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国外钢铁 1994年第7期19卷 50-53页

作者： maki,H 白明华

一种在线高速的（１０００－ｆｐｍ）超高灵敏度的磁检测系统已经研制出来，并被用于检测罐头盒原料的微缺陷。

关键词：带钢在线检测磁探伤系统

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一开始就赢得的胜利！快速抗衰老篇

国际服装技术 2006年第11期 148-155页

作者： maki Tezuka Mina Ihara cola-chen（翻译）

抗衰老……言之过早的话题？真这样认为吗？大错特错了！干燥，毛孔，晦暗，粉刺，色斑，细纹……“把衰老扼杀在萌芽状态！”只有这样，10年以后的皮肤才会一如今昔。所以，别再无视和沉默，现在就把“老化”的恐惧一举击退！

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Experiment of Removing Traces of Phosphorus in Water Using Bottom Sludge of Ise-Bay

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材料科学与工程（中英文A版） 2019年第1期9卷 8-12页

作者： Yukimasa Takemoto Masaaki Takahashi Kati Nabin Adhikari Jayaram maki Ooyagi Shrestha Rashim Bahadur Eiji Yuki Takanori Terazawa Yokkaichi University Research Laboratory on Environmental TechnologyKayo-cho 1200YokkaichiMie 512- 8512Japan Mie Chuo Kaihatsu Co. LtdHachiya 4713YonoIgaMie 518-1152Japan Mie prefectural Environmental Conservation Agency Ueno 3258KawageTsuMie 510-0304Japan

Large amounts of sludge has accumulated in the Inner Bay,which is one factor of environmental *** found that this sludge has an effect of absorbing low concentrations of phosphorus in *** the purpose of development of water treatment agents and effective utilization of the sludge,phosphorus removal performance was investigated using wet sludge collected in Ise-Bay.A small amount of sludge was added to the test water having a phosphorus concentration of about 1~2 mg/L,and the phosphorus concentration of the filtrate after stirring and filtration was *** on the sludge conditions,it showed 30% to 80% of phosphorus removal *** investigated the relationship between the physical properties of the sludge and the removal performance.

关键词： Bay sediment phosphorus removal water treatment

Isolated Para-Aortic Nodal Recurrence in Endometrial Cancer

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Open Journal of Obstetrics and Gynecology 2018年第7期8卷 669-675页

作者： Motoki Matsuura Akimasa Takahashi Hidetaka Nomura maki Matoda Sanshiro Okamoto Hiroyuki Kanao Kohei Omatsu Kazuyoshi Kato Kuniko Utsugi Nobuhiro Takeshima Department of Gynecologic Oncology Cancer Institute Hospital Tokyo Japan

Aim: While cytoreductive surgery should be considered for patients with regional recurrence of endometrial cancer, the management of isolated para-aortic lymph node recurrence remains controversial. We investigated the frequency of isolated recurrence in the para-aortic lymph nodes and the effectiveness of surgery for such recurrence. Methods: A retrospectively maintained endometrial cancer database at the Cancer Institute Hospital in Japan was reviewed to identify sites of metastasis and recurrence. Results: A total of 2322 patients with endometrial cancer underwent primary treatment with systemic lymphadenectomy between 1984 and 2015. Systematic pelvic and para-aortic lymph node dissection was performed in 889 patients (Group 1), while 1433 patients underwent dissection of only the pelvic lymph nodes (Group 2). Although 16 patients (1.1%) in Group 2 had isolated para-aortic recurrences, only 3 patients (0.3%) in Group 1 had documented recurrences in the para-aortic lymph nodes (p = 0.043). Although second recurrence occurred in 30.0% of patients who underwent surgical recurrence treatment, second recurrence occurred in 77.8% of patients who underwent non-surgical recurrence treatment (p = 0.037). In addition, the overall survival rate for patients who underwent surgical recurrence treatment (80.0%) was significantly higher than that for patients who underwent non-surgical recurrence treatment (33.3%) (p = 0.026). Conclusions: Patients who underwent dissection of only the pelvic lymph nodes had a higher frequency of isolated recurrence in the para-aortic lymph nodes. In addition, a relatively good prognosis could be achieved with surgical treatment for isolated recurrence in the para-aortic lymph nodes, which was better than that achieved using non-surgical methods.

