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Outcomes of endoscopic submucosal dissection in cirrhotic patients: First American cohort

World Journal of Hepatology 2024年第5期16卷 784-790页

作者： Robert Luke Pecha Fares Ayoub Ankur Patel Abdullah Muftah Michael W Wright mai a.khalaf Mohamed O Othman Department of Gastroenterology and Hepatology UC DavisSacramentoCA 95817United States Department of Gastroenterology and Hepatology Baylor College of MedicineHoustonTX 77030United States Internal Medicine Baylor College of MedicineHoustonTX 77030United States Department of Gastroenterology and Hepatology University of Texas Medical Branch at GalvestonGalvestonTX 77550United States Medical School Baylor College of MedicineHoustonTX 77030United States Department of Tropical Medicine Tanta UniversityTanta 31527Egypt

BACKGROUND Among patients with cirrhosis and pre-malignant or early malignant mucosal lesions,surgical intervention carries a much higher bleeding *** such lesions are discovered,endoscopic submucosal dissection(ESD)may offer curative therapy with lower risks than surgery and improved outcomes compared to traditional endoscopic *** To evaluate the outcomes of ESD in patients with *** Patients with cirrhosis undergoing ESD between July 2015 and August 2022 were retrospectively matched in 1:2 fashion to controls based on lesion location,size,and anticoagulation *** outcomes were compared between *** A total of 64 Lesions from 59 patients were included(16 cirrhosis,43 control).There were no differences in patient or lesion characteristics between *** bloc and curative resection was achieved in 84.21%,78.94%of the cirrhosis group and 88.89%,68.89%of controls,respectively,with no significant *** patients had significantly higher rates of intra-procedural coagulation grasper use for control of bleeding(47.37%vs 20%;P=0.02).There were otherwise no significant differences in adverse event *** the 29 patients with follow up,we found higher rates of recurrence in the cirrhosis group compared to controls(40%vs 5.26%;P=0.019),however this effect did not persist on multivariable analysis controlling for known *** ESD may be safe and effective in patients with *** procedure related outcomes were not significantly different between ***-procedural bleeding requiring use of the coagulation grasper use was expectedly higher in the cirrhosis group given the known effects of liver disease on hemostasis.

关键词： Endoscopic aubmucosal dissection Cirrhosis Advanced polypectomy Intraprocedural bleeding Colon cancer

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Multicomponent synthesis and designing of tetrasubstituted imidazole compounds catalyzed via ionic-liquid for acid steel corrosion protection:Experimental exploration and theoretical calculations

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Chinese Journal of Chemical Engineering 2023年第3期55卷 304-319页

作者： Hany M.Abd El-Lateef mai M.khalaf K.Shalabi Antar A.Abdelhamid Department of Chemistry College of ScienceKing Faisal UniversityAl-Ahsa 31982Saudi Arabia Department of Chemistry Faculty of ScienceSohag UniversitySohag 82524Egypt Chemistry Department Faculty of ScienceMansoura UniversityMansouraEgypt Chemistry Department Faculty of ScienceAlbaha UniversityAlbaha 1988Saudi Arabia

Five new tetrasubstituted imidazoles were designed with outstanding yields(83%-92%) in the occurrence of ionic liquid-based-pyridinium as a catalyst. The constructions of all synthesized derivatives were established by spectral tools and their purities were verified using thin-layer chromatography(TLC), displaying single-spot. The performance of corrosion protection of the prepared imidazole derivatives was examined theoretically and practically for acid steel corrosion. The experimental study was conducted by electrochemical(electrochemical impedance spectroscopy(EIS) and Tafel polarization(PPS)) *** findings from the used approaches concluded that the synthesized compounds were wellorganized inhibitors with an efficiency of 90.7%-98.5% at 50℃ and 0.7 mmol·L^(-1). The Tafel polarization results indicate the protective action of the additives was under mixed-monitoring. The additive adsorption on the electrode interface performed as a distinguished aspect for protection. The surface exploration on the blank and protected metal was completed by field emission scanning electron microscopy(FESEM). Computational studies by Monte Carlo(MC) simulation and quantum chemical calculation(DFT)were related to practical findings. The corrosion protection adsorption mechanism was reinforced by the preferable fitted Langmuir isotherm model. All findings from the applied-inspected approaches alternately confirm each other.

关键词： Adsorption Ionic-liquid catalyst Tetrasubstituted imidazoles Corrosion Pickling acid Mathematical modeling

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Expanding endoscopic boundaries:Endoscopic resection of large appendiceal orifice polyps with endoscopic mucosal resection and endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 386-396页

作者： Ankur P Patel mai a.khalaf Margarita Riojas-Barrett Tara Keihanian Mohamed O Othman Department of Internal Medicine Baylor College of MedicineHoustonTX 77030United States Department of Tropical Medicine Tanta UniversityTanta 31527Egypt Department of Gastroenterology Baylor College of MedicineHoustonTX 77030United States

BACKGROUND Large appendiceal orifice polyps are traditionally treated ***,endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)have been utilized as alternative resection *** To evaluate the efficacy and safety of endoscopic resection techniques for the management of large appendiceal orifice *** This was a retrospective observational study conducted to assess the feasibility and safety of EMR and ESD for large appendiceal orifice *** project was approved by the Baylor College of Medicine Institutional Review *** who underwent endoscopic resection of appendiceal orifice polyps≥1 cm from 2015 to 2022 at a tertiary referral endoscopy center in the United States were *** main outcomes of this study included en bloc resection,R0 resection,post resection adverse events,and polyp *** A total of 19 patients were *** patients were female(53%)and Caucasian(95%).The mean age was 63.3±10.8 years,and the average body mass index was 28.8±*** mean polyp size was 25.5±14.2 mm.74%of polyps were localized to the appendix(at or inside the appendiceal orifice)and the remaining extended into the cecum.68%of polyps occupied≥50%of the appendiceal orifice *** mean procedure duration was 61.6±37.9 *** were resected via endoscopic mucosal resection,endoscopic submucosal dissection,and hybrid procedures in 5,6,and 8 patients,*** pathology was remarkable for tubular adenoma(n=10)[one with high grade dysplasia],sessile serrated adenoma(n=7),and tubulovillous adenoma(n=2)[two with high grade dysplasia].En bloc resection was achieved in 84%with an 88%R0 resection *** the large polyp sizes and challenging procedures,89%(n=17)of patients were discharged on the same day as their *** patients were admitted for post-procedure observation for conservative pain *** patients underwent repeat colonoscopy without evide

关键词： Appendiceal orifice polyps Endoscopic mucosal resection Endoscopic submucosal dissection Polyp resection Adenomatous polyps En bloc resection

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