high-mobility users, one of the promising solution proposed by 3 GPP is the deployment of moving-relays. In this article, we introduce the concept of Moving-Personal-Cell(mPC), which is a type of moving-relays. mPC is a user-centric network, which aims to provide reliable network services to moving users. A mPC receives data-traffic from eNB and its neighboring mPCs via wireless backhaul and sidehual links respectively and forwards the received data to its serving users. In addition to this, mPC can also increase the network capacity by caching and distributing the popular contents to its serving users. Besides these pros, the mPC also has some limitations, as its performance is highly affected by cross-tier and co-tier interferences. In this article, we analyze the effect of these interferences on mPCs performance. Our results show that the performance of mPC network is equally affected by the capacity of wireless backhaul, sidehaul, and access links. Moreover, since mPCs accommodate data traffic from wireless backhaul, sidehaul links, and content cache, their performance is also affected by the ratio of data-traffic delivered via these links.

关键词： heterogeneous networks moving small cells fixed small cells moving cache network performance evaluation next generation networks

Dual cycloid gear mechanism for automobile safety pretensioners

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2012年第2期19卷 365-373页

作者： shin Joong-ho KIM Chang-hyun YUN Pyeong-hwa KWON soon-man Department of Mechanical Design and Manufacturing Changwon National University

The most conventional vehicle pretensioner system consists of an internal gear pair with involute teeth. However, it has been well known that the corresponding gear pairs are relatively weak under the situation of impact loadings. To improve this phenomenon, a new pretensioning gear system with cycloid teeth rather than the involute ones was proposed, and dual cycloidal gear mechanisms were designed for satisfying geometric constraints and dynamic loading conditions. The simulations of the prototypes were conducted by LS-DYNA program and the experiments for a prototype were performed for a dynamic model with impact loading devices. The results show that the better operation and the smoother motion are confirmed in the proposed cycloidal gear system rather than the conventional one without interferences between gear teeth under the impact of a crash.

关键词： seat belt pretensioner internal gear pairs involute gear dual cycloid gear

Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subhash Kanase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed Kwang-soon Ahn Jun-Seok Ha Uk Sim Hyeyoung shin soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

Effects of intravenous administration of polysaccharide purified from fermented barley on tumor metastasis inhibition via immunostimulating activities

在线全文

学校读者我要写书评

暂无评论

Food Bioscience 2022年第5期49卷 130-138页

作者： Seung-U Son Han Wool Kim Min Seung Park Kwang-soon shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceGraduate SchoolKorea UniversitySeoul02841Republic of Korea

The present study was aimed that determine the effects of polysaccharide isolated from fermented barley about tumor metastasis inhibition via immune related factors such as complementary system,macrophages,natural killer(NK)cells,and cytotoxic T lymphocyte(CTL).To characterize the tumor inhibition effects through immunostimulation of polysaccharides purified from fermented barley,the active crude polysaccharide(BF-CP)was isolated from fermented barley and further fractionated into three purified polysaccharides(BF-I,-II,and-III)with different molecular weights through gel permeation ***-I was mainly composed of four monosaccharides,including xylose(32.90%),arabinose(26.71%),and glucose(33.43%).BF-I augmented the secretion of cytokines,such as interleukin(IL)-6,IL-12,and tumor necrosis factor-α,through peritoneal macrophages and potently activated the complement *** the experiment for NK cells and CTL activities,intravenous(i.v.)administration of BF-I significantly augmented the cytotoxicity of NK cells and CTL-mediated cytotoxicity against tumor *** addition,*** of BF-I potently inhibited tumor metastasis in a mouse model of lung cancer and tumor metastasis in mice with suppressed NK cell function through anti-asialo ***,BF-I shows potent tumor inhibition effects,and these effects are related to various immune factors such as macrophages,the complement system,NK cells,and ***,BF-I,the polysaccharide purified from fermented barley possess the new possibility for developing functional foods and medical ingredients.

关键词： Fermented barley Polysaccharide Immune system Anti-cancer