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Innate Immunity in the Development of Connective Tissue Dysplasia: Pilot Study in Children with Congenital Hip Dislocation

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Journal of Biosciences and Medicines 2022年第7期10卷 155-170页

作者： Anna Borisovna Yazykova Irina Vladimirovna Musikhina maksim valeryevich vlasov Petr Stanislavovich Vvedenskiy Mikhail Yuryevich Lebedev Biochemistry Department Privolzhsky Research Medical University Nizhniy Novgorod Russian Federation Department of Children Orthopedics Privolzhsky Research Medical University Nizhniy Novgorod Russian Federation Laboratory of Immunology Privolzhsky Research Medical University Nizhniy Novgorod Russian Federation

Introduction: Observing and treatment of hip dysplasia in children have always been in the sphere of interest of modern molecular medicine. The role of molecular factors in the formation of connective tissue dysplasia in children is considered crucial for such multisystem disorders, and connective tissue dysplasia progressing involves immune system parameters and biochemical markers. The aim of this work was to establish the relationship between immune status indicators and biochemical markers of connective tissue using bioinformatics and modeling methods. Materials and Methods: 27 patients with congenital hip dislocation, admitted to the University Clinic of Privolzhsky Research Medical University, Department of children orthopedics for surgical treatment, were examined. Determination of 10 blood parameters was conducted by modern biochemical and immunological methods. Statistica 12.0 software from StatSoft was used for statistical data processing. Methods of nonparametric statistics were used since the samples in the control group partially follow the normal distribution. Correlation methods and regression modeling methods were used to evaluate the relationship of indicators. Results and Conclusion: In our investigation we have shown the presence of statistical and mathematical interactions between the parameters of innate immunity and indicators of connective tissue metabolism. The leading role of the immune system in the development of pathologies associated with connective tissue dysplasia is assumed. In further investigations it is necessary to clarify the role hypoxia in HIF-1 stimulated control of skeletal dysplasia, collagen modification, connective tissue dysplasia development.

关键词： Congenital Dysplasia Congenital Hip Dislocation Connective Tissue Metabolism Biomarkers Immune System

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The Global Energy and Water Exchanges(GEWEX)Project in Central Asia:The Case for a Regional Hydroclimate Project

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Advances in Atmospheric Sciences 2024年第5期41卷 777-783页

作者： Michael BRODY maksim KULIKOV Sagynbek ORUNBAEV Peter J.VAN OEVELEN International Agricultural University Tashkent 111200Uzbekistan George Mason University FairfaxVirginia 22030USA University of Central Asia Bishkek 720001Kyrgyz Republic American University of Central Asia Bishkek 720060Kyrgyz Republic International GEWEX project George Mason UniversityFairfaxVirginia 22030USA

Central Asia consists of the former Soviet Republics,Kazakhstan,Kyrgyz Republic,Tajikistan,Turkmenistan,and *** region’s climate is continental,mostly semi-arid to *** is a significant part of the region’s *** its nature of intensive water use,agriculture is extremely vulnerable to climate *** growth and irrigation development have significantly increased the demand for water in the *** climate change issues include melting glaciers and a shrinking snowpack,which are the foundation of the region’s water resources,and a changing precipitation *** glaciers are located in Kyrgyzstan and Tajikistan,leading to transboundary water resource *** already has extremely high *** indicate that Central Asia has been warming and precipitation might be *** warming is expected to increase,but its spatial and temporal distribution depends upon specific global *** of future precipitation show significant uncertainties in type,amount,and *** Hydroclimate Projects(RHPs)are an approach to studying these *** steps to develop an RHP began in 2021 with a widely distributed online survey about these climate *** was followed up with an online workshop and then,in 2023,an in-person workshop,held in Tashkent,*** for the Global Energy and Water Exchanges(GEWEX)project for the region include both observations and modeling,as well as development of better and additional precipitation observations,all of which are topics for the next workshop.A well-designed RHP should lead to reductions in critical climate uncertainties in policy-relevant timeframes that can influence decisions on necessary investments in climate adaptation.

关键词： GEWEX Central Asia climate change agriculture

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Agglomeration of coal and polyethylene mixtures during fixed‑bed co‑gasification

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International Journal of Coal Science & Technology 2024年第2期11卷 91-100页

作者： Igor G.Donskoy Aleksandr N.Kozlov maksim V.Penzik Denis A.Svishchev Lu Ding Melentiev Energy Systems Institute Russian Federation130 Lermontova StreetIrkutskRussia 664033 East China University of Science and Technology 130 Meilong RoadShanghai 200237China

The article presents the results of experimental studies on the gasification of mixtures of brown coal and polyethylene(up to 20 wt%fraction)in a laboratory *** work aims to study the agglomeration process during the heating and oxidation of the *** measurement results(gas composition,pressure drop)provide indirect information on the dynamics of thermal decomposition and structural changes in the fuel *** have shown that the interaction between polyethylene and a coal surface leads to the formation of dense agglomerates,in which the molten polymer acts as a *** form as a result of interfacial interactions between components and filtration flow *** hydrogen/carbon ratio in the solid residue of coal-polyethylene co-gasification increases from 0.07–0.2 to 1.11,indicating the formation of stable hydrocarbon compounds on the carbon *** conducted research makes it possible to identify possible interactions between chemical reactions and transfer processes that lead to agglomeration in mixtures of coal with polyethylene.

