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Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第8期24卷 723-733页

作者： mai a.abd-elmawla Heba R.GHAIAD Enas S.GAD Kawkab A.AHMED Maha.abdELMONEM Department of Biochemistry Faculty of PharmacyCairo UniversityCairo 11562Egypt Department of Pharmaceutical Sciences Faculty of PharmacyKing Faisal UniversityAl-Ahsa 31982Saudi Arabia Department of Pharmacology and Toxicology Faculty of PharmacySinai UniversityIsmailia 45511Egypt Department of Pathology Faculty of Veterinary MedicineCairo UniversityCairo 12211Egypt

Ivermectin is a US Food and Drug Administration(FDA)-approved antiparasitic agent with antiviral and anti-inflammatory *** recent studies reported the possible anti-inflammatory activity of ivermectin in respiratory injuries,its potential therapeutic effect on pulmonary fibrosis(PF)has not been *** study aimed to explore the ability of ivermectin(0.6 mg/kg)to alleviate bleomycin-induced biochemical derangements and histological changes in an experimental PF rat *** can provide the means to validate the clinical utility of ivermectin as a treatment option for idiopathic *** results showed that ivermectin mitigated the bleomycin-evoked pulmonary injury,as manifested by the reduced infiltration of inflammatory cells,as well as decreased the inflammation and fibrosis ***,ivermectin decreased collagen fiber deposition and suppressed transforming growth factor-β1(TGF-β1)and fibronectin protein expression,highlighting its anti-fibrotic *** study revealed for the first time that ivermectin can suppress the nucleotide-binding oligomerization domain(NOD)-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome,as manifested by the reduced gene expression of NLRP3 and the apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),with a subsequent decline in the interleukin-1β(IL-1β)*** addition,ivermectin inhibited the expression of intracellular nuclear factor-κB(NF-κB)and hypoxia‑inducible factor‑1α(HIF-1α)proteins along with lowering the oxidative stress and apoptotic ***,this study revealed that ivermectin could ameliorate pulmonary inflammation and fibrosis induced by *** beneficial effects were mediated,at least partly,via the downregulation of TGF-β1 and fibronectin,as well as the suppression of NLRP3 inflammasome through modulating the expression of HIF‑1αand NF-κB.

关键词： Intra-tracheal instillation Immunohistochemistry Transforming growth factor-β1(TGF-β1) Nuclear factor-κB(NF-κB) Lung fibrosis

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伊维菌素抑制NLRP3炎症小体可改善博来霉素诱导的肺纤维化（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第8期 723-737页

作者： mai a.abd-elmawla Heba R.GHAIAD Enas S.GAD Kawkab A.AHMED Maha.abdELMONEM 埃及开罗大学药学院生物化学系费萨尔国王大学药学院药学系埃及西奈大学药学院药理毒理学系埃及开罗大学兽医学院病理学系

伊维菌素是美国食品药品监督管理局（FDA）批准的抗寄生虫剂，具有抗病毒和抗炎特性。尽管最近有研究表明伊维菌素在呼吸系统损伤中可能具有抗炎活性，但其对肺纤维化（PF）的潜在影响尚未得到验证。本研究旨在探讨伊维菌素（0.6 mg/kg... 详细信息

