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World Journal of Gastroenterology 2014年第6期20卷 1623-1625页

作者： Hirohito Mori Kazi Rafiq Hideki Kobara Noriko Nishiyama Shintaro Fujihara Tatsuo Yachida maki ayagi Joji Tani Hisaaki Miyoshi Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University

Previously, we reported the efficacy of a newly developed inverted overtube in shortening the hemostatic time and obtaining a clear endoscopic view in emergency endoscopic hemostasis. This device also helped us to perform gastric endoscopic submucosal dissection(ESD) more safely by changing the direction of gravity in the right lateral position. To perform a safe ESD, it is important to make an appropriate angle and distance between the electric knife and the gastric mucosa. In this position, the distance to gastric mucosa is reduced, and the angle of the electric knife changes from vertical to somewhat oblique, facilitating safer cutting.

关键词： Gastric endoscopic submucosal dissection Direction of gravity Right lateral position Appropriate angle and distance

Radical excision of Barrett's esophagus and complete recovery of normal squamous epithelium

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World Journal of Gastroenterology 2013年第31期19卷 5195-5198页

作者： Hirohito Mori Hideki Kobara Kazi Rafiq Noriko Nishiyama Shintaro Fujihara maki ayagi Tatsuo Yachida Kiyohito Kato Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University Kagawa 761-0793 Japan Department of Pharmacology Kagawa UniversityKagawa 761-0793 Japan

To treat Barrett's esophagus(BE),radiofrequency ablation or cryotherapy are effective treatments for eradicating BE with dysplasia and intestinal metaplasia,and reduce the rates of Barrett's esophageal adenocarcinoma(BAC).However,patients with BE and dysplasia or early cancer who achieved complete eradication of intestinal metaplasia,BE recurred in 5% within a year,requiring expensive endoscopic *** performed endoscopic submucosal dissection as complete radically curable treatment procedure for BE with dysplasia,intestinal metaplasia and BAC.

关键词： Barrett’s esophagus Radiofrequency ablation Cryotherapy Endoscopic submucosal dissection Radically curable treatment

Endoscopic management of a rare granulation polyp in a colonic diverticulum

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World Journal of Gastroenterology 2013年第48期19卷 9481-9484页

作者： Hirohito Mori Takaaki Tsushimi Hideki Kobara Noriko Nishiyama Shintaro Fujihara Tae Matsunaga maki ayagi Tatsuo Yachida Tsutomu Masaki Departments of Gastroenterology and Neurology Kagawa University School of Medicine Kagawa 761-0793 Japan Department of Gastroenterological Surgery Ehime Rosai Hospital Ehime 792-8550 Japan

There are many case reports on colon diverticula that cause irritable bowel syndrome,constipation,bleeding,diverticulitis,stricture due to multiple recurrences of diverticulitis,and ***,few articles have examined neoplasms that arise from a diverticulum,such as adenoma and adenocarcinoma,and there have been no reports of granulation polyps that arise from a colon diverticulum after recurrent *** observed a rare granulation polyp that arose from a diverticulum as a result of repeated episodes of local *** band imaging magnified colonoscopy was very useful to diagnose the polyp as a granulation polyp because of the absence of a pit pattern on the surface of the *** successfully resected the polyp using endoscopic mucosal *** inverted the diverticulum,and the resected stalk of the polyp was used to close the diverticulum with an over-thescope *** a granulomatous polyp could arise from a diverticulum,differential diagnosis between a colon neoplasm and a granulomatous polyp would not only be difficult but also necessary for suitable endoscopic treatment.

关键词： Diverticulitis Endoscopy Granulation polyp Mucosal resection Neoplasm Recurrence

Assessing mixing uniformity in microreactors via in-line spectroscopy

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Chinese Journal of Chemical Engineering 2024年第2期66卷 119-124页

作者： Shusaku Asano Shinji Kudo Taisuke maki Yosuke Muranaka Kazuhiro Mae Jun-ichiro Hayashi Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan Department of Chemical Engineering Graduate School of EngineeringKyoto UniversityJapan

Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors.A high Reynolds number(Re)improves the mixing rate and selectivity of the reactions,but some exceptions of increasing side product yield with the higher Re have been *** study investigated the mixing uniformity in microreactors with in-line UV-vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re.A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed ***-uniformity significantly increased with *** the same time,the degree of mixing,which was measured by a usual decolorization experiment,showed that the mixing rate increased with *** in-line analysis of the Villermaux-Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around *** results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive *** mixing,characterized by a larger Re,can disturb mixing uniformity and,in some cases,decrease reaction selectivity.

