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A glycine-rich nuclear effector vdCE51 of verticillium dahliae suppresses plant immune responses by inhibiting the accumulation of GhtRXH2

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the Crop Journal 2024年第4期12卷 1137-1149页

作者： Chi Li Yingqi Huang Wenjing Shang Jieyin Chen Steven J.Klosterman Krishna v.Subbarao Jun Qin Xiaoping Hu State Key Laboratory of Crop Stress Resistance and High-Efficiency Production Key Laboratory of Plant Protection Resources and Pest Management of Ministry of EducationKey Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural AffairsCollege of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Western Agricultural Research Center Chinese Academy of Agricultural SciencesChangji 831100XinjiangChina Agricultural Research Service United States Department of AgricultureSalinasCA 93905USA Department of Plant Pathology University of CaliforniaDavisc/o United States Agricultural Research StationSalinasCA 93905USA

verticillium dahliae is an important soil-borne fungal pathogen that causes great yield losses in many cash *** of this fungus are known to regulate plant immunity but the mechanism much remains unclear.A glycine-rich nuclear effector,vdCE51,was able to suppress immune responses in tobacco against Botrytis cinerea and Sclerotinia *** effector was a required factor for full virulence of ***,and its nuclear localization was a requisite for suppressing plant *** thioredoxin GhtRXH2,identified as a positive regulator of plant immunity,was a host target of *** findings show a virulence regulating mechanism whereby the secreted nuclear effector vdCE51 interferes with the transcription of PR genes,and the SA signaling pathway by inhibiting the accumulation of GhtRXH2,thus suppressing plant immunity.

关键词： verticillium dahliae Plant immunity Effector thioredoxin

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In vivo measurement of NADH fluorescence lifetime in skeletal muscle via -ber-coupled time-correlated single photon counting

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn M.Priest Jacob v.Schluns Nathania Nischal Colton L.Gattis Jeffrey C.Wolchok timothy J.Muldoon Department of Biomedical Engineering University of Arkansas FayettevilleARUSA

Nicotinamide adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetime can be used to infer metabolic dynamics in living ***-coupled time-correlated single photon counting(tCSPC)equipped with an implantable needle probe can be used to measure NADH lifetime in vivo,enabling investigation of changing metabolic demand during muscle contraction or tissue *** study illustrates a proof of concept for point-based,minimally-invasive NADHfluorescence lifetime measurement in *** muscle loss(vML)injuries were created in the left tibialis anterior(tA)muscle of male Sprague Dawley *** lifetime measurements were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured tA muscles,which was subsequently-t to a biexponential decay model to yield a metric of NADH utilization(cytoplasmic vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninjured muscle compared to muscle at rest,suggesting higher levels of free NADH in contracting and recovering muscle,indicating increased rates of *** injured muscle,this ratio was higher than uninjured muscle overall but decreased over time,which is consistent with current knowledge of inflammatory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled tCSPC has the potential to measure changes in NADH binding in vivo in a minimally invasive manner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy metabolism volumetric muscle loss

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Life under tension: the relevance of force on biological polymers

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Biophysics Reports 2024年第1期10卷 48-56页

作者： Matthew t.J.Halma Longfu Xu Department of Physics and Astronomy and Laser Lab Vrije Universiteit Amsterdam LUMICKS B.v.

Optical tweezers have elucidated numerous biological processes, particularly by enabling the precise manipulation and measurement of tension. One question concerns the biological relevance of these experiments and the generalizability of these experiments to wider biological systems. Here, we categorize the applicability of the information garnered from optical tweezers in two distinct categories: the direct relevance of tension in biological systems, and what experiments under tension can tell us about biological systems, while these systems do not reach the same tension as the experiment, still, these artificial experimental systems reveal insights into the operations of biological machines and life processes.

