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Cell Research 2006年第4期16卷 337-346页

作者： YukutoYasuhiko KoichiroShiokawa Toshio Mochizuki makoto asashima Takahiko Yokoyama Department of Biological Sciences Graduate School of ScienceUniversity of Tokyo7-3-1 HongoBunkyo-kuToyo113-0033Japan Department of Medicine Kidney CenterTokyo Women's Medical UniversitySchool of MedicineJapan Department of Life Science University of Tokyo3-8-1 Komaba.Meguro-kuTokyo 158-8902.Japan Department of Anatomy and Developmental Biology Tokyo Women's Medical College8-1 Kawada-choShinjuku-kuTokyo 162-8666Japan

The homozygous inv(inversion of embryonic turning)mouse mutant shows situs inversus and polycystic kidney disease,both of which result from the lack of the inv ***,we suggested that inv may be important for the ieft-rightaxis formation,not only in mice but also in Xenopus,and that calmodulin regulates this inv protein ***,weisolated and characterized two Xenopus laevis homologs(Xinv-1 and Xinv-2)of the mouse inv gene,and performedfunctional analysis of the conserved IQ motifs that interact with ***-1 expresses early in development in thesame manner as mouse inv ***,a full-length Xenopus inv mRNA did not randomize cardiac orientationwhen injected into Xenopus embryos,which is different from mouse inv *** to mouse inv mRNA,Xenopusinv mRNA with mutated IQ randomized cardiac *** present study indicates that calmodulin binding sites(IQ motifs)are crucial in controlling the biological activity of both mouse and Xenopus inv *** mouseand Xenopus inv genes have a quite similar structure,the interaction with calmodulin and IQ motifs ofXenopus inv andmouse inv proteins may regulate their function in different ways.

关键词： Left-right asymmetry inv calmodulin ankyrin IQ motif Xenopus calcium

Molecular analyses of Xenopus laevis Mesp-related genes

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Integrative Zoology 2009年第4期4卷 387-394页

作者： Keisuke HITACHI Akiko KONDOW Hiroki DANNO Yusuke NISHIMURA Koji OKABAYASHI makoto asashima Department of Life Sciences(Biology) Graduate School of Arts and SciencesThe University of TokyoTokyoJapan Department of Biological Sciences Graduate School of ScienceThe University of TokyoTokyoJapan ICORP Organ Regeneration Project Japan Science and Technology AgencyTokyoJapan Organ Development Research Laboratory National Institute of Advanced Industrial Science and TechnologyIbarakiJapan

During vertebrate somitogenesis,somites bud off from the anterior end of the presomitic mesoderm(PSM).Meso-dermal posterior(Mesp)-related genes play essential roles in somitogenesis,particularly in the definition of the somite boundary *** vertebrates,two types of Mesp-related genes have been identified:Mesp1 and Mesp2 in the mouse;Meso-1 and Meso-2 in the chicken;Xl-mespa and Xl-mespb(also known as Thylacine1)in the African clawed frog(Xenopus laevis);and mesp-a and mesp-b in the ***,the functional differences between two Mesp-related genes remain *** the present study,we carried out comparative analyses of the Xl-mespa and Xl-mespb *** amino acid sequences of the Xl-mespa and Xl-mespb proteins showed a high level of *** expression of Xl-mespa started broadly in the ventrolateral mesoderm and gradually shifted to a striped pattern of *** contrast,Xl-mespb showed a striped pattern of expression from the *** expression profiles completely overlapped at the PSM during *** investigate the functional differ-ences between Xl-mespa and Xl-mespb in terms of target gene regulation,we carried out a luciferase assay using the murine Lunatic fringe(L-fng)*** of the L-fng promoter was activated more strongly by Xl-mespb than by *** same pattern was observed for the murine Mesp-related *** results suggest that the functional differences between the two types of Mesp-related genes are evolutionally conserved in vertebrates.

关键词： homology presomitic mesoderm somite segmentation somitogenesis Xenopus laevis.

Organogenesisi and cell diffemtiation during early amphibian development

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Organogenesisi and cell diffemtiation during early amphibian...

走在时代前列的大学——全球知识前沿的办学目标(英文)

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： makoto asashima Takashi Ariizumi Noomi Moriya Akimasa Fukui Department of Life Sciences (Biology) Graduate School of Arts and SciencesThe University of Tokyo3-8-1 KomabaMeguro-kuTokyo 153-8902Japan CREST Project Graduate School of Arts and SciencesThe University of Tokyo3-8-1 KomabaMeguro-kuTokyo 153-8902Japan Department of Life Sciences(Biology)Graduate School of Arts and SciencesThe University of Tokyo3-8-1 KomabaMeguro-kuTokyo 153-8902Japan

In the process of early vertebrate development, formation of an embryonic body pattern is established through cell division, gene expression, morphogenesis and cell differentiation. The mechanism of body patterning is complex and includes multiple induction events. In the induction events occurring between two cells or tissues, factors secreted by the inducing cells may cause the directive differentiation of the reacting cells. In mesoderm induction the expected factors from vegetal cells are referred to as mesodermal inducing factors (MIFs).

