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局部枸橼酸抗凝在儿童单重血浆置换中的应用研究

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中国血液净化 2024年第10期23卷 763-766,789页

作者：寻劢张良李志辉张翼湖南省儿童医院肾脏风湿免疫科长沙410007

目的探讨应用局部枸橼酸抗凝(regional citrate anticoagulation,RCA)行儿童血浆置换(plasma exchange,PE)的效果及安全性。方法选取湖南省儿童医院肾脏风湿免疫科2021年2月—2023年6月接受PE治疗且因出血风险评估为中危或以上等级而使... 详细信息

目的探讨应用局部枸橼酸抗凝(regional citrate anticoagulation,RCA)行儿童血浆置换(plasma exchange,PE)的效果及安全性。方法选取湖南省儿童医院肾脏风湿免疫科2021年2月—2023年6月接受PE治疗且因出血风险评估为中危或以上等级而使用RCA的患儿18例(共48例次),对照组为同期行肝素抗凝的患儿28例(共84例次)。比较RCA组患儿治疗前、后血钙离子及碳酸氢根离子水平,并比较2组间滤器凝血和患儿出血情况。结果RCA-PE治疗期间,患儿治疗1 h及治疗后外周血钙离子水平均较治疗前下降(t=9.543,Pt=15.948,Pt=9.942,P<0.001),治疗后代谢性碱中毒发生率高于治疗前(χ_(2)=10.723,P<0.001)。所有患儿均未发生需中断治疗的体外循环凝血事件,治疗后评估滤器凝血等级,RCA组患儿滤器凝血率与肝素组无显著差别(χ_(2)=0.475,P=0.488),RCA组滤器后离子钙<0.45 mmol/L的患者抗凝有效率高于滤器后离子钙≥0.45 mmol/L的患者(P=0.005)。所有患儿治疗中均未出现肢体麻木、肌肉痉挛、心律失常等低钙血症症状。结论儿童血浆置换治疗时使用局部枸橼酸抗凝模式较为简便,局部枸橼酸抗凝能安全、有效的用于儿童血浆置换治疗。

关键词：局部枸橼酸抗凝血浆置换儿童

Suzuki Reaction of Aryl Bromides Using a Phosphine-Free Magnetic Nanoparticle-Supported Palladium Catalyst

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催化学报 2011年第11期32卷 1667-1676页

作者： Nghia t. BUI trung B. DANG Ha v. LE Nam t. S. PHAN Department of Chemical Engineering HCMC University of Technology VNU-HCM 268 Ly Thuong Kiet Distriet 10 Ho Chi Minh City Viet Nam

A palladium catalyst immobilized on superparaganetic nanoparticles was prepared with a palladium loading of 0.30 mmol/g. the catalyst was characterized using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric analysis, Fourier transform infrared, atomic absorption spectrophotometry, and nitrogen adsorption. the immobilized palladium catalyst was an efficient catalyst without added phosphine ligands for the Suzuki cross-coupling reaction of several aryl bromides with phenylboronic acid. the recovery of catalyst was simply by magnetic decantation in the presence of a magnet. the immobilized palladium catalyst can be reused many times without significant degradation in catalytic activity. No leaching of active palladium species into the reaction solution was detected.

关键词： superparamagnetic nanoparticle Suzuki reaction palladium aryl bromide

Biochemical Factors Affecting the Quality of Products and the technology of Processing Deep-Sea Fish, the Giant Grenadier Albatrossia pectoralis

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Journal of Ocean University of China 2020年第3期19卷 681-690页

作者： PIvNENKO t.N. KARPENKO Yu.v. KRASHCHENKO v.v. POZDNYAKOvA Yu.M. ESIPENKO R.v. Far Eastern State technical Fisheries University Vladivostok 690087Russia

the composition of muscle tissues of a deep-sea species, the giant grenadier(Albatrossia pectoralis), and a mesopelagic species, the Alaska pollock(theragra chalcogramma), are compared. Grenadier is proved to have a higher moisture content(91.7%) and lower protein(7.4%) and lipid(0.3%) contents. the factors responsible for the softening and moisture separation during processing of grenadier are identified. Contents of some fractions of non-protein nitrogenous components, including trimethylamine oxide(tMAO) and free amino acids, are clarified. the proportion of the main myofibrillar proteins myosin and actin, which is considered as an indicator of efficiency of structure formation in fish muscle tissue during processing, is almost 20% lower in giant grenadier than in pollock. the effects of endogenous protease, Са^2+-AtPase and transglutaminase on the processes of autolysis, denaturation, and possibility of myofibrillar proteins cross-linking were also studied. the proposed technology of getting a nutritionally balanced, gel-like, ready-to-use foodstuff from grenadier fillet includes its enrichment with pollock muscle tissue and supplementing with a binary structure-forming agent containing collagen and chitosan. Nutritional value of the products is assessed by the method of biological assay and by determining the denaturation changes of myofibrillar proteins. the modes of fine mincing and thermal processing, as well as the shelf-life of the finished product are justified. the developed technology of producing a ready-to-eat food from giant grenadier will allow a more efficient use of this underutilized resource.

