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Geoscience Frontiers 2013年第1期4卷 105-111页

作者： Tetsuya Tokiwa Kimikazu Tsusaka makoto matsubara Taiki Ishikawa Daisuke Ogawa Horonobe Underground Research Unit Japan Atomic Energy AgencyHokkaido 098-3224Japan Geoscience Research Laboratory Kanagawa 242-0014Japan Mitsubishi Materials Techno Corporation Tokyo 102-8205Japan

This paper focuses on the formation mechanism of fractures induced by excavation of a gallery in soft sedimentary rocks in the Horonobe area of Japan. Detailed fracture mapping of the gallery indicates that the fractures consist of both pre-existing shear fractures and excavation damaged zone （EDZ） fractures. EDZ fractures correspond to weak planes associated with bedding planes or transgranular cracks. The EDZ fractures terminate against pre-existing shear fractures. Therefore, even for excavations in soft sedimentary rocks, formation of the EDZ fractures are controlled by pre-existing fractures and earlier weak planes.

关键词： Fracture Excavation damaged zone (EDZ)Weak plane Soft rock Excavation

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy

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World Journal of Gastroenterology 2014年第15期20卷 4316-4328页

作者： Kazuyuki Matsushita Hideaki Shimada Yasuji Ueda makoto Inoue Mamoru Hasegawa Takeshi Tomonaga Hisahiro matsubara Fumio Nomura Department of Molecular Diagnosis Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Surgery School of MedicineToho UniversityTokyo 143-8541Japan DNAVEC Corporation 6 OhkuboTsukuba CityIbaraki 300-2611Japan Proteome Research Center Proteome Research ProjectNational Institute of Biomedical InnovationOsaka 567-0085Japan Department of Frontier Surgery Chiba UniversityGraduate School of MedicineChiba 260-8670Japan

AIM: To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element (FUSE)-binding protein-interacting repressor (FIR).

关键词： Cancer gene therapy c-myc suppressor Far up stream element-binding protein-interacting repressor Sendai virus vector

Surface Characteristics and Indentation Deformation of Porous Anodic TiO_2 Layer Before and After Hot Water Treatment

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稀有金属材料与工程 2012年第S1期41卷 38-42页

作者： T matsubara Research Institute for Applied Mechanics Kyushu UniversityFukuoka 816-8580Japan

Hot water treatment was performed to modify the surface of porous TiO2 layer prepared by anodic spark oxidation technique for better *** oxide layer without water treatment exhibited a porous surface with few nanometer features and consisted of poorly crystallized *** water treatment,the poorly crystallized oxides were transformed into crystalline anatase gradually and numerous nanoparticles formed on the oxide surface,leading to increased surface roughness at the *** indentation deformation behaviors of oxide layer before and after water treatment were investigated and *** show that under the indentation load,the untreated anodic TiO2 layer exhibited good adhesion to the *** contrast,after water treatment,apparent oxides pile-up and spallation were observed around the indentation,indicating decreased adhesion strength.

关键词： titanium anodic spark oxidation hot water treatment nanostructure indentation

Efficient Task Decomposition for Sequential Crowdsourced Task Solving

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Chinese Journal of Electronics 2020年第3期29卷 468-475页

作者： JIANG Huan ZUO Min matsubara Shigeo National Engineering Laboratory for Agri-product Quality Traceability School of Computer and Information EngineeringBeijing Technology and Business University

In order to facilitate crowdsourcing-based task solving, complex tasks are decomposed into smaller subtasks that can be executed by individual *** task into sequential subtasks attracts a plenty of empirical explorations. The absence of formal studies makes it difficult to provide task requesters with explicit guidelines on task decomposition *** formally present the vertical task decomposition model by specifying the positive quality dependencies among sequential subtasks. Our focus is on addressing solutions of low quality intentionally provided by selfinterested workers who are paid equally or based on their contributions. By combining the theoretical analysis on workers’ strategic behaviors and experimental exploration on the efficiency of task decomposition, our study demonstrates the relationship between the incentive and the worker’s performance, and gives the explicit instructions on vertical task decomposition, which show promise on improving the quality of the final outcome.

关键词： Crowdsourcing Task decomposition Subtask dependence Solution quality Revenue sharing

MDP-Based Budget Allocation for Efficient Cooperative Task Solving

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Chinese Journal of Electronics 2017年第5期26卷 966-972页

作者： JIANG Huan ZUO Min matsubara Shigeo School of Computer and Information Engineering Beijing Technology and Business University

In order to facilitate crowdsourcing-based task solving,complex tasks are decomposed into interdependent subtasks that can be executed cooperatively by individual *** to maximize the quality of the final solution subject to the self-interested worker’s utility maximization,a key challenge is to allocate the limited budget among the subtasks as the rewards for workers having various levels of *** study is the first attempt to show the value of Markov decision processes(MDPs)for the problem of optimizing the quality of the final solution by dynamically determining the budget allocation on sequentially dependent subtasks under the budget constraints and the uncertainty of the workers’ *** simulation-based approach verifies that compared to some offline methods where workers’ abilities are fully known,our proposed MDP-based payment planning is more efficient at optimizing the final quality under the same limited budget.

