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Current Zoology 2019年第1期65卷 121-128页

作者： Yoshimasa seki Kenta Tomyta Department of Psychology Aichi University Machihatacho Toyohashi Aichi Japan

The origin of rhythmic synchronization or entrainment to a musical beat in animals has been widely discussed. Parrots are suitable animals to exami ne the relati on ship betwee n the capability of vocal learning and spontaneous rhythmic synchronization. In this study, budgerigars Melopsittacus undulatus learned to tap (peck) 2 keys alternately at a self-paced rate. Then, the metronomic sounds were played in the background during test sessions while the birds were performing the key pecking task, although they were not required to synchronize tap timing with the metronome. We found modest but significant effects of the metronome rhythms on the tap timing in some subjects. We also tested humans Homo sapiens using almost the same method. In contrast to the birds, a number of huma n subjects synchr on ized tap timing to the on set of the metronome without verbal or documented instructions. However, we failed to find an effect of the metronome on self-paced tap timing in some human subjects, although they were capable of rhythmic synchronization. This is the first report describing the effects of metronomic sounds on self-paced tapping in nonhuman vocal learners. This study introduces a new method that can be used in future research comparing birds that differ in vocal learning capacities, social structure, age, sex, hormonal status, and so on as part of exami nations of the evolutionary foun dati ons of beat processing.

关键词： opera nt con ditioning parrots rhythm synchronization vocal learning

WWW Business Applications Based on the Cellular Model

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Journal of Computer Science & Technology 2008年第2期23卷 176-187页

作者： Toshio Kodama Tosivasu L.Kunii Yoichi seki Venture Business Department Maeda Corporation2-10-26 FujimiChiyoda-kuTokyo 102-0071Japan Morpho Inc.The University of TokyoEntrepreneur Plaza 5F 7-3-1 HongoBunkyo-ku Tokyo 113-0033Japan Software Consultant 3-8-2 SakaemachiHino CityTokyo 191-0001Japan

A cellular model based on the Incrementally Modular Abstraction Hierarchy （IMAH） is a novel model that can represent the architecture of and changes in cyberworlds, preserving invariants from a general level to a specific one. We have developed a data processing system called the Cellular Data System （CDS）. In the development of business applications, you can prevent combinatorial explosion in the process of business design and testing by using CDS. In this paper, we have first designed and implemented wide-use algebra on the presentation level. Next, we have developed and verified the effectiveness of two general business applications using CDS： 1） a customer information management system, and 2） an estimate system.

关键词： cyberworlds incrementally modular abstraction hierarchy formula expression topological space adjunction space cellular space presentation level

Reachability of Patterned Conditional Pushdown Systems

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Journal of Computer Science & Technology 2020年第6期35卷 1295-1311页

作者： Xin Li Patrick Gardy Yu-Xin Deng Hiroyuki seki Shanghai Key Laboratory of Trustworthy Computing East China Normal UniversityShanghai 200062China Graduate School of Informatics Nagoya UniversityNagoya 464-8601Japan

Conditional pushdown systems (CPDSs) extend pushdown systems by associating each transition rule with a regular language over the stack alphabet. The goal is to model program verification problems that need to examine the run-time call stack of programs. Examples include security property checking of programs with stack inspection, compatibility checking of HTML5 parser specifications, etc. Esparza et al. proved that the reachability problem of CPDSs is EXPTIME-complete, which prevents the existence of an algorithm tractable for all instances in general. Driven by the practical applications of CPDSs, we study the reachability of patterned CPDS (pCPDS) that is a practically important subclass of CPDS, in which each transition rule carries a regular expression obeying certain patterns. First, we present new satura-tion algorithms for solving state and configuration reachability of pCPDSs. The algorithms exhibit the exponential-time complexity in the size of atomic patterns in the worst case. Next, we show that the reachability of pCPDSs carrying sim-ple patterns is solvable in fixed-parameter polynomial time and space. This answers the question on whether there exist tractable reachability analysis algorithms of CPDSs tailored for those practical instances that admit efficient solutions such as stack inspection without exception handling. We have evaluated the proposed approach, and our experiments show that the pattern-driven algorithm steadily scales on pCPDSs with simple patterns.

