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Septic cardiomyopathy phenotype in the critically ill may depend on antimicrobial resistance

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Journal of Intensive Medicine 2024年第3期4卷 355-361页

作者： Vasiliki Tsolaki Kyriaki Parisi George E.Zakynthinos Efrosini Gerovasileiou Nikitas Karavidas Vassileios Vazgiourakis Epaminondas Zakynthinos Demosthenes makris Intensive Care Unit University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece Third Cardiology Clinic University of AthensSotiria HospitalAthensGreece Respiratory Department University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece

Background Sepsis is a life-threatening organ dysfunction,and septic cardiomyopathy(SCM)may complicate the course of the *** with multidrug-resistant(MDR)pathogens has been linked with worse *** study aims to evaluate SCM in patients with infections caused by different antimicrobial-resistant *** This retrospective study included patients with sepsis/septic shock,hospitalized,and intubated in the intensive care unit of the University Hospital of Larissa between January 2022 and September 2023 with echocardiographic data during the first two days after infection *** patients were divided into two groups:non-MDR-SCM group and MDR-SCM *** cardiac function was compared between the two *** A total of 62 patients were included in the ***-four patients comprised the MDR-SCM and 18 the non-MDR-SCM ***-six patients(41.9%)presented with left ventricular(LV)systolic dysfunction,and≤35%right ventricular fractional area change(RVFAC)was present in 56.4%.LV systolic function was more severely impaired in the non-MDR-SCM group(left ventricular ejection fraction,35.8%±4.9%vs.45.6%±2.4%,P=0.049;LV outflow tract velocity time integral,[10.1±1.4]cm vs.[15.3±0.74]cm,P=0.001;LV-Strain,–9.02%±0.9%vs.–14.02%±0.7%,P=0.001).The MDR-SCM group presented with more severe right ventricular(RV)dilatation(right ventricular end-diastolic area/left ventricular end-diastolic area,0.81±0.03 vs.0.7±0.05,P=0.042)and worse RV systolic function(RVFAC,32.3%±1.9%vs.39.6%±2.7%,P=0.035;tricuspid annular plane systolic excursion,[15.9±0.9]mm vs.[18.1±0.9]mm,P=0.165;systolic tissue Doppler velocity measured at the lateral tricuspid annulus,[9.9±0.5]cm/s vs.[13.1±0.8]cm/s,P=0.002;RV-strain,–11.1%±0.7%vs.–15.1%±0.9%,P=0.002).Conclusion SCM related to MDR infection presents with RV systolic dysfunction predominance,while non-MDR-SCM is mainly depicted with LV systolic dysfunction impairment.

关键词： Septic cardiomyopathy Multidrug-resistant pathogen Left ventricular failure Right ventricular dysfunction Left/right ventricular longitudinal strain Ventriculoarterial Coupling

Atherosclerosis,hypertension and diabetes melitys in pantients with SLE

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Atherosclerosis,hypertension and diabetes melitys in pantien...

Prevalence and sociodemographic determinants of selected noncommunicable diseases among the general population of Cyprus:A large population-based cross-sectional study

The 8th International Congress on SLE

作者： Raptakis Emmanuel Kiagiadaki Hrisi Drigiannakis Dimitris makris konstantinos Zacharioudaki Anna orthopaedist Greece general doctor Greece immunologist Greece nurse Greece rheumatologist Greece

＜正＞Background:Systemic lupus erythematosus（SEL）is a connective tissue disease of unkown origin that is characteried dy premature development of atherosclerosis. Low glucose tolerance,dyslipidamia,hypertension is ...

