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CRYSTAL AND ELECTRONIC STRUCTURES OF 5-(BENZAL)-2,2-DIMEThYL-1,3-DIOXAN-4,6-DIONE, AND CONFORMATIONAL ANALYSIS OF MOLECULAR MEChANICS

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Chinese Science Bulletin 1989年第23期34卷 1955-1960页

作者：董南蔡国强吴念慈黄宪胡盛志陈明旦 Thomas C.W.mak Department of Chemistry Hangzhou University Hangzhou 310028 PRC Department of Chemistry Xiamen University Xiamen 361005 PRC Department of Chemistry The Chinese University of Hong Kong

I. INTRODUCTION Recently, much attention is attracted to applying of isopropylidene malonates for organic synthesis. Refs. [1—4] reported a new synthetic method of 5-substitute isopropylidene malonates. There are 2,2... 详细信息

关键词： crystal structure electronic structure conformational analysis

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The Bimechanics of Wheelchair Maneuvers

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The Bimechanics of Wheelchair Maneuvers

Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era

中国康复医学会第四届会员代表大会暨第三届中国康复医学学术大会

作者： Arhtur FT mak WN LAM Jockey Club Rehabilitation Engineering Center The hong kong Polytechnic University

Wheelchair maneuvers are daily activities for many people with disabilities, just likewalking for those who can. lmproper wheelchair maneuvers, either due to inappropriate wheelchair pre-scriptions or inappropriate propulsion habits, could lead to secondary injuries to joints in the upper *** presentation would review the current literatures on the kinematics and kinetics of wheelchairpropulsion and present recent work in our Center on the biomechanics of wheelchair *** is a frequent indoor routine, but very few studies on wheelchair turning have not been re-ported so far. We have studied wheelchair turning with both non-disabled subjects and spinal cord in-jured subuects. Special instrumented smart wheels were used to measure the reaction forces acting on thehands by the push-rims. VICON motion analysis system was used to monitor the movements of both up-per extremities. Subjects were instructed to go through a simple protocol of wheelchair maneuvers that in-volved forward propulsion, left and right turing. Joint forces in the turning side and the pivtal side will becompared. Comparisons will also be made between joint forces in the dominant arms and the non-domi-nant *** will be made on the implications of these results on the consequences of inappropriatewheelchair maneuver habits and of inappropriate wheelchair prescriptions.

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世界胃肠病学杂志:英文版 2023年第33期29卷 4942-4961页

作者： Joyce Wing Yan mak Alvin Wing hin Law kimmy Wan Tung Law Rita ho Carmen ka Man Cheung Man Fai Law Department of Medicine and Therapeutics Prince of Wales HospitalHong Kong 852China West Island School Hong Kong 852China Department of Medicine North District HospitalHong Kong 852China

hepatitis due to hepatitis B virus(hBV)reactivation can be serious and potentially fatal,but is *** reactivation is most commonly reported in patients receiving chemotherapy,especially rituximab-containing therapy for hematological malignancies and those receiving stem cell *** with inactive and even resolved hBV infection still have persistence of hBV genomes in the *** expression of these silent genomes is controlled by the immune *** or ablation of immune cells,most importantly B cells,may lead to reactivation of seemingly resolved hBV ***,all patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved hBV infection by blood tests for hepatitis B surface antigen(hBsAg)and antibody to hepatitis B core *** found to be positive for hBsAg should be given prophylactic antiviral *** patients with resolved hBV infection,there are two *** first is pre-emptive therapy guided by serial hBV DNA monitoring,and treatment with antiviral therapy as soon as hBV DNA becomes *** second approach is prophy-lactic antiviral therapy,particularly for patients receiving high-risk therapy,especially anti-CD20 monoclonal antibody or hematopoietic stem cell *** and tenofovir are the preferred antiviral *** new effective therapies for hematological malignancies have been introduced in the past decade,for example,chimeric antigen receptor(CAR)-T cell therapy,novel monoclonal antibodies,bispecific antibody drug conjugates,and small molecule inhibitors,which may be associated with hBV *** there is limited evidence to guide the optimal preventive measures,we recommend antivi-ral prophylaxis in hBsAg-positive patients receiving novel treatments,including Bruton’s tyrosine kinase inhibitors,B-cell lymphoma 2 inhibitors,and CAR-T cell *** studies are needed to determine the risk o

关键词： hepatitis B hematologic neoplasms Chimeric antigen receptor-T cell therapy Monoclonal antibodies Bruton’s tyrosine kinase inhibitors Antiviral agents

Relationship between hepatitis C virus infection and type 2 diabetes mellitus:Meta-analysis

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World Journal of Gastroenterology 2012年第14期18卷 1642-1651页

作者： Cho Naing Joon Wah mak Syed Imran Ahmed Mala Maung Faculty of Medicine and health International Medical UniversityKuala Lumpur 57000Malaysia

