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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1197-1206页

作者： Remi Nakajima Risa kobayashi Marie Kawai Eriko Sakamoto Miho Matsuda Rieko Kanda makoto Kawamura Department of Obstetrics and Gynecology Kohseichuo General Hospital. Tokyo Japan

Polycystic ovary syndrome (PCOS) is a major cause of anovulatory infertility. Laparoscopic ovarian drilling (LOD) is a treatment for PCOS that allows the laparoscopic identification of other intra-abdominal lesions and the provision of diagnostic treatment. This study reports a case of PCOS with an ovarian mass in which LOD was aggressively used and a granulosa cell tumor (GCT) was found. A 34-year-old woman with secondary amenorrhea and irregular menstrual cycles presented to the emergency department with abdominal pain of unknown etiology. Imaging studies revealed a 6-cm left ovarian mass with an internal appearance suggestive of a hemorrhage. The patient’s secondary amenorrhea was subsequently diagnosed as PCOS, and LOD was performed to preserve her fertility. Simultaneously, a cystectomy was performed to evaluate the tumor in the left ovary;the diagnosis was adult-type GCT. Although concomitant GCT and PCOS are extremely rare, the two conditions have similar clinical manifestations. In women of reproductive age, the impact of surgery on future fertility should be considered, and the initial surgical technique should be chosen carefully.

关键词： Polycystic Ovary Syndrome Laparoscopic Ovarian Drilling Granulosa Cell Tumor

Synchrotron Small-Angle X-Ray Scattering Investigation on Integral Membrane Protein Light-Harvesting Complex LH2 from Photosynthetic Bacterium Rhodopseudomonas Acidophila

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Chinese Physics Letters 2006年第7期23卷 1861-1863页

作者：都鲁超翁羽翔洪新国冼鼎昌 kobayashi Katsumi Laboratory of Soft Matter Physics and Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 Beijing Synchrotron Radiation Facility (BSRF) Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 Photon Factory High Energy Accelerator Research Organization 1-10ho Tsukuba-shi Ibaraki-ken 305-0801 Japan

Structures of membrane protein in solution are different from that in crystal phase. We present the primary results of small angle x-ray scattering （SAXS） resolved topological structures of a light harvesting antenna membrane protein complex LH2 from photosynthetic bacteria Rhodopseudomonas acidophila in detergent solution for the first time. Our results show that the elliptical shape of the LH2 complex in solution clearly deviates from its circular structure in crystal phase determined by x-ray diffraction. This result provides an insight into the structure and function interplay in LH2.

关键词： HIGH-RESOLUTION B850 BAND SPECTROSCOPY SHAPE RHODOPSIN

STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrientmanagement

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Molecular Plant 2021年第10期14卷 1615-1617页

作者： Hiroyuki Koyama Liujie Wu Raj Kishan Agrahari Yuriko kobayashi Molecular PlantApplied Biological Sciences Gifu University501-1193 GifuJapan School of Environment and Life Science Nanning Normal UniversityNanning530001 GuangxiP.R.China.

Transcriptional regulation plays a crucial role in plant adaptation to diverse *** transcription factors(TFs),the so-called master switch TFs or hub TFs,regulate various genes critical for adaptation to different ***1(SENSITIVE TO PROTON RHIZOTOXICITY 1),a zinc-finger TF of Arabidopsis(Arabidopsis thaliana),is one such master/hub TF that transcriptionally regulates multiple stress tolerance(Sadhukhan et al.,2021).STOP1 plays a critical role in tolerance to acid soil syndrome(i.e.,H+and Al3+tolerance)(Iuchi et al.,2007)and hypoxia tolerance(Enomoto et al.,2019),and negatively regulates drought tolerance(Sadhukhan et al.,2019).In addition,Tian et al.

