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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2024年

作者： Ze-Min Lin mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal Chemistry Shanghai Institute of Materia Medica Chinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor,Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes i...

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第三方惩罚行为的认知神经机制

心理科学进展 2024年第2期32卷 398-412,I0015-I0021页

作者：郑好陈荣荣买晓琴中国人民大学心理学系北京100872

第三方惩罚(third-party punishment,TPP)指个体作为第三方或者观察者为维护社会规范对违规者所实施的惩罚行为。大量研究为揭示TPP行为的神经机制提供了启示,但鲜有研究关注不同功能性脑网络在其中发挥的整体作用。本文综述了近10年来... 详细信息

第三方惩罚(third-party punishment,TPP)指个体作为第三方或者观察者为维护社会规范对违规者所实施的惩罚行为。大量研究为揭示TPP行为的神经机制提供了启示,但鲜有研究关注不同功能性脑网络在其中发挥的整体作用。本文综述了近10年来TPP相关的研究,对相关理论模型和脑网络进行总结,并在此基础上提出TPP的认知神经网络模型,系统地对TPP行为背后的神经机制进行解释和整合。在该模型中,情绪系统和奖赏系统是TPP的动力来源,认知系统主要负责责任评估以及惩罚的选择;奖赏网络、突显网络、默认模式网络和中央执行网络分别参与不同认知加工阶段。该模型建立了TPP相关研究在心理层面和认知神经层面上的联系,对TPP行为的发生和发展机制进行了更加整体、全面的解释。未来可以引入元分析或基于机器学习的分析方法,在不同的背景信息和更加复杂的社交情境下探讨第三方干预偏好以及背后的认知神经机制。

关键词：第三方惩罚认知神经机制脑网络 fMRI

基于聚合物凝胶和纸基的超分子光学传感阵列研究进展

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中国科学：化学 2024年第2期54卷 218-230页

作者：李宏达姜迈于汇川中国刑事警察学院刑事科学技术学院沈阳110035 文件检验鉴定公安部重点实验室沈阳110035 中国刑事警察学院侦查与反恐怖学院沈阳110035

超分子光学传感器阵列是分析化学中分子识别信息可视化的有效工具之一,这种传感器的优点是它们可以利用阵列系统来检测多种分析物.然而,大多数的光学传感器阵列主要在溶液状态下进行检测,大大限制了其应用的范围.发展固态光学传感器阵列... 详细信息

超分子光学传感器阵列是分析化学中分子识别信息可视化的有效工具之一,这种传感器的优点是它们可以利用阵列系统来检测多种分析物.然而,大多数的光学传感器阵列主要在溶液状态下进行检测,大大限制了其应用的范围.发展固态光学传感器阵列,如聚合物凝胶和纸张,可以扩大光学传感器作为现场可视化分析工具的应用范围.本综述结合强大的数据处理技术和实际应用的便携式数字化检测技术,总结了固态介质参与的分子光学传感器阵列的应用与展望.

关键词：超分子传感器光学传感器阵列现场传感成像分析模式识别

Therapeutic Profile and Prognostic Factors of Patients Suffering from Upper Digestive Bleeding at Sikasso Regional Hospital

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Open Journal of Gastroenterology 2024年第9期14卷 300-312页

作者： Oumar Traoré Abdoul Salam Diarra Dramane Touré Tawfiq Abu Amadou Boubeye Maïga Kadiatou Cissé Saïdon Touré Mohomedine Touré Aboudou Dolo Youana Koné Madou Traoré Mamadou Togo Kalba Péliaba Mamadou samaké Hamadoun Sangho Service of Internal Medicine Regional Hospital Sikasso Mali National Center for Scientific and Technological Research Bamako Mali Department of Pediatric Health Referral Center of Kalaban Coro Koulikoro Mali Private Practice for Family and Emergency Medicine Casablanca Morocco Service of Nephrology Regional Hospital Sikasso Mali Department of Infectious Disease Regional Hospital Sikasso Mali Service de Mdecine Interne CHU Gabriel Tour Bamako Mali Service dHpato-Gastro-Entrologie CHU Gabriel Tour Bamako Mali Department of Public Health Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali

