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Asian Journal of Andrology 2010年第3期12卷 363-375,I0010页

作者： maja M. Kosanovic Miroslava M. Jankovic Department for Immunochemistry and Glycobiology Institute for the Application of Nuclear Energy-INEP University of Belgrade Banatska 31b Zemun-Belgrade 11080 Serbia

Defining the molecular characteristics of seminal plasma proteins is essential for understanding their function in physiological and pathological conditions. Starting from the predicted importance of human seminal plasma gelatin-binding proteins, comprising fibronectin （FN） and FN-related molecules, for male fertility, this study aims at gaining insight into their immuno-glycobiochemical properties. Human seminal plasma from subjects with normal semen parameters were separated on a gelatin-Sepharose column and analyzed by sodium dodecyl sulfate- polyacrylamide gel electrophoresis and immunoblotting using antibodies against distinct FN forms. Heterogeneity of the isolated molecular species was examined by protein chip arrays combined with surface-enhanced laser desorption/ionization time of flight mass spectrometry, on normal, metal and hydrophobic surfaces. Carbohydrate composition was investigated using mannose-, fucose- and sialic acid-specific plant lectins and galectin-1. The results obtained indicated a pattern of isolated proteins corresponding to that of known FN fragments, as confirmed by immunoreactivity. Among them heparin-binding ability was preferentially associated with low molecular mass species. As for posttranslational modifications, phosphorylation and glycosylation of distinct fragments were revealed. Lectin binding to fragments containing the gelatin-binding domain, particularly with Ricinus communis agglutinin I, was stronger than to fragments containing the cell-binding site of FN. A low level of sialylation and distinctive concanavalin A- and Lens culinaris agglutinin-reactive species were also observed. Galectin-1 did not interact with the isolated preparation. Resolving the molecular heterogeneity of normal human seminal plasma FN and gaining initial insight into possible similarities/differences with known FN molecular species may be considered a prerequisite step preceding challenging the clinical usefulness of these molecular properties.

关键词： fibronectin gelatin-binding glycosylation heparin-binding human seminal plasma

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社交型脑瘫康复训练系统人机交互关键技术综述

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高技术通讯 2023年第5期33卷 537-549页

作者：王乾卢振利沈玄霖单长考刘燕陈勇赵宇 PENCIC Marko CAVIC maja ROUMIANA Ilieva MARJAN Mernik 盐城工学院机械工程学院盐城224000 常熟理工学院电气与自动化工程学院常熟215500 常熟市第二人民医院康复医学科常熟215500 常熟理工学院商学院常熟215500 诺维萨德大学技术科学学院诺维萨德21000塞尔维亚索非亚工业大学管理学院索非亚1000保加利亚马里博尔大学电气工程和计算机科学学院马里博尔462000斯洛文尼亚

脑瘫是一种常见的脑部发育不良疾病,国内外针对脑瘫康复主要是在幼儿期进行针对性康复诊治。步入成年后,社交型障碍是一种常见症状,为了更好地使脑瘫患者融入社会生活,有必要针对语言、动作和表情进行康复训练。本文针对社交障碍中的关... 详细信息

脑瘫是一种常见的脑部发育不良疾病,国内外针对脑瘫康复主要是在幼儿期进行针对性康复诊治。步入成年后,社交型障碍是一种常见症状,为了更好地使脑瘫患者融入社会生活,有必要针对语言、动作和表情进行康复训练。本文针对社交障碍中的关键环节,结合传统康复手段,对人机交互技术在以机器人研发辅助工具来优化提升相关康复训练系统中的应用进行综述分析,为脑瘫患者康复训练设备智能化升级改造和研发提供有益借鉴。

关键词：脑瘫(CP) 社交障碍人机交互辅助系统

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Nonalcoholic fatty liver disease and liver transplantation-Where do we stand?

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World Journal of Gastroenterology 2018年第14期24卷 1491-1506页

作者： Ivana Mikolasevic Tajana Filipec-Kanizaj maja Mijic Ivan Jakopcic Sandra Milic Irena Hrstic Nikola Sobocan Davor Stimac Patrizia Burra Department of Gastroenterology UHC Rijeka School of Medicine University of Rijeka Department of Gastroenterology University Hospital MerkurSchool of Medicine University of Zagreb Department of Internal medicine General Hospital Pula Pula School of Medicine University of Rijeka and Zagreb Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital

Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis(NAFLD/NASH) is a challenging and multisystem disease that has a high socioeconomic impact. NAFLD/NASH is a main cause of macrovesicular steatosis and has multiple impacts on liver transplantation(LT), on patients on the waiting list for transplant, on posttransplant setting as well as on organ donors. Current data indicate new trends in the area of chronic liver disease. Due to the increased incidence of metabolic syndrome(Met S) and its components, NASH cirrhosis and hepatocellular carcinoma caused by NASH will soon become a major indication for LT. Furthermore, due to an increasing incidence of Met S and, consequently, NAFLD, there will be more steatotic donor livers and less high quality organs available for LT, in addition to a lack of available liver allografts. Patients who have NASH and are candidates for LT have multiple comorbidities and are unique LT candidates. Finally, we discuss long-term grafts and patient survival after LT, the recurrence of NASH and NASH appearing de novo after transplantation. In addition, we suggest topics and areas that require more research for improving the health care of this increasing patient population.

关键词： nonalcoholic steatohepatitis chronic liver disease liver transplantation nonalcoholic fatty liver disease outcome

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Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma

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World Journal of Gastroenterology 2009年第32期15卷 4009-4015页

作者： Rajko Milosevic Milena Todorovic Bela Balint Miodrag Jevtic Miodrag Krstic Elizabeta Ristanovic Nebojsa Antonijevic Mirjana Pavlovic maja Perunicic Milan Petrovic Biljana Mihaljevic Clinical Center of Serbia 11000 BelgradeSerbia Medical School Belgrade University11000 BelgradeSerbia Military Medical Academy 11000 BelgradeSerbia Institute for Medical Research Belgrade University11000 BelgradeSerbia Charles Smith College of Science FAU33 431Boca RatonFlUnited States

AIM:To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS).METHODS: A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined. Splenectomy plus chemotherapy was applied in 20 patients, while splenectomy as a single treatment-option was performed in 10 patients. Prognostic factor and overall survival rate were ***: Complete remission (CR) was achieved in 20 (66.7%), partial remission (PR) in seven (23.3%), and lethal outcome due to disease progression occurred in three (10.0%) patients. Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank=0.056, P>0.05). Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions, as measured by computerized tomography and ultra-sound (t=2.558, P=0.018). Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank=5.244, P0.05) effects on the OS. The expression of other antigens (immunohistochemistry) also had no effect on survival-rate, as measured by a χ2 test (P>0.05).CONCLUSION: Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration; however, a larger controlled clinical study is required to conf irm our findings.

关键词：淋巴瘤边缘带治疗化疗手术脾

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Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential

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BIOCELL 2021年第6期45卷 1543-1550页

作者： maja MILOSEVIC MILOS LAZAREVIC BOSKO TOLJIC MILAN PETROVIC MIROSLAV VUKADINOVIC ZORAN JEZDIC BOBAN ANICIC DRAGO JELOVAC SVETLANA JOVANOVIC JELENA MILASIN Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia Clinic for Maxillofacial Surgery School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia Department of Public Health School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia

Specific cell subpopulations identified as cancer stem cells(CSCs)can be found in basal cell carcinoma(BCC).Generally,CSCs have a marked trans-differentiation potential that could potentially be used in differentiation ***,there are no studies regarding BCC CSCs *** aim of the study was to analyze the characteristic of CSCs of BCC with emphasis on their differentiation potential upon specific *** staining and cell morphology were used for differentiation confirmation,along with the expression analysis of osteogenic(ALP,BSP,Runx2,OCN,BMP2),chondrogenic(COL1 and COL2A1),adipogenic(PPAR-γ)and neurogenic(Nestin and MAP2)*** CSCs differentiated into osteogenic and chondrogenic lineages,as judged by staining and high expression of specific markers(from 2-to 92-fold higher upon induction).Concomitantly with differentiation,the levels of cancer stem cell markers decreased in the ***-differentiation and neuro-differentiation were *** conclusion,BCC CSCs exhibit the capacity to trans-differentiate,a characteristic that may potentially be useful in the development of new strategies for the treatment of aggressive BCCs.