伊维菌素是美国食品药品监督管理局（FDA）批准的抗寄生虫剂，具有抗病毒和抗炎特性。尽管最近有研究表明伊维菌素在呼吸系统损伤中可能具有抗炎活性，但其对肺纤维化（PF）的潜在影响尚未得到验证。本研究旨在探讨伊维菌素（0.6 mg/kg）在PF大鼠模型中减轻博来霉素诱导的生化紊乱和组织学变化的效果。这可用于验证伊维菌素作为治疗特发性PF在临床上的效用。在本研究中，伊维菌素减轻了博来霉素诱发的肺损伤，表现为炎症细胞浸润减少以及炎症和纤维化评分降低。值得注意的是，伊维菌素减少了胶原纤维的沉积并抑制了转化生长因子-β1(TGF-β1)和纤连蛋白的表达，突显了其抗纤维化活性。本研究首次揭示伊维菌素可以抑制NOD样受体家族含吡啶结构域蛋白3(NLRP3)炎症小体，表现为NLRP3和含有半胱天冬酶募集结构域的凋亡相关斑点样蛋白（ASC）基因的表达减少，以及白细胞介素-1β(IL-1β)水平的下降。此外，伊维菌素抑制细胞内核因子-κB(NF-κB)和缺氧诱导因子-1α(HIF-1α)蛋白的表达，同时降低氧化应激和凋亡标志物的水平。本研究表明，伊维菌素可以改善博来霉素引起的肺部炎症和纤维化，并且部分功能是通过下调TGF-β1和纤连蛋白以及通过调节HIF-1α和NF-κB的表达抑制NLRP3炎性小体来介导的。

关键词：气管内滴注免疫组化转化生长因子-β1(TGF-β1) 核转录因子-κB(NF-κB) 肺纤维化

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Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： Mohamed Tharwat Elabbasy Mohamed R.Atteya mai A.Samak Mousa.abdelrahman Tahani AlMahmoud M.A.El-Morsy A.A.Menazea M.F.H.abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),Raman,and scanning electron microscopy(SEM),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible Rare earths

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Agmatine ameliorates diabetes type 2-induced nephropathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 8-16页

作者： Fatemah O.Kamel Ohoud Shagroud mai AAlim A.Sattar Ahmad Gamal S abd El-Aziz abdulhadi S.Burzangi Duaa Bakhshwin Maha Jamal Shahid Karim Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic ***:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar ***(40 and 80 mg/kg)was administered to rats for 12 *** body weight and fasting blood glucose were measured *** level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the ***,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney *** study was also performed using hematoxylin and eosin ***:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(P<0.05).Inflammatory markers and antioxidant effect were significantly improved in agmatine-treated ***,the histopathological changes in renal structure were ameliorated by agmatine ***:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative *** molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关键词： Agmatine Type 2 diabetes Nephropathy Oxidative stress Nephroprotection

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Dual-Porosity Apparent Permeability Models of Unconventional Gas Migration Based on Biot’s Porous Media

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Acta Mechanica Solida Sinica 2024年第3期37卷 406-415页

作者： Bin Gu Hongyuan Liu Yiuwing mai Bing Wang School of Manufacturing Science and Engineering Key Laboratory of Testing for Manufacturing ProcessMinistry of EducationSouthwest University of Science and TechnologyMianyang621010China School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneySydneyNSW2006Australia Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Stress-dependent permeability models are developed for the organic pores and inorganic cleats/fractures in unconventional gas reservoirs,which are modeled as Biot’s porous media of *** considering multiple flow mechanisms such as dynamic effects of gas flow and surface diffusion,apparent permeability models are obtained to investigate the characteristics of unconventional gas *** to the gas transfer in single-porosity reservoirs,the gas migration ability of cleats in dual-porosity stratums rarely changes while that of organic pores is greatly improved because cleats sustain major geomechanical shrinkage deformation when the pore pressure ***,the mass flux of reservoirs is dominated by the mass flux of cleats,which has a lower peak value,but a much longer production term than those in single-porosity reservoirs due to the interaction between organic pores and *** analysis is conducted to identify key factors significantly impacting mass flux in unconventional *** for the mass flux variation are also explored in terms of gas migration ability and pore pressure distribution.