关键词： tension Optical tweezers Molecular force

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Rigidity Symmetry Line for thermodynamic Fluid Equations-of-State

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Journal of Modern Physics 2024年第5期15卷 613-633页

作者： Leslie v. Woodcock Department of Physics University of Algarve Faro Portugal

We report progress towards a modern scientific description of thermodynamic properties of fluids following the discovery (in 2012) of a coexisting critical density hiatus and a supercritical mesophase defined by percolation transitions. the state functions density ρ(p,t), and Gibbs energy G(p,t), of fluids, e.g. CO2, H2O and argon exhibit a symmetry characterised by the rigidity, ω = (dp/dρ)t, between gaseous and liquid states along any isotherm from critical (tc) to Boyle (tB) temperatures, on either side of the supercritical mesophase. Here, using experimental data for fluid argon, we investigate the low-density cluster physics description of an ideal dilute gas that obeys Dalton’s partial pressure law. Cluster expansions in powers of density relate to a supercritical liquid-phase rigidity symmetry (RS) line (ω = ρrs(t) = Rt) to gas phase virial coefficients. We show that it is continuous in all derivatives, linear within stable fluid phase, and relates analytically to the Boyle-work line (BW) (w = (p/ρ)t = Rt), and to percolation lines of gas (PB) and liquid (PA) phases by: ρBW(t) = 2ρPA(t) = 3ρPB(t) = 3ρRS(t)/2 for t tB. these simple relationships arise, because the higher virial coefficients (bn, n ≥ 4) cancel due to clustering equilibria, or become negligible at all temperatures (0 t tB) within the gas phase. the Boyle-work line (p/ρBW)t is related exactly at lower densities as t → tB, and accurately for liquid densities, by ρBW(t) = −(b2/b3)t. the RS line, ω(t) = Rt, defines a new liquid-density ground-state physical constant (ρRS(0) = (2/3)ρBW(0) for argon). Given the gas-liquid rigidity symmetry, the entire thermodynamic state functions below tB are obtainable from b2(t). A BW

关键词： Liquid-State theory Cluster Physics Percolation Lines Fluid thermodynamics Boyle Line Rigidity-Symmetry Line

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Semiotics and political discourse in the post-truth era

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Language and Semiotic Studies 2024年第1期10卷 65-82页

作者： BetülÇanakpınar Murat Kalelioğlu v.Doğan Günay Istinye University IstanbulTürkiye School of Foreign Languages T C Mardin Artuklu UniversityMardinTürkiye Faculty of Literature Department of LinguisticsDokuz Eylül UniversityIzmirTürkiye

the concept of post-truth has been on the world’s agenda since *** this concept,which is frequently encountered in political life,provides the speaker with a freer speaking ***,instead of presenting the reality to their constituents as it is,want to reshape this reality according to their own ideology and present it to the *** have certain objectives in creating such a virtual *** aims can be listed as keeping the voters,increasing the voting potential,and attracting undecided voters to their *** common result of all these aims is to gain political power or to remain in the existing ***-truth reality is constructed relatively more easily in social media *** construction of reality can be through beliefs or *** such ways,the recipient is tried to be persuaded,and thus behavioral change is *** of the most necessary subjects for this artificial reality atmosphere is the *** idea that the anti-subject does not know the truth that we(you and I)know and believe and is trying to destroy it is the main theme of post-truth *** try to persuade the voters to believe in their own truth by expressing this idea to *** are many examples of this around the *** this study,firstly,the concept of post-truth is examined and its various definitions are *** distinctions between the concepts of real and truth are analyzed and then it is explained how and for what purposes the concept of post-truth is used in *** the comparison of post-truth and fake news,the concept is discussed within the framework of sender-receiver interaction in terms of *** concept is tried to be elucidated with the modalities such as/convincing/,/believing/,/being/,/appearing/.Besides,using the semiotic square,the study also tries to reveal the different purposes and forms of use of the concept of *** a result,it has been observed

关键词： semiotics discourse politics post-truth fake news

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Phytoconstituents Profiling of Indigenous Herbal Drugs and Its in vitro Microbial,in Silico Biological Examination against Severe Acute Respiratory Syndrome Coronavirus 2