关键词： STOP1 stress Arabidopsis

Stability of phases in (Ba, Gd)MnO_3 solid solution system

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Journal of Rare Earths 2008年第2期26卷 233-236页

作者： Migaku kobayashi Hidenori Tamura Hiromi Nakano Hirohisa Satoh Naoki Kamegashira Department of Chemistry and Biochemistry Numazu National College of Technology 3600 Ooka Numazu Electron Microscope Laboratory Ryukoku University Department of Materials Science Toyohashi University of Technology Tempaku-cho

The existing phases in BaxGd1-xMnO3 solid solution system （0≤x≤ 1） were studied by analyzing the detailed crystal structure of each composition from the results of the Rietveld method using powder X-ray diffraction data. For a small substitution of Ba for Gd （0≤x〈0. 1）, the orthorhombic phase with a perovskite type structure （Pnma space group） was stably formed and this fact was supported by the electron diffraction data. There existed an intermediate phase of Ba0.33Gd0.67MnO3, which was characterized as the tetragonal phase with perovskite structure. The composition range of this phase was narrow and almost line compound. Between the regions of these phases, there existed two-phase region. There was also a two-phase region between the intermediate tetragonal phase and BaMnO3. Measurement of electrical conductivities of these orthorhombic solid solutions and tetragonal phases showed semiconducting behaviors for both phases and the existence of the phase transition at high temperature for the orthorhombic phase, The transition temperature decreased as the Ba content increased.

关键词： rare earth manganite phase behavior X-ray diffractometry crystal structure electrical conductivity

Fluorescence quantum yield of Gd_(0.9-x)R_xEu_(0.1)OOH(R=Y, La) crystals

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Journal of Rare Earths 2015年第12期33卷 1256-1260页

作者： Hiroaki Samata Katsutoshi kobayashi Masashi Hanioka Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Materials Development Group Superconducting Properties Unit National Institute for Materials Science

*** （R=Y, La） crystals were synthesized by a flux method using a mixture of NaOH and KOH as the flux. X-ray diffraction data were well refined using the Rietveld method assuming that the crystals had a monoclinic structre belonging to the P21/m space group. The unit cell volumes of the Gdo.9 *** crystals increased with increasing x, whereas those of *** decreased with increasing x. The Commission Internationale de IEclairage （CIE） chromaticity coordinates of Gdo.9 *** （R=Y, La） crystals were located in the red region and were nearly constant over the range ofx values considered. The fluorescence quantum yield Dr monotonically decreased with increasing x regardless of the ionic radii of the substitute ions. The fact that the Dr value of Lao.9EuoAOOH was greater than that of *** indicated that the observed decrease in the values of the Gdo.9-,LaxEuo.1OOH crystals up to x=0.3 could not be attributed to an increase in the distance between Eu3＋ ions or to a decrease in the Gd3＋ content. The decrease might be due to an increase of killer centers introduced by elemental substitutions with the larger ion.

关键词： rare-earth oxyhydroxide phosphor elemental substitution fluorescence quantum yield

DISTRIBUTION OF FMRFAMIDE IN NERVOUS SYSTEM OF AMPHIOXUS——A STUDY OF THE IMMUNOHISTOCHEMISTRY

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Chinese Science Bulletin 1990年第7期35卷 580-582页

作者：方永强 HIDESHI kobayashi Third Institute of Oceanography ASO Xiamen 361005 PRC Research Laboratory Zenyaku Kogyo Co. Ltd 2-3377 Ohizumi-machi Nerima-ku Tokyo 178 Japan

Cardioexcitatory neuropeptide （FMRFamide） was discovered in the ganglia of the clam （Macrocallista nimbosa）. Neuropeptide consisting of four kinds of amino acid, Phe-Met-Arg-Phe-NH2, has already been artificially synthesized. FMRFamide may influence the rhythmicity of the heart of mollusc and the contraction of the antenna in the snail,

关键词： amphioxus cardioexcitatory neuropeptide (FMRF amide) immunohistochemistry.

Stem cell-derived embryo models:a frontier of human embryology

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Medical Review 2023年第4期3卷 343-346页

作者： Norio kobayashi Jianping Fu Department of Mechanical Engineering University of MichiganAnn ArborMIUSA Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA Department of Cell and Developmental Biology University of Michigan Medical SchoolAnn ArborMI 48109USA Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA

Studying human development remains difficult due to limited accessibility to human embryonic *** by the availability of human stem cells that share molecular and cellular similarities with embryonic and extraembryonic cells in peri-implantation human embryos,researchers have now successfully developed stem cellbased human embryo models that are promising as experimental tools for studying early human *** this Perspective,we discuss the current progress in mouse and human stem cell-derived embryo models and highlight their promising applications in advancing the fundamental understanding of mammalian development.

