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Geoscience Frontiers 2013年第1期4卷 105-111页

作者： Tetsuya Tokiwa Kimikazu Tsusaka makoto matsubara Taiki Ishikawa Daisuke Ogawa Horonobe Underground Research Unit Japan Atomic Energy AgencyHokkaido 098-3224Japan Geoscience Research Laboratory Kanagawa 242-0014Japan Mitsubishi Materials Techno Corporation Tokyo 102-8205Japan

This paper focuses on the formation mechanism of fractures induced by excavation of a gallery in soft sedimentary rocks in the Horonobe area of Japan. Detailed fracture mapping of the gallery indicates that the fractures consist of both pre-existing shear fractures and excavation damaged zone （EDZ） fractures. EDZ fractures correspond to weak planes associated with bedding planes or transgranular cracks. The EDZ fractures terminate against pre-existing shear fractures. Therefore, even for excavations in soft sedimentary rocks, formation of the EDZ fractures are controlled by pre-existing fractures and earlier weak planes.

关键词： Fracture Excavation damaged zone (EDZ)Weak plane Soft rock Excavation

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Surface Characteristics and Indentation Deformation of Porous Anodic TiO_2 Layer Before and After Hot Water Treatment

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稀有金属材料与工程 2012年第S1期41卷 38-42页

作者： T matsubara Research Institute for Applied Mechanics Kyushu UniversityFukuoka 816-8580Japan

Hot water treatment was performed to modify the surface of porous TiO2 layer prepared by anodic spark oxidation technique for better *** oxide layer without water treatment exhibited a porous surface with few nanometer features and consisted of poorly crystallized *** water treatment,the poorly crystallized oxides were transformed into crystalline anatase gradually and numerous nanoparticles formed on the oxide surface,leading to increased surface roughness at the *** indentation deformation behaviors of oxide layer before and after water treatment were investigated and *** show that under the indentation load,the untreated anodic TiO2 layer exhibited good adhesion to the *** contrast,after water treatment,apparent oxides pile-up and spallation were observed around the indentation,indicating decreased adhesion strength.

关键词： titanium anodic spark oxidation hot water treatment nanostructure indentation

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Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy

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World Journal of Gastroenterology 2014年第15期20卷 4316-4328页

作者： Kazuyuki Matsushita Hideaki Shimada Yasuji Ueda makoto Inoue Mamoru Hasegawa Takeshi Tomonaga Hisahiro matsubara Fumio Nomura Department of Molecular Diagnosis Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Surgery School of MedicineToho UniversityTokyo 143-8541Japan DNAVEC Corporation 6 OhkuboTsukuba CityIbaraki 300-2611Japan Proteome Research Center Proteome Research ProjectNational Institute of Biomedical InnovationOsaka 567-0085Japan Department of Frontier Surgery Chiba UniversityGraduate School of MedicineChiba 260-8670Japan

AIM: To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element (FUSE)-binding protein-interacting repressor (FIR).

关键词： Cancer gene therapy c-myc suppressor Far up stream element-binding protein-interacting repressor Sendai virus vector

Efficient Task Decomposition for Sequential Crowdsourced Task Solving

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Chinese Journal of Electronics 2020年第3期29卷 468-475页

作者： JIANG Huan ZUO Min matsubara Shigeo National Engineering Laboratory for Agri-product Quality Traceability School of Computer and Information EngineeringBeijing Technology and Business University

In order to facilitate crowdsourcing-based task solving, complex tasks are decomposed into smaller subtasks that can be executed by individual *** task into sequential subtasks attracts a plenty of empirical explorations. The absence of formal studies makes it difficult to provide task requesters with explicit guidelines on task decomposition *** formally present the vertical task decomposition model by specifying the positive quality dependencies among sequential subtasks. Our focus is on addressing solutions of low quality intentionally provided by selfinterested workers who are paid equally or based on their contributions. By combining the theoretical analysis on workers’ strategic behaviors and experimental exploration on the efficiency of task decomposition, our study demonstrates the relationship between the incentive and the worker’s performance, and gives the explicit instructions on vertical task decomposition, which show promise on improving the quality of the final outcome.

