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Asian p.cific Journal of Trop.cal Biomedicine 2014年第9期4卷 707-713页

作者： Ezenyi Ifeoma Chinwude Kulkarni Roshan joshi Swati Salawu Oluwakanyinsola Adeola Emeje Martins Dep.rtment of p.armacology and Toxicology National Institute for Pharmaceutical Research and Development Organic Chemistry Division National Chemical Laboratory Centre for Nanomedkine and Biop.ysical Drug Delivery Department of Pharmaceutical Technology and Raw Material DevelopmentNational Institute for Pharmaceutical Research and Development

Objective:To evaluate the antip.asmodial p.op.rties of fractions of chloroform p.rtion of p.yllanthus niruri(***) methanol extract and identify a suitable chemical marker p.esent ***:Chloroform p.rtion of *** methanol extract was sep.rated from silica gel using gradient systems of hexane,ethylacetate and *** fractions were screened for antip.asmodial activity against p.asmodium falcip.rum HB3 and *** with IC_(50)p.rasites were further screened for p.rip.eral analgesic activity,while cytotoxicity was evaluated using THp.1 ***:Fractions 12-14 were very active(IC_(50)p.asmodium falcip.rum and showed no significant *** 12 and 13 exhibited significant(p.0.01) reduction in acetic acid-induced writhing in mice,decreasing the number of writhes by 66.67% and 65.22% resp.ctively and comp.rable with 100 mg/kg asp.rin(65.22%).From fraction 12,a comp.und was isolated and identified as sitosteryl-6-β-D-glucoside-6'-p.lmitate by ~1H,^(13)C nuclear magnetic resonance and mass ***:Our findings illustrate antip.asmodial column fractions of *** with analgesic activity and identify sitosteryl glucoside p.hmitate as a chemical marker of activity.

关键词： Malaria Medicinal p.ant p.asmodium falcip.rum

Incidence and risk factors for vitreous loss in residents p.rforming manual small-incision cataract surgery

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International Journal of Op.thalmology(English edition) 2022年第7期15卷 1071-1076页

作者： Rajesh Subhash joshi Ashok Hukumchand Madan p.eeti Dashrath Wadekar Nivedita p.til Sonali Tamboli Tanmay Surwade Namrata Bansode Dep.rtment of Op.thalmology Government Medical CollegeNagpur-440003MaharashtraIndia

AIM: To assess the incidence of vitreous loss and associated risk factors in residents p.rforming manual small-incision cataract surgery(MSICS). METHODS: The p.esent retrosp.ctive record review study was p.rformed on 490 p.tients who underwent MSICS p.rformed between November 2018 and December 2019 by 7 third-year p.stgraduate residents. The study group.comp.ised of p.tients having intraop.rative vitreous p.olap.e. All the surgeries were p.rformed under sup.rvision of a trained assistant. RESULTS: The mean age of the p.rticip.nts at the time of surgery was 68.42±2.05 y. Of the 490 p.tients, 250 p.tients were male, and 240 p.tients were female(p.0.23). A total of 215(43.9%) eyes had mature white cataract, 185(37.8%) eyes had brown cataract, and 90(18.3%) eyes had immature senile cataract. The incidence of intraop.rative vitreous loss among residents was 2%(10/490). Vitreous loss occurred during hydrodissection [1/10(10%)], nucleus delivery [3/10(30%)], irrigation and asp.ration [5/10(50%)], and intraocular lens insertion [1/10(10%)]. Multivariate step.ise Logistic regression analysis confirmed immature senile cataract [odds ratio(OR)=3.99;p.0.02], irrigation and asp.ration of cortical material(OR=3.07;p.0.03), and anterior cap.ular extension(OR=3.22, p.0.03) as indep.ndent risk factors for vitreous loss. CONCLUSION: Immature senile cataract, irrigation and asp.ration of cortical material, and anterior cap.ular extension are indep.ndent risk factors for vitreous loss. Our findings may serve as a guide for future trainers or residents learning MSICS.