关键词： Unconventional gas migration Apparent permeability Dual-porosity Stress dependence Multiple flow mechanisms

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Integrated strategies on cobalt phosphides-based electrocatalysts for efficient hydrogen evolution reaction

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Tungsten 2024年第3期6卷 488-503页

作者： Thanh Dam mai Ha Huu Do Faculty of Mechanical Engineering and Technology Ho Chi Minh City University of Industry and Trade VKTech Research Center NTT Hi-Tech Institute Nguyen Tat Thanh University

The development of cost-effective and durable hydrogen evolution reaction(HER) electrocatalysts plays a vital role in dealing with the issues related to carbon dioxide *** phosphide-based nanomaterials are evaluated as promising advocates for HER due to high catalytic activities,good stability,and rich *** review commences with an exploration of the synthetic pathways of CoP,including solid-phase,solution-phase along with electrochemical ***,the mechanism of hydrogen formation is expressed thoroughly,after which various integrated strategies of morphology engineering with doping,assisted highly conductive materials,and construction of heterostructure were introduced for ***,burdensome tasks and possible guidance for the advancement of CoP-based nanomaterials were discussed for hydrogen production.

关键词： Cobalt phosphides Nanomaterials Electrocatalysts Hydrogen evolution reaction

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Dynamic COVID Zero Strategy triggered a significant increase of chlorine-based disinfectant

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 73-80页

作者： Xuhao Wang mai Su Chunyan Wang Yi Liu School of Environment Tsinghua UniversityBeijing 100084China

Chlorine-based disinfectants(CBDs)have been widely used to prevent and control the spread of the COVID-19,which may lead to the formation of carcinogenic *** China,strict disinfection strategies by local governments/communities or volunteering by residents have been implemented to meet the Dynamic COVID Zero(DCZ)***,the amount of CBDs used has not been *** author proposed an urban-scale disinfectant consumption estimation(ALICE)model to quantify weekly CBD *** results show that the CBD consumption for the urban region of Beijing during the DCZ strategy was 3704.0 t(0.43 kg/(cap-yr)),equivalent to a monthly increase of 15 g/cap(70.5%)in CBD consumption compared with that in *** to the scenario analysis,a stricter strategy with a shorter response time toward new cases will decrease the total CBD consumption by 1.2% compared with the baseline estimation.A more precise prevention strategy with a smaller delineation of risk area and a less stringent strategy with a longer response time will lower the total CBD consumption by 0.42% and 0.35%,***,the more precise prevention strategy will reduce CBD consumption of close off and lockdown area(COLD area)by 16.9%,and the stricter strategy will reduce this consumption by 37.7%.This study highlights the impact of pandemic prevention and control strategies on chlorine-based disinfectant consumption and some implications for future environmental pollution and risk assessments.

关键词： COVID-19 Dynamic COVID Zero Strategy Disinfectants consumption Bottom-up approach Scenario analysis

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Approaching high oxygen evolution reaction performance by synergetic dual-ion leaching

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Nano Research 2024年第9期17卷 7975-7983页

作者： Hancheng Ma Yao Ding Jianqi Li Wei Peng Liqiang mai School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Self-reconstruction of catalysts during oxygen evolution reaction(OER)is crucial for the development of energy conversion ***,the relationship between the specific atomic structure of pre-catalysts and their electrocatalytic behavior after reconstruction via dual-ion leaching has not been extensively *** this work,we design a highly effective non-noble metal OER catalyst with heterointerface through continuous self-reconstruction of Co_(2)(OH)_(3)Cl@NiMoO_(4)as pre-catalyst by a straightforward dual-ion(***_(4)^(2-)and Cl^(-))***-situ Raman and in-situ Fourier transform infrared(FT-IR)spectroscopy have precisely identified the progressive phase transformation of the pre-catalyst during self-reconstruction,which results in a stable heterojunction of CoOOH and NiOOH(CoOOH@NiOOH).Further calculations based on density functional theory(DFT)of CoOOH@NiOOH evident that more electrons will be aggregated in the Fermi level of ***,Gibbs free energy(ΔG)for different OER steps of CoOOH@NiOOH exhibit lower energy costs of all intermediates,implying the well catalytic ***,the catalyst derived from dual-ion leaching displays outstanding OER performance,characterized by an overpotential of 275 mV at a current density of 10 mA·cm^(-2)and exceptional stability over 12 h *** work successfully paves a way of finding high-performance OER catalysts based on non-noble metal through dual-ion leaching during self-reconstruction.

