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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 27-28页

作者： Maizels M. Burchette R. 陈云春 Kaiser Perm.nente Family Practice Woodland Hills CA United States Dr

Background. - m.od disorders of anxiety and depression are well known to be com.rbid with prim.ry headache disorders. Less is known of the com.rbidity of other som.tic sym.tom. with headache. m.thods. - Headache Clinic patients were screened with the Prim.ry Care Evaluation of m.ntal Disorders (PRIm.- m.), a m.ltidim.nsional psychiatric screening tool. The prevalence of som.tic sym.tom. was com.ared by headache diagnosis, frequency of severe headache, and psychiatric diagnosis. Follow- up data were obtained 6 m.nths after consultation. Results. - Clinical diagnoses and PRIm.- m. data were available for 289 patients. Associated som.tic sym.tom. were m.re frequent in patients with chronic m.graine (m.an 5.5, P m.ared to episodic m.graine (4.0); in patients with severe headache >2 days per week com.ared to ≤ 2 days per week (6.15 vs. 4.15, P m.ared to no anxiety or depression, (5.7, P = .05,5.2, P m.st com.on specific sym.tom. were fatigue (73% ), sleep difficulty (60% ), and nausea/indigestion (55% ). Com.ared to a prim.ry care sam.le, patients with severe headache >2 days per week had significantly higher som.tic counts (P = .01). Six- m.nth follow- up data were available for 140 patients. Associated sym.tom. decreased both for patients with and without decrease in severe headache frequency (m.an reduction of 1.0, P = .01 and 0.8, P = .003, respectively). Conclusion. - Associated som.tic sym.tom. are m.re com.on in patients with chronic m.graine and CDH, with m.re frequent severe headaches, and with associated anxiety or depression. Patients with episodic m.graine have sim.lar som.tic prevalence as a previously studied prim.ry care population. The spectrum.of headache disorders m.y be characterized as showing increasing som.tic prevalence as headaches, particularly severe headaches, becom. m.re frequent.

关键词：共病率躯体症状头痛患者情感障碍慢性每日头痛原发性头痛严重头痛症状发生率筛查工具临床诊断

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维普期刊数据库

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维生素B_2、镁剂和白菊联合预防偏头痛的一项临床随机试验

引用

世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 40-40页

作者： Maizels M. Blum.nfeld A. Burchette R. 李锐 Kaiser Perm.nente Family Practice Woodland Hills CAUnited States Dr.

Objective. To determ.ne the efficacy for m.graine prophylaxis of a com.ound containing a com.ination of riboflavin, m.gnesium. and feverfew. Background. P revious studies of m.gnesium.and feverfew for m.graine prophylaxis have found co nflicting results, and there has been only a single placebocontrolled trial of r iboflavin. Design/m.thods. Random.zed double blind placebo controlled trial of a com.ound providing a daily dose of riboflavin 400 m., m.gnesium.300 m., and feverfew 100 m.. The placebo contained 25 m. riboflavin. The study included a 1 m.nth run in phase and 3 m.nth trial. The protocol allowed for 120 patients to be random.zed, with a preplanned interim.analysis of the data after 48 patien ts had com.leted the trial. Results. Forty nine patients com.leted the 3 m.n th trial. For the prim.ry outcom. m.asure, a 50%or greater reduction in m.grain es, there was no difference between active and “placebo”groups, achieved by 10 (42%) and 11 (44%), respectively (P = .87). Sim.larly, there was no significa nt difference in secondary outcom. m.asures, for active versus placebo groups, r espectively: 50%or greater reduction in m.graine days (33%and 40%, P = .63); or change in m.an num.er of m.graines, m.graine days, m.graine index, or triptan doses. Com.ared to baseline, however, both groups showed a significant reductio n in num.er of m.graines, m.graine days, and m.graine index. This effect exceeds that reported for placebo agents in previous m.graine trials. Conclusion. Rib oflavin 25 m. showed an effect com.arable to a com.i nation of riboflavin 400 m.g, m.gnesium.300 m., and feverfew 100 m.. The placebo response exceeds that repo rted for any other placebo in trials of m.graine prophylaxis, and suggests that riboflavin 25 m. m.y be an active com.arator. There is at present conflicting sc ientific evidence with regard to the efficacy of these com.ounds for m.graine pr ophylaxis.

关键词：镁剂白菊安慰剂对照随机试验复合制剂试验用药随机双盲联合用药临床试验无显著性差异

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