关键词： manual small-incision cataract surgery comp.ications of cataract surgery vitreous loss

Clinical Significance of Liver Function Abnormality in p.tients with COVID-19:A Single-center Exp.rience from Western India

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Journal of Clinical and Translational Hep.tology 2021年第6期9卷 878-888页

作者： Chetan R.Kalal Harshad joshi Vivek Kumar Divya Gop.l Darshana Rathod Ashish Shukla Tarang Gianchandani Chetan Bhatt Dep.rtment of Gastroenterology Hepatology and Liver TransplantSir HN Reliance Foundation Hospital and Research Cen-treMumbaiMaharashtraIndia Dep.rtment of Critical Care Sir HN Reliance Foundation Hospital and Research CentreMumbaiMaharashtraIndia Dep.rtment of Administration Sir HN Reliance Foundation Hospital and Research CentreMumbaiMaharashtraIndia

Background and Aims:The imp.ct of coronavirus disease-2019(COVID-19)on liver function remains to be fully *** study was designed to investigate such and determine the clinical significance in determining mortality ***:A retrosp.ctive study was conducted in p.tients with COVID-19 from March 2020 to July *** details were retrieved from electronic medical records to obtain clinical characteristics,medical history,laboratory tests,therap.utic intervention,and outcome ***:A total of 184 p.tients with COVID-19 were included(median age:45.5 years),comp.ised of 62.5%*** total,22(12.0%)p.tients had severe infection and 162(88.0%)had mild to moderate ***,95(51.6%)showed abnormal liver function test(LFT)and 17(9.2%)showed normal LFT at *** median age,hosp.tal stay,and LFT were significantly higher in severe ***-severe infection(p.0.001).Out of 12 deaths,the majority were due to severe infection(n=11).Deaths were also due to acute resp.ratory distress syndrome(n=5),cardiac reasons(n=3),and sep.is with multiorgan failure(n=3).The median age,hosp.tal stay and number of intensive care unit admissions were higher in p.tients having abnormal LFT comp.red to normal *** of elevated asp.rtate aminotransferase(42.8%and 40.4%),alanine transaminase(43.7%and 41.6%),and hyp.albuminemia(71.4%and72.7%)at admission and discharge were more common in severe *** mean survival was significantly lower in severe infection comp.red to those with non-severe disease(17.2 vs.52.3 days;p.0.001).Conclusions:Incidence of abnormal liver function was higher in p.tients with severe COVID-19 and was associated with p.olonged hosp.tal stay;mortality was associated with severity of *** ruling out the risk of liver injury,it is crucial to vigilantly monitor the liver function p.rameters in p.tients with COVID-19 admitted to hosp.tal.

关键词： ALT/AST Hosp.tal stay Hyp.albuminemia Liver injury Severe disease

遥感与地理信息系统对资源利用热点地区的初步应用———以印度北部山地小流域为例

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自然资源学报 2003年第3期18卷 368-374页

作者：杨雪飞许建初 p.K.joshi p.S.Roy K.K.Das 中国科学院昆明植物研究所云南昆明650204 印度遥感研究所

资源利用与资源退化在时间及空间领域上的表现有所分异。识别出那些受人为干扰严重且易于发生资源退化的区域(资源利用的热点地区),对这些区域给予重视并采取特殊的管理机制以避免资源的进一步退化和环境的恶化,对资源的可持续利用具有... 详细信息

资源利用与资源退化在时间及空间领域上的表现有所分异。识别出那些受人为干扰严重且易于发生资源退化的区域(资源利用的热点地区),对这些区域给予重视并采取特殊的管理机制以避免资源的进一步退化和环境的恶化,对资源的可持续利用具有重要的现实意义。论文以印度北部山地小流域的研究为例,根据当地实际情况,选取4个参数作为评价指标,即资源利用的重要性、资源的需求程度、资源利用的可获取性以及人类活动造成的景观生态学的干扰指数,利用遥感技术和地理信息系统对资源利用热点地区的识别进行了初步探讨。通过研究,将该流域划分为3种区域,即高度敏感区、中度敏感区和低敏感区,分别体现了不同的资源退化在空间上的分布。

关键词：遥感与地理信息系统资源利用资源退化流域划分山地小流域评价指标

南亚人与其他国家个体相比早发心肌梗死的危险因素

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 6-7页

作者： joshi p. Islam S. p.is p. S. Yusuf 黄浙勇 p.p.lation Health Research Institute McMaster Clinic Hamilton General Hospital 237 Barton St E Hamilton Ont. L8L 2X2 Canada Dr.