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World Journal of traditional Chinese Medicine 2024年第1期10卷 121-136页

作者： t.H.Mohamed Ahadu Shareef MMohamed Divan Masood Irfan Navabshan MSaiyad Musthafa Department of Chemistry The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia School of Computer Applications B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Crescent School of Pharmacy B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Department of Zoology The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia

Background:Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no *** herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing South Asian *** traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(COvID-19).Aims and Objectives:this research article aimed at conducting phytochemistry,antimicrobial activity,COvID-19 docking and some spectroscopic(Infrared,Ultraviolet,13C-Nuclear Magnetic Resonance(13C-NMR),1H-NMR,and Mass Spectra)characterizations of the polyherbal drugs were carried ***,In-vitro and In-silico analyses were performed to measure activity against *** Performance-Liquid Chromatography(HPLC),Gas Chromatography-Mass Spectrometry(GC-MS),antimicrobial,and docking studies were carried *** preliminary phytochemical assay and bioactive compounds were screened using HPLC and *** study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(SARS-Co v-2).Materials and Methods:the extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely Streptococcus oralis,Staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal Candida albicans,Aspergillus fumigatus,and Aspergillus *** docking study evaluates the pharmacological activity of bioactive chemical compounds with SARS-Co v-2 NSP5(PDB ID:7nxh)and SARS-Co v-2 Omicron spike protein with human angiotensin-converting enzyme 2(ACE-2)(PDB ID:7wk6).Results:In this study,for the first time,we at

关键词： Antimicrobial herbal drug Omicron and coronavirus disease 2019 phytochemicals spectroscopic

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KIF2C在乳腺癌中的表达及其对肿瘤生长的影响

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肿瘤药学 2024年第4期14卷 448-456页

作者：麦孜悦曾健广西医科大学第一附属医院胃肠腺体外科广西南宁530021

目的探讨驱动蛋白家族成员2C(KIF2C)在乳腺癌中的表达及其对乳腺癌细胞增殖、迁移和侵袭的影响。方法收集tCGA数据库及GEO数据库的GSE1456、GSE9195、GSE4922和GSE96058数据集中乳腺癌患者的数据,采用生物信息学方法进行分析,鉴定关键基... 详细信息

目的探讨驱动蛋白家族成员2C(KIF2C)在乳腺癌中的表达及其对乳腺癌细胞增殖、迁移和侵袭的影响。方法收集tCGA数据库及GEO数据库的GSE1456、GSE9195、GSE4922和GSE96058数据集中乳腺癌患者的数据,采用生物信息学方法进行分析,鉴定关键基因KIF2C,预测KIF2C在乳腺癌中的表达及其预后价值。收集39例乳腺癌患者的癌组织及癌旁组织样本,采用免疫组织化学法检测KIF2C蛋白的表达。采用qPCR和JESS全自动蛋白分析仪检测正常乳腺细胞MCF10A和乳腺癌细胞系MCF7、t47D、SK-BR-3、MDA-MB-231、Bt474中KIF2C的mRNA和蛋白表达。选取mRNA及蛋白均呈高表达的细胞株进行慢病毒感染沉默KIF2C,采用免疫荧光检测Ki-67表达水平,transwell法检测细胞迁移和侵袭能力,流式细胞术检测细胞周期。结果在tCGA-BRCA数据库中收集到661个乳腺癌差异表达基因(DEG),与GSE1456、GSE9195、GSE4922和GSE96058数据集取交集后,得到37个表达有显著差异的乳腺癌复发相关预后基因。运用RAA算法鉴定出5个关键基因,并对其中的KIF2C进行初步生物信息学分析。免疫组织化学检测结果显示,KIF2C在乳腺癌组织中高表达。qRt-PCR和JESS全自动蛋白分析仪检测结果显示,与正常乳腺细胞MCF10A相比,乳腺癌细胞MDA-MB-231中KIF2C表达水平显著升高。沉默KIF2C可抑制MDA-MB-231细胞的增殖、迁移和侵袭能力,使细胞周期S期受到阻滞。结论KIF2C在乳腺癌组织和细胞中高表达,沉默KIF2C可抑制乳腺癌细胞增殖、迁移和侵袭。