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慢性疾病与转化医学:英文版 2023年第3期9卷 222-237页

作者： Maria Kyprianidou Demosthenes Panagiotakos konstantinos Cmakris Maria Kambanaros Costas AChristophi konstantinos Giannakou Department of Health Sciences School of SciencesEuropean University CyprusNicosiaCyprus Cyprus International Institute for Environmental and Public Health Cyprus University of TechnologyLimassolCyprus Department of Nutrition and Dietetics School of Health Sciences and EducationHarokopio UniversityAthensGreece Department of Allied Health and Human Performance University of South AustraliaAdelaideSouth AustraliaAustralia

Background:Noncommunicable diseases(NCDs)are the leading cause of morbidity and mortality *** aim of this study was to determine the prevalence of NCDs among the population of Cyprus and to identify the distribution of the socioeconomic and demographic determinants among individuals with the most frequent ***:A cross-sectional study was conducted using stratified *** and demographic characteristics and the presence of NCDs were collected through a standardized *** diseases were classified using the 10th revision of the International Classification of Diseases(ICD-10).Results:In total,1140 individuals participated in the study,among whom 590(51.7%)had at least one chronic *** most prevalent NCDs were hyperlipidemia(17.4%),hypertension(12.9%),and thyroid diseases(8.4%).We identified more males than females with hyperlipidemia aged 25–44 years old and>65 years old(p=0.024),more males compared to females with hypertension(p=0.001)and more females compared to males with thyroid diseases(p<0.001).Individuals with hypertension and hyperlipidemia were more likely to be married,to have completed a higher education,and to have a high annual ***:In Cyprus,the majority of the general population had at least one ***,hypertension,and thyroid disease are relatively common,even at younger ages,highlighting the need for the development of public health programs aimed at addressing and preventing NCDs.

关键词： chronic diseases hyperlipidemia hypertension noncommunicable diseases prevalence

Biomarkers of end of shift exposure to disinfection byproducts in nurses

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Journal of Environmental Sciences 2017年第8期29卷 217-223页

作者： Solomon Ioannou Xanthi D.Andrianou Pantelis Charisiadis konstantinos C.makris Cyprus International Institute for Environmental and Public Health Cyprus University of Technology Limassol 3041 Cyprus

Increased disinfectant use commonly takes place in hospitals and other health care settings. A cross-sectional study among active nurses in two Cypriot public hospitals（n = 179） was conducted to examine the prevalence of exposure to disinfection byproducts（DBPs）, such as trihalomethanes（THMs） using both self-reported information and biomarker *** objectives of this study were to： i） quantify the magnitude and variability of occupational exposure to disinfectants/DBPs in nurses, ii） generate job exposure matrices（JEM） and job task exposure matrices（JTEM） for disinfectants, and iii） assess the major determinants of urinary THMs in nurses. End of shift urinary total THM values showed high variability among the nurses, but did not differ between hospitals. The disinfectant group of alcohols/phenols was used by 〉 98% of nurses, followed by octenidine（82%）, iodine and chlorine（39%, each）,chlorhexidine（25%）, formaldehyde（12%）, hydrogen peroxide（11%）, and peracetic acid/ammonia/quaternary ammonium compounds（QACs）, all being 〈 8% each. Chlorine use during the past 24 hr was associated with significantly（p 〈 0.05） lower brominated THMs（Br THMs） after adjusting for age, gender and BMI, while a positive association was shown for TCM and the sum of all THMs（TTHMs）, albeit not significant. Nurses were exposed to nearly double the levels of TTHMs and BrT HMs（median and IQR, 1027 [560, 2475] ng/g and 323 [212,497] ng/g, respectively） when compared to those of the general population（552 [309,989] ng/g and 152 [87,261] ng/g, respectively）. This was the first occupational health dataset reporting measurements of biomarkers of end of shift exposures to disinfectants/DBPs.

关键词： Nurses Disinfectants Disinfection Exposure Biomarker Job exposure matrix Healthcare

Wave propagation through disordered media without backscattering and intensity variations

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Light(Science & Applications) 2017年第1期6卷 623-629页

作者： konstantinos G makris Andre Brandstötter Philipp Ambichl Ziad H Musslimani Stefan Rotter Crete Center for Quantum Complexity and Nanotechnology Department of PhysicsUniversity of CreteHeraklion 71003Greece Institute for Theoretical Physics Vienna University of Technology(TU-Wien)Vienna 1040Austria Department of Mathematics Florida State UniversityTallahasseeFL 32306USA

A fundamental manifestation of wave scattering in a disordered medium is the highly complex intensity pattern the waves acquire due to multi-path *** we show that these intensity variations can be entirely suppressed by adding disorder-specific gain and loss components to the *** resulting constant-intensity waves in such non-Hermitian scattering landscapes are free of any backscattering and feature perfect transmission through the *** experimental demonstration of these unique wave states is envisioned based on spatially modulated pump beams that can flexibly control the gain and loss components in an active medium.

