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Predictive value of C-reactive protein/albumin ratio in acute pancreatitis

Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 424-430页

作者： Mustafa Kaplan Ihsan Ates Muhammed Yener Akpinar mahmut yuksel Ufuk Baris Kuzu Sabite Kacar Orhan Coskun Ertugrul Kayacetin Department of Gastroenterology Turkey Yuksek Ihtisas Training and Research HospitalAnkara 06100Turkey Department of Internal Medicine Ankara Numune Training and Research HospitalAnkara 06100Turkey

BACKGROUND:Serum C-reactive protein(CRP) increases and albumin decreases in patients with inflammation and ***,their role in patients with acute pancreatitis is not *** present study was to investigate the predictive significance of the CRP/albumin ratio for the prognosis and mortality in acute pancreatitis ***:This study was performed retrospectively with 192 acute pancreatitis patients between January 2002 and June *** scores,Atlanta classification and CRP/albumin ratios of the patients were ***:The CRP/albumin ratio was higher in deceased patients compared to *** CRP/albumin ratio was positively correlated with Ranson score and Atlanta classification in particular and with important prognostic markers such as hospitalization time,CRP and erythrocyte sedimentation *** addition to the CRP/albumin ratio,necrotizing pancreatitis type,moderately severe and severe Atlanta classification,and total Ranson score were independent risk factors of *** was found that an increase of 1 unit in the CRP/albumin ratio resulted in an increase of 1.52 times in mortality risk.A prediction value about CRP/albumin ratio >16.28 was found to be a significant marker in predicting mortality with 92.1% sensitivity and 58.0% *** was seen that Ranson and Atlanta classification were higher in patients with CRP/albumin ratio >16.28 compared with those with CRP/albumin ratio ≤*** with CRP/albumin ratio >16.28 had a 19.3 times higher chance of ***:The CRP/albumin ratio is a novel but promising,easy-to-measure,repeatable,non-invasive inflammationbased prognostic score in acute pancreatitis.

关键词： Atlanta classification C-reactive protein Glasgow prognostic score Ranson score acute pancreatitis

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Thiol/disulphide homeostasis in celiac disease

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 120-126页

作者： Mustafa Kaplan Ihsan Ates mahmut yuksel Yasemin Ozderin Ozin Murat Alisik Ozcan Erel Ertugrul Kayacetin Department of Gastroenterology Turkey Yuksek Ihtisas Training and Research Hospital Department of Internal Medicine Ankara Numune Training and Research Hospital Department of Biochemistry Yildirim Beyazit University Medical Faculty

AIM To determine dynamic thiol/disulphide homeostasis in celiac disease and to examine the associate with celiac autoantibodies and gluten-free *** Seventy three patients with celiac disease and 73 healthy volunteers were enrolled in the study. In both groups, thiol/disulphide homeostasis was examined with a new colorimetric method recently developed by Erel and Neselioglu. RESULTS In patients with celiac disease, native thiol(P = 0.027) and total thiol(P = 0.031) levels were lower, while disulphide(P < 0.001) level, disulphide/native thiol(P < 0.001) and disulphide/total thiol(P < 0.001) ratios were higher compared to the control group. In patients who do not comply with a gluten-free diet, disulphide/native thiol ratio was found higher compared to the patients who comply with the diet(P < 0.001). In patients withany autoantibody-positive, disulphide/native thiol ratio was observed higher compared to the patients with autoantibody-negative(P < 0.05). It is found that there is a negative correlation between celiac autoantibodies, and native thiol, total thiol levels and native thiol/total thiol ratio, while a positive correlation is observed between disulphide, disulphide/native thiol and disulphide/total thiol *** This study is first in the literature which found that the patients with celiac disease the dynamic thiol/disulphide balance shifts through disulphide form compared to the control group.

关键词： Anti-gliadin antibodies Anti-tissue transglutaminase antibody Gluten-free diet Oxidative stress Thiol oxidation

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Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis:Single shot for two targets

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World Journal of Gastroenterology 2015年第13期21卷 4078-4081页

作者： mahmut yuksel Fatih Saygili Orhan Coskun Nuretdin Suna Mustafa Kaplan Ufuk Baris Kuzu Zeki Mesut Yalin Kilic Yasemin Ozderin Ozin Ertugrul Kayacetin Department of Gastroenterology Turkiye Yuksek Ihtisas Training and Education HospitalAnkara 06230Turkey

Coexistence of Crohn's disease(CD) and familial Mediterranean fever(FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.

关键词： Crohn’s disease Familial Mediterranean fever Leuko

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