关键词： Crowdsourcing Task decomposition Subtask dependence Solution quality Revenue sharing

MDP-Based Budget Allocation for Efficient Cooperative Task Solving

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Chinese Journal of Electronics 2017年第5期26卷 966-972页

作者： JIANG Huan ZUO Min matsubara Shigeo School of Computer and Information Engineering Beijing Technology and Business University

In order to facilitate crowdsourcing-based task solving,complex tasks are decomposed into interdependent subtasks that can be executed cooperatively by individual *** to maximize the quality of the final solution subject to the self-interested worker’s utility maximization,a key challenge is to allocate the limited budget among the subtasks as the rewards for workers having various levels of *** study is the first attempt to show the value of Markov decision processes(MDPs)for the problem of optimizing the quality of the final solution by dynamically determining the budget allocation on sequentially dependent subtasks under the budget constraints and the uncertainty of the workers’ *** simulation-based approach verifies that compared to some offline methods where workers’ abilities are fully known,our proposed MDP-based payment planning is more efficient at optimizing the final quality under the same limited budget.

关键词： Budget allocation Markov decision processes(MDPs) Cooperative task solving Task quality optimization Crowdsourcing

Developing Reliable Digital Healthcare Service Using Semi-Quantitative Functional Resonance Analysis

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Computer Systems Science & Engineering 2023年第4期45卷 35-50页

作者： Zhengshu Zhou Yutaka matsubara Hiroaki Takada Graduate School of Informatics Nagoya UniversityNagoya464-8601Japan

Since entering the era of Industry 4.0,the concept of Healthcare 4.0 has also been put forward and explored by *** to use Information Technology(IT)to better serve people’s healthcare is one of the most featured emerging directions in the academic *** important field of Healthcare 4.0 research is the reliability engineering of healthcare *** healthcare systems often affect the health and even life of their users,developers must be very cautious in the design,development,and operation of these healthcare systems and *** problems to be solved include the reliability of business process,system functions,and personal healthcare *** Functional Resonance Analysis Method(FRAM)has been applied in reliability engineering for safety-critical systems in available studies,using both qualitative and quantitative ***,the method has not been applied in the field of digital healthcare services ***,to narrow the gap,we present in this paper a semi-quantitative functional resonance analysis method to develop reliable healthcare services for ***,this paper has tried to improve the reliability design of the service-oriented architecture(SOA)of traditional insulin pump therapy by system thinking.

关键词： Reliability safety-critical system functional resonance analysis method systemigram

Role of sirtuins in esophageal cancer:Current status and future prospects

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 794-807页

作者： Ryota Otsuka Koichi Hayano Hisahiro matsubara Department of Frontier Surgery Graduate School of MedicineChiba UniversityChiba 260-8670Japan

Esophageal cancer(EC)is a malignant cancer that still has a poor prognosis,although its prognosis has been improving with the development of multidisciplinary treatment modalities such as surgery,chemotherapy and ***,identifying specific molecular markers that can be served as biomarkers for the prognosis and treatment response of EC is highly desirable to aid in the personalization and improvement of the precision of medical *** are a family of nicotinamide adenine dinucleotide(NAD+)-dependent proteins consisting of seven members(SIRT1-7).These proteins have been reported to be involved in the regulation of a variety of biological functions including apoptosis,metabolism,stress response,senescence,differentiation and cell cycle *** the variety of functions of sirtuins,they are speculated to be associated in some manner with cancer ***,while the role of sirtuins in cancer progression has been investigated over the past few years,their precise role remains difficult to characterize,as they have both cancer-promoting and cancer-suppressing properties,depending on the type of *** conflicting characteristics make research into the nature of sirtuins all the more ***,the role of sirtuins in EC remains unclear due to the limited number of reports concerning sirtuins in *** herein review the current findings and future prospects of sirtuins in EC.