关键词： Anderson localisation complex media non-Hermitian physics scattering

Additional risk factors associated with thrombosis and pregnancy morbidity in a unique cohort of antiphospholipid antibody-positive patients

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Chinese Medical Journal 2022年第6期135卷 658-664页

作者： Chun Li Yu Zuo Song Zhang Una E.makris David R.Karp Zhanguo Li Department of Rheumatology and Immunology Peking University People's HospitalBeijing 100044China Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMichiganUSA Division of Biostatistics Department of Clinical SciencesUT Southwestern Medical CenterDallasTXUSA Medical Service VA North Texas Health Care SystemDallasTXUSA Division of Rheumatic Disease Department of Internal MedicineThe University of Texas Southwestern Medical CenterDallasTXUSA

Background:Antiphospholipid syndrome(APS)is an autoimmune prothrombotic condition with significant *** objective of this study was to identify additional clinical and epidemiological risks of arterial thrombosis,venous thrombosis,and pregnancy morbidities in a large cohort of persistent antiphospholipid antibodies(aPLs)-positive ***:This was a cross-sectional cohort study of 453 consecutive patients with a documented positive aPL who attended Peking University People's *** 453 patients screened,297 patients had persistent positive *** compared asymptomatic aPL carriers with thrombotic and obstetric APS *** the univariate analysis and multivariable logistic regression were used to evaluate the association between different risk factors and APS clinical *** levels of circulating markers of neutrophil extracellular traps(NETs)(cell-free DNA and citrullinated histone H3[Cit-H3])were assessed and compared among aPL-positive carriers with or without autoimmune disease and APS ***:Additional risk factors associated with arterial thrombosis among aPL-positive carriers included:smoking(odds ratio[OR]=6.137,95%confidence interval[CI]=2.408-15.637,P=0.0001),hypertension(OR=2.368,95%CI=1.249-4.491,P=0.008),and the presence of underlying autoimmune disease(OR=4.401,95%CI=2.387-8.113,P<0.001).Additional risks associated with venous thrombosis among aPL carriers included:smoking(OR=4.594,95%CI=1.681-12.553,P=0.029)and the presence of underlying autoimmune disease(OR=6.330,95%CI=3.355-11.940,P<0.001).The presence of underlying autoimmune disease(OR=3.301,95%CI=1.407-7.744,P=0.006)is the additional risk,which demonstrated a significant association with APS pregnancy *** circulating levels of cell-free DNA and Cit-H3 were observed among APS patients and aPL patients with autoimmune diseases compared with those aPL carriers without underlying autoimmune ***,control neutrophils that

关键词： Antiphospholipid antibodies Antiphospholipid syndrome Arterial thrombosis Pregnancy risk Venous thrombosis

The future of training in intensive care medicine: A European perspective

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Journal of Intensive Medicine 2023年第1期3卷 52-61页

作者： Demosthenes makris Vasiliki Tsolaki Ross Robertson George Dimopoulos Jordi Rello Medical School University of ThessalyLarisa 41110Greece Third Department of Critical Care Medical SchoolNational and Kapodistrian University of AthensAthens 12462Greece CRIPS Department Vall d'Hebron Institut of ResearchBarcelona 08035Spain Clinical Research CHU NîmesNîmes 30029France Medical School Universitat Internacional de CatalunyaCampus Sant CugatSant Cugat del VallesBarcelona 08195Spain

Introduction Intensive care medicine(ICM)is the science and art of preventing,caring for,and curing acutely ill *** specialty originated from the need to provide technology-centered organ support to the most fragile patients presenting with sequential and progressive organ failure.[1]Despite its genesis in Europe and extensive clinical and research achievements in the field,ICM has not been recognized as a distinct discipline in the European Union(EU).This has a negative impact on the free movement of intensivists across *** fact,it has been a major obstacle for knowledge and competence sharing,communication,and professional interweaving across borders—all of which are crucial requirements,especially when contending with pandemics and disasters.

