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Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain

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Biomedical and Environmental Sciences 2017年第3期30卷 185-193页

作者： YU Juan GUO Qian mu Jian Bing ZHANG ting li Ren ke XIE Jun Department of Biochemistry and Molecular Biology Shanxi Key Laboratory of Birth Defect and Cell RegenerationShanxi Medical UniversityTaiyuan 030001ShanxiChina Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMD 20892-8132USA Capital Institute of Pediatrics Beijing 100020China Division of Cardiovascular Surgery and Toronto General Research Institute University Health NetworkToronto M3J 1P3Canada

Objective This study aimed to investigate the expression pattern and function of Nuclear receptor subfamily 2 group E member 1 （Nr2e1） in retinoic acid （RA）-induced brain abnormality. Methods The mouse model of brain abnormality was established by administering 28 mg/kg RA, and neural stem cells （NSCs） were isolated from the mouse embryo and cultured in vitro. Nr2e1 expression was detected by whole mount in situ hybridization, RT-PCR, and Western blotting. Nr2e1 function was determined by transducing Nr2e1 sh RNA into NSCs, and the effect on the sonic hedgehog （Shh） signaling pathway was assessed in the cells. In addition, the regulation of Nr2e1 expression by RA was also determined in vitro. Results Nr2e1 expression was significantly downregulated in the brain and NSCs of RA-treated mouse embryos, and knockdown of Nr2e1 affected the proliferation of NSCs in vitro. In addition, a similar expression pattern of Nr2e1 and RA receptor （RAR） α was observed after treatment of NSCs with different concentrations of RA. Conclusion Our study demonstrated that Nr2e1 could be regulated by RA, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality.

关键词： Retinoic acid Brain abnormality Nr2e1 gene Neural stem cells

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卟啉/酞菁光电材料分子电场调控

中国科学：化学 2022年第8期52卷 1341-1356页

作者：穆希皎买嗣备李丛平曹靖功能有机分子化学国家重点实验室甘肃省有色金属化学与资源利用重点实验室兰州大学化学化工学院兰州730000

卟啉/酞菁是一类高度共轭的杂环化合物,如何实现光电性质的精准调控是推动其光电应用的关键.分子电场是分子偶极或者分子晶体中偶极在分子或晶体内部引发的一种局域电场.对分子电场的调变相当于改变了分子或晶体的固有偶极,进而影响材... 详细信息

卟啉/酞菁是一类高度共轭的杂环化合物,如何实现光电性质的精准调控是推动其光电应用的关键.分子电场是分子偶极或者分子晶体中偶极在分子或晶体内部引发的一种局域电场.对分子电场的调变相当于改变了分子或晶体的固有偶极,进而影响材料的载流子传输及光学性质,因此分子电场优化是调控材料光电性能的一种有效方法.本文阐述了分子偶极与分子电场的关系,综述了卟啉/酞菁分子电场调控其光电性能的研究工作,并介绍了本课题组发展的分子电场有效调控电荷传输行为的研究工作,阐明了分子电场对光电材料电荷分离传输及光学性质调变机制,对新型卟啉/酞菁光电材料理性设计提供了全新的研究思路.

关键词：卟啉酞菁光电材料分子电场光电应用

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压力容器无损检验中的涡流检验技术

装备制造技术 2016年第9期 194-196页

作者：木合塔尔.买买提依明阿里玛斯.阿里木新疆维吾尔自治区特种设备检验研究院新疆乌鲁木齐830011

在实际生产中,对压力容器的检验,是保证产品质量的主要措施,常规手段一般都会对容器有所损坏。由于绝大部分在用压力容器不能进行有损的检验,所以压力容器无损检验技术被广泛运用,其中的涡流检测技术在实际生产中具有相当好的效果,非常... 详细信息

在实际生产中,对压力容器的检验,是保证产品质量的主要措施,常规手段一般都会对容器有所损坏。由于绝大部分在用压力容器不能进行有损的检验,所以压力容器无损检验技术被广泛运用,其中的涡流检测技术在实际生产中具有相当好的效果,非常适用于压力容器的无损检验。