关键词： Coal Polyethylene Gasification Combustion Agglomeration

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Fibroblasts:Origins,definitions,and functions in health and disease

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四川生理科学杂志 2024年第4期46卷 735-735页

作者： maksim V Plikus 不详

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and disease by producing complex extracellular matrix and creating signaling niches through biophysical and biochemical *** and functionally heterogeneous across and within organs,fibroblasts encode regional positional information and maintain distinct cellular *** summarize their development,lineages,functions,and contributions to fibrosis in four fibroblast-rich organs:skin,lung,skeletal muscle,and *** propose that fibroblasts are uniquely poised for tissue repair by easily reentering the cell cycle and exhibiting a reversible plasticity in phenotype and cell fate.

关键词： organs homeostasis maintain

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Digital Earth surface maps for radar ground clutter simulation

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Journal of Systems Engineering and Electronics 2022年第2期33卷 340-344页

作者： ORESHKINA Margarita STEPANOV maksim KISELEV Alexey Novosibirsk State Technical University Novosibirsk 630073Russia

This paper dwells upon optimizing the azimuth samp-ling interval of digital surface maps used to model radar ground *** resulting equations can be used to find the digital map sampling interval for the required calculation error and modeled power of the simulated signal,which determines the resulting distribution of backscatter *** paper further showcases how the sampling interval could be increased by pre-processing the map.

关键词： ground clutter mathematical modelling radar simulation

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The influence of collision energy on magnetically tuned^(6)Li-^(6)Li Feshbach resonance

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Chinese Physics B 2022年第6期31卷 326-333页

作者：张蓉韩永昌丛书林 maksim B Shundalau Department of Physics Dalian University of TechnologyDalian 116024China DUT-BSU Joint Institute Dalian University of TechnologyDalian 116024China Physics Department Belarusian State UniversityMinskBelarus

The effect of collision energy on the magnetically tuned^(6)Li-^(6)Li Feshbach resonance(FR)is investigated theoretically by using the coupled-channel(CC)method for the collision energy ranging from 1μK·kBto 100μK·*** the collision energy of 1μK·kB,the resonance positions calculated are 543.152 Gs(s wave,the unit 1 Gs=10^(-4)T),185.109 Gs(p wave|ml|=0),and 185.113 Gs(p wave|ml|=1),*** p-wave FR near 185 Gs exibits a doublet structure of 4 mGs,associated with dipole-dipole *** the increase of the collision energy,it is found that the splitting width remains the same(4 mGs),and that the resonance positions of s and p waves are shifted to higher magnetic fields with the increase of collision *** variations of the other quantities including the resonance width and the amplitude of the total scattering section are also discussed in *** thermally averaged elastic rate coefficients at T=10,15,20,25 K are calculated and compared.

关键词： Feshbach resonance collision energy ^(6)Li-^(6)Li system

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Azoximer bromide and hydroxyapatite:promising immune adjuvants in cancer

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Cancer Biology & Medicine 2023年第12期20卷 1021-1034页

作者： Jean-François Rossi Patrick Frayssinet maksim Matciyak Nikolai Tupitsyn Institut du Cancer Avignon-Provence Sainte Catherine–Department of Hematology-BiotherapyAvignon 84918France University of Montpellier UFR MédecineMontpellier 34090France HASTIM Inc. Rue de CauletToulouse 31300France Petrovax NPO Pharm Moscow 123112Russia Laboratory of Immunology of Hematopoiesis N.N.Blokhin Cancer Research Center(RCRC)Moscow 123112Russia

Immune adjuvants are immune modulators that have been developed in the context of infectious *** is currently a growing interest in immune adjuvants due to the development of immunotherapy against *** adjuvant mechanisms of action are focused on the initiation and amplification of the inflammatory response leading to the innate immune response,followed by the adaptive immune *** main activity lies in the support of antigen presentation and the maturation and functions of dendritic *** immune adjuvants are associated with a vaccine or incorporated into the new generation of m RNA *** immune adjuvants are used as ***(HA)ceramics and azoximer bromide(AZB)are overlooked molecules that were used in early clinical trials,which demonstrated clinical efficacy and excellent tolerance *** combined in an autologous vaccine was previously developed in the veterinary field for use in canine spontaneous ***,an original immune modulator derived from a class of heterochain aliphatic polyamines that is licensed in Russia,the Commonwealth of Independent States,and Slovakia for infectious and inflammatory diseases,is and now being developed for use in cancer with promising *** two immune adjuvants can be combined in various immunotherapy strategies.

