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Hepatic pseudolesions caused by alterations in intrahepatic hemodynamics

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World Journal of Gastroenterology 2021年第46期27卷 7894-7908页

作者： Satoshi kobayashi Department of Quantum Medical Technology Kanazawa University Graduate School of Medical SciencesKanazawa 9200942IshikawaJapan

Hepatic pseudolesion may occur in contrast-enhanced computed tomography and magnetic resonance imaging due to the unique haemodynamic characteristics of the *** concept of hepatic arterial buffer response(HABR)has become mainstream for the understanding of the mechanism of the reciprocal effect between hepatic arterial and portal venous *** HABR is thought to be significantly related to the occurrence of the abnormal imaging findings on arterial phase of contrast enhanced images,such as hepatic arterial-portal vein shunt and transient hepatic attenuation difference,which mimic hypervascular tumor and may cause clinical *** inflow to the liver also cause hepatic pseudolesion,and some of the cases may show histopathologic change such as focal hyperplasia,focal fatty liver,and focal sparing of fatty liver,and called *** understand these phenomena might be valuable for interpreting the liver imaging findings.

关键词： Pseudolesion Focal sparing of fatty liver Computed tomography Hepatic blood flow Hepatic hemodynamics Hyperplastic change

On Human Autonomic Nervous Activity Related to Behavior, Daily and Regional Changes Based on Big Data Measurement via Smartphone

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Health 2016年第9期8卷 827-845页

作者： makoto Komazawa Kenichi Itao Hiroyuki kobayashi Zhiwei Luo Graduate School of System Informatics Kobe University Kobe Japan WINFrontier Co. Ltd. Tokyo Japan JUNTENDO University Tokyo Japan Organization of Advanced Science and Technology Kobe University Kobe Japan

This research uses a large amount of autonomic nervous system data (approximately 100,000 entries) to investigate the relationship between human autonomic nervous activity and behaviors, daily and regional changes. Data were measured via a heart rate variability analysis system that utilizes the camera of smartphones. This system was developed by the authors during previous research. The relations between autonomic nervous system and behaviors, total power and sympathetic nervous activity were found to rise after waking, while during leisure time, the total power rises and sympathetic nervous activity is inhibited. Concerning the relationship between autonomic nervous system and day of the week, it was found that total power decreases from the middle through the latter part of the week (namely, Wednesday, Thursday, and Friday), while it rises on Saturday, while the sympathetic nervous activity is suppressed on Saturday. Regarding the relationship between autonomic nervous system and region, it was found that total power is lower in the Kanto region of Japan than in others. This study also shows statistical proof (using a large amount of measurement data) to ideas held by the public for years. Thus, the data can be considered meaningful to the society, and the authors hope that it helps to improve work-life balance.

关键词： Heart Rate Variability Autonomic Nervous System Large Amount of Measurement Data Activity Day of the Week Region

On Human Autonomic Nervous Activity Related to Weather Conditions Based on Big Data Measurement via Smartphone

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Health 2016年第9期8卷 894-904页

This research uses our previously-developed smartphone camera-based heart rate change analysis system to survey the correlation between weather patterns and the autonomic nervous activity across a big data set of approximately 200,000 entries. The results showed a trend in which a significant decrease was seen in sympathetic nervous activity in both males and females—the higher the temperature. In addition, a significant increase was seen in the sympathetic nervous system in both males and females—the higher the atmospheric pressure. Lastly, a significant decrease was seen in the sympathetic nervous system in both males and females—the more precipitation there was. These results accord with prior research and with human biological phenomena, and we were able to use a data set of approximately 200,000 entries to statistically demonstrate our hypothesis. We believe this represents a valuable set of reference data for use in the health care.