AIM:To investigate the association between hepatitis C infection and type 2 diabetes ***:Observational studies assessing the relationship between hepatitis C infection and type 2 diabetes mellitus were identified via electronic and hand *** published between 1988 to March 2011 were screened,according to the inclusion criteria set for the present *** performed separate analyses for the comparisons between hepatitis C virus(hCV) infected and not infected,and hCV infected and hepatitis B virus *** included studies were further subgrouped according to the study *** was assessed using I2 *** summary odds ratios with their corresponding 95% CIs were calculated based on a random-effects *** included studies were subgrouped according to the study *** assess any factor that could potentially affect the outcome,results were further stratified by age group(proportion of ≥ 40 years),gender(proportion of male gender),body mass index(BMI)(pro-portion of BMI ≥ 27),and family history of diabetes(i.e.,self reported).For stability of results,a sensitivity analysis was conducted including only prospective ***:Combining the electronic database and hand searches,a total of 35 observational studies(in 31 articles) were identified for the final *** on random-effects model,17 studies(n = 286 084) compared hepatitis C-infected patients with those who were uninfected [summary odds ratio(OR):1.68,95% CI:1.15-2.45].Of these 17 studies,7 were both a cross-sectional design(41.2%) and cohort design(41.2%),while 3 were case-control studies(17.6%).Nineteen studies(n = 51 156) compared hepatitis C-infected participants with hepatitis B-infected(summary OR:1.92,95% CI:1.41-2.62).Of these 19 studies,4(21.1%),6(31.6%) and 9(47.4%) were cross-sectional,cohort and case-control studies,respectively.A sensitivity analysis with 3 prospective studies indicated that hepatitis C-infected patients had a

关键词： hepatitis C Type 2 diabetes mellitus Observational studies Meta-analysis

Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis

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Journal of Clinical and Translational hepatology 2023年第5期11卷 1143-1149页

作者： ka-Shing Cheung Chiu-hang Mok Lok-ka Lam Xian-hua Mao Lung-Yi mak Wai-kay Seto Man-Fung Yuen Department of Medicine School of Clinical MedicineThe University of Hong KongQueen Mary HospitalHong KongChina Department of Medicine The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina School of Clinical Medicine The University of Hong KongHong KongChina State key Laboratory of Liver Research The University of Hong KongHong KongChina

Background and Aims:We aimed to perform a network meta-analysis(NWM)to examine comparative effectiveness of non-selective beta blockers(NSBBs)on prophylaxis of gastroesophageal variceal bleeding(GVB)and mortality ***:MEDLINE(OVID)and EMBASE databases were searched for eligible randomized clinical trials(RCTs)from inception to July 3,*** of interest included primary/secondary prophylaxis of GVB,failure to achieve hepatic venous pressure gradient(hVPG)decremental response,liver-related and all-cause mortality.A Bayesian NWM was performed to derive relative risk(RR)with 95%credible intervals(CrIs).The ranking probability of each NSBB was assessed by surface under cumulative ranking curve(SUCRA).Results:Thirty-three RCTs including 3,188 cirrhosis patients with gastroesophageal varices were *** with placebo,nadolol ranked first for reducing variceal bleeding[RR:0.25,(95%CrI:0.11–0.51);SUCRA:0.898],followed by carvedilol[RR:0.33,(95%CrI:0.11–0.88);SUCRA:0.692]and propranolol[RR:0.52,(95%CrI:0.37–0.75);SUCRA:0.405].Carvedilol was more effective than propranolol in achieving hVPG decremental response[RR:0.43,(95%CrI:0.26–0.69)].Carvedilol ranked first for reducing all-cause mortality[RR:0.32,(95%CrI:0.17–0.57);SUCRA:0.963],followed by nadolol[RR:0.48,(95%CI:0.29–0.77);SUCRA:0.688],and propranolol[RR:0.77,(95%CI:0.58–1.02);SUCRA:0.337].Similar findings were observed for liver-related *** ranked the *** RR of adverse events was 4.38,(95%CrI:0.33–161.4);SUCRA:0.530,followed by propranolol[RR:7.54,(95%CrI:1.90–47.89);SUCRA:0.360],and nadolol[RR:18.24,(95%CrI:91.51–390.90);SUCRA:0.158].Conclusions:Carvedilol is the preferred NSBB with better survival benefit and lower occurrence of adverse events among patients with gastroesophageal varices.

关键词： NSBB Carvedilol Nadolol Propranolol Varices Cirrhosis CPSh

室内通风系统气流噪声预测方法的改进(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 104-107页

作者：麦卓明香港理工大学屋宇设备工程系

管道气流噪声是室内通风系统中的常见问题.由于后期改造十分困难,在设计阶段对由管道内障碍物等因素产生的气流噪声进行精确的预测计算是非常必要的.目前已有一些管道气流噪声预测的基本方法,但是很多预测手段都基于传统声学测量得到的... 详细信息

管道气流噪声是室内通风系统中的常见问题.由于后期改造十分困难,在设计阶段对由管道内障碍物等因素产生的气流噪声进行精确的预测计算是非常必要的.目前已有一些管道气流噪声预测的基本方法,但是很多预测手段都基于传统声学测量得到的数据.笔者近来不依赖于传统的测量数据,研究了运用计算流体动力学理论对管道内气流噪声进行预测的可行性,文中讨论了采用该方法遇到的问题以及近期在采用计算流体动力学计算气流噪声方面的研究工作.