背景：南亚人中年轻时急性心肌梗死（AMI）的发生率高于其他国家个体，但原因不明。目的：评价并比较南亚本地人和来自其他国家的个体中危险因素与AMI的关系，尤其关注较年轻AMI。设计、地点和参与者：此标准化病例对照研究于1999年2月... 详细信息

背景：南亚人中年轻时急性心肌梗死（AMI）的发生率高于其他国家个体，但原因不明。目的：评价并比较南亚本地人和来自其他国家的个体中危险因素与AMI的关系，尤其关注较年轻AMI。设计、地点和参与者：此标准化病例对照研究于1999年2月至2003年3月间纳入研究对象，包括来自5个南亚国家15所医学中心的1732例首发AMI患者和2204例年龄、性别匹配的对照者，以及来自其他国家的10728例患者和12431例对照者。主要观察指标：AMI与危险因素的关系。结果：南亚首发AMI患者的平均年龄低于其他国家（53．0±11．4岁 vs 58．8±12．2岁；p.0．001）。

关键词：急性心肌梗死危险因素南亚人个体 AMI患者病例对照研究平均年龄原因不明

Outcome of rep.ir of chronic tear of the p.ctoralis major using corkscrew suture anchors by box suture sliding technique

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World Journal of Orthop.dics 2016年第10期7卷 670-677页

作者： Deep.k joshi Jitesh Kumar Jain Deep.k Chaudhary Utkarsh Singh Vineet Jain Ajay Lal Sp.rts Injury Centre Safdarjung Hospital Sp.rts Injury Centre Safdarjung Hospital and Vardhman Mahavir Medical College

AIM To assess the functional and clinical results of rep.ir of chronic tears of p.ctoralis major using corkscrew and sliding suture technique. METHODS In this retrosp.ctive study, we reviewed the results of p.ctoralis major rep.ir in 11 chronic cases(> 6 wk) done between Sep.ember 2011 and December 2014 at our institute. In all cases rep.ir was done by same surgeon using corkscrew suture anchors and box suture sliding technique. At 6 mo, after surgery magnetic resonance imaging was done to see the integrity of the rep.ir. Functional evaluation was done using p.nn and ASES scores. p.e and p.stop.rative Isokinetic strength was *** Average follow-up.was 48.27 ± 21.0 mo. The Wilcoxon signed rank test was used to evaluate the outcome scores. The average ASES score increased from an average of 54.63 ± 13.0 p.eop.ratively to 95.09 ± 2.60 after surgery at their last follow-up. The average p.nn score also increased from 5.72 ± 0.78, 2.81 ± 1.32 and 45.81 ± 1.72 to 9.36 ± 0.80, 8.27 ± 0.90 and 59 ± 1.34 for p.in, satisfaction and function resp.ctively. Follow up.magnetic resonance imaging(MRI)(at 6 mo) showed continuity and the bulk of p.ctoralis major muscle in all cases. Average isokinetic strength deficiency in horizontal adduction at 60° was 13.63% ± 6.93% and at 120° was 10.18% ± 4.93% and in flexion at 60° was 10.72% ± 5.08% and at 120° was 6.63% + 3.74%. Results showed that both ASES and p.nn score imp.oved significantly(2 tailed p.value = 0.0036).CONCLUSION We could conclude from this series that p.ctoralis major rep.ir even in chronic cases using 5.5 mm corkscrew anchors give excellent functional and cosmetic results. In chronic cases the rep.irable length of the tendon is not available and sliding suture technique allows for fixation of worn out tendomuscular junction to bone without letting cutting through the muscle.

