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Research Progress of Jianpi Qushi Powder Combined with Standard Anti Hp Quadruple Therapy in the Treatment of Hp Infectious Gastritis with Spleen Deficiency and Dampness Stagnation

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Chinese Medicine 2022年第1期13卷 15-21页

作者： Qiangcai mai Shoulan Gong Guosheng su Lihua Qin Guigang Orthopedic Hospital of Integrated Traditional Chinese and Western Medicine Guigang China Guigang Skin Disease Prevention and Treatment Hospital Guigang China People’s Hospital of Guangxi ASEAN Economic and Technological Development Zone/Nanning Tenth People’s Hospital Nanning China

Stomach Helicobacter pylori infection is one of the common gastric diseases. Helicobacter pylori infectious gastritis of spleen deficiency and dampness stagnation is a relatively intractable chronic disease. In recent years, traditional Chinese medicine methods have emerged one after another in the treatment of gastric Helicobacter pylori infection. By collecting references, the author reviewed the clinical characteristics of gastric Helicobacter pylori infection and the new progress of traditional Chinese medicine treatment.

关键词： Traditional Chinese Medicine Jianpi Qushi Powder Quadruple Therapy Spleen Deficiency Dampness Stagnation Type Helicobacter Pylori Infection Gastritis

基于网络药理学和分子对接技术探讨补阳还五汤加减防治脑小血管病的作用机制

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实用中医内科杂志 2024年第10期38卷 4-8,I0001-I0005页

作者：梁怡陈炜廖乃彬廖世锋李倩倩麦芳瑜苏明阳广西中医药大学广西南宁530001 广西中医药大学第一附属医院脑病科广西南宁530023 广西中医基础研究重点实验室广西南宁530001 江西中医药大学研究生院江西南昌330004

目的基于网络药理学和分子对接技术,探讨补阳还五汤加减有效成分治疗脑小血管病(CSVD)的潜在机制。方法从中药分子机制的生物信息学分析工具(BATMAN-TCM)和中药系统药理学数据库与分析平台(TCNSP)筛选出补阳还五汤加减的活性成分和靶... 详细信息

目的基于网络药理学和分子对接技术,探讨补阳还五汤加减有效成分治疗脑小血管病(CSVD)的潜在机制。方法从中药分子机制的生物信息学分析工具(BATMAN-TCM)和中药系统药理学数据库与分析平台(TCNSP)筛选出补阳还五汤加减的活性成分和靶点,通过在线人类孟德尔遗传(OMIM)和GeneCards数据库收集脑小血管病的靶点,将两者靶点去重后利用Venny 2.1.0制作药物和疾病的靶点韦恩图,导出其交集靶点,使用STRING数据库构建蛋白质与蛋白质相互作用的PPI网络作用图,并通过Cytoscape 3.8.2软件中的插件CytoNCA筛选关键靶点,并将交集靶点导入David数据库,利用微生信程序进行基因本体(GO)和京都和基因组百科全书(KEGG)富集分析,并通过Cytoscape3.8.2构建补阳还五汤加减药物-有效成分-靶点和补阳还五汤加减药物-成分-靶点-通路网络,最后用AutoDock vinna软件进行分子对接验证。结果筛选得到补阳还五汤加减活性成分有80个,对应潜在241个靶点,网络图显示槲皮素、β-谷甾醇、山柰酚、豆甾醇、黄芩素为补阳还五汤加减治疗CSVD的关键成分,丝氨酸/苏氨酸蛋白应激酶1(AKT1)、白蛋白(ALB)、肿瘤坏死因子(TNF)、核内磷酸化蛋白(TP53)、血管内皮生长因子A(VEGFA)为治疗CSVD的关键靶点,GO富集分析图可能通过对基因表达的负调控、老茧对缺氧的反应,细胞组主要涉及突触、RNA聚合酶Ⅱ转录因子复合物;分子功能包括递质门控离子通道活性参与突触后膜电位调控、类固醇激素受体活性等。KEGG富集分析显示主要与非小细胞肺癌、癌症中的蛋白多糖、IL-17等信号通路有关。分子对接结果表明补阳还五汤加减中的核心作用靶点和主要活性成分具备稳定性的结合活性。结论研究初步揭示了补阳还五汤加减可通过多靶点、多成分、多通路的机制来治疗CSVD,为临床上运用五阳还五汤加减治疗脑小血管病提供了可靠的使用依据。

