检索结果-南通市图书馆

Deciphering the enigmatic spikelet traits:Resolving trade-offs for enhancing rice yield

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第5期17卷 694-695页

作者： Hideki Yoshida makoto Matsuoka Institute of Fermentation Sciences Fukushima UniversityFukushima 960-1248Japan

Increasing the yield is one of the most important goals of crop *** the beginning of rice cultivation thousands of years ago,many efforts have been made to increase rice *** of the successes in this history was the Green *** tremendous improvement in the 1960s was achieved by increasing rice and wheat production through the development and widespread adoption of semi-dwarf varieties with the extensive use of fertilizers(Hedden,2003).Dwarfism in crops lowers the center of gravity of the plant body,reducing the risk of lodging and enabling farmers to use more fertilizer to increase ***-dwarf mutations in both rice and wheat created during the Green Revolution are related to the plant growth hormone gibberellin(GA).Although other mechanisms cause dwarf mutants,only GA-related semi-dwarf mutants were selected during the Green Revolution(Wang et al.,2021).While GA-related abnormalities only make plants shorter,most cases caused by other mechanisms involve not only dwarfism but also other morphological abnormalities.

关键词： dwarf crops traits

Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1241-1248页

作者： Tingting Han Yuxiang Xu Lin Sun makoto Hashimoto Jianshe Wei Institute for Brain Sciences Research School of Life Sciences Henan University College of Chemistry and Molecular Sciences Henan University Department of Basic Technology Tokyo Metropolitan Institute of Medical Science

Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging; they have a great impact on the aging process and are the main risk factors for neurodegeneration. Reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases. This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including Alzheimer’s disease, Huntington’s chorea, and Parkinson’s disease. This review also describes the potential benefits of treating neurodegenerative diseases by modulating changes in microglial states. Therefore, inducing a shift from the neurotoxic to neuroprotective microglial state in neurodegenerative diseases induced by aging and chronic inflammation holds promise for the treatment of neurodegenerative diseases in the future.

关键词： aging Alzheimer's disease cytokines Huntington's disease microglia neurodegenerative diseases neuroinflammation neuroprotection neurotoxicity Parkinson's disease

The optimal stent pusher position to achieve successful ureteral stent insertion under fluoroscopic guidance

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第2期11卷 311-315页

作者： makoto Taguchi Kaneki Yasuda Hidefumi Kinoshita Department of Urology Osaka Saiseikai Izuo Hospital Based on Social Welfare Organization“Saiseikai”Imperial Gift Foundation Inc.OsakaJapan Department of Urology and Andrology Kansai Medical UniversityHirakataOsakaJapan

Objective: To examine factors to predict the optimal stent pusher position when inserting ureteral stents under ***: We retrospectively reviewed 327 patients who underwent ureteral stent insertion. We considered the pubic bone as a useful anatomical landmark to insert ureteral stents under fluoroscopic guidance. Thus, we categorized patients into three groups (proximal, middle, and distal groups) according to the position of the radiopaque tip of the push catheter when inserting the ureteral stent. Success was defined as a completely curled ureteral stent tail. We compared stent insertion success rates among the three groups. A multivariate analysis was performed to identify the factors affecting stent insertion ***: In men, 36 (63.2%) cases were deemed successful in the proximal group compared with 40 (80.0%) cases in the middle group and 12 (20.7%) cases in the distal group (p<0.001). In women, 26 (45.6%) cases were deemed successful in the proximal group compared with 54 (98.2%) cases in the middle group and 38 (76.0%) cases in the distal group (p<0.001). With the multivariate analysis, the stent pusher position was the most significant factor influencing successful stent insertion (men: odds ratio 6.00, 95% confidence interval 2.66-13.51, p<0.001;women: odds ratio 37.80, 95% confidence interval 4.94-289.22, p<0.001).Conclusion: The position of the stent pusher affects stent insertion success. The middle of the pubic symphysis is the optimal position for the radiopaque tip of the pusher when inserting ureteral stents under fluoroscopic guidance.