关键词： Heart Rate Variability Autonomic Nervous System Large Amount of Measurement Data Weather

Measurement and Evaluation of the Autonomic Nervous Function in Daily Life

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Health 2016年第10期8卷 959-970页

We developed a smart-phone based system to measure the activities of autonomic nervous system during everyday life. Using commonly marketed smart phones, by touching your fingertips on the phone’s camera over a short time of about 30 seconds, it will detect changes in the brightness of the blood flow and in turn analyze your heart rate variability. By using this system, about 100,000 cases were measured and from this large amount of data regarding heart rate variability, we evaluated the autonomic nervous function in their daily life. As a result, for the correlation between autonomic nervous system and age, we found that as the increase of age, the total power becomes decreased and the sympathetic nervous system tends to increase between thirties and fifties. For the correlation between autonomic nervous system and BMI (Body Mass Index), it is found that in general, the higher the BMI, the lower the total power and the stronger the sympathetic nervous system. In other words, people who are fat are lower about the total power and stronger about the sympathetic nervous system. In addition, for the correlation between autonomic nervous system and one day life, it is found that total power and sympathetic function tend to increase, while as evening approaches, sympathetic function tends to become suppressed.

关键词： Heart Rate Variability Analysis Autonomic Nervous System Age BMI

Microfluidic-based flexible reflective multicolor display

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Microsystems & Nanoengineering 2018年第1期4卷 244-254页

作者： Kazuhiro kobayashi Hiroaki Onoe School of Integrated Design Engineering Graduate School of Science and TechnologyKeio UniversityYokohamaJapan

This paper describes a microfluidic-based flexible reflective display constructed using dyed water droplets and air gaps as pixel *** display is composed of a flexible polydimethylsiloxane sheet with a connected pixel-patterned *** types of dyed water droplets and air gaps are sequentially introduced to the microchannel through a suction process to display a multicolor *** displayed image is stable and can be retained without an energy *** ensure that images are displayed correctly,the geometric parameters of the dot pixel design and minimum differential pressure necessary to drive the water droplets are *** a demonstration,we successfully display three-color dot-matrix reflective images and bitmap characters in the *** proposed method can be applied to energy-less and color-changeable displays for use in future daily-life accessories,such as bags,shoes,and clothes,and can change the surface color and pattern of these accessories.

关键词： reflective fluid sequentially

The Gauss maps of Demoulin surfaces with conformal coordinates

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Science China Mathematics 2021年第7期64卷 1479-1492页

作者： Jun-ichi Inoguchi Shimpei kobayashi Institute of Mathematics University of TsukubaTsukuba 305-8571Japan Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan

Demoulin surfaces in the real projective 3-space are investigated. Our result enables us to establish a generalized Weierstrass type representation for definite Demoulin surfaces by virtue of primitive maps into a cer... 详细信息

关键词： Demoulin surface Wilczynski frame Gauss map

In Vivo Development of Fetal Pig Kidneys in Mature Monkeys under Clinically Approved Immunosuppressant Drugs

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Engineering 2022年第3期8卷 65-73页

作者： Tsuyoshi Takamura Kenji Matsui Naoto Matsumoto Yatsumu Saito Toshinari Fujimoto Susumu Tajiri Shuichiro Yamanaka Kei Matsumoto Akimitsu kobayashi Izumi Yamamoto Hiroshi Sasaki Haruyuki Hirayama Hitomi Matsunari Kazuaki Nakano Hiroshi Nagashima Akihiko Kiyoshi Takao Kuroda makoto Inoue Takeshi Miyawaki Takashi Yokoo Eiji kobayashi Division of Nephrology and Hypertension Department of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan Department of Urology The Jikei University School of MedicineTokyo 105-8461Japan Department of Plastic and Reconstructive Surgery The Jikei University School of MedicineTokyo 105-8461Japan Meiji University International Institute for Bio-Resource Research Kanagawa 214-8571Japan Sumitomo Dainippon Pharma Co. Ltd.Osaka-fu 564-0053Japan Department of Kidney Regenerative Medicine The Jikei University School of MedicineTokyo 105-8461Japan