关键词：补阳还五汤加减脑小血管病网络药理学分子对接作用机制

Thymic lipofibroadenomas:Three case reports

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World Journal of Clinical Cases 2023年第1期11卷 164-171页

作者： mai-Qing Yang Zhi-Qiang Wang Li-Qian Chen su-Mei Gao Xing-Ning Fu Hai-Ning Zhang Ke-Xin Zhang Hong-Tao Xu Department of Pathology Weifang People's Hospital(First Affiliated Hospital of Weifang Medical University)Weifang 261041Shandong ProvinceChina Department of Orthopedics and Trauma Weifang People's Hospital(First Affiliated Hospital of Weifang Medical University)Weifang 261041Shandong ProvinceChina Department of Pathology The First Hospital and College of Basic Medical Sciences of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Thymic lipofibroadenomas are extremely *** this study,we investigated the clinicopathological characteristics of thymic *** suMMARY This study included three patients with thymic *** retrospectively analyzed the patient data to determine the clinicopathological characteristics of thymic *** study included one man and two women[mean age,43(33–59)years].All patients were non-smokers and presented with well-defined anterior mediastinal *** cut surfaces of the tumors were solid,with a mixture of yellow and white *** evaluation of resected specimens showed scattered cord-like structures of epithelial cells embedded within abundant fibrotic and hyaline stroma admixed with variable quantities of adipose *** patient showed hyperplastic thymic tissue in a part of the *** Thymic lipofibroadenomas are an extremely rare type of benign thymic *** removal of lipofibroadenomas is usually curative.

关键词： Lipofibroadenoma Thymoma Rare thymic tumor Clinicopathological characteristics Thoracic tumor Case report

Pretreatment platelet count improves the prognostic performance of the TNM staging system and aids in planning therapeutic regimens for nasopharyngeal carcinoma:a singleinstitutional study of 2,626 patients

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Chinese Journal of Cancer 2015年第3期34卷 137-146页

作者： Yu-Pei Chen Bing-Cheng Zhao Chen Chen Lu-Jun Shen Jin Gao Zhuo-Yao mai Meng-Kun Chen Gang Chen Fang Yan su Liu Yun-Fei Xia Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine sun Yat-sen University Cancer Center Zhongshan School of Medicine Sun Yat-sen University Department of Radiation Oncology Anhui Provincial Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center

Introduction:Thrombocytosis has been identified as an unfavorable prognostic factor in several types of *** study aimed to evaluate the prognostic value of pretreatment platelet count in association with the TNM staging system and therapeutic regimens in patients with nasopharyngeal carcinoma(NPC).Methods:A total of 2,626 patients with NPC were retrospectively *** count >300 × 10~9/L was defined as ***-pair analysis was performed between patients receiving chemoradiotherapy and ***:Multivariate analysis showed that platelet count was an independent unfavorable prognostic factor for overall survival(OS)[hazard ratio(HR) = 1.810,95%confidence interval(CI) = 1.531-2.140,P survival(DMFS)(HR = 1.873,95%CI = 1.475-2.379,P subgroup analysis revealed that increased platelet count was an independent unfavorable prognostic factor for OS and DMFS in patients with NPC stratified by early and advanced T category,N category,or TNM classification(all P survival in patients with *** may improve the predictive value of the TNM classification and help to identify patients likely to benefit from more aggressive therapeutic regimens.

关键词：血小板计数治疗方案鼻咽癌 TNM 预处理患者预后系统

Effects of the Fhb1 gene on Fusarium head blight resistance and agronomic traits of winter wheat

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The Crop Journal 2019年第6期7卷 799-808页

作者： Teng Li Hongjun Zhang Yiwen Huang Zhenqi su Yun Deng Hongwei Liu Chunyan mai Guangjun Yu Huili Li Liqiang Yu Tongquan Zhu Li Yang Hongjie Li Yang Zhou National Engineering Laboratory for Crop Molecular Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Institute of Cereal and Oil Crops Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050035HebeiChina Nanping Institute of Agricultural Sciences of Fujian Province Jianyang 354200FujianChina Xinxiang Innovation Center for Breeding Technology of Dwarf-Male-Sterile Wheat Xinxiang 453731HenanChina Zhaoxian Experiment Station Shijiazhuang Academy of Agricultural and Forestry SciencesZhaoxian 051530HebeiChina Wheat Research Institute Zhumadian Academy of Agricultural SciencesZhumadian 463000HenanChina