Introduction: Upper digestive hemorrhage is one of the main digestive emergencies and remains a major cause of morbidity and mortality in Mali. The aim of this study was to describe the therapeutic profile and outcome of patients suffering from upper digestive haemorrhage. Methodology: This was a prospective study carried out in the internal medicine department of the Sikasso Regional Hospital from August 2022 to July 2023. All adult patients presenting with upper digestive haemorrhage and having given their consent, were included. Data were analyzed using SPSS version 21 software. Results: Sixty-three patients were enrolled. The mean age was 49.7 ± 18.99 years, with a male-female sex ratio of 2.2. Ruptured esophageal varices (37.5%) and peptic ulcer (25%) were the main etiologies. Pharmacological treatment was dominated by proton pump inhibitors (85.7%). Hemostasis endoscopy accounted for 3.17%. The evolution was marked by hemorrhagic arrest (69.84%), recurrence of hemorrhage (11.11%) and death (19.04%), the main cause of which was hemorrhagic shock (58.3%). We found no statistically significant relationship between prognosis and etiologies (P = 0.11), and length of hospital stay (P = 0.18). Conclusion: Hemostasis endoscopy remains a challenge for Sikasso Hospital. A holistic strategy of communication and community awareness-raising, combined with adequate technical facilities, will help to improve patient care and outcomes.

关键词： Digestive Hemorrhage Digestive Endoscopy Treatment Outcome

Epidemiological-Clinical Aspects of Uterine Leiomyoma at the Reference Health Center of Commune VI of the Bamako District

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 674-681页

作者： Alou samaké Lasseny Diarra Mamadou Keita Dramane Haidara Mamadou Haidara Coulibaly Soumana Mamadou Diallo Moussa Konaté Mariam maiga MS Ag Med Elméhdi Elansari Kassogue Djibril Dao Seydou Zana samake Hawa Konate Karim Dembele Bertin Coulibaly Moussa Mariko Seydou Colette Dohino Reference Health Center of Commune VI of the Bamako District Bamako Mali Bamako Dermatology Hospital (HDB) Bamako Mali Kalaban Coro Reference Health Center Bamako Mali Hangadoumbo Moulaye Touré Hospital in Gao Gao Mali Timbuktu Hospital Tomboctou Mali Reference Health Center of Commune II of the Bamako District Bamako Mali Reference Health Center in Commune V of the Bamako District Bamako Mali National Institute for Training in Health Sciences Bamako Mali Mali Hospital Bamako Mali

Introduction: Uterine fibroid is a mixed mesenchymal tumor, developing from smooth muscle cells of the myometrium, separated by connective tissue. The majority of fibroids are asymptomatic and do not require any intervention or other exploratory measures. However, in some cases fibroids are symptomatic, their treatment should aim to improve symptoms and quality of life. Objectives: Describe the epidemiological-clinical aspects of uterine fibroids in the gynecology and obstetrics department of the reference health center of commune VI of the Bamako district. Methodology: This was a retrospective descriptive study carried out over a period of one year. It concerns all patients seen in consultation in the gynecology and obstetrics department of the reference health center of commune VI. Results: during the study period, the uterine fibroid frequency was 1.80%. During this same period, fibroids represented 5.59% of gyneco-obstetric pathologies operated on in the department. The 30 - 45 year old age group was the most represented with a frequency of 75.63%. The average age was 36.87 years ± 6.2 years with extremes of 25 and 63 years. Married women were the most represented 97.48%. The vast majority of our patients 95.8% were not postmenopausal. The multigravidas were the most represented, i.e. 37.50% with a large part of the pauciparous 41.29%. In our patients, 96.64% had a clinical symptom on their fibroid with the main reason for consultation being the sensation of a pelvic mass in 97.48%. We recorded three cases of infertility as associated factors. Ultrasound was performed in all patients. The location of the myxomatous nuclei was subserosal in the majority in 42.86% and with multiple nodules in 84.85% of cases. The main indication for myomectomy was the failure of medical treatment in 86.49% of cases. Surgical treatment was mainly a myomectomy 93.30%, a hysterectomy was indicated in 6.70%. No cases of death were recorded. Conclusion: Uterine fibroid is a gynecologic