关键词：压力容器无损检验涡流检验

The trend of emerging non-volatile TCAM for parallel search and AI applications

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Chip 2022年第2期1卷 16-26页

作者： ke-Ji Zhou Chen mu Bo Wen Xu-Meng Zhang Guang-Jian Wu Can li Hao Jiang Xiao-Yong Xue Shang Tang Chi-Xiao Chen Qi liu Frontier Institute of Chip and System Fudan UniversityShanghai 200438China Shanghai Qi Zhi Institute Shanghai 200232China Frontier Institute of Chip and System Fudan UniversityShanghai 201203China Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China State key Laboratory of ASIC and System Fudan UniversityShanghai 201203China BirenTech Research Shanghai 201114China

In this paper, we review the recent trends in parallel search and artificial intelligence (AI) applications using emerging non-volatile ternary content addressable memory (TCAM). Firstly, the principle and development of four typical emerging memory used to implement the non-volatile TCAM are discussed. Then, we analyze the principle and challenges of SRAM-based TCAM and non-volatile TCAM for the parallel search. Finally, the research trends and challenges of non-volatile TCAM used for AI application are presented, which include computer-science oriented and neuroscience oriented computing.

关键词： Artificial Intelligence(AI) Non-volatile memory Ternary content addressable memory(TCAM) Computing in memory Neuromor-phic computing

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大型常压容器检验中的内表面腐蚀分析

装备制造技术 2016年第8期 247-248,259页

作者：阿里玛斯.阿里木木合塔尔.买买提依明新疆维吾尔自治区特种设备检验研究院新疆乌鲁木齐830011

大型常压容器的内表面腐蚀会影响其使用的安全性,要保证大型常压容器使用过程的安全性,进行必要的常压容器检验很关键。分析了大型容器内表面腐蚀的成因,并根据成因制定相应的预防措施,为相关从业人员提供一定的借鉴意义。

关键词：常压容器检验内表面腐蚀分析

电刺激治疗脑性瘫痪:对粗大运动被动踝关节活动、足背屈角的作用

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中国组织工程研究 2015年第9期19卷 1470-1476页

作者：苗伟逯霞木塔力甫艾克拜尔买尔阿芭闫宝锋栾新平新疆医科大学第二附属医院神经外科新疆维吾尔自治区乌鲁木齐市830063

背景:目前治疗脑性瘫痪有多种方法,已有研究表明电刺激作为一种新型的治疗方式,现已经应用于脑性瘫痪的治疗,但尚缺乏关于电刺激治疗脑性瘫痪的系统评价发表。目的:评价电刺激治疗脑性瘫痪对粗大运动被动踝关节活动、足背角屈的作用。方... 详细信息

背景:目前治疗脑性瘫痪有多种方法,已有研究表明电刺激作为一种新型的治疗方式,现已经应用于脑性瘫痪的治疗,但尚缺乏关于电刺激治疗脑性瘫痪的系统评价发表。目的:评价电刺激治疗脑性瘫痪对粗大运动被动踝关节活动、足背角屈的作用。方法:根据所纳入文献必须是随机对照试验、基线具有可比性及诊断明确的标准,制定文献检索策略,分别检索万方数据库、维普中文科技期刊数据库、中国知网、中国生物医学文献数据库、PubM ed、Ovid数据库,按照Cochrane Reviewer’s Handbook评价文献质量的评价标准,在严格质量评价的基础上,采用RevM an5.1软件对纳入的文献进行分析评价。结果与结论:最终纳入8篇文献。Meta分析结果显示:电刺激治疗组对患者流涎情况的改善(OR=8.37,95%CI:2.86-24.51,P=0.000 1);对腓肠肌痉挛程度的改善(OR=-0.62,95%CI:-0.84至-0.41),P<0.000 01);对粗大运动功能评分的改善D区(站立)功能评分(OR=9.86,95%CI:1.70-18.02,P=0.02);E区(走跑跳)功能评分(OR=9.54,95%CI:7.47-11.62,P<0.000 01);对步行能力的改善(OR=6.12,95%CI:3.65-8.58,P<0.000 01),均明显优于单纯康复治疗的患者。结果证实,电刺激治疗脑性瘫痪在临床方面有效,电刺激治疗脑性瘫痪对粗大运动被动踝关节活动、足背角屈有改善作用,同时联合康复治疗,效果更加显著。

关键词：植入物关节植入物电刺激器官组织脑性瘫痪治疗 Meta分析疗效康复系统评价流涎粗大运动新疆维吾尔自治区自然科学基金

Landscape dynamitic change in mu Us Desert derived from landsat TM data

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Journal of Environmental Sciences 2003年第2期15卷 222-226页

