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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 248-252页

作者： Christopher Steevens maisa abdalla Truptesh H Kothari Vivek Kaul Shivangi Kothari Division of Gastroenterology and Hepatology Center for Advanced Therapeutic Endoscopy University of Rochester Medical Center Developmental Endoscopy Lab at UR Division of Gastroenterology and Hepatology Center for Advanced Therapeutic Endoscopy University of Rochester Medical Center

Bleeding from duodenal varices is reported to be a catastrophic and often fatal event. Most of the cases in the literature involve patients with underlying cirrhosis. However, approximately one quarter of duodenal variceal bleeds is caused by extrahepatic portal hypertension and they represent a unique population given their lack of liver dysfunction. The authors present a case where a 61-year-old male with history of remote crush injury presented with bright red blood per rectum and was found to have bleeding from massive duodenal varices. Injection sclerotherapy with ethanolamine was performed and the patient experienced a favorable outcome with near resolution of his varices on endoscopic follow-up. The authors conclude that sclerotherapy is a reasonable first line therapy and review the literature surrounding the treatment of duodenal varices secondary to extrahepatic portal hypertension.

关键词： Extrahepatic portal hypertension Duodenal varices

Enteric neuropathy in diabetes:Implications for gastrointestinal function

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World Journal of Gastroenterology 2024年第22期30卷 2852-2865页

作者： Mona Mohamed Ibrahim abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes,commonly known for its metabolic effects,also critically affects the enteric nervous system(ENS),which is essential in regulating gastrointestinal(GI)motility,secretion,and absorption.The development of diabetes-induced enteric neuropathy can lead to various GI dysfunctions,such as gastroparesis and irregular bowel habits,primarily due to disruptions in the function of neuronal and glial cells within the ENS,as well as oxidative stress and inflammation.This editorial explores the pathophysiological mechanisms underlying the development of enteric neuropathy in diabetic patients.Additionally,it discusses the latest advances in diagnostic approaches,emphasizing the need for early detection and intervention to mitigate GI complications in diabetic individuals.The editorial also reviews current and emerging therapeutic strategies,focusing on pharmacological treatments,dietary management,and potential neuromodulatory interventions.Ultimately,this editorial highlights the necessity of a multidisciplinary approach in managing enteric neuropathy in diabetes,aiming to enhance patient quality of life and address a frequently overlooked complication of this widespread disease.

关键词： Diabetic neuropathy Gastrointestinal Insulin resistance Diabetes Enteric nervous system Enteric neuropathy

Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

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Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos Ch.Tsirogiannis Evangelos Daskalakis Mohamed H.Hassan abdalla M.Omar Paulo Bartolo EODH SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance Hybrid composites Vehicle protection

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Mechanical performance of cold mix asphalt containing cup lump rubber as a sustainable bio-modifier

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 424-440页

作者： Syed Abdul Ghafar Muhammad Naqiuddin Mohd Warid Norhidayah Abdul Hassan Zulfiqar Ali Jattak Ashraf abdalla Mohammed Radwan Faculty of Civil Engineering Universiti Teknologi MalaysiaSkudai 81310Malaysia Department of Civil Engineering Balochistan University of Information TechnologyEngineering&Management SciencesQuettaPakistan Department of Civil Engineering Balochistan University of Engineering and TechnologyKhuzdarPakistan Department of Civil Engineering Faculty of EngineeringUniversity of TripoliTripoliLibya

The road construction industry aims to contribute to the protection of already compromised environment.Cold mix asphalt(CMA)is a measure initiated by the road industry to protect the environment and preserve energy.Despite having additional benefits,CMA has attracted little attention due to its inferior performance.CMA's performance is enhanced using a sustainable binder bio-modifier,natural cup lump rubber(CLR)is one of them.This study evaluated the tensile properties,rutting,moisture susceptibility,and adhesion properties of CLR-modified CMA(CMA-CR).The tensile property was enhanced by 26%due to CLR modification.CMA-CR had excellent rutting resistance of less than 2 mm rut depth at 10,000 load cycles,showing 70%improvement compared with conventional CMA.Moisture susceptibility evaluation indicated that CMA-CR had tensile strength ratio(TSR)value of 104%,satisfying the minimum 80%requirement of AASHTO T283.It also retained more than 96%bitumen coating.The moisture damage resistance was improved by 12%and 10%in terms of TSR and stripping,respectively.The durability results revealed that the CMA-CR mixture prevented higher mass loss,representing 14%improvement compared with conventional CMA.

