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Stress Coping and Issues among Evacuees Four Years after the Nuclear Disaster in Fukushima: An Interview Study

Open Journal of Nursing 2018年第3期8卷 210-220页

作者： Toshiko Tomisawa Yuki Kimura maiko kitajima Kasumi Mikami Department of Nursing Science Hirosaki University Graduate School of Health Sciences Hirosaki Japan Tokai University Medical Hospital Kanagawa Japan

Purpose: The purpose of the present study was to clarify issues related to the evacuation process, including stress coping, psychological conditions, and health problems, through interviews with long-term evacuees 4 years after the Great East Japan earthquake and nuclear disaster. Methods: Group interviews focusing on stress and health conditions were conducted with eight older adults at a meeting space in Y city in Fukushima Prefecture, Japan, in May 2015. Two months later, based on the results of the first group interview, four (two men, two women, age range, 60 - 70 years) of those eight individuals participated in 60-min individual semi-structured interviews and were assessed according to the Tri-axial Coping Scale revised for the elderly. The interviewees were asked about their anxiety and hardships, escape routes, and other points of importance. Results: Stress coping scores were higher for males than for females, especially that for “Catharsis”. The “Giving up” score was higher among these participants than the general population. In the interviews, the participants described how evacuees from “Q” area were experiencing high levels of stress because of problems communicating with their neighborhoods and receiving compensation from the government and Tokyo Electric Power Company. Conclusion: Evacuees experienced hardships immediately after the earthquake, including issues related to compensation from the government and communication with their neighborhoods. Men showed higher scores for “Avoidance-like thinking” and “Giving up” than for other factors related to stress coping, suggesting that they might not use “Catharsis” as a means of coping with stress. The results also suggested that men experienced repeatedly that alone, they made little headway or could not do something. The present study suggests the importance of providing support to long-term evacuees so that original residents can better understand their situation.

关键词： Stress Coping Nuclear Disaster Earthquake Evacuation

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Attitude survey of nursing students in Madagascar and Japan

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Open Journal of Nursing 2012年第2期2卷 79-84页

作者： Satomi Kubosawa Narindra Rajaonarison Ny Ony maiko kitajima Yuka Noto Hideaki Yamabe Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar School of Health Sciences Hirosaki University Hirosaki Japan

Background: Few investigations have focused on nursing students from a developing country in relation to a developed country like Japan. Objective: This study explored differences between the nursing students in Madagascar and Japan. Subjects and Methods: This is a prospective analytical study of 63 nursing students—32 Japanese and 31 Malagasy. Questionnaires were distributed to students in Madagascar and Japan in 2010 and collected for statistical analysis. Results: Malagasy students tended to think that nursing plays a psychological role, and they have positive view for this function. In contrast, Japanese students tended to think that nursing is physical work and they make a point of its outcome and the need for social and economic guarantees. Conclusion: The nursing students in Madagascar and Japan expressed different views and goals. While several factors may be involved in these differences, their distinct medical situations are most likely the major contributor.

关键词： Madagascar Japan Nursing Student Image to Nurse

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Single Oral Administration of Anthocyanin Rescues Smoking-Induced Endothelial Dysfunction in Young Smokers but Facilitates Oxidative Stress in Non-Smokers

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Food and Nutrition Sciences 2018年第3期9卷 179-190页

作者： Akane Yoshizaki Toshiko Tomisawa Tomohiro Osanai Naoki Nanashima maiko kitajima Kasumi Mikami Toshifumi Fujita Hayato Maeda Yoji Kato Hirosaki University Medical Hospital Hirosaki Japan Department of Nursing Science Hirosaki University Graduate School of Health Sciences Hirosaki Japan Department of Biomedical Sciences Hirosaki University Graduate School of Health Sciences Hirosaki Japan Department of Disability and Health Hirosaki University Graduate School of Health Sciences Hirosaki Japan Faculty of Agriculture and Life Science Hirosaki University Hirosaki Japan Faculty of Education Hirosaki University Hirosaki Japan