关键词：乳腺癌 KIF2C 增殖侵袭迁移

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Indoor Formaldehyde Removal techniques through Paints: Review

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Green and Sustainable Chemistry 2024年第1期14卷 1-15页

作者： Prajyot Dhawale Ravindra v. Gadhave Department of Polymer and Surface Engineering Institute of Chemical Technology Mumbai India

Due to its ability to cause illnesses and discomfort even at low concentrations, formaldehyde pollution of indoor air poses a significant risk to human health. Sources of formaldehyde in indoor environments include textiles, paints, wallpapers, glues, adhesives, varnishes, and lacquers;furniture and wooden products like particleboard, plywood, and medium-density fiberboard that contain formaldehyde-based resins;shoe products;cosmetics;electronic devices;and other consumer goods like paper products and insecticides. According to the World Health Organisation, indoor formaldehyde concentrations shouldn’t exceed 0.1 mg/m3. the methods include membrane separation, plasma, photocatalytic decomposition, physisorption, chemisorption, biological and botanical filtration, and catalytic oxidation. Materials based on metal oxides and supported noble metals work as oxidation catalysts. Consequently, a paint that passively eliminates aldehydes from buildings can be developed by adding absorbents and formaldehyde scavengers to the latex composition. It will be crucial to develop techniques for the careful detection and removal of formaldehyde in the future. Additionally, microbial decomposition is less expensive and produces fewer pollutants. the main goal of future research will be to develop a biological air quality control system that will boost the effectiveness of formaldehyde elimination. the various methods of removing formaldehyde through paints have been reviewed here, including the use of mixed metal oxides, formaldehyde-absorbing emulsions, nano titanium dioxide, catalytic oxidation, and aromatic formaldehyde abating materials that can improve indoor air quality.

关键词： Formaldehyde Absorption Paints Catalytic Oxidation Nanofillers

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Notch信号通路在感染过程中对免疫应答的调控作用

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中国免疫学杂志 2024年第4期40卷 872-879页

作者：麦文豪陈楚溪刘巧媛宁云山李妍南方医科大学检验与生物技术学院广州510515

感染启动的先天性和适应性免疫应答依赖于巨噬细胞、树突状细胞以及t细胞等对病原体的识别与控制。Notch信号是一种高度保守的信号通路,通过相邻细胞间配受体结合被激活,进而协调细胞的重要生命过程。目前已证实Notch信号通路参与多种... 详细信息

感染启动的先天性和适应性免疫应答依赖于巨噬细胞、树突状细胞以及t细胞等对病原体的识别与控制。Notch信号是一种高度保守的信号通路,通过相邻细胞间配受体结合被激活,进而协调细胞的重要生命过程。目前已证实Notch信号通路参与多种免疫细胞发育、分化、成熟和激活,并在感染性疾病中发挥重要作用。本文综述Notch信号通路在不同病原体感染过程中的免疫调控作用及其与其他通路的相互作用,并讨论在感染性疾病中以Notch信号为靶点的治疗方法及面临的挑战。

关键词： Notch信号通路感染免疫应答巨噬细胞树突状细胞 t细胞

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排卵期女性用自然周期、改良自然周期或人工子宫内膜制剂进行一次冷冻胚胎移植后活产率的临床研究

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中国临床药理学杂志 2024年第16期40卷 2456-2456页

作者： HO v N A PHAM t D NGUYEN N t 孟海峰

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促... 详细信息

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促性腺激素(hCG);改良自然周期组使用hCG来触发排卵;人工周期组使用口服戊酸雌二醇(从月经第2~4天开始,每天8mg)和阴道孕酮(从子宫内膜厚度≥7mm开始,每天800mg)。

关键词：人工周期戊酸雌二醇子宫内膜厚度活产率自然周期冷冻胚胎移植排卵期孕酮

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