关键词： dual-ion leaching oxygen evolution reaction chemical reconstruction NiMoO_(4) Co_(2)(OH)_(3)Cl

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Chloride ion battery:A new emerged electrochemical system for next-generation energy storage

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Journal of Energy Chemistry 2024年第1期88卷 154-168,I0004页

作者： Shulin Chen Lu Wu Yu Liu Peng Zhou Qinyou An Liqiang mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070HubeiChina State Key Laboratory of Refractories and Metallurgy Institute of Advanced Materials and NanotechnologyWuhan University of Science and TechnologyWuhan 430081HubeiChina

In the scope of developing new electrochemical concepts to build batteries with high energy density,chloride ion batteries(CIBs)have emerged as a candidate for the next generation of novel electrochemical energy storage technologies,which show the potential in matching or even surpassing the current lithium metal batteries in terms of energy density,dendrite-free safety,and elimination of the dependence on the strained lithium and cobalt ***,the development of CIBs is still at the initial stage with unsatisfactory performance and several challenges have hindered them from reaching *** this review,we examine the current advances of CIBs by considering the electrode material design to the electrolyte,thus outlining the new opportunities of aqueous CIBs especially combined with desalination,chloride redox battery,*** respect to the developing road of lithium ion and fluoride ion batteries,the possibility of using solid-state chloride ion conductors to replace liquid electrolytes is tentatively *** beyond,perspectives and clear suggestions are concluded by highlighting the major obstacles and by prescribing specific research topics to inspire more efforts for CIBs in large-scale energy storage applications.

关键词： Chloride ion battery Anion shuttling Conversion reaction Chloride redox

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Hollow Metal-Organic Framework/MXene/Nanocellulose Composite Films for Giga/Terahertz Electromagnetic Shielding and Photothermal Conversion

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Nano-Micro Letters 2024年第9期16卷 161-179页

作者： Tian mai Lei Chen Pei‑Lin Wang Qi Liu Ming‑Guo Ma Research Center of Biomass Clean Utilization MOE Engineering Research Center of Forestry Biomass Materials and BioenergyBeijing Key Laboratory of Lignocellulosic ChemistryCollege of Materials Science and TechnologyBeijing Forestry UniversityBeijing 100083People’s Republic of China State Silica-Based Materials Laboratory of Anhui Province Bengbu 233000People’s Republic of China

With the continuous advancement of communication technology,the escalating demand for electromagnetic shielding interference(EMI)materials with multifunctional and wideband EMI performance has become *** the electrical and magnetic components and designing the EMI material structure have attracted extensive interest,but remain a huge ***,we reported the alternating electromagnetic structure composite films composed of hollow metal-organic frameworks/layered MXene/nanocellulose(HMN)by alternating vacuum-assisted filtration *** HMN composite films exhibit excellent EMI shielding effectiveness performance in the GHz frequency(66.8 dB at Kaband)and THz frequency(114.6 dB at 0.1-4.0 THz).Besides,the HMN composite films also exhibit a high reflection loss of 39.7 dB at 0.7 THz with an effective absorption bandwidth up to 2.1 ***,HMN composite films show remarkable photothermal conversion performance,which can reach 104.6℃under 2.0 Sun and 235.4℃under 0.8 W cm^(−2),*** unique micro-and macrostructural design structures will absorb more incident electromagnetic waves via interfacial polarization/multiple scattering and produce more heat energy via the local surface plasmon resonance *** features make the HMN composite film a promising candidate for advanced EMI devices for future 6G communication and the protection of electronic equipment in cold environments.

关键词： Metal-organic frameworks MXene Nanocellulose Electromagnetic shielding Photothermal conversion

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