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Insulin therapy in type 2 diabetes: Insights into clinical efficacy, patient-reported outcomes, and adherence challenges

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World Journal of Diabetes 2024年第5期15卷 828-852页

作者： mahmoud emad-eldi. Gehan F Balata Eman A Elshorbagy Mona S Hamed Mohamed S Attia Department of Pharmacy Practice Faculty of PharmacyZagazig UniversityZagazig HFQM+872Al-Sharqia GovernorateEgypt Department of Pharmacy Practice Faculty of PharmacyHeliopolis UniversityCairo 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt Department of Internal Medicine Faculty of MedicineZagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt Department of Community at Faculty of Medicine Zagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt

Insulin therapy plays a crucial role in the management of type 2 diabetes as the disease *** the past century,insulin formulations have undergone significant modifications and bioengineering,resulting in a diverse range of available insulin *** products show distinct pharmacokinetic and pharmacodynamic ***,various insulin regimens have em-erged for the management of type 2 diabetes,including premixed formulations and combinations of basal and bolus *** utilization of different insulin regimens yields disparate clinical outcomes,adverse events,and,notably,patient-reported outcomes(PROs).PROs provide valuable insights from the patient’s perspective,serving as a valuable mine of information for enhancing healthcare and informing clinical *** to insulin therapy,a critical patient-reported outcome,significantly affects clinical outcomes and is influenced by multiple *** review provides insights into the clinical effectiveness of various insulin preparations,PROs,and factors impacting insulin therapy adherence,with the aim of enhancing healthcare practices and informing clinical decisions for individuals with type 2 diabetes.

关键词： Adherence Diabetes Insulin Patient-reported outcomes Pharmacokinetic Pharmacodynamic

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Evaluating the Efficacy of Latent Variables in Mitigating Data Poisoning Attacks in the Context of Bayesian Networks:An Empirical Study

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1635-1654页

作者： Shahad Alzahrani Hatim Alsuwat emad Alsuwat Independent Researcher Specializing in Data Security and Privacy Taif26571Saudi Arabia Department of Computer Science College of Computer and Information SystemsUmm Al-Qura UniversityMakkah24382Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif26571Saudi Arabia

Bayesian networks are a powerful class of graphical decision models used to represent causal relationships among ***,the reliability and integrity of learned Bayesian network models are highly dependent on the quality of incoming data *** of the primary challenges with Bayesian networks is their vulnerability to adversarial data poisoning attacks,wherein malicious data is injected into the training dataset to negatively influence the Bayesian network models and impair their *** this research paper,we propose an efficient framework for detecting data poisoning attacks against Bayesian network structure learning *** framework utilizes latent variables to quantify the amount of belief between every two nodes in each causal model over *** use our innovative methodology to tackle an important issue with data poisoning assaults in the context of Bayesian *** regard to four different forms of data poisoning attacks,we specifically aim to strengthen the security and dependability of Bayesian network structure learning techniques,such as the PC *** doing this,we explore the complexity of this area and offer workablemethods for identifying and reducing these sneaky ***,our research investigates one particular use case,the“Visit to Asia Network.”The practical consequences of using uncertainty as a way to spot cases of data poisoning are explored in this inquiry,which is of utmost *** results demonstrate the promising efficacy of latent variables in detecting and mitigating the threat of data poisoning ***,our proposed latent-based framework proves to be sensitive in detecting malicious data poisoning attacks in the context of stream data.

关键词： Bayesian networks data poisoning attacks latent variables structure learning algorithms adversarial attacks

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Bearing capacity of circular footings on multi-layered sand-waste tire shreds reinforced with geogrids

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1085-1094页

作者： mahmoud Ghazavi Ehsan Khosroshahi Faculty of Civil Engineering K.N.Toosi University of TechnologyTehranIran

The presence of waste tires poses an environmental challenge as they occupy a significant amount of land and are expensive to dispose in ***,reusing waste tires can address this issue when waste tires are used in geotechnical *** determine the viability of this approach,laboratoryscale tests were conducted to investigate load-bearing capacity of circular footings on sand-tire shred(STS)mixtures with shredded waste tire contents of 5%e15%by weight and three different widths of *** investigation focused on analyzing the thickness of layers composed of STS mixtures,the soil cap,and the impact of geogrids on bearing *** results indicate that a specific mixture of sand and tire shreds provides the highest footing-bearing *** addition,the optimal shred content and size were found to be 10%by weight and 2 cm×10 cm,***,for a given tire shred width,a particular length provides the largest bearing *** results agree well with that of previous research conducted by the first author and his colleagues in direct shear and California bearing ratio(CBR)*** primary finding of this research is that the use of two-layered STS mixtures reinforced by geogrids significantly enhances the bearing capacity.