关键词： Endometrial Cancer Recurrence Isolated Para-Aortic Nodal Recurrence

Post-dose 12-hour trough concentration of mycophenolate mofetil co-administrated with cyclosporine in dog

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畜牧与兽医 2012年第S2期44卷 51-51页

作者： Yijyun Li Zheng Cao Akiyoshi Hayashi Keichiro Mie maki Ishibashi Toshiyuki Tanaka Katsuhito SoneFumihito Ohashi Laboratory of Veterinary SurgeryGraduate School of Life and Environmental Sciences Osaka Prefecture University

Mycophenolate mofetil (MMF) is a pro-drug for mycophenolic acid (MPA) which reduces the likelihood of allograft rejection after renal transplantation. It was known that post-dose 12-hour trough concentration of MMF will be influenced by several factors including renal function and cyclosporine (CsA) co-administration and need adjustment when used in clinical renal transplanted patients,but there is still few data in dog. The objective of this study is to investigate Post-dose 12-hour trough concentration and determine the optimal dose of MMF in renal transplanted dog. Study 1: Investigate the relationship between oral dose and Post-dose 12-hour trough concentration of MPA in healthy dogs. Study 2: Investigate the changes of post-dose 12-hour trough concentration of MPA in healthy dogs when co-administrating with CsA. Study 3: Investigate the relationship between dose and Post-dose 12-hour trough concentration of MPA in low glomerular filtration rate (GFR) model dogs with CsA co-administration. 8 Adult female beagle dogs aged 1-2 years old,weight in 1. 5-13. 5kg. Study 1: After 7 days of prier oral administration of MMF (10 mg/kg,n = 4; 30 mg/kg,n = 4),MMF was oral administrated in the same dose in day 8,and MPA blood concentrations were measured at 0,20,40,60,90,120, 240,360,480,and 720 min after oral dose. Study 2: After 7 days of prier administration of 10 mg/kg MMF with (n = 4) or without (n = 4) 10 mg/kg CsA,MMF was oral administrated in the same dose with or without CsA in day 8,and post-dose 12-hour trough concentrations were measured. Study 3: Low GFR model dogs were prepared with renal artery ligation before this study. After 7 days of prier co-administration of 10 mg/kg (n = 4) or 20 mg/kg (n = 4) MMF with 10 mg/kg CsA,MMF was oral administrated in the same dose in day 8 and 12-hour trough concentrations of MPA were measured. MPA concentrations were measured by high performance liquid chromatography method. 12-hour trough concentrations of MPA of healthy do

关键词： Mycophenolate Mofetil mycophenolic acid trough concentrations cyclosporine dog

Prognostic Value of SUVmax of <sup>18</sup>F-FDG PET/CT in Early Stage Breast Cancer with No LN Metastasis

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Open Journal of Medical Imaging 2017年第3期7卷 112-123页

作者： Ryusuke Murakami Yoshimitsu Fukushima Hitomi Tani Kotomi Iwata Shinichiro Kumita maki Nakai Tomoko Kurita Keiko Yanagihara Hiroyuki Takei Miyuki Matsubara Department of Radiology Nippon Medical School Hospital Tokyo Japan Department of Breast Surgery Nippon Medical School Hospital Tokyo Japan Division of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan

Purpose: To investigate the correlation between SUVmax of FDG-PET/CT and pathological findings including prognostic factors in early-stage T1-T2 breast cancer patients with no LN metastasis. Materials and Methods: This retrospective study investigated 75 patients (mean age 58.9 years;age range 30 - 82 years) with invasive breast cancer who underwent FDG-PET/CT for preoperative staging. All patients underwent subsequent surgery without prior neoadjuvant chemotherapy or endocrine therapy, and those who were confirmed to have T1- or T2-stage by histopathology with no LN metastasis were included. Two patients who had no perceptible FDG accumulation on PET/CT scans were excluded. The correlations between the SUVmax of the tumor and the pathological and immunohistochemical data were evaluated. Results: The mean SUVmax for the total 73 tumors was 5.46 ± 4.05. The mean SUVmax was 3.95 ± 3.28 for the T1 stage group (n = 36) and 7.23 ± 4.10 (p p p p = 0.008), and high Ki-67 status (p < 0.001), respectively. Conclusion: In T1-T2 breast cancer with no LN metastasis, the SUVmax of FDG-PET/CT had significant positive relationships with several prognostic parameters of pathological status. Even in early-stage breast cancer patients, pretreatment FDG-PET/CT is useful for predicting malignant behavior and prognosis).