关键词： acute originated spite

Taking central nervous system regenerative therapies to the clinic: curing rodents versus nonhuman primates versus humans

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Neural Regeneration Research 2020年第3期15卷 425-437页

作者： Magdalini Tsintou Kyriakos Dalamagkas Nikos makris Departments of Psychiatry and Neurology Services Center for Neural Systems InvestigationsCenter for Morphometric AnalysisAthinoula A.Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Psychiatry Psychiatry Neuroimaging LaboratoryBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA University College of London Division of Surgery&Interventional Science Center for Nanotechnology&Regenerative MedicineUniversity College LondonLondonUK Department of Physical Medicine and Rehabilitation The University of Texas Health Science Center at HoustonHoustonTXUSA The Institute for Rehabilitation and Research Memorial Hermann Research Center The Institute for Rehabilitation and Research Memorial Hermann HospitalHoustonTXUSA Department of Anatomy&Neurobiology Boston University School of MedicineBostonMAUSA

The central nervous system is known to have limited regenerative *** only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of effective and safe therapeutic options for such *** the high prevalence of stroke and spinal cord injury in the general population,these conditions remain incurable and place a heavy burden on patients’families and on society more *** and neural engineering are diverse biomedical fields that attempt reparative treatments,utilizing stem cells-based strategies,biologically active molecules,nanotechnology,exosomes and highly tunable biodegradable systems(e.g.,certain hydrogels).Although there are studies demonstrating promising preclinical results,safe clinical translation has not yet been accomplished.A key gap in clinical translation is the absence of an ideal animal or ex vivo model that can perfectly simulate the human microenvironment,and also correspond to all the complex pathophysiological and neuroanatomical factors that affect functional outcomes in humans after central nervous system *** an ideal model does not currently exist,but it seems that the nonhuman primate model is uniquely qualified for this role,given its close resemblance to *** review considers some regenerative therapies for central nervous system repair that hold promise for future clinical *** addition,it attempts to uncover some of the main reasons why clinical translation might fail without the implementation of nonhuman primate models in the research pipeline.

关键词： animal models central nervous system regeneration clinical translation exosomes hydrogels neural tissue engineering nonhuman primates spinal cord injury stem cells stroke

Personalized real-time pricing for efficient and fair demandresponse in energy cooperatives and highly competitive flexibility markets

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Journal of Modern Power Systems and Clean Energy 2019年第1期7卷 151-162页

作者： Georgios TSAOUSOGLOU Nikolaos EFTHYMIOPOULOS Prodrommos makris Emmanouel VARVARIGOS Department of Electrical and Computer Engineering Institute of Communication and Computer Systems National Technical University of Athens Electrical and Computer Systems Engineering Monash University

This paper contributes to the well-known challenge of active user participation in demand side management(DSM).In DSM, there is a need for modern pricing mechanisms that will be able to effectively incentivize selfishly behaving users in modifying their energy consumption pattern towards system-level goals like energy *** generally desired properties of DSM algorithms are: user satisfaction, energy cost minimization and *** this paper, a personalized real-time pricing(P-RTP) mechanism design framework is proposed that fairly allocates the energy cost reduction only to the users that provoke ***, the proposed mechanism achieves significant reduction of the energy cost without sacrificing at all the welfare(user satisfaction)of electricity *** business model that the proposed mechanism envisages is highly competitive flexibility market environments as well as energy cooperatives.

关键词： Demand response Smart grid Electricity pricing Scheduling Demand side management Personalized real-time pricing Energy cooperative