The gene Fhb1 has been used in many countries to improve wheat Fusarium head blight(FHB) resistance. To make better use of this gene in the Yellow-Huai River Valleys Winter Wheat Zone(YHWZ), the most important wheat-producing region of China, it is desirable to elucidate its effects on FHB resistance and agronomic traits in different genetic backgrounds. Based on a diagnostic marker for Fhb1, six BC2 populations were developed by crossing dwarf-male-sterile(DMS)-Zhoumai 16 to three Fhb1 donors(Ningmai 9, Ningmai 13, and Jianyang 84) and backcrossing to Zhoumai 16 and Zhoumai16’s derivative cultivars(Lunxuan 136 and Lunxuan 13) using marker-assisted backcross breeding. The progenies were assessed for FHB resistance and major agronomic *** Fhb1 alleles were identified using the gene-specific molecular marker. The plants with the Fhb1-resistant genotype(Fhb1-R) in these populations showed significantly fewer infected spikelets than those with the Fhb1-susceptible genotype(Fhb1-S). When Lunxuan 136 was used as the recurrent parent, Fhb1-R plants showed significantly fewer infected spikelets per spike than Fhb1-R plants produced using Lunxuan 13 as the recurrent parent, indicating that the genetic backgrounds of Fhb1 influence the expression of FHB resistance. Fhb1-R plants from the DMS-Zhoumai 16/Ningmai 9//Zhoumai 16/3/Lunxuan 136 population showed the highest FHB resistance among the six populations and a significantly higher level of FHB resistance than the moderately susceptible control Huaimai 20. No significant phenotypic differences between Fhb1-R and Fhb1-S plants were observed for the eight agronomic traits investigated. These results suggest that it is feasible to improve FHB resistance of winter wheat withoutreducing yield potential by introgressing Fhb1 resistance allele into FHB-susceptible cultivars in the YHWZ.

关键词： Triticum aestivum L. Fhb1 gene Marker-assisted selection Fusarium head blight resistance Agronomic traits

Interwoven scaffolded porous titanium oxide nanocubes/carbon nanotubes framework for high-performance sodium-ion battery

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Journal of Energy Chemistry 2021年第8期30卷 38-46,I0002页

作者： Wen-Bei Yu Wen-Da Dong Chao-Fan Li Nasiruddin Macadam Jiu-Xiang Yang Guo-Bin Zhang Zhi-Yi Hu Tien-Chun Wu Yu Li Tawfique Hasan Li-Hua Chen Li-Qiang mai Bao-Lian su State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Cambridge Graphene Centre University of Cambridge9 JJ Thomson AvenueCB30FA CambridgeUnited Kingdom Nanostructure Research Centre(NRC) Wuhan University of TechnologyWuhan 430070China Laboratory of Inorganic Materials Chemistry(CMI) University of Namur61 rue de Bruxelles5000 NamurBelgium

supercapacitor-like Na-ion batteries have attracted much attention due to the high energy density of batteries and power density of *** dioxide(TiO_(2)),is a promising anode *** performance is however seriously hindered by its low electrical conductivity and the sluggish diffusion of sodium ions(Na^(+))in the TiO_(2)***,this work combines porous TiO_(2)nanocubes with carbon nanotubes(CNTs)to enhance the electrical conductivity and accelerate Na^(+)diffusivity for Na-ion batteries(NIBs).In this composite,an interwoven scaffolded TiO_(2)/CNTs framework is formed to provide abundant channels and shorter diffusion pathways for electrons and *** in-situ X-ray diffraction and cyclic voltammetry confirm the low strain and superior transport kinetics in Na^(+)intercalation/extraction *** addition,the chemically bonded TiO_(2)/CNTs hybrid provides a more feasible channel for Na^(+)insertion/extraction with a much lower energy ***,the TiO_(2)/CNTs composite exhibits excellent electrochemical performance with a capacity of 223.4 m Ah g^(-1)at 1 C and a capacity of 142.8 m Ah g^(-1)at 10 C(3.35 A g^(-1)).The work here reveals that the combination of active materials with CNTs can largely improve the utilization efficiency and enhance their sodium storage.

