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Ocular hypertension secondary to obesity: cortisol, the missing piece of the pathophysiological puzzle?

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 1050-1051页

作者： Andrej Belancic Marija Krpina Sanja Klobucar majanovic maja Merlak University of Rijeka Faculty of MedicineRijeka 51000Croatia Department of Endocrinology Diabetes and Metabolic DiseasesClinical Hospital Centre RijekaRijeka 51000Croatia Department of Ophthalmology Clinical Hospital Centre RijekaRijeka 51000Croatia

Dear Editor,Obesity has nowadays become a global public health challenge due to its rapidly growing prevalence and interconnection with a wide spectrum of comorbidities.

关键词： Ocular hypertension secondary obesity cortisol the missing piece of the pathophysiological puzzle

Oscillating droplet tribometer for sensitive and reliable wetting characterization of superhydrophobic surfaces

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Droplet 2022年第1期1卷 38-47页

作者： Muhammad Junaid Heikki A.Nurmi Mika Latikka maja Vuckovac Robin H.A.Ras Department of Applied Physics School of ScienceAalto UniversityEspooFinland Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityEspooFinland

Accurate wetting characterization is crucial for the development of next‐generation superhydrophobic ***,wetting properties are measured with a contact angle goniometer(CAG)suitable for a broad range of ***,due to optical errors and challenges in baseline positioning,the CAG method suffers from inaccuracies on superhydrophobic *** we present an improved version of the oscillating droplet tribometer(ODT),which can reliably assess wetting properties on superhydrophobic surfaces by measuring the frictional forces of a water‐based ferrofluid droplet oscillating in a magnetic *** demonstrate that ODT has superior accuracy compared to CAG by measuring the wetting properties of four different superhydrophobic surfaces(commercial Glaco and Hydrobead coatings,black silicon coated with fluoropolymer,and nanostructured copper modified with lauric acid).We show that ODT can detect the small but significant changes in wetting properties caused by the thermal restructuring of surfaces that are undetectable by *** more,unlike any other wetting characterization technique,ODT features an inverse sensitivity:the more repellent the surface,the lower the error of measurement,which was demonstrated by experiments and simulations.

关键词： oscillating frictional wetting

In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal

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Journal of Environmental Sciences 2019年第7期31卷 136-147页

作者： Bojana Nedic Vasiljevic Milena Obradovic Danica Bajuk-Bogdanovic maja Milojevic-Rakic Zoran Jovanovic Nemanja Gavrilov Ivanka Holclajtner-Antunovic Faculty of Physical Chemistry University of Belgrade Belgrade 11158 Serbia Laboratory of Physics Vin?a Institute of Nuclear Sciences University of Belgrade Belgrade 11001 Serbia

Potassium tungstophosphate is supported on BEA zeolite by in situ synthesis for glyphosate removal. Spectroscopic measurements identified hydrogen bonding as a primal interaction of potassium salt and BEA zeolite. Composites are evaluated for glyphosate herbicide removal and adsorption process is analyzed using two isotherm models. Obtained adsorption capacities for all prepared composites lay between 45.2 and 92.2 mg of glyphosate per gram of investigated composite. Suspension acidity revealed that glyphosate is adsorbed mainly in the zwitter-ion form at the composite surface while the amount of potassium salt in the composites is crucial for the adsorption application. Exceptional adsorption behavior is postulated to come from a high degree of homogeneity among surface active sites which is confirmed by different experimental methods. Temperature programmed desorption of glyphosate coupled with mass spectrometer detected one broad, high-temperature peak which represents overlapped desorption processes from active sights of similar *** of potassium tungstophosphate affects active sites present in BEA zeolite for glyphosate desorption and significantly increases the amount of adsorbed pesticide in comparison to BEA zeolite. Supporting of potassium tungstophosphate on BEA zeolite via in situ synthesis procedure enables the formation of highly efficient adsorbents and revealed their perspective environmental application.