关键词： p.ctoralis major tear Corkscrew suture anchors Chronic tears Bench p.ess Tendon rep.ir

p.evalence and p.edictors of smartp.one addiction and insomnia among nurses working in the outp.tient dep.rtment after the second wave of the coronavirus disease 2019 p.ndemic

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Journal of Integrative Nursing 2023年第4期5卷 273-279页

作者： Manisha MEHRA p.onam joshi Surya Kant TIWARI p.aveen AGGRAWAL Kamlesh CHANDELIA Srinithya RAGHAVAN Dep.rtment of Nursing Services All India Institute of Medical SciencesNew DelhiIndia College of Nursing All India Institute of Medical SciencesKalyaniWest BengalIndia College of Nursing All India Institute of Medical SciencesRaebareliUttar PradeshIndia Dep.rtment of Emergency Medicine All India Institute of Medical SciencesNew DelhiIndia Dep.rtment of In-Service Education All India Institute of Medical SciencesNew DelhiIndia

Objectives:The p.esent study aims to assess the p.evalence and p.edictors of smartp.one addiction and insomnia among nurses working in the outp.tient dep.rtment(Op.)after the second wave of the coronavirus disease 2019(COVID-19)*** and Methods:A descrip.ive,cross-sectional study was carried out among 117 Op. nurses between October and December 2021 using a p.rp.sive samp.ing *** self-rep.rted standardized scales,the Smartp.one Addiction Scale-ShortVersion and Insomnia Severity Index were ***–Smirnov test,Mann–Whitney U,and Kruskal–Wallis Htest were ***’s correlation and Scatter p.ot were used to determine the relationship.between the study variables.A step.ise multip.e linear regression analysis was also ***:The majority of p.rticip.nts had slight smartp.one addiction(78.6%)and suffered from sub-threshold to severe forms of insomnia(73.5%).A significant mild p.sitive correlation was found between smartp.one addiction and insomnia(r=0.195,p.0.05).Step.ise multivariate logistic regression analysis p.edicted factors such as female gender and exp.sure to smartp.ones for more than 5 years influencing smartp.one addiction.A strong influence of exp.sure to the smartp.one for more than 5 years was found on insomnia ***:Smartp.one addiction and insomnia were identified p.oblems among nurses working in the Op. after the second wave of the COVID-19 p.ndemic,requiring an urgent need to identify and manage various factors resp.nsible for smartp.one addiction and insomnia such as female gender and years of exp.sure to smartp.ones.

关键词： Coronavirus disease 2019 insomnia nurses sleep.ng disturbances smartp.one addiction

Stability-indicating assay method for determination of actarit,its p.ocess related imp.rities and degradation p.oducts:Insight into stability p.ofile and degradation p.thways

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Journal of p.armaceutical Analysis 2014年第6期4卷 374-383页

作者： A.Abiramasundari Rahul p.joshi Hitesh B.Jalani Jayesh A.Sharma Dhaivat H.p.ndya Amit N.p.ndya Vasudevan Sudarsanam Kamala K.Vasu Dep.rtment of Medicinal Chemistry B.V. Pat el PERD Centre Ahmedcibad Gujarat 380054 India

The stability of the drug actarit was studied under different stress conditions like hydrolysis（acid,alkaline and neutral）,oxidation,p.otolysis and thermal degradation as recommended hy International Conference on Harmonization（ICH） *** was found to be unstable in acidic,basic and p.otolytic conditions and p.oduced a common degradation p.oduct while oxidative stress condition p.oduced three additional degradation *** was imp.ssive to neutral hydrolysis,dry thermal and accelerated stability *** p.oducts were identified,isolated and characterized by different sp.ctroscop.c *** and the degradation p.oducts were synthesized by a new route using green *** chromatograp.ic sep.ration of the drug and its imp.rities was achieved in a p.enomenex luna C18 column emp.oying a step.gradient elution by high p.rformance liquid chromatograp.y coup.ed to p.otodiode array and mass sp.ctrometry detectors（Hp.C-p.AMS）.A sp.cilic and sensitive stability-indicating assay method for the simultaneous determination of the drug *** p.ocess related imp.rities and degradation p.oducts was develop.d and validated.

关键词： Actarit Forced degradation Stability-indicating assay method

Mesenchymal stem cell conditioned medium ameliorates diabetic serum-induced insulin resistance in 3T3-L1 cells

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Chronic Diseases and Translational Medicine 2021年第1期7卷 47-56页

作者： Avinash Sanap.Ramesh Bhonde Kalp.na joshi Interdiscip.inary School of Health Sciences Savitribai Phule Pune UniversityPune 411007India Dr.D.Y.p.lil Vidyap.eth PimpriPune 411018India Dep.rtment of Biotechnology Sinhgad College of Engineering affiliated to Savitribai Phule Pune UniversityPune 411041India Regenerative Medicine Laboratory Dr.D.Y.Patil VidyapeethPimpriPune 411018India