Objectives: Smoking causes endothelial dysfunction, but it still remains unclear whether oral administration of anthocyanin brings benefits to endothelial function and redox states in young healthy smokers. We tested the hypothesis that supplement anthocyanin may rescue endothelial dysfunction and redox states in young healthy smokers. Methods: Young healthy male non-smoker (n = 8) and smokers (n = 14) were enrolled to measure the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) levels and brachial artery flow-mediated dilation (FMD) before and 2 hours after one cigarette smoking or resting under administration of blackcurrant supplements (anthocyanins 210 mg) or not. Results: FMD, d-ROMs, and BAP at baseline were similar between non-smokers and smokers. One cigarette smoking induced a decrease in FMD at 2 hours (9.0% ± 2.6% vs 7.5% ± 2.3%, p Conclusions: Single oral administration of anthocyanin rescued smoking-induced endothelial dysfunction in young healthy smokers, but facilitated oxidative stress in non-smokers. When anthocyanin is taken as supplements, it seems important to pay attention to the dose and timing of administration.

关键词： Blackcurrant Anthocyanin Young Health Smoker Oxidative Stress Antioxidants

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Salivary Biomarkers May Be Useful to Assess Stress State in Patients with Lung Cancer Undergoing Chemotherapy

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International Journal of Clinical Medicine 2011年第5期2卷 576-581页

作者： maiko kitajima Yuka Noto Umi Kudo Mayumi Urushizaka Toshiko Tomisawa Chieko Itaki Kumiko Kawasaki Hideaki Yamabe Akihito Hayashi Shingo Takanashi 不详

Objective: As it is important for medical staff to understand the stress state of patients with cancer, this study investigated the stress state in patients with lung cancer undergoing chemotherapy using salivary biomarkers and questionnaires. Materials and Methods: The subjects included 19 men and 9 women, with a mean age of 66.1 ± 7.1 years who received chemotherapy for lung cancer. Salivary samples of the participants were collected before and the 7 day after chemotherapy. Simultaneously, they completed the POMS (profile of mood states) and QOL (quality of life) questionnaires. The salivary cortisol and secretory IgA as stress markers were measured by enzyme immunoassay. Results: The salivary secretory IgA level was significantly higher at the 7th day after chemotherapy than before chemotherapy (p < 0.05), although the salivary cortisol level did not change. The tension-anxiety score, which is one of POMS subclasses, and total mood disturbance score were lower at day 7 of chemotherapy than before chemotherapy (p < 0.05), although no correlations were observed between POMS scores and salivary markers. However, a negative correlation was observed between the salivary cortisol level and the QOL full score (r= -0.411, p < 0.05). Conclusion: Measurement of salivary stress markers is noninvasive and may be useful for assessing the stress state of the patients.

关键词： Lung Cancer Chemotherapy Secretory-IgA Saliva Stress Marker

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Factors Influencing Behavior of Taking Medicine in Elderly Patients Undergoing Hemodialysis

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Open Journal of Nephrology 2012年第3期2卷 38-43页

作者： Kumiko Ozawa Setsuko Niki Seiko Yamanouchi Hideaki Yamabe Toshiko Tomisawa maiko kitajima Mayumi Urushizaka Kumiko Kawasaki Chieko Itaki Yuka Noto Morito Endo Faculty of Human Health Science Hachinohe University Hachinohe Japan Hirosaki University Graduate School of Health Sciences Hirosaki Japan School of Nursing Hachinohe Junior College Hachinohe Japan

Purpose: The elderly are often faced with multiple diseases, in particular hemodialysis (HD) which requires many kinds of medication. This study examined the factors influencing the behavior of taking medicine in elderly patients undergoing HD. Subjects and Methods: The subjects comprised 70 outpatients > 65 years undergoing HD (48 male and 22 female). The mean age of the patients was 72.5 ± 4.4 years. The mean duration of dialysis history was 6.1 ± 5.2 years. We performed a questionnaire survey using Medication Assessment Tool, The Kidney Disease Quality of Life (QOL)-Short Form and Acceptance for Dialysis Instrument. Result: Two factors related to poor behavior of taking medicine: dialysis history < 2 years and poor acceptance of dialysis. The multiple regression analysis showed patient satisfaction (β = –0.329, p < 0.01) and symptoms/problems (β = –0.273, p<0.05) as significant independent variables relating to behavior of taking medicine. Conclusion: Poor behavior of taking medicine is related to a short dialysis period, poor acceptance and poor satisfaction of dialysis therapy in elderly patients.