关键词： conditional pushdown system pattern reachability saturation algorithm

Molecular mechanism of noradrenaline during the stress-induced major depressive disorder

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Neural Regeneration Research 2018年第7期13卷 1159-1169页

作者： Kenjiro seki Satomi Yoshida Manoj Kumar Jaiswal Department of Pharmacology School of Pharmaceutical ScienceOhu University Department of Psychiatry Icahn School of Medicine at Mount Sinai

Chronic stress-induced depression is a common hallmark of many psychiatric disorders with high morbidity ***-induced dysregulation of noradrenergic system has been implicated in the pathogenesis of *** of monoamine in the brain has been believed to be the main causative factor behind pathophysiology of major depressive disorder（MDD） and several antidepressants functions by increasing the monoamine level at the synapses in the ***,it is undetermined whether the noradrenergic receptor stimulation is critical for the therapeutic effect of *** to noradrenergic receptor stimulation,it has been suggested that the desensitization of β-adrenoceptor is involved in the therapeutic effect of *** addition,enhanced noradrenaline（NA） release is central response to stress and thought to be a risk factor for the development of ***,fast acting antidepressant suppresses the hyperactivation of noradrenergic neurons in locus coeruleus（LC）.However,it is unclear how they alter the firing activity of LC *** inconsistent reports about antidepressant effect of NA-reuptake inhibitors（NRIs） and enhanced release of NA as a stress response complicate our understanding about the pathophysiology of *** this review,we will discuss the role of NA in pathophysiology of stress and the mechanism of therapeutic effect of NA in *** will also discuss the possible contributions of each subtype of noradrenergic receptors on LC neurons,hypothalamic-pituitary-adrenal axis（HPA-axis） and brain derived neurotrophic factor-induced hippocampal neurogenesis during stress and therapeutic effect of NRIs in MDD.

关键词： major depression stress noradrenaline noradrenaline-reuptake inhibitors serotonin receptors hypothalamic-pituitary-adrenal axis locus coeruleus selective serotonin reuptake inhibitors serotonin noradrenaline-reuptake inhibitors

Methods of induced pluripotent stem cells for clinical application

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World Journal of Stem Cells 2015年第1期7卷 116-125页

作者： Tomohisa seki Keiichi Fukuda Department of Cardiology Keio University School of Medicine Tokyo 160-8582 Japan Department of Emergency and Critical Care Medicine Keio University School of Medicine Tokyo 160-8582 Japan

Reprograming somatic cells using exogenetic gene expression represents a groundbreaking step in regenerative medicine. Induced pluripotent stem cells(i PSCs) are expected to yield novel therapies with the potential to solve many issues involving incurable diseases. In particular, applying i PSCs clinically holds the promise of addressing the problems of immune rejection and ethics that have hampered the clinical applications of embryonic stem cells. However, as i PSC research has progressed, new problems have emerged that need to be solved before the routine clinical application of i PSCs can become established. In this review, we discuss the current technologies and future problems of human i PSC generation methods for clinical use.

关键词： Induced pluripotent stem cells Cell reprogramming

Unsteady Operation of New Type Turbofan Engine with Aerodynamic Torque Converter Reducing Front Fan Speed

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Journal of Thermal Science 2005年第3期14卷 206-210页

作者： Toshiaki KANEMOTO Seita seki Kazunori IDENO Ahmed Mohamed GALAL Kyushu Institute of Technology Sensui 1-1 Tobata Kitakyushu 804-8550 Japan ProfessorKyushu Institute of Technology Sensui 1-1 Tobata Kitakyushu 804-8550 JapanKyushu Institute of Technology Sensui 1-1 Tobata Kitakyushu 804-8550 JapanKyushu Institute of Technology Sensui 1-1 Tobata Kitakyushu 804-8550 Japan

It is desired to increase the rotational speed of the core engine of the turbofan so as to get the best efficiency for the next leap of engine technology. The conventional mechanism in which the front fan is directly connected to the output shaft of a core engine, have a limit of increasing the spool speed, because the fan diameter is very large. The authors have proposed a new driving system in which the front fan is driven through the aerodynamic torque converter. The front fan can work at the best performance at slower speed while the core engine runs more efficiently at higher speed. Continuously, this paper discusses the response of the front fan in the unsteady operation of the core engine, accompanying with the internal flow. The system has the acceptable responsibility in the unsteady operation which is very important for the aircrafts.