关键词： Immune adjuvants cancer azoximer bromide hydroxyapatite Toll receptor agonists immunotherapy

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Triggering of Major Brain Disorders by Protons and ATP:The Role of ASICs and P2X Receptors

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Neuroscience Bulletin 2023年第5期39卷 845-862页

作者： Andri Cherninskyi maksim Storozhuk Oleksandr Maximyuk Vyacheslav Kulyk Oleg Krishtal Bogomoletz Institute of Physiology of National Academy of Sciences of Ukraine Kyiv 01024Ukraine

Adenosine triphosphate(ATP)is well-known as a universal source of energy in living *** known is that this molecule has a variety of important signaling func-tions:it activates a variety of specific metabotropic(P2Y)and ionotropic(P2X)receptors in neuronal and non-neu-ronal cell ***,a wide variety of signaling func-tions well fits the ubiquitous presence of ATP in the *** more ubiquitous are *** from the unspe-cific interaction of protons with any protein,many physi-ological processes are affected by protons acting on specific ionotropic receptors--acid-sensing ion channels(ASICs).Both protons(acidification)and ATP are locally elevated in various pathological *** these fundamentally important molecules as agonists,ASICs and P2X receptors signal a variety of major brain *** we briefly outline the physiological roles of ASICs and P2X receptors,focusing on the brain pathologies involving these receptors.

关键词： ASICs P2X receptors Stroke Chronic pain Epilepsy Neurodegenerative Psychiatric diseases

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Thermal performance of a metal hydride reactor for hydrogen storage with cooling/heating by natural convection

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Energy Storage and Saving 2023年第4期2卷 597-607页

作者： Konstantin Borisovich Minko maksim Nashchekin Department of Engineering Thermophysics Moscow Power Engineering Institute(MPEI)National Research UniversityMoscow111250Russia

Metal hydride(MH)systems can be used for storage in stationary facilities of hydrogen with a high volume density at temperatures and pressures close to ambient ***,the possibility of using passive heating/cooling systems or regenerative heat exchangers has been studied to improve the energy efficiency of MH systems for hydrogen storage without the need for forced circulation of a heating/cooling *** convection of air may be used to passively remove/add heat as required for proper operation of a MH *** these conditions,the MH reactor can operate at a constant ambient air temperature and be driven by a difference in pressure between the source and the consumer of *** operation of MH systems with natural convective heating/cooling has not been systematically investigated as yet,a tubular MH reactor based on this principle is examined in this ***-thirds of the internal volume ofø25.4×1 mm tube is occupied by a composition of LaNi5 and aluminium foam(one linear metre contains 1.1 kg of LaNi5 with a hydrogen capacity of 153 NL H2).Annular fins are used to increase heat transfer to *** and simplified mathematical models of the systems of this class are proposed and *** is shown that acceptable hydrogen charging/discharging rates in such systems are achieved with proper selection of fining *** from a hydrogen source at a pressure of 10 atm and an ambient air temperature of 10 to 30℃ takes 15 min.A reactor with a length of 1 m can desorb almost all stored hydrogen at a minimum outlet pressure of 0.45 bar to feed 30-300 W fuel cells.

关键词： Metal hydride Hydrogen storage Natural convection Annular fins CFD Numerical simulation Optimization

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The Objective Assessment of Event-Related Potentials:An Influence of Chronic Pain on ERP Parameters

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Neuroscience Bulletin 2023年第7期39卷 1105-1116页

作者： maksim Zhuravlev Mikhail Novikov Ruzanna Parsamyan Anton Selskii Anastasiya Runnova Coordinating Center for Fundamental Research National Medical Research Center for Therapy and Preventive MedicineMoscow 101000Russia Institute of Physics Saratov State UniversitySaratov 410012Russia Department of Fundamental Research in Neurocardiology Institute of Cardiological ResearchSaratov State Medical UniversitySaratov 410012Russia

The article presents an original method for the automatic assessment of the quality of event-related potentials(ERPs),based on the calculation of the coefficientε,which describes the compliance of recorded ERPs with some statistically significant *** method was used to analyze the neuropsychological EEG monitoring of patients suffering from *** frequency of migraine attacks was correlated with the spatial distribution of the coefficientsε,calculated for EEG *** than 15 migraine attacks per month was accompanied by an increase in calculated values in the occipital *** with infrequent migraines exhibited maximum quality in the frontal *** automatic analysis of spatial maps of the coefficientεdemonstrated a statistically significant difference between the two analyzed groups with different means of migraine attack numbers per month.

关键词： Event-related potential Chronic migraine ERP quality Automatic evaluation

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