关键词： Breast Cancer Molecular Subtype Prognosis PET/CT SUVmax

Advantage of Introducing Quantitative Light-Induced Fluorescence in School Dental Checkups

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Health 2018年第8期10卷 1095-1106页

作者： Koji Watanabe Takashi Sasabe Akihiro Nakamura Kosuke Eda Kosuke Tanase Hidefumi Ikeda Naoko Ohata Yukiko Minohara Kenshi maki Shigeru Watanabe Division of Developmental Stomatognathic Function Science Department of Health Promotion Kyushu Dental University Kitakyushu Japan Division of Pediatric Dentistry Department of Human Development and Fostering Meikai University School of Dentistry Sakado Japan

Background: Caries detection in school oral examinations insufficient accuracy. Objective: To evaluate advantages of introducing quantitative light-induced fluorescence-digital (QLF-D) in school oral examinations. Methods: Experiment No. 1. Early demineralized lesions in the upper and lower incisors and canines were visually inspected by three dentists and by QLF-D. The numbers of tooth planes with early demineralized lesions were compared between the methods. Experiment No. 2. Approximal demineralized lesions in molars were assessed by visual inspection, x-ray imaging, and QLF-D. The numbers of tooth planes with demineralized lesions were compared among the methods. Experiment No. 3. Plaque distribution was evaluated by QLF-D and a traditional staining method. The ratio of the diameter of plaque to tooth crown in the tooth axis direction in each method was calculated. The results were evaluated by Pearson’s correlation coefficient analysis and Bland-Altman plot. Results: Experiment No. 1. The three dentists found 0.67 tooth planes on average. QLF-D found 22 tooth planes with early demineralized lesions in the same samples. Experiment No. 2. Fourteen approximal tooth planes of molars were found to have demineralized lesions by x-ray imaging. QLF-D detected 71.4% of the tooth planes out of the 14, whereas visual inspection found 7.1%. Experiment No. 3. The Pearson’s correlation coefficient for the evaluations of plaque distribution between the QLF-D and traditional staining methods was 0.77 (P Conclusion: The results support introduction of QLF-D for use in school dental examinations.

关键词： Oral Checkup Early Demineralized Lesion Approximal Demineralized Lesion Quantitative Light-Induced Fluorescence-Digital

Curcumin Inhibits Adipogenesis Elicited by Clozapine in 3T3-L1 Cells

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Food and Nutrition Sciences 2018年第5期9卷 584-594页

作者： Satoru Sakuma maki Sumida Asami Sakabe Ayaka Nakamura Chisato Noda Kaho Tsujimoto Maimi Kobayashi Tomohiko Sano Yohko Fujimoto Tetsuya Kohda Department of Physiological Chemistry Osaka University of Pharmaceutical Sciences Osaka Japan

Although clozapine (CZP), which is used for schizophrenia treatment, causes weight gain, the mechanism remains unclear. We recently reported that the naturally occurring compound curcumin (CUR) suppresses adipogenesis in 3T3-L1 cells. The aims of the present study were to determine the mechanism by which CZP induces adipocyte differentiation of 3T3-L1 cells, and whether CUR reduces CZP-induced adipogenesis. We found that cells grown in the presence of CZP had significantly higher triacylglycerol levels, numbers of lipid-filled adipocytes, and mRNA expression levels of CCAAT-enhancer binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) than those grown without CZP. Treatment with CZP plus CUR resulted in major reductions in these four parameters. These results suggest that CZP enhances adipogenesis in 3T3-L1 cells via the C/EBPα-PPARγ pathway and that by interrupting CZP’s effects, CUR might be a potent agent for preventing CZP-induced weight gain.