关键词： Composite materials Chemical synthesis Kinetics Adsorption Ultrasonics

Demand Driven Growth in Small Open and Import Dependable Economy

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Economics World 2014年第1期2卷 1-10页

作者： maja Bacovic University of Montenegro Podgorica Montenegro

Demand driven growth is rather a common approach in many countries in the short run. Growth in aggregate demand pushes production to higher level, increasing employment and income. But what is the case in small open economies, which are highly import dependable, service-oriented, and have to import most consumers＇ goods？ Research is focused on the case of small open economy （Montenegro）. Research will be based on statistical data for Montenegro, for period from 2000 to 2011. Data are processed in Eviews, using Least Square method to estimate equations and models. Research has shown that gross domestic product （GDP） growth in the short run, prior to global financial crisis, was achieved through growth in consumption and investment, which led to growth in import and growth in foreign debt, as consumption was financed significantly borrowing foreign financial resources. After the crisis, financial inflows dropped, leaving Montenegrin economy to struggle with increased debt （both public and private）, unfinished investment project to provide value added and low level of domestic production leading to even higher trade deficit. Future growth can be achieved only if it is driven by investments, as growth in consumption will more likely lead to higher trade deficit than production growth.

关键词： aggregate demand growth consumption investments import dependency production

Insights into hepatitis E virus epidemiology in Croatia

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World Journal of Gastroenterology 2022年第37期28卷 5494-5505页

作者： Pavle Jelicic Thomas Ferenc Anna Mrzljak Lorena Jemersic Natasa Janev-Holcer Milan Milosevic maja Bogdanic Ljubo Barbic Branko Kolaric Vladimir Stevanovic Mateja Vujica Zeljka Jurekovic Jadranka Pavicic Saric maja Vilibic Tatjana Vilibic-Cavlek Department of Environmental Health Croatian Institute of Public HealthZagreb 10000Croatia Department of Radiology Merkur University HospitalZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Virology Croatian Veterinary InstituteZagreb 10000Croatia Department of Social Medicine and Epidemiology Faculty of Medicine University of RijekaRijeka 51000Croatia Department of Occupational and Environmental Health Andrija Stampar School of Public HealthZagreb 10000Croatia Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of ZagrebZagreb 10000Croatia Department of Gerontology and Social Medicine Andrija Stampar Teaching Institute of Public HealthZagreb 10000Croatia Institute of Emergency Medicine of Krapina-Zagorje County Krapina 49000Croatia Department of Nephrology Merkur University HospitalZagreb 10000Croatia Department of Anesthesiology University Hospital MerkurZagreb 10000Croatia Department for Social Psychiatry Psychotherapy and PsychodiagnosticsUniversity Clinical Hospital Center“Sestre Milosrdnice”Zagreb 10000Croatia

BACKGROUND Hepatitis E virus(HEV)is an emerging virus of global health *** seroprevalence rates differ greatly according to geographic region and population *** To analyze the seroprevalence of HEV in exposed(animal-related professions)and nonexposed populations,as well as solid organ and hematopoietic stem cell transplant *** Forestry workers(n=93),hunters(n=74),and veterinarians(n=151)represented the exposed *** general population(n=126)and pregnant women(n=118)constituted the control *** patients included liver transplant recipients(LTRs)(n=83),kidney transplant recipients(KTRs)(n=43),and hematopoietic stem cell transplant recipients(HSCRs)(n=39).HEV immunoglobulin G antibodies were detected using the enzyme-linked immunosorbent assay and confirmed by the immunoblot *** The HEV seroprevalence significantly differed between groups:Veterinarians 15.2%,hunters 14.9%,forestry workers 6.5%,general population 7.1%,and pregnant women 1.7%.In transplant patients,the seropositivity was highest in LTRs(19.3%),while in KTRs and HSCRs,the seroprevalence was similar to the general population(6.9%and 5.1%,respectively).A significant increase in seropositivity with age was observed from 2.9%in individuals less than 30 years to 23.5%in those older than 60 *** characteristics(sex,educational level,area of residence,and number of household members),eating habits(game meat,offal,and pork products consumption),and environmental and housing conditions(drinking water supply,type of water drainage/sewer,waste disposal,domestic animals)were not associated with HEV ***,individuals who reported a pet ownership were more often seropositive compared to those who did not have pet animals(12.5%vs 7.0%).CONCLUSION The results of this study showed that individuals in professional contact with animals and LTRs are at higher risk for HEV *** addition,age is a significant risk factor for HEV

关键词： Hepatitis E virus Seroprevalence Veterinarians Hunters Forestry workers Transplant patients Croatia