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走在时代前列的大学——全球知识前沿的办学目标(英文)

Deciphering the enigmatic spikelet traits:Resolving trade-offs for enhancing rice yield

北京论坛（2007）文明的和谐与共同繁荣——人类文明的多元发展模式

作者： asashima makoto The University of Tokyo

Universities are being exposed to fierce competition on a global scale and required to make changes *** institutions that fail to adapt to the changing environment will certainly *** University of Tokyo,while recognized as one of the world’s leading universities,is no *** take these demands of the times as an excellent motivator for us to work toward

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Molecular Plant 2024年第5期17卷 694-695页

作者： Hideki Yoshida makoto Matsuoka Institute of Fermentation Sciences Fukushima UniversityFukushima 960-1248Japan

Increasing the yield is one of the most important goals of crop *** the beginning of rice cultivation thousands of years ago,many efforts have been made to increase rice *** of the successes in this history was the Green *** tremendous improvement in the 1960s was achieved by increasing rice and wheat production through the development and widespread adoption of semi-dwarf varieties with the extensive use of fertilizers(Hedden,2003).Dwarfism in crops lowers the center of gravity of the plant body,reducing the risk of lodging and enabling farmers to use more fertilizer to increase ***-dwarf mutations in both rice and wheat created during the Green Revolution are related to the plant growth hormone gibberellin(GA).Although other mechanisms cause dwarf mutants,only GA-related semi-dwarf mutants were selected during the Green Revolution(Wang et al.,2021).While GA-related abnormalities only make plants shorter,most cases caused by other mechanisms involve not only dwarfism but also other morphological abnormalities.

关键词： dwarf crops traits

Spaceborne and ground-based sensor collaboration:Advancing resident space objects’orbit determination for space sustainability

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Astrodynamics 2024年第3期8卷 325-347页

作者： Niki Sajjad Mehran Mirshams Andreas makoto Hein Space Research Laboratory Department of Aerospace EngineeringK.N.Toosi University of TechnologyTehran16569-83911Iran Interdisciplinary Centre for Security Reliability and Trust(SnT)University of LuxembourgLuxembourg1855Luxembourg

The limited space around the Earth is getting cluttered with leftover fragments from old missions,creating a real *** more satellites are launched,even debris pieces as small as 5 mm must be tracked to avoid ***,it is an arduous and challenging task in *** paper presents a technical exploration of ground-based and in-orbit space debris tracking and orbit determination *** highlights the challenges faced during on-ground and in-orbit demonstrations,identifies current gaps,and proposes solutions following technological advancements,such as low-power pose estimation *** to the numerous atmospheric barriers to ground-based sensors,this study emphasizes the significance of spaceborne sensors for precise orbit determination,complemented by advanced data processing algorithms and collaborative *** ultimate goal is to create a comprehensive catalog of resident space objects(RSO)around the Earth and promote space environment *** exploring different methods and finding innovative solutions,this study contributes to the protection of space for future exploration and the creation of a more transparent and precise map of orbital objects.

关键词： resident space objects(RSO) space debris orbit determination tracking ground-based sensors spaceborne sensors

Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1241-1248页

作者： Tingting Han Yuxiang Xu Lin Sun makoto Hashimoto Jianshe Wei Institute for Brain Sciences Research School of Life SciencesHenan UniversityKaifengHenan ProvinceChina College of Chemistry and Molecular Sciences Henan UniversityKaifengHenan ProvinceChina Department of Basic Technology Tokyo Metropolitan Institute of Medical ScienceTokyoJapan.

Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for *** the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative *** review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases,including Alzheimer's disease,Huntington's chorea,and Parkinson's *** review also describes the potential benefits of treating neurodegenerative diseases by modulating changes in microglial ***,inducing a shift from the neurotoxic to neuroprotective microglial state in neurodegenerative diseases induced by aging and chronic inflammation holds promise for the treatment of neurodegenerative diseases in the future.

关键词： aging Alzheimer's disease cytokines Huntington's disease microglia neurodegenerative diseases neuroinflammation neuroprotection neurotoxicity Parkinson's disease

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The optimal stent pusher position to achieve successful ureteral stent insertion under fluoroscopic guidance

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Asian Journal of Urology 2024年第2期11卷 311-315页

作者： makoto Taguchi Kaneki Yasuda Hidefumi Kinoshita Department of Urology Osaka Saiseikai Izuo Hospital Based on Social Welfare Organization“Saiseikai”Imperial Gift Foundation Inc.OsakaJapan Department of Urology and Andrology Kansai Medical UniversityHirakataOsakaJapan