关键词： Esophageal cancer Sirtuin Esophageal squamous cell carcinoma Esophageal adenocarcinoma Biomarker Treatment

Paradoxical brain embolism followed by percutaneous atrial septal closure： Stroke in a patient＇s thirties highlighting some issues surrounding brain stroke in an emergency setting

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World Journal of Emergency Medicine 2017年第4期8卷 308-309页

作者： Daisuke matsubara Koichi Kataoka Teppei matsubara Takaomi Minami Takanori Yamagata Department of Pediatrics Jichi Medical University Tochigi Japan Department of Clinical Neurophysiology Neurological Institute Graduate School of Medical Sciences Kyushu UniversityFukuoka Japan

Brain stroke in patients younger than 40 deprivessociety of its work force. Paradoxical brain embolism（PBE） is sometimes responsible. PBE should never beoverlooked in emergency settings because its recurrencemay be ... 详细信息

关键词： Brain stroke patients younger PBE

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Stochastic model predictive braking control for heavy-duty commercial vehicles during uncertain brake pressure and road profile conditions

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Control Theory and Technology 2022年第2期20卷 248-262页

作者： Ryota Nakahara Kazuma Sekiguchi Kenichiro Nonaka Masahiro Takasugi Hiroki Hasebe Kenichi matsubara Graduate School of Integrative Science and Engineering Tokyo City UniversityTamazutsumiSetagaya-kuTokyo 1588557Japan Nabtesco Automotive Co. Ltd.HirakawachoChiyoda-kuTokyo 1020093Japan

When heavy-duty commercial vehicles(HDCVs)must engage in emergency braking,uncertain conditions such as the brake pressure and road profile variations will inevitably affect braking *** minimize these uncertainties,we propose a combined longitudinal and lateral controller method based on stochastic model predictive control(SMPC)that is achieved via Chebyshev–Cantelli *** our method,SMPC calculates braking control inputs based on a finite time prediction that is achieved by solving stochastic programming elements,including chance *** accomplish this,SMPC explicitly describes the probabilistic uncertainties to be used when designing a robust control *** main contribution of this paper is the proposal of a braking control formulation that is robust against probabilistic friction circle uncertainty *** specifically,the use of Chebyshev–Cantelli inequality suppresses road profile influences,which have characteristics that are different from the Gaussian distribution,thereby improving both braking robustness and control performance against statistical ***,since the Kalman filtering(KF)algorithm is used to obtain the expectation and covariance used for calculating deterministic transformed chance constraints,the SMPC is reformulated as a KF embedded deterministic ***,the effectiveness of our proposed method is verified via a MATLAB/Simulink and TruckSim co-simulation.

关键词： Heavy-duty commercial vehicle Brake system Stochastic model predictive control Road profile

Cancer cachexia,mechanism and treatment

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World Journal of Gastrointestinal Oncology 2015年第4期7卷 17-29页

作者： Tomoyoshi Aoyagi Krista P Terracina Ali Raza Hisahiro matsubara Kazuaki Takabe Division of Surgical Oncology Department of SurgeryVirginia Commonwealth University School of Medicine and the Massey Cancer Center Department of Frontier Surgery Graduate School of Medicine Chiba University

It is estimated that half of all patients with cancer eventually develop a syndrome of cachexia, with anorexia and a progressive loss of adipose tissue and skeletal muscle mass. Cancer cachexia is characterized by systemic inflammation, negative protein and energy balance, and an involuntary loss of lean body mass. It is an insidious syndrome that not only has a dramatic impact on patient quality of life, but also is associated with poor responsesto chemotherapy and decreased survival. Cachexia is still largely an underestimated and untreated condition, despite the fact that multiple mechanisms are reported to be involved in its development, with a number of cytokines postulated to play a role in the etiology of the persistent catabolic state. Existing therapies for cachexia, including orexigenic appetite stimulants, focus on palliation of symptoms and reduction of the distress of patients and families rather than prolongation of life. Recent therapies for the cachectic syndrome involve a multidisciplinary approach. Combination therapy with diet modification and/or exercise has been added to novel pharmaceutical agents, such as Megestrol acetate, medroxyprogesterone, ghrelin, omega-3-fatty acid among others. These agents are reported to have improved survival rates as well as quality of life. In this review, we will discuss the emerging understanding of the mechanisms of cancer cachexia, the current treatment options including multidisciplinary combination therapies, as well an update on new and ongoing clinical trials.

关键词： Physical exercise Pharmacological treatment Cancer cachexia