关键词： Behavior of Taking Medicine Hemodialysis Adherence Elderly Patient

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Stress Assessment by Salivary Biomarkers in Patients with Lung Cancer Undergoing Chemotherapy

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Journal of Cancer Therapy 2012年第2期3卷 127-131页

作者： maiko kitajima Yuka Noto Umi Kudo Mayumi Urushizaka Toshiko Tomisawa Chieko Itaki Kumiko Kawasaki Hideaki Yamabe Akihito Hayashi Shingo Takanashi Department of Respiratory Medicine Hirosaki University Hospital Hirosaki Japan. Graduate School of Health Sciences Hirosaki University Hirosaki Japan

Background: It is important for medical staffs to understand the state of stress of patients with cancer. The authors investigated stress assessment in patients with lung cancer undergoing chemotherapy. Materials and Method: Salivary cortisol and α-amylase were measured as stress markers before and after chemotherapy in 10 patients. Emotional status was assessed using the Profile of Mood States (POMS) questionnaire, and Quality of Life (QOL) was assessed using the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire. Results: No significant differences were found between the before and after chemotherapy in salivary levels of cortisol or α-amylase, the POMS and QOL scores. The salivary cortisol levels correlated with the POMS subscales of anger-hostility, and confusion. A negative correlation was observed between the salivary cortisol level and the QOL full score. The FACT-L full score correlated with the POMS subscales of depression-dejection, fatigue, and confusion. Conclusions: Measurements of salivary stress markers are noninvasive and may be useful for assessing the stress state of the

关键词： Stress Lung Cancer Chemotherapy Cortisol QOL

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Journal of Diabetes Mellitus 2014年第1期4卷 67-71页

作者： Kumiko Ozawa Toshiko Tomisawa Sakiko Sakuraba Mayumi Urushizaka maiko kitajima Chieko Itaki Yuka Noto Kumiko Kawasaki Hideaki Yamabe Kyoko Tagami Aichi Prefectural University Aichi Japan Department of Nursing Hachinohe Gakuin Junior College Hachinohe Japan Hirosaki University Graduate School of Health Sciences Hirosaki Japan Hirosaki University Hospital Hirosaki Japan

Purpose: To identify factors related to changes in foot status and foot care in patients with diabetes mellitus participating in an exercise program. Methods: The subjects were 21 patients with Type 2 diabetes mellitus (8 males, 13 females). The mean age of the patients was 62.3 ± 12.5 years old. Foot status, physical measurements and daily activities were monitored and several surveys were performed. Results: Changes in foot status were significantly positively correlated with walking at normal speed (r = 0.54, p < 0.05) and fast speed (r = 0.68, p p < 0.05). Foot care showed a significant negative correlation with burden of diet therapy (r = -0.48, p < 0.05) and a significant positive correlation with the self-efficacy of diet therapy (r = 0.65, p < 0.01). Conclusions: Subjects who were fast walkers showed greater changes in foot status. Poor foot care behavior is also related to greater changes in foot status. Regular interventions for foot care are important to improve self-care behavior during an exercise program.

关键词： Change in Foot Status Foot Care Diabetes Mellitus Exercise

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Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells

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Cellular & Molecular Immunology 2010年第6期7卷 440-446页

作者： Tomoyuki Suzuki Myint Oo Chang Masayuki kitajima Hiroshi Takaku Department of Life and Environmental Sciences Chiba Institute of TechnologyChibaJapan High Technology Research Center Chiba Institute of TechnologyChibaJapan Immunology Program Benaroya Research InstituteSeattleWAUSA