关键词： giant grenadier Alaska pollock myosin actin proteases AtPase transglutaminase softening structure formation ready-to-eat foodstuffs

Multitarget thiol-Activated tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer therapy

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CCS Chemistry 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang Sebastian türck Maxime ASiegler Uttara Basu Ingo Ott Rongfang Liu Adriaan PIJzerman Sylvestre Bonnet Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Institute of Chemistry Leiden University2333 CC Leiden Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig38106 Braunschweig Department of Chemistry Johns Hopkins UniversityBaltimoreMaryland 21218 Division of Drug Discovery&Safety Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(trxR)inhibition,which disturbs the redox balance of cancer ***,in this model,the role of the ligand(s)coordinated to gold is often *** this work,we present a series of tetrapyridyl Au(Ⅲ)complexes that exhibit thiol-induced release of a Au(Ⅰ)ion and a tetrapyridyl *** formation of a free Au(Ⅰ)center is responsible for the expected trxR ***,the released ligand,which was visible in cells due to its intense blue fluorescence,showed excellent binding properties to the hERG potassium ***,these ligands ended up in the lysosomes,resulting in significant lysosome ***,the Au(Ⅲ)complexes presented in this work showed broad-spectrum anticancer properties,both in hypoxic 2D monolayers and 3D tumor *** suggest that the interaction of the released Au(Ⅰ)center and the tetrapyridyl ligand with two different protein targets may combine into prodrugs that overcome hypoxia-induced drug deactivation.

关键词： anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging prodrug

Microstructure and mechanical properties of friction welded carbon steel(EN24) and nickel-based superalloy(IN718)

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International Journal of Minerals,Metallurgy and Materials 2021年第1期28卷 111-119页

作者： v.t.Gaikwad M.K.Mishra v.D.Hiwarkar R.K.P.Singh Kalyani Centre for technology and Innovation Bharat Forge LimitedPune 411036India Department of Materials Engineering Defense Institute of Advance TechnologyPune 411025India

Continuous-drive rotary friction welding was performed to join cylindrical specimens of carbon steel(EN24) and nickel-based superalloy(IN718), and the microstructures of three distinct weld zones—the weld interface(WI)/thermo-mechanically affected zone(tMAZ),the heat-affected zone(HAZ), and the base metal—were *** joint was observed to be free of defects but featured uneven flash *** backscatter diffraction(EBSD) analysis showed substantial changes in high-angle grain boundaries, low-angle grain boundaries, and twin boundaries in the tMAZ and ***, significant refinement in grain size(2 –5 μm) was observed at the WI/tMAZ with reference to the base *** possible causes of these are *** microhardness profile across the welded joint shows variation in *** changes in hardness are ascribed to grain refinement, phase transformation, and the dissolution of strengthening *** tensile test results reveal that a joint efficiency of 100% can be achieved using this method.

关键词： friction welding dissimilar metals EN24 IN718 microstructure mechanical properties

two-dimensional Nitrogen-doped Mesoporous Carbon/Graphene Nanocomposites from the Self-assembly of Block Copolymer Micelles in Solution

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Chinese Journal of Polymer Science 2018年第3期36卷 266-272页

作者： Nan Wang Hao tian Shu-Yan Zhu De-Yue Yan Yi-Yong mai School of Chemistry and Chemical Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong University Shanghai 200240China

the self-assembly of block copolymer in solution has proven to be an effective strategy for building up a wide range of nanomaterials with diverse structures and *** paper reports a facile self-assembly approach towards two-dimensional(2D)sandwich-like mesoporous nitrogen-doped carbon/reduced graphene oxide nanocomposites(denoted as mNC/rGO)with well-defined large *** strategy involves the synergistic self-assembly ofpolystyrene-block-poly(ethylene oxide)(PS-b-PEO)spherical micelles,m-phenylenediamine(mPD)monomers and GO in solution and the subsequent carbonization at 900~*** resultant mNC/rGO nanosheets have an average pore size of 19 nm,a high specific surface of 812 m^(2)'g^(-1)and a nitrogen content of 2.2 wt%.As an oxygen reduction reaction(ORR)catalyst,the unique structural features render the metal-free nanosheets excellent electrocatalytic *** a 0.1 mol.L-~KOH alkaline medium,mNC/rGO exhibits a four-electron transfer pathway with a high half-wave-potential(El/2)of+0.77 v versus reversible hydrogen electrode(RHE)and a limiting current density(JL)of 5.2 mA'cm^(-2),which are well comparable with those of the commercial Pt/C catalysts.

关键词： Block copolymer Self-assembly 2D materials Mesoporous carbon ORR

Analgesic and anti-inflammatory activities of Passiflora foetida L.