关键词： Microreactor Villermaux-Dushman reaction In-line analysis Mixing Mass transfer Uniformity

日本学界中国古代逻辑思想研究的历程及其特点

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逻辑学研究 2024年第1期17卷 30-54页

作者：深川真树南京师范大学公共管理学院哲学系

19世纪西方文明的冲击,促使东亚知识分子重新审视传统学术,并在中国古代思想中发现逻辑思想。日本学界较早接受西方学术,其对中国古代逻辑思想的研究也取得丰硕成果。日本学者最初是以西方传统形式逻辑为标准,考察中国古代思想,后来逐... 详细信息

19世纪西方文明的冲击,促使东亚知识分子重新审视传统学术,并在中国古代思想中发现逻辑思想。日本学界较早接受西方学术,其对中国古代逻辑思想的研究也取得丰硕成果。日本学者最初是以西方传统形式逻辑为标准,考察中国古代思想,后来逐渐开始关注中国古代汉语的特性,从语言学的角度探究中国古代逻辑思想。这些是日本学界中国古代逻辑思想研究的独特途径。此外,日本在这个领域的研究,从以西方逻辑学为标准看待中国的逻辑思想,转向探究中国独有的逻辑思想。中国学界对中国古代逻辑思想的研究也呈现出类似的趋势。两国学界应加强交流,共同推动中国古代逻辑思想的研究。

关键词：日本中国逻辑思维汉学

Effect of the Arrangement of a New-Type of Turbulator Inserts on Heat Pipe Exchanger Performances

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Fluid Dynamics & Materials Processing 2023年第10期19卷 2749-2759页

作者： Ibtisam A.Hasan Wafa maki Department of Electromechanical Engineering The University of TechnologyBaghdadIraq

This research tests the effect of introducing turbulators of a new type into a circular tube heat exchanger under a constant and uniform longitudinal heatﬂux condition.A 45 mm diameter copper tube with a length of 1,350 mm is utilized with a solid disk being inserted inside the tube,which consists of three sections,each one containing two *** slot is cut at a 45 degree angle toward the inner tube surface,which results in diverging theﬂow toward the inner hot tube surface in order to enhance the heat transfer *** is considered as the workingﬂuid with Prandtl number *** Reynolds number spans the interval from 6,000–13,500,which indicates that the consideredﬂow is *** heat exchanger performance is studied and analyzed in terms of average Nusselt *** experimental results show that the Nusselt number value is directly proportional to the increase of the Reynolds number,and the number of turbulators *** the use of three novel turbulators,the heat transfer was about 3.15 times higher than that in the smooth tube and the friction factor was about 1.11.

关键词： Heat pipe exchanger heat transfer inserts(NT inserts) turbulators(novel turbulators) disk(solid disk)

Direct ethanol production from rice straw by coculture with two high-performing fungi

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 139-145页

作者： maki TAKANO Kazuhiro HOSHINO Graduate School of Science and Engineering University of Toyama Toyama 930-8555 Japan

To develop efficient and economical direct ethanol production from fine rice straw crashed mechanically, two high-performing fungi, which can secret hyperactive cellulases and/or ferment effectively various sugars, were selected from some strains belong to Mucor circinelloides preserved in our laboratory. The simultaneous saccharification and fermentation （SSF） by coculture with these fungi was investigated. The screening of high- performing fungi resulted in the selection of NBRC 4572 as an ethanol-producing fungus and NBRC 5398 as a cellulase-secreting fungus. The strain 4572 produced ethanol aerobically from glucose and xylose in high yields of 0.420 g/g at 36 h and 0.478 g/g at 60 h, respectively, but secreted fairly low cellulases. On the other hand, the strain 5398 also produced ethanol from glucose in yield of 0.340 g/g though it had a little growth in xylose culture. However, it secreted hyperactive cellulases that are essential for hydrolysis of rice straw in culture and the maximum activities of endo-β-glucanase and β-glucosi- dase were 2.11 U/L and 1.47 U/L, respectively. In SSF of rice straw by coculture with two fungi selected, the ethanol production reached 1.28 g/L after 96 h when the inoculation ratio of the strain 5398 to the strain 4572 was 9.

关键词： Mucor circinelloides ethanol production cellulase secretion SSF coculture rice straw

Antibodies in celiac disease:implications beyond diagnostics

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Cellular & Molecular Immunology 2011年第2期8卷 103-109页

作者： Sergio Caja Markku maki Katri Kaukinen Katri Lindfors Pediatric Research Centre University of Tampere and Tampere University HospitalTampereFinland Medical School University of Tampere and Department of Gastroenterology and Alimentary Tract SurgeryTampere University HospitalTampereFinland

Celiac disease is a multisystemic dietary,gluten-induced autoimmune disorder characterized by the presence of transglutaminase(TG)2 serum *** autoantibodies targeting members of the TG family(TG2,TG3 and TG6)are found deposited in small-bowel mucosa and in extraintestinal tissues affected by the *** autoantibodies against other self-antigens also emerge in untreated celiac disease *** villous atrophy and crypt hyperplasia in small-bowel biopsy samples are still the gold standards in diagnostics,celiac disease-specific antibodies are widely used as diagnostic ***-induced small-bowel mucosal T-cell response is the cornerstone in the pathogenesis of the disorder,but humoral immunity may also play a central *** review article is focused on the autoantibodies that occur in the context of celiac *** article summarizes the diagnostic utility of different celiac-related antibodies and discusses their roles in the pathogenesis of the disease.