A dendritic cell(DC)vaccine strategy has been developed as a new cancer immunotherapy,but the goal of complete tumor eradication has not yet been *** have previously shown that baculoviruses potently infect DCs and induce antitumor immunity against hepatomas in a mouse ***-infected,bone marrow-derived DCs(BMDCs)display increased surface expression of costimulatory molecules,such as CD80,CD86 and major histocompatibility complex(MHC)classes I and II,and secrete interferons and other proinflammatory *** this study,we evaluated the induction of antitumor immunity in mice by baculovirus-infected BMDCs against lung cancer and *** treatment with baculovirus-infected BMDCs,murine lung tumors caused by Lewis lung carcinoma(LLC)cells were significantly reduced in size,and the survival of the mice was *** addition,experiments using a melanoma mouse model showed that baculovirus-infected BMDCs inhibited tumor growth and improved survival compared with *** alanine aminotransferase(ALT),aspartate aminotransferase(AST)and creatinine levels remained normal in baculovirus-infected BMDC-treated *** findings show that baculovirus-infected DCs induce antitumor immunity and pave the way for the use of this technique as an effective tool for DC immunotherapy against malignancies.

关键词： dendritic cells natural killer cells T cells tumor Immunity

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Methylation-mediated gene silencing as biomarkers of gastric cancer:a review

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World Journal of Gastroenterology 2014年第34期20卷 11991-12006页

作者： Jun Nakamura Tomokazu Tanaka Yoshihiko kitajima Hirokazu Noshiro Kohji Miyazaki Department of Surgery Saga University Faculty of MedicineSaga 849-8501Japan Department of Surgery National Hospital Organization Higashi-Saga Hospital7324 HarakogaMiyaki TownSaga 849-0101Japan

Despite a decline in the overall incidence of gastric cancer(GC),the disease remains the second most common cause of cancer-related death worldwide and is thus a significant global health *** best means of improving the survival of GC patients is to screen for and treat early ***,GC is often diagnosed at an advanced stage and is associated with a poor *** diagnostic and therapeutic strategies have not been successful in decreasing the global burden of the disease;therefore,the identification of reliable biomarkers for an early diagnosis,predictive markers of recurrence and survival and markers of drug sensitivity and/or resistance is urgently *** initiation and progression of GC depends not only on genetic alterations but also epigenetic changes,such as DNA methylation and histone *** DNA methylation is the most well-defined epigenetic change in human cancers and is associated with inappropriate gene ***,an increasing number of genes methylated at the promoter region have been targeted as possible biomarkers for different purposes,including early detection,classification,the assessment of the tumor prognosis,the development of therapeutic strategies and patient *** review article summarizes the current understanding and recent evidence regarding DNA methylation markers in GC with a focus on the clinical potential of these markers.

关键词： Gastric cancer Methylation Biomarker Early detection Drug sensitivity

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Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer

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World Journal of Gastroenterology 2010年第3期16卷 330-338页

作者： Masatsugu Hiraki Yoshihiko kitajima Seiji Sato Jun Nakamura Kazuyoshi Hashiguchi Hirokazu Noshiro Kohji Miyazaki Department of Surgery Saga University Faculty of Medicine

AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer ***: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain reaction (PCR). Eighty patients were divided into 3 groups; Group A (n=35):the depth of cancer invasion was less than the muscularis propria; Group B (n=31): the depth of cancer invasion was beyond the muscularis propria. Both group A and B were diagnosed as no cancer cells in peritoneal cytology and histology; Group C (n=14): disseminated nodule was histologically diagnosed or cancer cells were cytologically defi ned in the peritoneal ***: The positive rates of methylation in CHFR, E-cadherin and BNIP3 were significantly different among the 3 groups and increased in order of group A, B and C (0%,0% and 21% in CHFR, P<0.05; 20%, 45% and 50% in E-cadherin, P<0.05;26%,35% and 71% in BNIP3, P<0.05). In addition, the multigene methylation rate among CHFR, E-cadherin and BNIP3 was correlated with group A, B and C (9%,19% and 57%, P<0.001). Moreover, the prognosis was analyzed in group B, excluding 3 patients who underwent a non-curative resection. Two of the 5 patients with multigene methylation showed peritoneal recurrence after surgery, while those without or with a single gene methylation did not experience recurrence (P<0.05).CONCLUSION: This study suggested that gene methylation in the PF could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis.

关键词： Ascites Dissemination Gastric cancer Methylation Peritoneal fluid Quantitative methylation-specific polymerase chain reaction

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