Objective: To examine factors to predict the optimal stent pusher position when inserting ureteral stents under ***: We retrospectively reviewed 327 patients who underwent ureteral stent insertion. We considered the pubic bone as a useful anatomical landmark to insert ureteral stents under fluoroscopic guidance. Thus, we categorized patients into three groups (proximal, middle, and distal groups) according to the position of the radiopaque tip of the push catheter when inserting the ureteral stent. Success was defined as a completely curled ureteral stent tail. We compared stent insertion success rates among the three groups. A multivariate analysis was performed to identify the factors affecting stent insertion ***: In men, 36 (63.2%) cases were deemed successful in the proximal group compared with 40 (80.0%) cases in the middle group and 12 (20.7%) cases in the distal group (p<0.001). In women, 26 (45.6%) cases were deemed successful in the proximal group compared with 54 (98.2%) cases in the middle group and 38 (76.0%) cases in the distal group (p<0.001). With the multivariate analysis, the stent pusher position was the most significant factor influencing successful stent insertion (men: odds ratio 6.00, 95% confidence interval 2.66-13.51, p<0.001;women: odds ratio 37.80, 95% confidence interval 4.94-289.22, p<0.001).Conclusion: The position of the stent pusher affects stent insertion success. The middle of the pubic symphysis is the optimal position for the radiopaque tip of the pusher when inserting ureteral stents under fluoroscopic guidance.

关键词： Stent Cystoscopy Fluoroscopy Ureter

Symmetric silicon microring resonator optical crossbar array for accelerated inference and training in deep learning

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Photonics Research 2024年第8期12卷 1681-1688页

作者： RUI TANG SHUHEI OHNO KEN TANIZAWA KAZUHIRO IKEDA makoto OKANO KASIDIT TOPRASERTPONG SHINICHI TAKAGI MITSURU TAKENAKA Department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-8656Japan Quantum ICT Research Institute Tamagawa UniversityTokyo 194-8610Japan National Institute of Advanced Industrial Science and Technology Ibaraki 305-8568Japan

Photonic integrated circuits are emerging as a promising platform for accelerating matrix multiplications in deep learning,leveraging the inherent parallel nature of *** various schemes have been proposed and demonstrated to realize such photonic matrix accelerators,the in situ training of artificial neural networks using photonic accelerators remains challenging due to the difficulty of direct on-chip backpropagation on a photonic *** this work,we propose a silicon microring resonator(MRR)optical crossbar array with a symmetric structure that allows for simple on-chip backpropagation,potentially enabling the acceleration of both the inference and training phases of deep *** demonstrate a 4×4 circuit on a Si-on-insulator platform and use it to perform inference tasks of a simple neural network for classifying iris flowers,achieving a classification accuracy of 93.3%.Subsequently,we train the neural network using simulated on-chip backpropagation and achieve an accuracy of 91.1%in the same inference task after ***,we simulate a convolutional neural network for handwritten digit recognition,using a 9×9 MRR crossbar array to perform the convolution *** work contributes to the realization of compact and energy-efficient photonic accelerators for deep learning.

关键词： resonator neural matrix

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Electronic structure and effective mass of pristine and Cl-doped CsPbBr_(3)

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Chinese Physics B 2024年第5期33卷 167-171页

作者：魏志远魏愉昊徐申东彭舒婷 makoto Hashimoto 路东辉潘旭匡泯泉肖正国何俊峰 Department of Physics and CAS Key Laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Chongqing Key Laboratory of Micro & Nano Structure Optoelectronics and School of Physical Science and TechnologySouthwest UniversityChongqing 400715China Key Laboratory of Photovoltaic and Energy Conservation Materials Institute of Applied TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Stanford Synchrotron Radiation Lightsource and Stanford Institute for Materials and Energy Sciences SLAC National Accelerator LaboratoryMenlo ParkCalifornia 94025USA

Organic–inorganic lead halide perovskites(LHPs) have attracted great interest owing to their outstanding optoelectronic ***,the underlying electronic structure would determinate the physical properties of *** as for now,limited studies have been done to reveal the underlying electronic structure of this material system,comparing to the huge amount of investigations on the material *** effective mass of the valance band is one of the most important physical parameters which plays a dominant role in charge transport and photovoltaic *** pristine CsPbBr_(3),the Fr?hlich polarons associated with the Pb–Br stretching modes are proposed to be responsible for the effective mass *** this regard,it would be very interesting to explore the electronic structure in doped ***,we report high-resolution angle-resolved photoemission spectroscopy(ARPES) studies on both pristine and Cl-doped CsPbBr_(3).The experimental band dispersions are extracted from ARPES spectra along both ■ and ■ high symmetry *** calculations are performed and directly compared with the ARPES *** results have revealed the band structure of Cl-doped CsPbBr_(3) for the first time,which have also unveiled the effective mass renormalization in the Cl-doped CsPbBr_(3) *** dependent measurements indicate that the chlorine doping could moderately tune the renormalization *** results will help understand the physical properties of LHPs as a function of doping.

关键词： lead halide perovskites electronic structure effective mass

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