关键词： Budget allocation Markov decision processes(MDPs) Cooperative task solving Task quality optimization Crowdsourcing

Delivery or previous cesarean？ A comment on ＂Antepartum hemorrhage from previous-cesarean-sectioned uterus as a potential sign of uterine artery pseudoaneurysm＂

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第8期18卷 723-724页

作者： Shigeki matsubara Hironori TAKAHASHI Daisuke matsubara Yosuke BABA Department of Obstetrics and Gynecology Jichi Medical University329-0498 Tochigi Japan Department of Pediatrics Jichi Medical University 329-0498Tochigi Japan

Uterine artery pseudoaneurysm （UAP）, an im-portant disorder causing postpartum hemorrhage, hasbeen considered to occur after ＂traumatic delivery＂such as cesarean section （CS）. Our recent study （Babaet al., 2016... 详细信息

关键词：浙江大学学报英文版

Placenta Previa Accreta and Previous Cesarean Section：Some Clarifications

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Chinese Medical Journal 2018年第12期131卷 1504-1505页

作者： Shigeki matsubara Hironori Takahashi Department of Obstetrics and Gynecology Jichi Medical University Tochigi Japan

To the Editor： Placenta accreta （accreta, increta, or percreta） is challenging： effort to reduce its incidence is of paramount importance. We already know well that cesarean section （CS） increases the risk ofacc... 详细信息

关键词： DELIVERY

Developing Reliable Digital Healthcare Service Using Semi-Quantitative Functional Resonance Analysis

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Computer Systems Science & Engineering 2023年第4期45卷 35-50页

作者： Zhengshu Zhou Yutaka matsubara Hiroaki Takada Graduate School of Informatics Nagoya UniversityNagoya464-8601Japan

Since entering the era of Industry 4.0,the concept of Healthcare 4.0 has also been put forward and explored by *** to use Information Technology(IT)to better serve people’s healthcare is one of the most featured emerging directions in the academic *** important field of Healthcare 4.0 research is the reliability engineering of healthcare *** healthcare systems often affect the health and even life of their users,developers must be very cautious in the design,development,and operation of these healthcare systems and *** problems to be solved include the reliability of business process,system functions,and personal healthcare *** Functional Resonance Analysis Method(FRAM)has been applied in reliability engineering for safety-critical systems in available studies,using both qualitative and quantitative ***,the method has not been applied in the field of digital healthcare services ***,to narrow the gap,we present in this paper a semi-quantitative functional resonance analysis method to develop reliable healthcare services for ***,this paper has tried to improve the reliability design of the service-oriented architecture(SOA)of traditional insulin pump therapy by system thinking.

关键词： Reliability safety-critical system functional resonance analysis method systemigram

Role of sirtuins in esophageal cancer:Current status and future prospects

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 794-807页

作者： Ryota Otsuka Koichi Hayano Hisahiro matsubara Department of Frontier Surgery Graduate School of MedicineChiba UniversityChiba 260-8670Japan

Esophageal cancer(EC)is a malignant cancer that still has a poor prognosis,although its prognosis has been improving with the development of multidisciplinary treatment modalities such as surgery,chemotherapy and ***,identifying specific molecular markers that can be served as biomarkers for the prognosis and treatment response of EC is highly desirable to aid in the personalization and improvement of the precision of medical *** are a family of nicotinamide adenine dinucleotide(NAD+)-dependent proteins consisting of seven members(SIRT1-7).These proteins have been reported to be involved in the regulation of a variety of biological functions including apoptosis,metabolism,stress response,senescence,differentiation and cell cycle *** the variety of functions of sirtuins,they are speculated to be associated in some manner with cancer ***,while the role of sirtuins in cancer progression has been investigated over the past few years,their precise role remains difficult to characterize,as they have both cancer-promoting and cancer-suppressing properties,depending on the type of *** conflicting characteristics make research into the nature of sirtuins all the more ***,the role of sirtuins in EC remains unclear due to the limited number of reports concerning sirtuins in *** herein review the current findings and future prospects of sirtuins in EC.

关键词： Esophageal cancer Sirtuin Esophageal squamous cell carcinoma Esophageal adenocarcinoma Biomarker Treatment