关键词： Cup lump rubber Cup lump modified cold mix asphalt Moisture damage Tensile property Rutting Digital imaging

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A gated recurrent unit model to predict Poisson’s ratio using deep learning

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 123-135页

作者： Fahd Saeed Alakbari Mysara Eissa Mohyaldinn Mohammed abdalla Ayoub Ibnelwaleed A.Hussein Ali Samer Muhsan Syahrir Ridha Abdullah Abduljabbar Salih Petroleum Engineering Department Universiti Teknologi PETRONAS32610Bandar Seri IskandarPerakMalaysia Institute of Hydrocarbon Recovery Universiti Teknologi PETRONAS32610Bandar Seri IskandarPerakMalaysia Gas Processing Center College of EngineeringQatar UniversityP.O.Box 2713DohaQatar Department of Chemical Engineering College of EngineeringQatar UniversityP.O.Box 2713DohaQatar Mechanical Engineering Department Universiti Teknologi PETRONAS32610Bandar Seri IskandarPerakMalaysia

Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to specific data ranges with an average absolute percentage relative error(AAPRE)of more than 10%.The published gated recurrent unit(GRU)models do not consider trend analysis to show physical behaviors.In this study,we aim to develop a GRU model using trend analysis and three inputs for predicting n s based on a broad range of data,n s(value of 0.1627-0.4492),bulk formation density(RHOB)(0.315-2.994 g/mL),compressional time(DTc)(44.43-186.9 μs/ft),and shear time(DTs)(72.9-341.2μ s/ft).The GRU model was evaluated using different approaches,including statistical error an-alyses.The GRU model showed the proper trends,and the model data ranges were wider than previous ones.The GRU model has the largest correlation coefficient(R)of 0.967 and the lowest AAPRE,average percent relative error(APRE),root mean square error(RMSE),and standard deviation(SD)of 3.228%,1.054%,4.389,and 0.013,respectively,compared to other models.The GRU model has a high accuracy for the different datasets:training,validation,testing,and the whole datasets with R and AAPRE values were 0.981 and 2.601%,0.966 and 3.274%,0.967 and 3.228%,and 0.977 and 2.861%,respectively.The group error analyses of all inputs show that the GRU model has less than 5% AAPRE for all input ranges,which is superior to other models that have different AAPRE values of more than 10% at various ranges of inputs.

关键词： Static Poisson’s ratio Deep learning Gated recurrent unit(GRU) Sand control Trend analysis Geomechanical properties

合理设计多电子转移机制实现更好的水系锌-有机电池

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Science China Materials 2024年第5期67卷 1367-1378页

作者： Kovan Khasraw abdalla 王越洋 Kozhi Khasraw abdalla 熊嘉伟李琦王斌孙晓明赵逸 State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Department of Biomedical Science Komar University of Science and TechnologySulaimaniyahIraq College of Education University of GeorgiaAthensGA30605USA Minmetals Exploration&Development CO. LTDBeijing100010China Advanced Technology Research Institute Beijing Institute of TechnologyJinan250300China

由于环境相容性好、分子结构可定制和有机物资源丰富等优势,水系锌-有机物电池(AZOBs)成为构建新一代大规模储能系统的关键技术.然而,电导率差、有机物溶解和单一活性基团等问题严重限制了有机物正极材料的倍率性能、稳定性和比容量.因... 详细信息

由于环境相容性好、分子结构可定制和有机物资源丰富等优势,水系锌-有机物电池(AZOBs)成为构建新一代大规模储能系统的关键技术.然而,电导率差、有机物溶解和单一活性基团等问题严重限制了有机物正极材料的倍率性能、稳定性和比容量.因此,具备多氧化还原中心和稳定骨架的有机物正极材料对于实现高性能有机物正极材料至关重要.这些多官能团有机物可协同作用并激发基于多电子转移的氧化还原反应,进而促进H^(+)/Zn^(2+)共嵌以显著提升电池性能.本文探索了多官能团有机物电极的分子结构与其氧化还原反应机理之间的构效关系.本文综述了多官能团有机正极材料在提高氧化还原电位、比容量、动力学以及稳定性等方面面临的挑战和解决策略,为进一步开发先进AZOBs的关键正极材料提供了重要基础.