关键词： Basal cell carcinoma Cancer stem cells Differentiation potential Osteo-differentiation Chondro-differentiation

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Conservation and characterization of unique porcine interstitial telomeric sequences

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Science China(Life Sciences) 2012年第12期55卷 1029-1037页

作者： JI GuangZhen LIU Kai CHEN ChengBin RUAN WeiMin GLYTSOU Christina YANG Yang OKUKA maja SONG WenQing GAGOS Sarantis LINing LIU Lin State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China" State Key Laboratory far Agrobiotechnology College of Biological Sciences China Agricultural Universi~ Beijing 100193 China" Genettcs Dtvlslon Center of Basic Research H Biomedical Research Foundation of the Academy of Athens Greece Athens 11527 Greece Department of Obstetrics and Gynecology University of South Florida College of Medicine Tampa FL 33612 USA

Telomeres are composed of TTAGGG repeats and located at the ends of chromosomes. Telomeres protect chromosomes from instability in mammals, including mice and humans. Repetitive TTAGGG sequences are also found at intrachromosomal sites, where they are named as interstitial telomeric sequences (ITSs). Aberrant ITSs are implicated in chromosomal instability and found in cancer cells. Interestingly, in pigs, vertebrate telomere sequences TTAGGG (vITSs) are also localized at the centromeric region of chromosome 6, in addition to the end of all chromosomes. Surprisingly, we found that botanic telomere sequences, TTTAGGG (bITSs), also localize with vITSs at the centromeric regions of pig chromosome 6 using telomere fluorescence in situ hybridization (FISH) and by comparisons between several species. Furthermore, the average lengths of vITSs are highly correlated with those of the terminal telomeres (TTS). Also, pig ITSs show a high incidence of telomere doublets, suggesting that pig ITSs might be unstable and dynamic. Together, our results show that pig cells maintain the conserved telomere sequences that are found at the ITSs from of plants and other vertebrates. Further understanding of the function and regulation of pig ITSs may provide new clues for evolution and chromosomal instability.

关键词：端粒序列保护间质常染色体猪不稳定性表征荧光原位杂交

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Non-Native Insects in Urban and Forest Areas of Slovenia and the Introduction of Torymus sinensis with Dryocosmus kuriphilus

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Open Journal of Forestry 2017年第4期7卷 416-427页

作者： maja Jurc Srdjan Bojovic Dusan Jurc Biotechnical Faculty Department for Forestry and Renewable Forest ResourcesUniversity of LjubljanaLjubljanaSlovenia Department of Ecology Institute for Biological Research“Sinisa Stankovic”University of BelgradeBelgradeSerbia Department for Forest Protection Slovenian Forestry InstituteLjubljanaSlovenia

We survey non-native insects species in whole territory of Slovenia. Data on non-native species were collected in field, and we also used results of projects in which we participated and with overview of literature data in scientific pub-lications. Correspondence Analysis (CA) of data was carried out with the soft-ware Statgraphics Centaurion XVI, U.S.A. Up to 254 non-native insect species are present: around 83% are phytophagous (43% feed on woody plants, 40% on other plants);around 12% are non-phytophagous;and 5% are parasitoids or predators of other insects or mammals. Among the phytophagous species, Hemiptera predominates (with 38.2%), followed by Coleoptera (29.8%) and Lepidoptera (14.5%). Non-native insects that do not feed on plants include Coleoptera (80%), Lepidoptera (6.5%), Hymenoptera (6.5%) and Diptera (6.5%). Most of phytophagous species are associated with introduction of plants on which they are specialists, but some have also shifted from introduced to native plant hosts. 36 non-native phytophagous species (14.17% of all non-native insects) have become harmful plant pests of urban trees and crops. 20 appear on woody plants, but only Dryocosmus kuriphilus, appears in urban forest areas. In the past decades species such as D. kuriphilus, Leptoglossus occidentalis, Xylosandrus germanus, Gnathotrichus materiarius, Dasineura gledichiae, Phyllonorycter issikii, Cinara curvipes, Ophiomyia kwansonis have been recorded in parks and forests. Some non-native species are spreading in Slovenian urban forests and affect economic, ecological and other forest and urban forest functions. The number of harmful insects in forests is extremely small probably due to high diversity of the forest ecosystem, where close-to-nature forest management is practiced, which retains forest’s self-regulatory ability to control pests. Such management enables for example the reduction of D. kuriphilus with expansion of its parasitoid, Torymus sinensis. We attempt to explain this phen

关键词： Urban Forest Areas Forests Non-Native Insects Non-Native Parasitoids Dryocosmus kuriphilus Torymus sinensis

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A Wideband Circularly Polarized Jeans-Based Antenna at 2.45 GHz

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Open Journal of Antennas and Propagation 2020年第1期8卷 1-18页

作者： Miroslav Joler Anamaria Kolonic maja Boljkovac Department of Computer Engineering Faculty of EngineeringUniversity of RijekaRijekaCroatia