关键词： Stent Cystoscopy Fluoroscopy Ureter

Quantitative Assessment of Chronic Skin Reactions Including Erythema and Pigmentation after Breast Conserving Therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Breast Cancer Research 2016年第3期5卷 121-128页

作者： Miho Kawashima Miwako Nozaki Kazuhiro Komazaki Ryuko Yamamuro Kazuo Ishizuna makoto kojima Department of Radiology Dokkyo Medical University Koshigaya Hospital Saitama Japan Breast Center Dokkyo Medical University Koshigaya Hospital Saitama Japan

Purpose: To evaluate long-term skin reactions following breast-conserving therapy by using the melanin-erythema index meter. Patients and Methods: 164 patients were followed for at least three years after breast-conserving therapy. For both the erythema and the melanin indices, the ratio of the irradiated-side index to the non-irradiated-side index was calculated. The time course of index ratios alternation was examined. Influences from additional therapies and patients’ age were also evaluated. Result: Both erythema and melanin index ratios of the breast skin were recovered to pre-radiation level three years after radiotherapy. However, both index ratios of the area administrated with 10-Gy boost irradiation were still high even after five years after radiotherapy. Endocrine therapy, chemotherapy and age had no significant influence on skin color reactions three years after radiotherapy. Conclusion: Quantitative assessment using the melanin-erythema index meter demonstrated that chronic skin reactions following breast conserving therapy had recovered to pre-radiation level for three years after irradiation except for the 10-Gy boost irradiated area.

关键词： Breast Cancer Erythema Index Melanin Index Breast-Conserving Therapy

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Factors Influence Hanoians’ Choice of Non-Motorized Transport Mode to Access Bus Stations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Transportation Technologies 2024年第3期14卷 372-389页

作者： Ngo Trung Phuong Masahiko Kikuchi Aya kojima Hisashi Kubota Graduate School of Science and Engineering Saitama University Saitama Japan Department of Engineering Affairs City Bureau Ministry of Land Infrastructure Transportation and Tourism Tokyo Japan

Hanoi’s rapid urbanization has led to a surge in private vehicle ownership, particularly motorcycles, amidst inadequate public transportation infrastructure. Despite government efforts, many still prefer motorized transport, citing mobility and safety concerns, exacerbated by insufficient pedestrian infrastructure. This study examines the motivations behind this reliance on motorized vehicles, particularly motorcycles, in Hanoi. Findings reveal safety and convenience as primary factors driving motorized transport use, especially for accessing bus stations. Economic incentives could promote non-motorized travel and public transport adoption. Policy implications highlight the importance of addressing economic factors and improving access infrastructure to manage motorized vehicle reliance and foster sustainable urban mobility in Hanoi.

关键词： Access Mode Choice Non-Motorized Vehicles Motorized Vehicles Bus User Urban Transport Behavior

Electronic structure and effective mass of pristine and Cl-doped CsPbBr_(3)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第5期33卷 167-171页

作者：魏志远魏愉昊徐申东彭舒婷 makoto Hashimoto 路东辉潘旭匡泯泉肖正国何俊峰 Department of Physics and CAS Key Laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Chongqing Key Laboratory of Micro & Nano Structure Optoelectronics and School of Physical Science and TechnologySouthwest UniversityChongqing 400715China Key Laboratory of Photovoltaic and Energy Conservation Materials Institute of Applied TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Stanford Synchrotron Radiation Lightsource and Stanford Institute for Materials and Energy Sciences SLAC National Accelerator LaboratoryMenlo ParkCalifornia 94025USA

Organic–inorganic lead halide perovskites(LHPs) have attracted great interest owing to their outstanding optoelectronic ***,the underlying electronic structure would determinate the physical properties of *** as for now,limited studies have been done to reveal the underlying electronic structure of this material system,comparing to the huge amount of investigations on the material *** effective mass of the valance band is one of the most important physical parameters which plays a dominant role in charge transport and photovoltaic *** pristine CsPbBr_(3),the Fr?hlich polarons associated with the Pb–Br stretching modes are proposed to be responsible for the effective mass *** this regard,it would be very interesting to explore the electronic structure in doped ***,we report high-resolution angle-resolved photoemission spectroscopy(ARPES) studies on both pristine and Cl-doped CsPbBr_(3).The experimental band dispersions are extracted from ARPES spectra along both ■ and ■ high symmetry *** calculations are performed and directly compared with the ARPES *** results have revealed the band structure of Cl-doped CsPbBr_(3) for the first time,which have also unveiled the effective mass renormalization in the Cl-doped CsPbBr_(3) *** dependent measurements indicate that the chlorine doping could moderately tune the renormalization *** results will help understand the physical properties of LHPs as a function of doping.