关键词： embryo models embryonic development pluripotent stem cells

Method for the proposal and evaluation of urban structures for compact cities using an expert system

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Frontiers of Architectural Research 2016年第4期5卷 403-411页

作者： Shirou Tsuboi Shinji Ikaruga Takeshi kobayashi Graduate School of Science and Engineering Yamaguchi University Yamaguchi-shi 753-8511 Japan

The world population is continually increasing, but the Japanese population is decreasing. By 2050, the Japanese population is calculated to be close to 100 million people, and by 2060, 40% of the Japanese are estimated to be aged 65 years or more. Data show an increase in the declining birth and aging rates of the population. The development of high-concentration urban structures will be needed to solve such problems. However, a detailed vision of the future is yet to be clarified and in the process of consideration. In this study, we developed an instrument called ＂Population Migration Tool,＂ which is based on plural planning and policy, after we formed a future population distribution model. In addition, We also established a high- concentration urban structure model with this tool with the aim of considering the kind of urban structure local cities should target in the future.

关键词： Local city Compact city Future population Visualization Concentration urbanstructure

Current research of idiopathic normal pressure hydrocephalus:Pathogenesis,diagnosis and treatment

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World Journal of Clinical Cases 2023年第16期11卷 3706-3713页

作者： Tetsuro Ishida Tomonori Murayama Seiju kobayashi Department of Psychiatry Japan Health Care CollegeSapporo 062-0053HokkaidoJapan Department of Psychiatry Asahikawa Keisenkai HospitalAsahikawa 078-8208HokkaidoJapan Department of Psychiatry Shinyukai Nakae HospitalSapporo 001-0022HokkaidoJapan

Idiopathic normal pressure hydrocephalus(iNPH)is caused by impaired cerebrospinal fluid absorption in the elderly;it is a surgically treatable form of *** disturbance,dementia,and urinary incontinence are the triad of signs for *** addition to these clinical findings,imaging studies show characteristic ventricular *** Evans Index and‘disproportionately enlarged subarachnoid hydrocephalus’are other well-known imaging findings of *** the tap test shows improved symptoms,shunt surgery is *** disease was first described by Hakim and Adams in 1965,followed by the publication of the first,second,and third editions of the guidelines in 2004,2012,and 2020,*** studies signal the glymphatic system and classical cerebrospinal fluid(CSF)absorption from the dural lymphatics as aetiological mechanisms of CSF *** is also underway on imaging test and biomarker developments for more precise diagnosis,shunting technique options with fewer sequelae and complications,and the influence of ***,the newly introduced‘suspected iNPH’in the third edition of the guidelines may be useful for earlier ***,less well-studied areas remain,such as pharmacotherapy in non-operative indications and neurological findings other than the triadic *** review briefly presents previous research on these and future issues.

关键词： Review Idiopathic normal pressure hydrocephalus Treatable dementia Shunt surgery Drug therapy

Solvent effect for ruthenium porphyrin

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Science China(Physics,Mechanics & Astronomy) 2010年第6期53卷 1005-1012页

作者： IWAKURA Izumi YABUSHITA Atshi kobayashi Takayoshi Innovative Use of Light and Materials/life PRESTJST4-1-8 HonchoKawaguchiSaitama 332-0012Japan Department of Electrophysics National Chiao-Tung University University of Electro-Communications ICORP JST4-1-8 HonchoKawaguchiSaitama 332-0012Japan Institute of Laser Engineering Osaka University

Relaxation of electronic excited-state and vibrational dynamics in the electronic excited state in Ru II(TPP)(CO) [TPP=tetraphenylporphyrin] dissolved in N2 bubbled benzene,O2 bubbled benzene,N2 bubbled chloroform and N2 bubbled acetone were clarified using a sub-5fs laser pulse. The result showed that the transition energy from the 1Q x states,consisting of the 1Q x(1,0)(π,π*) state(existing at 18800 cm-1 ) and 1Q x(0,0)(π,π*) state(existing at 17800 cm-1 ),to the 1M state of six-coordinated ruthenium complex is lower than that of the five-coordinated ruthenium complex. The intersystem crossing 1Q x(0,0)(π,π*)→ 3(d,π*) in the five-coordinate Ru II(TPP)(CO) in the solution was found to take place in about 1 ps.

关键词： femtosecond laser ruthenium porphyrin complex real-time spectroscopy