关键词： antibody celiacdisease diagnostics pathogenesis

Structure and function of ALG-2,a penta-EF-hand calcium-dependent adaptor protein

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Science China(Life Sciences) 2011年第8期54卷 770-779页

作者： Masatoshi maki Hironori SUZUKI Hideki SHIBATA Department of Applied Molecular Biosciences Graduate School of Bioagricultural SciencesNagoya University Structural Biology Research Center Photon FactoryInstitute of Materials Structure ScienceHigh Energy Accelerator Research Organization

ALG-2(a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand(PEF) family,including the subunits of typical ***-2 is the most conserved protein among the PEF family members and its homologs are widely found in eukaryotes.X-ray crystal structures of various PEF proteins including ALG-2 have common features:presence of eightα-helices and dimer formation via paired EF5s that are positioned in anti-parallel ***-2 forms a homodimer and a heterodimer with its closest paralog *** calmodulin,a well-known four-EF-hand protein,ALG-2 interacts with various proteins in a Ca2+-dependent fashion,but the binding motifs are completely *** some exceptions,ALG-2-interacting proteins commonly contain Pro-rich regions,and ALG-2 recognizes at least two distinct Pro-containing motifs:PPYP(X) nYP(X,variable;n=4 in ALIX and PLSCR3) and PXPGF(represented by Sec31A) .A shorter alternatively spliced isoform,lacking two residues and designated ALG-2 GF122,does not bind ALIX but maintains binding capacity to Sec31A.X-ray crystal structural analyses have revealed that binding of calcium ions induces the configuration of the side chain of R125 so that it opens Pocket 1,which accepts PPYP,but Pocket 1 remains closed in the case of ALG-2 ***-2 dimer has two ligand-binding sites,each in a monomer molecule,and appears to function as a Ca2+-dependent adaptor protein to either stabilize a preformed complex or to bridge two proteins on scaffolds in systems of the endosomal sorting complex required for transport(ESCRT) and ER-to-Golgi transport.

关键词： ALG-2 calcium penta-EF-hand X-ray crystal structure protein-protein interaction membrane trafficking

Machining Robot with Vibrational Motion and 3D Printer-like Data Interface

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International Journal of Automation and computing 2018年第1期15卷 1-12页

作者： Fusaomi Nagata Keigo Watanabe maki K. Habib Department of Mechanical Engineering Faculty of Engineering Tokyo University of Science Yamaguchi 1-1-1 Daigaku-Dori Sanyo-Onoda 756-0884 Japan Department of Intelligent Mechanical Systems Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology Okayama University 3-1-1 Tsushima-naka Kita-ku Okayama 700-8530 Japan American University 113 Kasr E1 Eini Street Cairo 11511 Egypt

In this paper, a vibration motion control is proposed and implemented on a foamed polystyrene machining robot to suppress the generation of undesirable cusp marks, and the basic performance of the controller is verified through machining experiments of foamed polystyrene. Then, a 3 dimensional （3D） printer-like data interface is proposed for the machining robot. The 3D data inter- face enables to control the machining robot directly using stereolithography （STL） data without conducting any computer-aided man- ufacturing （CAM） process. This is done by developing a robotic preprocessor that helps to remove the need for the conventional CAM process by directly converting the STL data into cutter location source data called cutter location （CL） or cutter location source （CLS） data. The STL is a file format proposed by 3D systems, and recently is supported by many computer aided design （CAD）/CAM soft- waxes. The STL is widely used for rapid prototyping with a 3D printer which is a typical additive manufacturing system. The STL deals with a triangular representation of a curved surface geometry. The developed 3D printer-like data interface allows to directly control the machining robot through a zigzag path, rectangular spiral path and circular spiral path generated according to the information included in STL data. The effectiveness and usefulness of the developed system are demonstrated through actual machining experiments.

关键词： Computer integrated manufacturing machining robot computer aided design (CAD)/computer-aided manufacturing(CAM) cutter location (CL) data vibrational motion stereolithography (STL) data preprocessor 3 dimensional (3D) printer-likedata interface.