Development of textile antennas is an important segment towards the goal of creating smart clothing. In this paper, we report on a jeans-based circularly polarized textile antenna designed for the E-band (around 2.45 GHz). We present three variations of the design and the respective results. The antenna comprises a multi-layer jeans-fabric as the substrate, a conductive fabric as the patch, which is concealed with another layer of jeans, and the ground plane is formed by either a cooper foil or another conductive fabric. A multi-layer structure was chosen to provide a wider bandwidth and better efficiency, whereas the upper surface of the antenna was covered by one more layer of jeans to both make the antenna less conspicuous, when worn on the arm, and protect the patch and substrate from mechanical damages and moisture. All three variants are characterized by a good realized gain of about 3 dB, a wide beam width and a wide bandwidth of 21% or better, around 2.45 GHz, having the radiation efficiency around 36%, and front-to-back ratio of 5 dB or better, with the ground plane being just slightly larger than the patch.

关键词： Textile Antenna Circular Polarization Jeans-Based Antenna Probe Feed

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Fraud Detection in Interoperable Information Systems

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Computer Technology and Application 2011年第7期2卷 530-538页

作者： Saga Mladenovie Marko Rosic maja Stula Computer Science Department Faculty of Science University of Split Split 21000 Croatia Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture University of Split Split 21000 Croatia

Interoperability is broad and complex subject being the most critical issue facing businesses that need to access information from multiple systems. The concept of unwanted interoperability can result in fault decision making based on counterfeit data produced by hostile interoperable system. Research in this paper is based on highway toll collection system analysis as representative of hierarchical heterogeneous systems where integration becomes more important than development due to the short time in disposal between the contract signature and implementation. Unwanted interoperability detect mechanism is presented using information collected from different information system levels.

关键词：信息系统互操作性欺诈检测公路收费系统异构系统信息使用检测机制

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Obesity Paradox in Chronic Liver Diseases:Product of Bias or a Real Thing?

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 275-279页

作者： Ines Bilic Curcic maja Cigrovski Berkovic Lucija Kuna Hrvoje Roguljic Robert Smolic Silvija Canecki Varzic Lucija Virovic Jukic Martina Smolic Department of Pharmacology Faculty of MedicineJ.J.Strossmayer University of OsijekOsijekCroatia Department of Diabetes Endocrinology and Metabolism DisordersOsijek University Hospital CentreFaculty of MedicineJosip Juraj Strossmayer University of OsijekOsijekCroatia Department for Endocrinology Diabetes and Metabolism University Hospital Center"Sestre Milosrdnice"ZagrebCroatia Department of Pharmacology and Biochemistry Faculty of Dental Medicine and HealthJ.J.Strossmayer University of OsijekOsijekCroatia Department for Cardiovascular Disease Osijek University HospitalOsijekCroatia Department of Gastroenterology and Hepatology Osijek University Hospital CentreFaculty of MedicineJosip Juraj Strossmayer University of OsijekOsijekCroatia Department of Pathophysiology Faculty of MedicineJosip Juraj Strossmayer University of OsijekOsijekCroatia Department of Internal Medicine Faculty of MedicineJosip Juraj Strossmayer University of OsijekOsijekCroatia Department of Gastroenterology and Hepatology Sisters of Mercy University HospitalUniversity of Zagreb School of MedicineZagrebCroatia Department of Pharmacology J.J.Stross-mayer University of Osijek Faculty of Medicine OsijekJ.Huttlera 4Osijek 31000Croatia

In recent years,evidence supporting the theory of obesity paradox has increased,showing that obese/overweight people with prevalent chronic diseases experience lower mortality compared with patients of normal *** far,evidence is most comprehensive in cardiovascular and chronic renal diseases;however,published studies are prone to many biases,enabling us to reach a definite *** data in chronic liver disease is scarce and *** is traditionally associated with nonalcoholic fatty liver disease and steatosis in viral hepatitis and as such one would not expect the obesity paradox to be a real possibility in liver ***,there seem to be new data indicating the opposite-the obesity paradox exists in severe and end-stage liver cirrhosis,which could be attributed to a better lean mass in patients with higher body mass index,meaning that sarcopenia,as one of the most important prognostic factors of survival,is less likely to be ***,the problem of various methodological problems addressing the association between body weight and mortality,which is present both in liver disease and other chronic diseases,are preventing us from attaining an unanimous ***,we should be aware that the obesity paradox might be true,especially in severe and end-stage *** suggests focusing our efforts toward preserving or building up fat-free mass and decreasing infiammatory activity responsible for catabolism and sarcopenia,and implying that the underlaying cause should be treated.

关键词： Obesity paradox Chronic liver disease NAFLD NASH Cirrhosis

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