作者： Guan, Yan-ning Guo, Shan Xue, Yong li, Rui Yang, Qin-ke Inst. of Remote Sensing Application Chinese Academy of Sciences Beijing 100101 China Institute of Soil/Water Conservation Chinese Academy of Sciences Xi'an Yangling 712100 China

Landscape ecology emphasizes large areas and ecological effects of the spatial patterning of ecosystem. Recent developments in landscape ecology have emphasized the important relationship between spatial patterns and many ecological processes. Quantitative methods in landscape ecology link spatial patterns and ecological processes at broad spatial and temporal scales. In turn the increased attention on temporal change of ecosystem has highlighted the need for quantitative methods that can analyze patterns. This research applies quantitative methods——change detection to assess the ecosystem temporal change in the arid and semiarid area. Remote sensing offers the temporal change of ecosystem on landscape characteristics.

关键词： landscape ecology ecosystem change change detection remote sensing

反刍动物冷应激作用机理及其调控技术研究进展

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饲料研究 2024年第6期47卷 148-153页

作者：李林贵陈翔宇阿不夏合满·穆巴拉克秦荣艳刘艳丰王彦王乐乐王文奇新疆农业大学动物科学学院新疆乌鲁木齐830052 新疆畜牧科学院饲料研究所新疆乌鲁木齐830011

我国北方地区畜牧业具有很大的发展潜力,但冬季持续低温易引起反刍动物的冷应激反应,导致反刍动物的生产性能、免疫力、抗氧化功能降低,给动物生产造成巨大损失。因此,研究反刍动物冷应激的作用机理及其调控技术对北方畜牧业的健康发展... 详细信息

我国北方地区畜牧业具有很大的发展潜力,但冬季持续低温易引起反刍动物的冷应激反应,导致反刍动物的生产性能、免疫力、抗氧化功能降低,给动物生产造成巨大损失。因此,研究反刍动物冷应激的作用机理及其调控技术对北方畜牧业的健康发展具有重要作用。文章综述了反刍动物冷应激的作用机理,以及冷应激对反刍动物生产性能、免疫和血液生理生化指标影响的研究进展,并提出抗冷应激相关的调控技术,为反刍动物冷应激相关的研究提供参考。

关键词：反刍动物冷应激生理功能预防和调控

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Influence of chronic HBV infection on superimposed acute hepatitis E

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World Journal of Gastroenterology 2013年第35期19卷 5904-5909页

作者： Si-Hong Cheng li mai Feng-Qin Zhu Xing-Fei Pan Hai-Xia Sun Hong Cao Xin Shu Wei-Min ke Gang li Qi-Huan Xu Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen University

AIM:To investigate the influence of chronic hepatitis B virus(HBV)infection[based on the status of hepatitis B e antigen(HBeAg),HBV DNA,and cirrhosis]on superimposed acute hepatitis ***:A total of 294 patients were recruited from the Department of Infectious Diseases of the Third Affiliated Hospital,Sun Yat-sen University,from January 2003 to January *** patients were classified into two groups:an HBV+hepatitis E virus(HEV)group(a group with chronic HBV infection that was superinfected with acute hepatitis E,n=118)and an HEV group(a group with acute hepatitis E,n=176).We retrospectively analyzed and compared the clinical features of the two *** analyses were performed using theχ2test or Fisher’s exact test for categorical variables and the Student’s t test forcontinuous variables.A P valueered statistically ***:The peak values of prothrombin time,serum total bilirubin,and Model for End-Stage liver Disease scores were significantly higher in the HBV+HEV *** patients in the HBV+HEV group had complications(39.8%vs 16.5%,P=0.000)and developed liver failure(35.6%vs 8.5%,P=0.000).Additionally,the mortality of the HBV+HEV group was significantly higher(20.3%vs 7.4%,P=0.002).Further analysis of the HBV+HEV group showed that there were no significant differences in complication occurrence,liver failure incidence,or mortality between patients with different HBeAg and HBV DNA ***,in patients with underlying cirrhosis,complication occurrence and liver failure incidence significantly *** total,12.7%of the patients in the HBV+HEV group received anti-HBV treatment,but this therapy failed to reduce mortality in patients who developed liver ***:The presence of underlying cirrhosis in chronic HBV infection results in more severe clinical outcomes with superimposed acute hepatitis *** treatment cannot improve the prognosis of liver failure caused by HBV-HEV superinfection.

关键词： Chronic hepatitis B virus infection Acute hepatitis E Superinfection Clinical profile Anti-hepatitis B virus treatment