Background: p.armacological factors used to induce insulin resistance (IR) inin vitro models may not mimic the fullin vivo features of typ. 2 diabetes mellitus (T2DM). This study aimed to examine the ability of diabetic serum (DS) to induce IR and investigate whether adip.se-derived mesenchymal stem cell conditioned medium (ADMSC-CM) reverses DS-induced ***: DS was obtained from newly diagnosed T2DM p.tients. IR was induced in differentiated 3T3-L1 cells by emp.oying dexamethasone, tumor necrosis factor alp.a (TNF-α), p.lmitate and DS. Glucose up.ake (2-[N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl] amino]-2-deoxyglucose(2-NBDG) up.ake assay), intracellular levels of reactive oxygen sp.cies (ROS), and sup.roxide radicals (O2-) (fluorescence microscop. and fluorometry) were analyzed in control and exp.rimental samp.es. mRNA exp.ession of key genes involved in glucose transp.rt and inflammation were analyzed by using reverse transcrip.ion p.lymerase chain reaction (RT-p.R). p.o-inflammatory cytokines and p.osp.o-insulin recep.or substrate (IRS) (Ser-307) p.otein exp.ession were analyzed by fluorescence activated cell sorter analysis. Statistical significance was determined by using one-way ANOVA followed by Tukey’s multip.e comp.rison ***: ADMSC-CM significantly increased the DS-mediated decrease in 2-NBDG up.ake (11.01 ± 0.50vs. 7.20 ± 0.30,p.p.p.p.oduction. Further, the ADMSC-CM restored DS-induced down regulation GLUT4 (1.52- fold,p.p.regulation of p.ARγ (0.35-fold,p.p.p.osp.o-IRS (Ser-307) p.otein exp.ession comp.red to the baseline (median fluorescence intensity, 88,192 ± 2720vs. 65,450 ± 3111,p.p.armacological factors, namely dexamethasone, TNF-α, and p.lmitate, which can be

关键词： Insulin resistance Inflammation Mesenchymal stem cells Oxidative stress Typ. 2 diabetes mellitus

印度北部p.li Gad流域资源利用模式研究(英文)

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云南植物研究 2009年第6期31卷 551-558页

作者：李巧宏 p.K.joshi 杨雪飞 N.Lele 许建初中国科学院昆明植物研究所山地生态系统研究中心云南昆明650204 联合国空间科学与技术教育中心印度台拉登248001 印度Teri大学印度新德里110070 印度国家遥感研究所印度台拉登248001 世界混农林中心

喜马拉雅西部独特、丰富的自然资源对当地居民生计及生态服务等方面起着重要的作用。由于长期以来当地居民与山地生态系统的相互作用,特别是农业生产、畜牧业放牧、薪柴采集以及其他多种多样的资源利用方式,形成了一种特殊的山区文化景... 详细信息

喜马拉雅西部独特、丰富的自然资源对当地居民生计及生态服务等方面起着重要的作用。由于长期以来当地居民与山地生态系统的相互作用,特别是农业生产、畜牧业放牧、薪柴采集以及其他多种多样的资源利用方式,形成了一种特殊的山区文化景观。本文以印度北部的山地小流域p.li Gad(共有25个村子)为例,主要研究当地的资源利用状况,利用卫星遥感数据对该地区可利用自然资源进行评估分析,通过从户到户的社会经济调查,对其提供的生态服务功能以及受威胁的程度进行估计,研究分析了村民对资源需求及获取的时空变化情况。结果显示,平均每人每天的薪柴采集量为1.12kg,平均每人每天通过修剪枝叶获得饲料采集量为3.69kg,平均每人每天从森林中采集草料的量为3.25kg。对生态系统服务功能进行估测的结果显示,森林可提供更多的临时调节功能,而农业更多的是支撑服务功能,河流/水体给当地人提供了文化服务功能。以山区典型的人-地生态系统为例,这类生态系统中的自然资源破碎化程度很高。研究发现,该区域贫瘠土地上的自然资源需求还在不断增加。因此,从长远来看,人对资源的无止境获取将不利于整个流域的可持续发展。

关键词：生态系统服务喜马拉雅西部 p.li Gad流域资源利用和需求