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MicroRNA-based therapeutics for optic neuropathy:opportunities and challenges

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Neural Regeneration Research 2021年第10期16卷 1996-1997页

作者： Heather k.mak Christopher k.S.Leung Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Optic nerve degeneration is a major cause of irreversible blindness worldwide with glaucoma being the most common optic neuropathy,affecting approximately 76 million people worldwide in *** optic nerve comprises axons of retinal ganglion cells(RGCs),the output neurons of the inner *** RGCs and axons from degeneration and regenerating RGC axons to preserve and recover vision in patients with progressive optic neuropathy is an unmet *** embryonic neurons,mature neurons of the mammalian central nervous system fail to regenerate their axons following *** age-related loss of axon regenerative capacity of RGCs over time renders vision loss from optic neuropathy *** failure of injured RGCs to regenerate axons is largely attributed to inhibitory molecules in the extrinsic environment and a change in the intrinsic molecular makeup of aging *** studies have demonstrated that RGCs require specific molecular signals for the stimulation of axon growth even without inhibitory molecules in the extrinsic environment,leading successive efforts to focus on uncovering the intrinsic signaling pathways that control axon extension during RGC development.

关键词： neuropathy degeneration stimulation

A pathophysiology-based approach to the management ot early priapism

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Asian Journal of Andrology 2013年第1期15卷 20-26页

作者： Jason R kovac Siu k mak Maurice M Garcia Tom FLue Scott Department of Urology Baylor College of Medicine Houston TX 77030 USA The Chinese University of Hong kong Department of Surgery Prince of Wales HosPital Hong Kong China Department of Urology University of California San Francisco CA 94143 USA

Priapism is a rare condition that involves persistent penile erection for greater than 4 h. Distinct variants exist, each with unique characteristics. Ischemic priapism is a painful medical emergency that may occur as a result of veno-occlusion leading to hypoxia and tissue death. Recurrent bouts of ischemic priapism, or stuttering priapism, require treatment for individual attacks as well as long-term prevention. Non-ischemic priapism is associated with trauma and may be managed conservatively. Recent advances into the pathophysiology of priapism have allowed the development of treatment algorithms that specifically target the mechanisms involved. In this review, we outline the basics of smooth muscle contraction and describe how derangement of these pathways results in priapism. A pathophysiological approach to the treatment of priapism is proposed with duration-based algorithms presented to assist in management.

关键词： algorithm ischemic management priapism T-shunt tunneling

On the Integrability of the Abel and of the Extended Liénard Equations

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 722-736页

作者： Man kwong mak Tiberiu HARkO Departamento de Fsica Facultad de Ciencias Naturales Universidad de Atacama Copayapu 485 Copiapo Chile Department of Physics Babes-Bolyai University Kogalniceanu Street Cluj-Napoca 400084 Romania School of Physics Sun Yat-Sen University Guangzhou 510275 China

We present some exact integrability cases of the extended Liénard equation y′′+ f(y)(y′)n +k(y)(y′)m + g(y)y′+ h(y) = 0, with n > 0 and m > 0 arbitrary constants, while f(y), k(y), g(y), and h(y) are arbitrary functions. The solutions are obtained by transforming the equation Liénard equation to an equivalent first kind first order Abel type equation given bydv/dy= f(y)v3-n+ k(y)v3-m+ g(y)v2+ h(y)v3, with v = 1/y′.As a first step in our study we obtain three integrability cases of the extended quadratic-cubic Liénard equation,corresponding to n = 2 and m = 3, by assuming that particular solutions of the associated Abel equation are known. Under this assumption the general solutions of the Abel and Liénard equations with coefficients satisfying some differential conditions can be obtained in an exact closed form. With the use of the Chiellini integrability condition, we show that if a particular solution of the Abel equation is known, the general solution of the extended quadratic cubic Liénard equation can be obtained by quadratures. The Chiellini integrability condition is extended to generalized Abel equations with g(y) ≡ 0 and h(y) ≡ 0, and arbitrary n and m, thus allowing to obtain the general solution of the corresponding Liénard equation. The application of the generalized Chiellini condition to the case of the reduced Riccati equation is also considered.

关键词： Abel equation Liénard equation general solutions integrability conditions

Continuity Adjustment for Control Charts for Attributes

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Acta Mathematicae Applicatae Sinica 2003年第3期19卷 397-404页

作者： L.k.Chan T.k.mak B.Tao Department of Management Sciences City University of Hong Kong 83 Tat Chee AvenueKowloonHong KongDepartment of Decision Sciences & M.I.S.Concordia University 1445 De Maisonneuve Blvd.WestMontrealH3G 1M8 CanadaAcademy of Mathematics and System SciencesChinese Academy of SciencesBeijing 100081China

A unified approach is proposed for making a continuity adjustment on some control charts for attributes, e.g., np-chart and c-chart, through adding a uniform (0, 1) random observation to the conventional sample statistic (e.g., and c i ). The adjusted sample statistic then has a continuous distribution. Consequently, given any Type I risk α (the probability that the sample statistic is on or beyond the control limits), control charts achieving the exact value of α can be readily constructed. Guidelines are given for when to use the continuity adjustment control chart, the conventional Shewhart control chart (with ±3 standard deviations control limits), and the control chart based on the exact distribution of the sample statistic before adjustment.