关键词： lead halide perovskites electronic structure effective mass

Co-infection with Neisseria mucosa in a patient with tuberculous otitis media

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Otology 2024年第1期19卷 1-4页

作者： Tatsuya Hioki Kazuaki Soejima Yuki Goto makoto Sugiura Takumi Umemura Yoshimi Ishihara Yoshikazu Mutoh Daisuke Sakanashi Hiroshige Mikamo Department of Clinical Laboratory Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Respiratory Medicine and Allergy Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Otolaryngology Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infection Control Team Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infectious Diseases Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infection Prevention and Control Aichi Medical University Hospital1-1 YazakokarimataNagakuteAichi480-1195Japan Department of Clinical Infectious Diseases Aichi Medical University1-1 YazakokarimataNagakuteAichi480-1195Japan

Tuberculous otitis media(TOM) is a rare manifestation caused by Mycobacterium tuberculosis with low incidence rates among extrapulmonary tuberculosis cases. Diagnosis is often delayed because of the presence of several clinical manifestations and the high prevalence of secondary bacterial infections. Few reports have attributed secondary bacterial infections in patients with TOM to commensal Neisseria. Thus, understanding the pathogenic mechanisms and clinical features of commensal Neisseria is important, considering its recent presentation as an infection-causing pathogen. Neisseria mucosa is a commensal inhabitant in humans and is generally considered non-pathogenic but can cause infection in rare cases. Here, we report an atypical secondary infection caused by Neisseria mucosa in an 81-year-old woman with TOM being treated for pulmonary tuberculosis. Direct purulent otorrhea smear microscopy revealed no acid-fast bacilli using Ziehl-Neelsen staining, whereas the phagocytosis of gram-negative cocci by white blood cells was confirmed using Gram staining. Otorrhea culture revealed the growth of N. mucosa. Subsequently, M. tuberculosis infection in the otorrhea was identified using a culture-based method. Vigilance is critical for the early detection of TOM to prevent further complications. This report raises awareness regarding TOM and provides insight into the pathogenicity of N. mucosa in otitis media.

关键词： Commensal neisseria Miliary tuberculosis Mycobacterium tuberculosis Neisseria mucosa Tuberculous otitis media

Impact of sleep on gastrointestinal cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第6期15卷 677-683页

作者： Joshua Lo Pahnwat T Taweesedt makoto Kawai Department of Internal Medicine Santa Clara Valley Medical CenterSan JoseCA 95128United States Department of Psychiatry and Behavioral Sciences Stanford UniversityStanfordCA 94305United States Sierra Pacific Mental Illness Research Educationand Clinical Center(MIRECC)VA Palo Alto Health Care SystemPalo AltoCA 94304United States Department of Psychiatry and Behavioral Sciences School of MedicineStanford UniversityRedwood CityCA 94063United States

Sleep problems have become a significant public health concern,affecting a large portion of the global population and have been linked to increased morbidity and *** incidence of gastrointestinal(GI)cancers continues to rise,posing a substantial burden on healthcare systems *** editorial aims to delve into the impact of sleep on GI cancers,including esophageal,gastric,colorectal,hepatobiliary,and pancreatic *** literature investigating the potential connections between GI cancers and sleep was *** considered aspects such as sleep duration,sleep disorders,and circadian rhythmicity,in order to explore the underlying mechanisms that can contribute to the development of GI cancers and propose avenues for future research.

关键词： Sleep Cancer Gastrointestinal cancer Esophagus Stomach Colon Liver