关键词： Myomas Surgery Myomectomy

Knowledge Practical Attitude of Health Professionals on Breast Cancer at the Hospital of the District of the Commune IV of Bamako

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Surgical Science 2024年第5期15卷 342-356页

作者： Moussa samaké Souleymane B. Dembelé Sirama Diarra Yely Dianessy Abdou Guiré Dorcas Laurel Sodjiné Yede Amaguiré Saye Brahima Dembele Birama Traoré Thierno Nadio Ibrahima maiga Mahamane Dicko Modibo Diarra Siaka Konaté Amadou maiga Bakary Tientigui Dembele Adégné Togo General Surgery Department of Bamako District IV Hospital Bamako Mali Obstetric Gynecology Department of the Bamako District IV Hospital Bamako Mali Department of Ophthalmology of the Hospital of the District of the Commune IV of Bamako Bamako Mali Imaging Service of the Bamako District IV Hospital Bamako Mali Anesthesia and Resuscitation Service of the Hospital of the District of the Commune IV of Bamako Bamako Mali Internal Medicine Department of the District Hospital of Commune IV of Bamako Bamako Mali General Surgery Department Kolondjeba Referral Health Centre Sikasso Mali General Surgery Department of the Gabriel Touré University Hospital Bamako Mali

Introduction: The level of knowledge and attitude of health professionals about breast cancer are important determinants. General objective: To study the knowledge, attitude and practice of health professionals of the hospital of the district of the commune IV on breast cancer. Methodology: This was a cross-sectional, prospective, descriptive, qualitative and quantitative study. The study period was from 01 October 2022 to December 2022. Results: In one week of survey, 110 health workers (intern, obstetrician nurse, general practitioners and specialists) received the survey sheet, 80 health workers informed it, a participation rate of 73%. The male sex was most represented at 63.75% with a sex ratio of 1.76. The average age was 39.59 years with extremes of 22 and 61 years. The clinical signs evoked by the participants were: breast nodule (81.25%), followed by breast discharge (48.75%). In relation to risk factors: interns and obstetrician nurses had no good knowledge, 51.72% of general practitioners had good knowledge, 43.48% of specialist doctors had good knowledge, and 5.88% of the wise had good knowledge. Conclusion: Breast cancer is a common pathology around the world, health professionals are at the forefront of the fight against breast cancer, and this fight cannot be effective without trained personnel.

关键词： Knowledge Attitude Practice Health Personnel Breast Cancer

Hollow Multishelled Structure: Synthesis Chemistry and Application

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Chemical Research in Chinese Universities 2024年第3期40卷 346-393页

作者： MAO Dan WANG Chao LI Wei ZHOU Liang LIU Jian ZHENG Zjian ZHAO Yong CAO An-min WANG Shutao HUANG Jiaxing HUO Fengwei CHEN Hongyu mai Liqiang YU Ranbo WANG Lianzhou LU Yunfeng YU Chengzhong YANG Qihua YANG Zhenzhong ZENG Hua Chun ZHAO Hujun TANG Zhiyong ZHAO Dongyuan WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChineseAcademy of SciencesBeijing 100190P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBejing 100190P.R.China School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong Kong SARP.R.China Department of Chemistry Fudan UniversityShanghai 200433P.R.China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070P.R.China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China School of Chemistry Beihang UniversityBejing 100191P.R.China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190P.R.China School of Engineering Westlake UniversityHangzhou 310024P.R.China School of Flexible Electronics(Future Technologies) Nanjing Tech UniversityNanjing 211816P.R.China School of Science Westlake UniversityHangzhou 310024P.R.China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070P.R.China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083P.R.China School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072Australia College of Life Science and Technology Bejing University of Chemical TechnologyBejing 100029P.R.China School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200241P.R.China College of Life Sciences Zhejiang Normal UniversityJinhua 321004P.R.China Department of Chemical Engineering Tsinghua UniversityBeijing 100

Hollow multishelled structure(HoMS),a promising and complex multifunctional structural system,features at least two shells that are separated by internal *** unique structure endows it with numerous advantages including low density,high loading capacity,large specific surface area,facilitated mass transport,and multiple spatial confinement *** the past twenty years,benefiting from the booming development of synthesis methods,various HoMS materials have been prepared and show promising applications in diverse areas.