Sodium-glucose cotransporter 2 inhibitors’ mechanisms of action in heart failure

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World Journal of Diabetes 2020年第7期11卷 269-279页

作者： Petra Grubić Rotkvić maja Cigrovski Berković Nikola Bulj Luka Rotkvić Ivana Ćelap Department of Cardiology University Hospital10000 ZagrebCroatia Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyUniversity HospitalZagreb 10000Croatia Department for Medicine of Sports and Exercise Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Cardiology University Hospital CentreZagreb 10000Croatia Department of Cardiology Magdalena Clinic for Cardiovascular DiseaseKrapinske Toplice 49217Croatia Department of Clinical Chemistry University Hospital CentreZagreb 10000Croatia

Three major cardiovascular outcome trials(CVOTs)with a new class of antidiabetic drugs-sodium-glucose cotransporter 2(SGLT2)inhibitors(EMPAREG OUTCOME trial with empagliflozin,CANVAS Program with canagliflozin,DECLARE-TIMI 58 with dapagliflozin)unexpectedly showed that cardiovascular outcomes could be improved possibly due to a reduction in heart failure risk,which seems to be the most sensitive outcome of SGLT2 *** other CVOT to date has shown any significant benefit on heart failure *** more impressive findings came recently from the DAPA-HF trial in patients with confirmed and well-treated heart failure:Dapagliflozin was shown to reduce heart failure risk for patients with heart failure with reduced ejection fraction regardless of diabetes ***,despite their possible wide clinical implications,there is much doubt about the mechanisms of action and a lot of questions to unravel,especially now when their benefits translated to nondiabetic patients,rising doubts about the validity of some current mechanistic *** time frame of their cardiovascular benefits excludes glucoselowering and antiatherosclerotic-mediated effects and multiple other mechanisms,direct cardiac as well as systemic,are suggested to explain their early cardiorenal *** are:Anti-inflammatory,antifibrotic,antioxidative,antiapoptotic properties,then renoprotective and hemodynamic effects,attenuation of glucotoxicity,reduction of uric acid levels and epicardial adipose tissue,modification of neurohumoral system and cardiac fuel energetics,sodiumhydrogen exchange *** most logic explanation seems that SGLT2 inhibitors timely target various mechanisms underpinning heart failure *** the proposed mechanisms of their action could interfere with evolution of heart failure and are discussed separately within the main text.

关键词： Sodium-glucose cotransporter 2 inhibitors Heart failure Cardiovascular outcomes Diabetes mellitus Physiological mechanisms Pleiotropic effects

Study on spiral winding swimming motion control of a slender legless creature model

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High Technology Letters 2021年第4期27卷 415-421页

作者： Lu Zhenli Ma Zhipeng Marko Pencic maja Cavic Borovac Branislav Roumiana Ilieva Bojan Nemec Marjan Mernik School of Electrical Engineering and Automation Changshu Institute of TechnologyChangshu 215500P.R.China School of Information and Control Engineering China University of Mining and TechnologyXuzhou 221116P.R.China Faculty of Technical Sciences University of Novi SadNovi Sad 621000Serbia Faculty of Management Technical University of SofiaSofia 1000Bulgaria Department of Automatics Biocybernetics and RoboticsJožef Stefan InstituteLjubljana 1000Slovenia Faculty of Electrical Engineering and Computer Science University of MariborMaribor 462000Slovenia

Through the observation and analysis of the motion trajectory of spiral winding motion for slender legless biological creatures in water,V-REP software is adopted to build a dynamic simulator to study on the mechanism of spiral winding swimming(SWS)*** using the output of spiral function(SF),the dynamic simulation model of slender legless creature(SLC)realizes the SWS motion in *** corresponding experiments under the control of different bending angle of SF to control the dynamic model are also carried out to analyze the water performance of SWS in still *** with the output of two different bending angles of the spiral function,the dynamic model can be used to realize SWS and up/down *** work provides technical reserve and experimental platform for the corresponding study in related fields.