关键词： turbofan engine front fan torque converter rotational speed

Astrocyte elevated gene-1 (AEG-1): a new potential therapeutic target for the treatment of nonalcoholic steatohepatitis (NASH)

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 44-47页

作者： Qinglan Wang Ekihiro seki Division of Digestive and Liver Diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCAUSA E-Institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Biomedical Sciences Cedars-Sinai Medical CenterLos AngelesCAUSA Division of Gastroenterology Department of MedicineSchool of MedicineUniversity of California San DiegoLa JollaCAUSA Department of Medicine David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,which affects 25%of the general adult population and 70–80%of individuals with obesity and diabetes(1).

关键词： elevated liver NAFLD

Developing biomarkers for neurodegenerative diseases using genetically-modified common marmoset models

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Neural Regeneration Research 2018年第7期13卷 1189-1190页

作者： Ikuo Tomioka Yoshitaka Nagai Kazuhiko seki Institute for Biomedical Science Shinshu University Department of Neurophysiology National Institute of NeuroscienceNational Center of Neurology and Psychiatry Department of Degenerative Neurological Diseases National Institute of NeuroscienceNational Center of Neurology and PsychiatryTokyoJapan Department of Neurotherapeutics Osaka University Graduate School of Medicine

Mouse and non-human primate models of neurodegenerative disease：The prevalence of age-related neurodegenerative diseases continues to increase with ever increasing aging population over the age of *** the difficulties associated with neurodegenerative diseases present an urgent global issue,there is no effective treatment for these conditions.

关键词： Developing biomarkers for neurodegenerative diseases using genetically-modified common marmoset models Tet

Personal identification and missing persons initiatives in Santa Catarina state,Brazil:forensic perspectives from 2019 to 2021

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Forensic Sciences Research 2022年第4期7卷 590-598页

作者： Paulo Miamoto Clineu Julien seki Uehara Forensic Anthropology Division of the Medicolegal Direction(DATF-DML) Scientific Police of Santa Catarina(PCI)FlorianópolisBrazil Biochemistry Division of the Forensic Laboratory Analysis Direction(DBQA-DALF) Scientific Police of Santa Catarina(PCI)FlorianópolisBrazil

Santa Catarina is a small,developed,and relatively safe state in South *** having positive social economic indicators,it still faces multiple challenges regarding forensic practices for personal *** objective of this paper is to discuss the recent advances and current challenges in the region,from the perspectives of anthropological and dental postmortem human identification,missing persons,and disaster victim identification(DVI)from 2019 to *** recent creation of a Forensic Anthropology Sector(SAF)in the state’s official forensic institution(Polícia Científica-PCI)has significantly improved identification of unidentified remains and optimised resources available for DNA ***,SAF is still quite understaffed,which negatively affects the recovery of skeletal material,its preparation,and the time needed for filing *** Catarina has passed legislation for missing persons in 2015,4 years prior to the sanction of federal laws implementing the national policy for the ***,a lack of integration between stakeholders remains a problem that PCI has tried to circumvent with the Conecta Programme,a multidisciplinary and integrated initiative between families of the missing persons,police agencies,and the Public *** programme aims to collect not only reference DNA samples,but also relevant anthropological and dental *** also offers facial progression services in cases of disappearances that occurred many years *** a history of disasters in the state,PCI still needs to implement international DVI standards at an institutional *** training on Phase 1 DVI procedures,integrated with other responding institutions,indicates better preparation for future *** are many challenges ahead for Santa Catarina’s forensic institution and professionals that have yet to be addressed,but the overall situation on routine personal identification,missing persons initiatives,and DVI has impr

关键词： Forensic sciences forensic anthropology forensic odontology missing persons Brazil