关键词： Control charts for attributes continuity adjustments np, p, and c control charts statistical process control

Removal of Lead from Aqueous Solution by Acinetobacter calcoaceticus

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Biomedical and Environmental Sciences 1990年第2期3卷 202-210页

作者： N.k.mak Y.k.MOk V.W.D.CHUI M.H.WONG Department of Biology Hong Kong Baptist College 224 Waterloo Road Hong Kong

A bacterial strain tolerant to the presence of 400 ppm lead was isolated from digested sewage sludge. The organism was identified as Acinetobacter calcoaceticus var: anitraus (98% confidence). Both viable and formalin-inactivated bacterial cells could remove Pb from an aqueous solution. The Pb-binding ability of inactivated cells was compared with that of a commercial ion-exchange resin, Amberlite IR-I20. The metal-binding ability of A. calcoaceticus followed the sequence Pb≥Cu≥Cr≥ (Cd, Ni, and Zn)≥Co. The ability of the inactivated cells to remove Pb was pH sensitive, and the adsorption process was slightly affected at high temperature (70℃). The adsorption and desorption process worked equally well with A. calcoaceticus embedded in a polyacrylamide gel matrix. (c)1990 Academic Press, Inc.

关键词： Pb

On Identitiesand m-Neutral Sequencesof n-Ary Groups

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Communications in Mathematics and Statistics 2016年第4期4卷 495-508页

作者： Alexander M.Gal’mak Viktoria A.kovaleva Department of Technology Mogilev State University of Food Technologies212027 MogilevBelarus Department of Mathematics Francisk Skorina Gomel State University246019 GomelBelarus

In this paper,we study such polyadic analog of an identity of a group asm-neutral *** particular,we prove that all Post's equivalence classes of thefree covering group of any n-ary group[where n=k(m-1)+1 and k≥1]definedby m-neutral sequences form the(k+1)-ary group,which is isomorphic to the n-arysubgroup of all identities of the n-ary group in the case when m=2.

关键词： n-Ary group Identity m-Neutral sequence

Textile Fabric Flaw Detection Using Tensor Decomposition

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Textile Fabric Flaw Detection Using Tensor Decomposition

第11届粤港机械电子工程技术与应用研讨会

作者： k.L.mak Department of Industrial and Manufacturing Systems Engineering The University of Hong KongHong KongP.R.China

＜正＞this paper proposes a new textile fabric defect detection method based on tensor decomposition and a prototype textile inspection *** proposed method manipulates training images of a defect-free fabric as a tensor from which tensor decomposition extracts orthogonal matrices which carry structural characteristics of the given fabric and are used to label test images of the same *** to model-based fabric defect detection methods,the proposed method only assumes that extracted matrices are independent to each *** proposed method is evaluated with defective fabric images and the test results show that a high detection rate can be *** with the method based on matrix singular value decomposition（SVD） shows that tensor decomposition has some advantages over SVD in estimating the orthogonal matrices from training *** affecting the detection performance of the proposed method are also *** performance of the proposed detection scheme is further evaluated using the prototype inspection *** experimental results obtained clearly demonstrate that the proposed scheme is efficient and effective.

关键词： textile flaw detection tensor decomposition prototype inspection system

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Foreword

Foreword

The impacts of suspended mariculture on coastal zones in China and the scope for Integrated Multi-Trophic Aquaculture

第十九届中国控制会议

作者： k．L．mak The University of Hong kong Professor

＜正＞The year 2000 marks a new phase in the world’s development, as it does also for the Chinese Control Conference. This year, as we celebrate the new millennium, the 19th Chinese Control Conference is being held i...

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Ecosystem Health and Sustainability 2017年第6期3卷 32-51页

作者： Reece Wartenberg Limin Feng Jia Jun Wu Yim Ling mak Leo L.Chan Trevor C.Telfer Paul k.S.Lamab.c State key Laboratory in Marine Pollution City University of Hong KongKowloonHong Kong SARChina Research Centre for the Oceans and Human Health Shenzhen Key Laboratory for Sustainable Use of Marine BiodiversityCity University of Hong Kong Shenzhen Research Institute BuildingShenzhenGuangdongChina Department of Biology and Chemistry City University of Hong KongKowloonHong Kong SARChina Department of Biomedical Sciences City University of Hong KongKowloonHong Kong SARChina Institute of Aquaculture University of StirlingStirlingUK

Introduction:China is responsible for more than 60%of global aquaculture *** the frontiers of food production have expanded,the cultivation of marine organisms in coastal zones and the open ocean has grown *** dominant mariculture industry in China is suspended mariculture,which uses net cages,ropes,or other structures suspended in the water column to cultivate aquatic *** systematic,quantitative review provides a clear and comprehensive account of research that has investigated the adverse impacts of suspended mariculture in China and reviews research that has applied Integrated Multi-Trophic Aquaculture(IMTA)systems for mitigating *** work builds on 218 peer reviewed papers that have been published in English-language ***:Eighteen impacts were identified,including chemical,ecological,physical,and socioeconomic *** measures for improving suspended mariculture were recommended consisting of government department,farm management,and ecological engineering *** was the most frequently recommended *** capabil-ities of IMTA for bioremediation and increased farm production were the most frequently studied *** other benefits have been explored but remain *** current challenges facing the expansion of commercial IMTA include limited use of new technology,limited skills development,decreasing production of low trophic-level species,biogeographic and temporal barriers,and negative system ***:Despite challenges,implementing commercial IMTA is a promising measure for reducing the impacts of sus pended mariculture because it presents a range of secondary benefits that can improve the overall sustainability of aquaculture in the coastal zone.

关键词： Aquaculture bioremediation China impacts Integrated Multi-Trophic Aquaculture pollution suspended mariculture