关键词： aqueous zinc organic battery multifunctional organic cathodes energy storage mechanism molecular structure optimization high performance

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Insulin resistance as the molecular link between diabetes and Alzheimer's disease

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World Journal of Diabetes 2024年第7期15卷 1430-1447页

作者： Mona Mohamed Ibrahim abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence worldwide.Recent studies have indicated a possible link between DM and an increased risk of developing AD.Insulin,while primarily known for its role in regulating blood sugar,also plays a vital role in protecting brain functions.Insulin resistance(IR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's development.When insulin signalling becomes dysfunctional,it can negatively affect various brain functions,making individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein tangles.Emerging research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to AD.This review aims to explore the relationship between DM and AD,with a focus on the role of IR.It also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target IR.Understanding IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关键词： Alzheimer's disease Insulin resistance Obesity Dementia Diabetes Metabolic syndrome

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硫醇介导细胞摄取机制与应用研究进展

精细化工 2024年

作者：魏泓贝张慧 MASTER Mwafulirwa KHAMIS abdalla 孙晓龙西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室

细胞摄取是生物体内多种生物活性物质进入细胞的主要途径之一。硫醇介导的摄取通过巯基化物与细胞内的巯基-二硫键进行动态共价交换，然后通过融合、内吞或直接跨膜转运等方式完成对物质的递送，在提高治疗效果和生物活性物质的应用效... 详细信息

细胞摄取是生物体内多种生物活性物质进入细胞的主要途径之一。硫醇介导的摄取通过巯基化物与细胞内的巯基-二硫键进行动态共价交换，然后通过融合、内吞或直接跨膜转运等方式完成对物质的递送，在提高治疗效果和生物活性物质的应用效率方面具有优势。该文综述了具有不同环张力二硫化物、聚二硫醚、环状寡硫族化合物、二硒化物、动态硫醚键、迈克尔受体等分子结构与巯基的相互作用机制；总结了通过这一途径对量子点、核酸、蛋白质、纳米颗粒、药物和脂质体等物质在细胞内的递送，以及通过封闭细胞内的巯基来抑制细胞对通过这一途径进入的化合物的摄取；此外，介绍了硫醇介导摄取在植物和微生物中的应用；最后，展望了硫醇介导摄取未来的发展趋势。

关键词：动态共价交换硫醇介导摄取作用机制物质递送治疗

Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第5期16卷 293-305页

作者： Muhammad Ahmed Ali Fahim Afia Salman Hira Anas Khan Syed Muhammad Hasan Muskan FatimaBhojani Sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul Abdul Moeed Abdelrahman S abdalla Muhammad Majid Muhammad Sohaib Asghar Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States Department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States Department of Cardiovascular Imaging Cleveland ClinicClevelandOH 44195United States Division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising results.The stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent types.METHODS The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August 2023.Primary outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were included.Though statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs DESs.In addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS arm.Baseline analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of MACE.CONCLUSION TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关键词： Stents Drug-eluting Major adverse cardiac events All-cause death Meta-analysis

Repeated Attribute Optimization for Big Data Encryption

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Computer Systems Science & Engineering 2022年第1期40卷 53-64页

作者： abdalla Alameen Department of Computer Science College of Arts and SciencesPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia

Big data denotes the variety,velocity,and massive volume of data.Existing databases are unsuitable to store big data owing to its high volume.Cloud computing is an optimal solution to process and store big data.However,the significant issue lies in handling access control and privacy,wherein the data should be encrypted and unauthorized user access must be restricted through efficient access control.Attribute-based encryption(ABE)permits users to encrypt and decrypt data.However,for the policy to work in practical scenarios,the attributes must be repeated.In the case of specific policies,it is not possible to avoid attribute repetition even after the application of Boolean optimization approaches to obtain a Boolean formula.For these policies,there exists a variety of evaluated secret shares for the repeated attributes.Therefore,the calculation of cipher text for these irreducible policies seems to be lengthy and computationally intensive.To address this problem,an improved meta-heuristic-based repeated attributes optimization on cipher-text policy-ABE(CP-ABE)is developed in this study.Here,the improved meta-heuristic concept is developed in the encryption phase,which returns the optimized single share value of each repeated attribute after considering all the attribute shares.The optimization process not only minimizes the encryption cost but also the communication cost.Herein,the improved sun flower optimization(SFO),called the newly updated SFO(NU-SFO)is used to perform the repeated attribute optimization in CP-ABE.Finally,the performance evaluation confirms the reliability and robustness of the developed scheme through comparisons with traditional constructions.

关键词： Bigdata repeatedattributeoptimization ciphertextpolicy encryption