关键词： Hollow multishelled structure Synthesis chemistry Energy storage Catalysis Electromagnetic wave absorption Drug delivery Sensor

河下浅埋厚煤层采动覆岩裂隙-涌水量时空演化的FDEM-CFD耦合分析

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煤炭科学技术 2024年第6期52卷 176-184页

作者：杨泽斌李浩马立强麦龙泉太原理工大学原位改性采矿教育部重点实验室山西太原030024 中国矿业大学矿业工程学院江苏徐州211116

河下浅埋厚煤层采动覆岩裂隙分布与涌水量是工作面安全生产的决定性因素之一。数值模拟是二者重要预测方法,其合理性的关键在于建立岩体破坏-裂隙流体耦合理论及相应的模拟方法。以路家村矿15404工作面为研究背景,构建拉/剪应力下非贯... 详细信息

河下浅埋厚煤层采动覆岩裂隙分布与涌水量是工作面安全生产的决定性因素之一。数值模拟是二者重要预测方法,其合理性的关键在于建立岩体破坏-裂隙流体耦合理论及相应的模拟方法。以路家村矿15404工作面为研究背景,构建拉/剪应力下非贯通裂隙开裂、贯通裂隙的法向与切向本构关系,并基于二相流质量守恒、动量守恒与状态方程,结合增强的浸没边界算法识别流-固界面,通过流体体积法实现裂隙内流体自由面的追踪和重构。在此基础上形成FDEM-CFD河下采煤覆岩裂隙与涌水量预测数值模型耦合程序,通过相邻工作面地面钻孔冲洗液消耗量观测法验证导水裂隙带发育高度,以及采用大井法理论对涌水量结果进行对比。结果表明:采动岩体破坏-裂隙流体耦合理论及相应的FDEM-CFD程序,可数值实现河下浅埋厚煤层采动覆岩裂隙形成,以及裂隙内流体运移过程。当工作面推进至80~120 m时覆岩内形成贯通地表的导水裂隙。招山河水的主要下泄路径为工作面后方8~20 m位置处的导水裂隙,其斜向采空区、倾角65°~72°。模拟所得采空区涌水量为18.78 m^(3)/h,与大井法计算结果接近。上述成果在路家村矿区得到初步应用,为进一步开展河下浅埋厚煤层防治水工程提供理论支撑。

关键词：河下浅埋煤层覆岩裂隙涌水量本构模型 FDEM-CFD耦合

基于化学学科的跨学科创新实践——奇迹赛车竞速

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化学教育（中英文） 2024年第1期45卷 67-73页

作者：孙华车麦平广州市第八十九中学广东广州510520

科学知识生产要为解决具有经济和社会目标的科学问题而服务,化学跨学科实践活动应以学科价值引领凸显学科地位。借鉴科技运动会形式,开展自制新能源小车5米竞速比快,小组惊喜研制出刷新原有成绩的“奇迹赛车”。围绕“奇迹赛车”如何制... 详细信息

科学知识生产要为解决具有经济和社会目标的科学问题而服务,化学跨学科实践活动应以学科价值引领凸显学科地位。借鉴科技运动会形式,开展自制新能源小车5米竞速比快,小组惊喜研制出刷新原有成绩的“奇迹赛车”。围绕“奇迹赛车”如何制成、为什么会想到这种制作方法、其背后原理是什么等系列问题的深入探索,实验论证其氢氧燃料电池动力的本质。在物能循环利用的真实问题解决的跨学科实践活动中感受氢能源魅力。

关键词：跨学科科技运动会新能源氢氧燃料电池小车竞速