Controlling the immune response with only clinically approved immunosuppressant drugs is difficult in renal heterotra ns plantation from pigs to nonhuman ***,to the best of our knowledge,no reports exist on the use of fetal pigs as kidney *** study aimed to compare the degree of transplant rejection between neonatal and fetal kidneys,with genetically unmodified pigs as donors and cynomolgus monkeys as *** left kidneys of the recipient monkeys were removed,followed by transplantation of neonatal as well as fetal pig kidneys,which had undergone vascular anastomosis at the same site,into the *** was performed with only US Food and Drug Administration-approved *** fetal kidneys were transplanted into the omentum and paraaortic regions of cynomolgus ***,the engraftment and development of the transplanted tissues were pathologically examined by sampling over time(twice in each experiment).An acute rejection was observed after a few weeks in neonatal renal grafts with vascular ***,fetal pig kidneys were spared from rejection despite the administration of the same immunosuppressive protocol to the monkeys and the recipient blood vessels flowing into the fetal *** immunogenicity of fetal kidneys in pig-monkey renal heterotransplantation was lower than that of neonatal kidneys.

关键词： Cynomolgus monkey Pig Kidney Fetal kidney Immunosuppression

Repetitive administration of cultured human CD34+cells improve adenine-induced kidney injury in mice

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World Journal of Stem Cells 2023年第4期15卷 268-280页

作者： Takayasu Ohtake Shoichi Itaba Amankeldi A Salybekov Yin Sheng Tsutomu Sato Mitsuru Yanai makoto Imagawa Shigeo Fujii Hiroki Kumagai Masamitsu Harata Takayuki Asahara Shuzo kobayashi Regenerative Medicine The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Kidney Disease and Transplant center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Regenerative Medicine Shonan Research Institute of Innovative MedicineKamakura 247-8533KanagawaJapan Kamakura Techno-science Inc. Kamakura 248-0036Japan Advanced Medicine Science Tokai University School of MedicineIsehara 259-1193Japan Department of Pathology Sapporo Tokushukai HospitalSapporo 004-0041Japan Department of Pathology Sapporo Medical CenterSapporo 004-0041Japan Human Life CORD Japan Inc Chuo-ku 103-0012TokyoJapan Cell Processing and Cell/Genome Analysis Center The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Kidney Disease and Transplant Center Shonan Kamakura General HospitalKamakura 247-8533KanazawaJapan

BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in *** Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning *** culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming *** tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine *** Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control *** interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(P<0.01).Microvasculature integrity was significantly preserved(P<0.01)and macrophage infiltration into kidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(P<0.001).CONCLUSION Early intervention using human cultured CD34+cells significantly improved the progression of tubulointerstitial kidney *** administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects.

关键词： Chronic kidney disease CD34+cell Adenine Tubulointerstitial injury Quality and quantity control culture Umbilical cord blood

Creep-fatigue interaction properties of nickel-based superalloy 617

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 125-131页

作者： Kazuo kobayashi Masao HAYAKAWA Megumi KIMURA National Institute for Materials Science (NIMS) Materials Reliability Center

High-temperature fatigue properties were investigated for a nickel-based superalloy 617 as a typical candidate material for high-temperature components using an advanced ultra super critical （A-USC） power plant. Creep-fatigue data obtained by strain-controlled tests at 700 ？ C was analyzed for the superalloy 617 focused on position of hold at peak strain in comparison with continuously cycled tests. The fatigue life was the shortest with the hold tensile strain wave, which showed mainly intergranular fracture appearance. The life was the longest with symmetrical triangular wave which fractured from the specimen surface, while the wave with the hold compressive strain showed partially intergranular fracture appearance and the life was middle in the both waves. In this study, it is discussed with the creep-fatigue interaction for the superalloy 617.

关键词： A-USC power plant Nickel-based superalloy Creep-fatigue interaction Fractography