关键词： Clozapine Curcumin Adipocyte Differentiation 3T3-L1 Cell Atypical Antipsychotic Drug

Decreased Ratios of Interleukin-1<i>β</i>and Intercellular Adhesion Molecule 1 in Gingival Crevicular Fluid after Scaling and Root Planing Associated with Periodontal Pocket Healing

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Open Journal of Stomatology 2017年第9期7卷 361-376页

作者： Yuriko Hieda Michihiko Usui Taiji Nakamura Masaki Morishita Tomoya Hanatani Yuki Moritani Yukiko Koga Shingo Kasai maki Inoue Keisuke Nakashima Division of Periodontology Department of Oral Functions Kyushu Dental University Kitakyushu Japan

Objectives: Several researchers have investigated inflammatory cytokines in gingival crevicular fluid (GCF) from chronic periodontitis with clinical parameters after periodontal treatment. The aim of the present study was to identify the inflammatory cytokines present in GCF associated with periodontal pocket healing after scaling and root planing (SRP). Methods: Twenty patients were enrolled, and clinical examinations including probing pocket depth (PPD) and bleeding on probing (BOP) were performed at the first visit, and before and after SRP. The periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were also calculated. GCF samples were collected before and after SRP to measure the levels of 40 inflammatory cytokines using antibody array. Correlations between changes in cytokine levels and clinical improvements were assessed by single and multiple regression analyses. Results: PPD, PESA and PISA significantly decreased after SRP, while there were no significant differences in the levels of cytokines before (PreSRP) and one week after SRP (PostSRP). Clinical improvements (ΔPPD, ΔPESA and ΔPISA) were calculated using the formula PreSRP-PostSRP, while changes in the levels of inflammatory cytokines were calculated using three formulas: PreSRP-PostSRP, PostSRP/PreSRP and Log(PostSRP/PreSRP). Log (PostSRP/PreSRP) for interleukin-1β (IL-1β) significantly correlated with ΔPESA (R = -0.512). PostSRP/PreSRP and Log(PostSRP/PreSRP) for intercellular adhesion molecule 1 (ICAM-1) significantly correlated with ΔPISA (R = -0.669, -0.573). Two good fit models were generated by multiple linear regression. Log(PostSRP/PreSRP) for IL-1β significantly affected ΔPESA (R2 = 0.566). PostSRP/PreSRP for ICAM-1 significantly affected ΔPISA (R2 = 0.615). Conclusion: Changes (PreSRP-PostSRP) in any cytokines in GCF after SRP were not associated with clinical improvements. However, the present study indicates that lower PostSRP/PreSRP ratios for IL-1β and I

关键词： IL-1β ICAM-1 GCF SRP Wound Healing

Establishing a Calculation Method for Estimating the Normal Circumference of the Proximal Interphalangeal Finger Joints

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第4期7卷 186-195页

作者： Satoru Nakamura Daisaku Tokunaga Ryo Oda Daigo Taniguchi Shogo Toyama maki Asada Hiroyoshi Fujiwara Yutaka Kawahito Takahiro Seno Toshikazu Kubo Department of Orthopaedics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan

Objective: To estimate the normal circumference of the interphalangeal (IP) thumb joint and the proximal IP (PIP) joints from the index finger to the little finger using individual physical parameters such as body height and body weight. Methods: The maximum size on the ring gauge was recorded which caused resistance when the IP joint of the thumb or PIP joints of the index to small fingers were passed through the gauge. RG was defined as the ring gauge number with the same diameter as the circumference of the IP thumb joint and PIP finger joints from the index finger to the little finger. There were 300 healthy subjects and 600 hands. Univariate and multivariate analyses were used to analyze the relationships between RG and the parameters of age, sex, height, weight, and dominant hand, and regression equations were derived. Results: Age, sex and body weight were all statistically significant predictive factors of RG in all fingers. R2, the coefficient of determination in the regression equation, was almost 0.7 for all fingers, indicating that a moderate or strong correlation was observed between RG and the regression equation. Conclusions: The circumference of the IP thumb joint and PIP finger joints from the index finger to the little finger can be estimated in healthy individuals using a calculation formula that takes age, sex, body height and body weight into account.

关键词： PIP Joint Circumference Ring Gauge