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Asian Pacific Journal of tropical Medicine 2011年第8期4卷 600-603页

作者： Sasikala v Saravanan S Parimelazhagan t Bioprospecting Laboratory Department of BotanyBharathiar UniversityCoimbatoreTamil NaduIndia

Objective:to investigate the analgesic and anti-inflammatory activities of ethanol extract of Passiflora foetida(***) ***:Ethanol extract of *** leaf was evaluated for analgesic action by acetic acid-induced writhing and hot plate method in albino *** anti-inflammatory property of ethanolic leaf extract was tested by carrageenan induced acute paw edema and histamine induced acute paw edema in ***:the dose 200 mg/kg of P. foetida leaf extract exhibited highest significant analgesic activity[(13.50±0.43) min]at a reaction time of 20 min in hot plate method in *** ethanol extract of leaf dose 100 mg/kg produced a highly significant anti inflammatory effect[(1.302±0.079) mL]in ***:It is very clear that *** also has analgesic and anti-inflammatory activities for the pharmaceuticals.

关键词： Passiflora foetida Carrageenan Histamine Analgesic Anti-inflammatory

Self-powered and broadband germanium/PEDOt:PSS heterojunction photodetectors for near-infrared biomedical imaging applications

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Science China(technological Sciences) 2021年第11期64卷 2523-2531页

作者： WU QiuYue LIU YuJin HUANG XinYue ZHENG Xu HE JieZhong JI Zhong mai WenJie Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsDepartment of PhysicsJinan UniversityGuangzhou 510632China

to develop high-performance photodetectors(PDs) as near-infrared(NIR) imaging sensors, researchers have either proposed new photoelectric materials, introduced complicated interface-processing steps, or created complex optical structures. In this study, we introduce a solution-processed organic material, PEDOt:PSS(PEDOt corresponds to a polymer of 3,4-ethylene dioxythiophene(EDOt), and PSS corresponds to a polystyrene sulfonate), to germanium(Ge) wafers using a convenient spincoating method to improve the photoresponse performance of Ge-based PDs. the Ge wafers and PEDOt:PSS form a heterojunction that reduces the dark current when compared with the Ge Schottky PD(Au/Ge/Ag PD). the experimental results show that the Au/PEDOt:PSS/Ge/Ag heterojunction PD with a bias voltage of 0 v at 1550 nm exhibits a responsivity(R) of 0.26 A/W,a detectivity(D*) of 6.5×1011 Jones, a linear dynamic range(LDR) of 124 d B, and a bandwidth(-3 dB) of 10 k Hz. this implies that the performance of the PD is comparable to that of previously reported Ge-based PDs. Subsequently, a biomedical imaging application of the PD is successfully demonstrated through foreign-body detection. therefore, it is expected that the selfpowered Au/PEDOt:PSS/Ge/Ag PD will be highly suitable for NIR imaging.

关键词： gemanium photodetectors PEDOt:PSS heterojunction self-powered photodetectors near-infrared biomedical imaging

Efficient Centralized Cooperative Spectrum Sensing techniques for Cognitive Networks

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Computer Systems Science & Engineering 2023年第1期44卷 55-65页

作者： P.Gnanasivam G.t.Bharathy v.Rajendran t.tamilselvi Department of Electronics and Communication Engineering Jerusalem College of EngineeringPallikaranaiChennai600100Tamil NaduIndia Department of Electronics and Communication Engineering Vels Institute of ScienceTechnology&Advanced StudiesPallavaramChennai600117Tamil NaduIndia

Wireless Communication is a system for communicating information from one point to other,without utilizing any connections like wire,cable,or other physical *** Radio(CR)based systems and networks are a revolutionary new perception in wireless *** sensing is a vital task of CR to avert destructive intrusion with licensed primary or main users and discover the accessible spectrum for the efficient utilization of the *** Cooperative Spectrum Sensing(CSS)is a kind of spectrum *** of the test metrics designed till now for sensing the spectrum is produced by using the Sample Covariance Matrix(SCM)of the received *** of the methods that use the SCM for the process of detection are Pietra-Ricci Index Detector(PRIDe),Hadamard Ratio(HR)detector,Gini Index Detector(GID),*** paper presents the simulation and comparative perfor-mance analysis of PRIDe with various other detectors like GID,HR,Arithmetic to Geometric Mean(AGM),volume-based Detector number 1(vD1),Maximum-to-Minimum Eigenvalue Detection(MMED),and Generalized Likelihood Ratio test(GLRt)using the MAtLAB *** PRIDe provides better performance in the presence of variations in the power of the signal and the noise power with less computational complexity.

关键词： Cohnitive radio network collaborative spectrum sensing sample covariance matrix pietra-ricci index detector cooperative spectrum sensing generalized likelihood ratio test maximum-to-minimum eigenvalue detection volume-based detector number