关键词： V-REP spiral winding swimming(SWS) motion control slender legless creature(SLC)

Targeting triple-negative breast cancer:A clinical perspective

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Oncology Research 2023年第3期31卷 221-238页

作者： LAZAR S.POPOVIC GORANA MATOVINA-BRKO maja POPOVIC KEVIN PUNIE ANA CVETANOVIC MATTEO LAMBERTINI Department of Medical Oncology Oncology Institute of VojvodinaSremska KamenicaSerbia Faculty of Medicine University of Novi SadNovi SadSerbia Department of General Medical Oncology and Multidisciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuvenBelgium Department for Oncology Medical Faculty NisUniversity of NisNisSerbia Clinic of Oncology Clinical Centre NisNisSerbia Department of Internal Medicine and Medical Sciences(DiMI) School of MedicineUniversity of GenovaGenovaItaly Department of Medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenovaItaly

Triple-negative breast cancer(TNBC)is a disease with often an aggressive course and a poor prognosis compared to other subtypes of breast *** accounts for approximately 10%–15%of all diagnosed breast cancer cases and represents a high unmet need in the *** to just a few years ago,chemotherapy was the only systemic treatment option for this subtype(1).To date,TNBC is considered a heterogeneous *** of the existing classifications is based on the analysis of mRNA expression in 587 TNBC cases,in which Lehman et *** six subtypes of TNBC as follows:two basal-like(BL1 and BL2)subtypes,a mesenchymal(M)subtype,a mesenchymal stem-like(MSL)subtype,an immunomodulatory(IM)subtype,and a luminal androgen receptor(LAR)subtype(2).Later studies have demonstrated that the IM and MSL subtypes do not correlate with independent subtypes but reflect background expression by dense infiltration of tumor-infiltrating lymphocytes(TILs)or stromal *** to this finding,the classification of TNBC has been revised into the following four subtypes:basal 1,basal 2,LAR,and mesenchymal subtypes(3).Over the last years,several new strategies have been investigated for the treatment of patients with *** them,immunotherapy,antibody drug conjugates,new chemotherapy agents,and targeted therapy have been and are currently being *** present article aims to provide an updated overview on the different treatment options that are now available or are still under investigation for patients with TNBC.

关键词： Triple-negative breast cancer Immunotherapy Antibody-drug conjugates Target therapy

Exploring new treatment options for polycystic ovary syndrome: Review of a novel antidiabetic agent SGLT2 inhibitor

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World Journal of Diabetes 2021年第7期12卷 932-938页

作者： Jelena Marinkovic-Radosevic maja Cigrovski Berkovic Egon Kruezi Ines Bilic-Curcic Anna Mrzljak Department of Endocrinology Diabetes and MetabolismSisters of Charity Clinical Hospital CentreZagreb 10000Croatia Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia Department of Gynecology and Obstetrics Sisters of Charity Clinical Hospital CentreZagreb 10000Croatia Department of Pharmacology Faculty of MedicineUniversity of J.J.Strossmayer OsijekOsijek 31000Croatia Clinical Hospital Center Osijek Osijek 31000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia

Polycystic ovary syndrome(PCOS)is the most common endocrinopathy in women of reproductive age associated with long-term metabolic and cardiovascular consequences.A plethora of symptoms and their severity differentiate on an individual level,giving the syndrome numerous *** to menstrual cycle abnormalities,women suffer from irregular menstrual bleeding,difficulty in conception,and ***,the risk of pregnancy complications such as gestational diabetes mellitus,hypertensive disorders of pregnancy,and preterm birth are higher in women with PCOS than in the general ***,women with PCOS have comorbidities such as dyslipidemia,obesity,glucose intolerance or diabetes type 2,non-alcoholic fatty liver disease,and metabolic syndrome,which all influence the treatment *** insulinsensitizing agents,although good for some of the metabolic derangements,do not offer long-term cardiovascular benefits;therefore,new treatment options are of paramount ***-glucose co-transporter-2(SGLT-2)inhibitors,a new class of antidiabetic agents with beneficial cardiovascular,bodyweight,and antihyperglycemic effects,although not approved for the treatment of PCOS,might be an attractive therapeutic addition in the PCOS ***,recent studies with SGLT-2 inhibitors showed promising improvements in anthropometric parameters and body composition in patients with *** is important to further explore the SGLT-2 inhibitors potential as an early therapeutic option because of the PCOS-related risk of metabolic,reproductive,and psychological consequences.

关键词： Polycystic ovary syndrome Sodium-glucose co-transporter-2 inhibitors Metabolic risk Cardiovascular risk Metabolic syndrome Insulin resistance Obesity Type 2 diabetes mellitus Dyslipidemia