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Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan

World Journal of Hematology 2014年第3期3卷 105-114页

作者： Hiroaki Ohnishi Osamu Imataki Yasunori Kawachi makoto ide Kimihiro Kawakami Masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto Kensuke Matsumoto Fusako Waki Akihito Matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka Takuya Matsunaga Department of Internal Medicine Division of En-docrinology and MetabolismHematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa University Department of Internal Medicine Division of HematologyTakamatsu Red Cross Hospital Department of Internal Medicine Division of HematologyKagawa Prefectural Central Hospital Department of Internal Medicine Division of HematologyKagawa Rosai Hospital Department of Internal Medicine Division of HematologyTakamatsu Municipal Hospital Department of Internal Medicine Division of HematologySakaide City Hospital

AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic ***: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age wou

关键词： Acute myeloid leukemia Elderly Adverse prognostic factor Overall survival Population-based study

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Effectiveness of entecavir in preventing hepatocellular carcinoma development is genotype-dependent in hepatitis B virus-associated liver cirrhosis

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World Journal of Hepatology 2021年第1期13卷 144-150页

作者： Kazuo Tarao Akito Nozaki makoto Chuma Masataka Taguri Shin Maeda Department of Gastroenterology Tarao’s Gastroenterological ClinicYokohama City 241-0821Japan Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Data Science Yokohama City University School of Data ScienceYokohama 236-0004Japan Division of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The oral nucleos(t)ide analogue,entecavir(ETV)was demonstrated to reduce the rate of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)-associated liver ***,the reduction of HCC differs in various regions of the *** To investigate the reduction of HCC development due to ETV therapy by *** We surveyed the differences in HCC development following ETV treatment based on published articles using PubMed(2004-2019).RESULTS The regions with the most marked reduction in HCC development due to ETV therapy were Spain(1.0%/year)and Canada(Southern part,1.3%/year),and the most ineffective areas were South Korea(3.6%-3.8%/year),China(3.3%/year),Taiwan(2.4%-3.1%/year),and Hong Kong(2.8%/year).Following ETV administration,the incidence of HCC in genotype D regions(1.89%±0.28%/year,mean±SE)was significantly lower than that in genotype C regions(2.91%±0.24%/year,Pidence of HCC on ETV *** The effectiveness of ETV in preventing HCC development in HBV-associated liver cirrhosis is genotype-dependent.

关键词： Hepatocellular carcinoma Entecavir Genotype of hepatitis B virus Oral nucleos(t)ide analogue

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Association between mucosal surface pattern under near focus technology and Helicobacter pylori infection

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World Journal of Gastrointestinal Endoscopy 2021年第10期13卷 518-528页

作者： Felipe Fiuza Fauze Maluf-Filho Edson ide Carlos Kiyoshi Furuya Jr Sonia Nadia Fylyk Jennifer Nakamura Ruas Luciana Stabach Gabriela Albuquerque Araujo Sergio Eiji Matuguma Ricardo Sato Uemura Christiano makoto Sakai Kendi Yamazaki Sergio Shiguetoshi Ueda Paulo Sakai Bruno Costa Martins Department of Endoscopy Hospital Alemão Oswaldo CruzSão Paulo 01323-020Brazil

BACKGROUND Many studies evaluated magnification endoscopy(ME)to correlate changes on the gastric mucosal surface with Helicobacter pylori(***)***,few studies validated these concepts with high-definition endoscopy without *** To access the association between mucosal surface pattern under near focus technology and *** infection status in a western *** Cross-sectional study including all patients referred to routine upper *** exams were performed using standard high definition(S-HD)followed by near focus(NF-HD)*** of erythema,erosion,atrophy,and nodularity were recorded during S-HD,and surface mucosal pattern was classified using NF-HD in the gastric *** were taken for rapid urease test and *** One hundred and eighty-seven patients were analyzed from August to November *** those,47(25.1%)were ***+,and 42(22.5%)had a previous *** *** the examination with S-HD,erythema had the best sensitivity for *** detection(80.9%).Exudate(99.3%),nodularity(97.1%),and atrophy(95.7%)demonstrated better specificity values,but with low sensitivity(6.4%-19.1%).On the other hand,the absence of erythema was strongly associated with ***-(negative predictive value=92%).With NF-HD,56.2%of patients presented type 1 pattern(regular arrangement of collecting venules,RAC),and only 5.7%of RAC+patients were ***+.The loss of RAC presented 87.2%sensitivity for *** detection,70.7%specificity,50%positive predictive value,and 94.3%negative predictive value,indicating that loss of RAC was suboptimal to confirm *** infection,but when RAC was seen,*** infection was *** The presence of RAC at the NF-HD exam and the absence of erythema at S-HD were highly predictive of *** negative *** the other hand,the loss of RAC had a suboptimal correlation with the presence of ***.

关键词： Diagnosis Endoscopy Gastric infection Gastritis Helicobacter pylori Sensitivity and specificity

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钢制扬克缸的节能效果

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中华纸业 2015年第14期36卷 75-79页

作者：松下淳井出丈史鲁玉欣

Hergen造纸机械公司研发出了最先进的钢制扬克缸取代传统铸铁制扬克缸,提供给薄页纸和卫生纸生产厂家,已取得显著技术效益,降低投资费用和作业成本。文中详细介绍了该缸的主要优势特征及使用厂家证实的增产节能效果。

关键词：钢制扬克缸铸铁制扬克缸增产节能

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