关键词： supercapacitor-like Interwoven scaffold Na-ion battery TiO_(2) Carbon nanotubes

Inhibition of H_(2)O_(2)-induced apoptosis of GC2-spg cells by functionalized selenium nanoparticles with lentinan through ROSmediated ERK/p53 signaling pathways

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BIOCELL 2023年第2期47卷 401-408页

作者： MIAOMIAO LI DANYANG CHEN JUNYI KE RUILIN ZHENG JINGYAO su ZILIN ZHENG JIEYI LUO HANRAN mai FAN JIANG YANXIA QU XIAOQIONG GU BING ZHU YINGHUA LI LIANDONG ZUO Department of Andrology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China Center Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China

AH_(2)O_(2)-induced oxidative stress injury cell model was established to investigate the antioxidant effect of nanoselenium on mouse spermatocyte lines and the regulation mechanism of the expression level and activity of seleniumcontaining antioxidant enzymes induced by oxidative stress.A safe and effective nano-drug system of functionalized selenium-containing nanoparticles(SeNPs)was developed with lentinan(LNT)(SeNPs@LNT).Mice spermatocyte line GC2-spg cells were treated with SeNPs@LNT(1,2,4,8,16,32μM)for 24-72 h to evaluate the cytotoxicity of ***2-spg cells were randomly divided into the following groups:control,hydrogen peroxide(H_(2)O_(2)),SeNPs@LNT,and H_(2)O_(2)+SeNPs@LNT groups.H_(2)O_(2)+SeNPs@LNT group was pretreated with SeNPs@LNT 4μM for 12 h,followed by H_(2)O_(2)600μM for 8 *** cell viability decreased in the H_(2)O_(2) group and increased significantly in the SeNPs@LNT *** with the H_(2)O_(2) group,the SeNPs@LNT+H_(2)O_(2) group exhibited obvious red fluorescence,indicating a higher level of mitochondrial membrane *** content of intracellular reactive oxygen species(ROS)in the SeNPs@LNT group reduced significantly,and the intensity of green fluorescence in the SeNPs@LNT+H_(2)O_(2) group decreased significantly compared with the H_(2)O_(2) group,indicating the inhibitory effect of SeNPs@LNT on the generation of ROS-induced oxidative *** activity of GPx and SOD increased significantly in the SeNPs@LNT *** expression of p53 decreased significantly under the intervention of nano-selenium,and GPx1 expression *** the oxidative stress group,the expressions of DNA damage-related proteins and apoptosis-related proteins were higher than those in other ***,SeNPs@LNT can promote GC2-spg cell proliferation,improve GPx and SOD activities,remove intracellular ROS,and reduce mitochondrial damage and functional abnormalities caused by oxidative stress by regulating the ERK and p53 protein ***@LNT

关键词： Selenium nanoparticles Lentinan ROS Antioxidant

Solving Fixed Point Problems in More General Nonconvex Sets Via an Interior Point Homotopy Method

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Chinese Quarterly Journal of Mathematics 2012年第1期27卷 74-78页

作者： su Meng-long LIU mai-xue College of Mathematics Luoyang Normal UniversityLuoyang 471000China

In this paper,we are mainly devoted to solving fixed point problems in more general nonconvex sets via an interior point homotopy *** suitable conditions,a constructive proof is given to prove the existence of fixed p... 详细信息

关键词： nonconvex sets interior point homotopy method

Fabricating ion-conducting channel in su-8 matrix for highperformance patternable polymer electrolytes

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Nano Research 2023年第1期16卷 496-502页

作者： Tianzhao Li Xuelei Pan Zhongzhuo Yang Fang Liu Kesong Yu Lin Xu Liqiang mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Advances in electrochemical energy storage technologies drive the need for battery safety performance and miniaturization,which calls for the easily processable polymer electrolytes suitable for on-chip microbattery ***,the low ionic conductivity of polymer electrolytes and poor-patternable capabilities hinder their application in ***,we modified su-8,as the matrix material,by poly(ethylene oxide)(PEO)with lithium salts to obtain a patternable lithium-ion polymer *** to the highly amorphous state and more Li-ion transport pathways through blending effect and the increase in number of epoxides,the ionic conductivity of achieved sample is increased by an order of magnitude to 2.9×10^(−4) S·cm^(−1) in comparison with the su-8 sample at 50°*** modified su-8 exhibits good thermal stability(>150°C),mechanical properties(elastic modulus of 1.52 GPa),as well as an electrochemical window of 4.3 ***-cell and microdevice were fabricated and tested to verify the possibility of the micro-sized on-chip *** of these results demonstrate a promising strategy for the integration of on-chip batteries with microelectronics.

关键词： polymer electrolytes patternable electrolytes on-chip battery lithium-ion battery