关键词：声压级气流管道气流噪声预测通风系统

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CONFORMATIONAL INVESTIGATIONS OF 5-SUBSTITUTED ISOPROPYLIDENE MALONATES 1. STRUCTURE OF 5-(α-PhENYLEThYL)-2,2-DIMEThYL-l,3-DIOXAN-4,6-DIONE

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Chinese Journal of Structural Chemistry 1985年第2期 107-110页

作者： Thomas C.W.mak New Territories shatin The Chinese University of hong kong Department of Chemistry

, Mr=248.28, monoclinic, P2!/n, a=ll.394（4）, b=5.770（1）, c=20.534（6） &, (3=106.09（2）? V=1297.1（4） X3, Z=4, 1^=1.265, Dx=l.271 Mgm’3, y（Moka）=0.87cm, F（000）=527.94, 295k. The structure was solved by direct methods and refined to R=0.057 for 1984 observed Moka reflections. The 1,3-dioxan-4,6-dione ring shows a twist-boat conformation with the a-phenylethyl group occupying a bow position. , . .

关键词： CONFORMATIONAL INVESTIGATIONS OF 5-SUBSTITUTED ISOPROPYLIDENE MALONATES 1 DIMEThYL-l,3-DIOXAN-4,6-DIONE PhENYLEThYL STRUCTURE OF 5 Chen

Aggregation-induced barrier to oxygen——a new AIE mechanism for metal clusters with phosphorescence

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National Science Review 2022年第8期9卷 71-79页

作者： Yan Jin Qiu-Chen Peng Si Li hui-Fang Su Peng Luo Ming Yang Xin Zhang kai Li Shuang-Quan Zang Ben Zhong Tang Thomas C.W.mak henan key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou University Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringChinese University of Hong Kong The hong kong Branch of the Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Hong Kong University of Science and Technology Department of Chemistry Chinese University of Hong Kong

Metal clusters are useful phosphors, but highly luminescent examples are quite rare. Usually, the phosphorescence of metal clusters is hindered by ambient O2molecules. Transforming this disadvantage into an advantage for meaningful applications of metal clusters presents a formidable challenge. In this work, we used ligand engineering to judiciously prepare colour-tuneable and brightly emitting Cu(I)clusters that are ultrasensitive to O2upon dispersion in a fluid solution or in a solid matrix. When the O2scavenger dimethyl sulfoxide(DMSO) was used as the solvent, joint photo-and oxygen-controlled multicolour switches were achieved for the first time for metal cluster-based photopatterning and photo-anticounterfeiting. More importantly, an aggregation-induced barrier to oxygen, a new aggregation-induced emission mechanism for metal clusters, was proposed, providing a new pathway to realizing the intense emission of metal clusters in the aggregated state. These results are expected to promote the application of metal clusters and enrich the luminescence theory of metal cluster aggregates.

关键词： metal clusters aggregation-induced emission phosphorescence photoresponse O_2 detection

Multi-mW,few-cycle mid-infrared continuum spanning from 500 to 2250cm^(−1)

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Light(Science & Applications) 2017年第1期6卷 1-6页

作者： Jinwei Zhang ka Fai mak Nathalie Nagl Marcus Seidel Dominik Bauer Dirk Sutter Vladimir Pervak Ferenc krausz Oleg Pronin Max-Planck-Institute of Quantum Optics Hans-Kopfermann-Str.1Garching 85748Germany Ludwig-Maximilians-University Munich Am Coulombwall 1Garching 85748Germany TRUMPF Laser Gmbh Aichhalder Straße 39Schramberg D-78713Germany

The demand for and usage of broadband coherent mid-infrared sources,such as those provided by synchrotron facilities,are *** most organic molecules exhibit characteristic vibrational modes in the wavelength range between 500 and 4000 cm^(−1),such broadband coherent sources enable micro-or even nano-spectroscopic applications at or below the diffraction limit with a high signal-to-noise ratio1–*** techniques have been applied in diverse fields ranging from life sciences,material analysis,and time-resolved *** we demonstrate a broadband,coherent and intrinsically carrier-envelope-phase-stable source with a spectrum spanning from 500 to 2250 cm^(−1)(−30 dB)at an average power of 24mW and a repetition rate of 77 *** performance is enabled by the first mode-locked thin-disk oscillator operating at 2μm wavelength,providing a tenfold increase in average power over femtosecond oscillators previously demonstrated in this wavelength ***-octave spectral coverage from this compact and power-scalable system opens up a range of time-and frequency-domain spectroscopic applications.

关键词： coherent repetition oscillator