关键词： Geogrid Sand Waste tire shred Bearing capacity Waste tire shred optimization Tire shred aspect ratio

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Role of endoscopic-ultrasound-guided biliary drainage with electrocautery-enhanced lumen-apposing metal stent for palliation of malignant biliary obstruction

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 1981-1985页

作者： Smit S Deliwala emad Qayed Department of Medicine Division of Digestive DiseasesEmory University School of MedicineAtlantaGA 30303United States

In this editorial,we discuss the article by Peng et al in the recent issue of the World Journal of Gastrointestinal Surgery,focusing on the evolving role of endoscopicultrasound-guided biliary drainage(EUS-BD)with electrocautery lumen apposing metal stent(LAMS)for distal malignant biliary *** endoscopy has rapidly advanced in decompression techniques,with growing evidence of its safety and efficacy surpassing percutaneous and surgical *** endoscopic retrograde cholangiopancreatography(ERCP)has been the gold standard for biliary decompression,its failure rate approaches 10.0%,prompting the exploration of alternatives like *** random-effects meta-analysis demonstrated high technical and clinical success of over 90.0% and an adverse event rate of 17.5%,mainly in the form of stent *** based on stent size were not reported but the majority used 6 mm and 8 mm *** the body of literature continues to demonstrate the effectiveness of this technique,the challenges of stent dysfunction need to be addressed in future *** strategy that has shown promise is placement of double-pigtail stents,only 18% received the prophylactic intervention in this *** expect this to improve with time as the technique continues to be refined and *** results above establish EUS-BD with LAMS as a reliable alternative after failed ERCP and considering EUS to ERCP upfront in the same session is an effective *** the promising results,studies must explore the role of EUS-BD as first-line therapy for biliary decompression.

关键词： Endoscopic-ultrasound Malignant biliary obstruction Lumen apposing metal stent Choledochoduodenostomy Hepaticogastrostomy

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On the analytical soliton approximations to fractional forced Korteweg–de Vries equation arising in fluids and plasmas using two novel techniques

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Communications in Theoretical Physics 2024年第8期76卷 3-12页

作者： Weaam Alhejaili emad A Az-Zo'bi Rasool Shah S A El-Tantawy Department of Mathematical Sciences College of Science Princess Nourah bint Abdulrahman University Department Mathematics and Statistics Mutah University Department of Computer Science and Mathematics Lebanese American University Department of Physics Faculty of Science Port Said University Department of Physics Faculty of Science Al-Baha University

The current investigation examines the fractional forced Korteweg–de Vries(FF-KdV) equation,a critically significant evolution equation in various nonlinear branches of science. The equation in question and other associated equations are widely acknowledged for their broad applicability and potential for simulating a wide range of nonlinear phenomena in fluid physics, plasma physics, and various scientific domains. Consequently, the main goal of this study is to use the Yang homotopy perturbation method and the Yang transform decomposition method, along with the Caputo operator for analyzing the FF-KdV equation. The derived approximations are numerically examined and discussed. Our study will show that the two suggested methods are helpful, easy to use, and essential for looking at different nonlinear models that affect complex processes.

关键词： Caputo operator forced fractional KdV equation solitons Yang homotopy perturbation method Yang transform decomposition method

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Numerical Treatments for Crossover Cancer Model of Hybrid Variable-Order Fractional Derivatives

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1619-1645页

作者： Nasser Sweilam Seham Al-Mekhlafi Aya Ahmed Ahoud Alsheri emad Abo-Eldahab Mathematics Department Faculty of ScienceCairo UniversityGiza12613Egypt Mathematics Department Faculty of EducationSana’a UniversitySana’a1247Yemen Mathematics Department Faculty of ScienceHelwan UniversityCairo11795Egypt Department of Mathematics College of ScienceUniversity of BishaAl Namas67398-5644Saudi Arabia

In this paper,two crossover hybrid variable-order derivatives of the cancer model are ***ünwald-Letnikov approximation is used to approximate the hybrid fractional and variable-order fractional *** existence,uniqueness,and stability of the proposed model are *** Bashfourth’s fifth-step method with a hybrid variable-order fractional operator is developed to study the proposed *** studies with generalized fifth-order Runge-Kutta method are *** examples and comparative studies to verify the applicability of the used methods and to demonstrate the simplicity of these approximations are *** have showcased the efficiency of the proposed method and garnered robust empirical support for our theoretical findings.

关键词： Cancer diseases hybrid variable-order fractional derivatives adams bashfourth fifth step generalized fifth order Runge-Kutta method

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Electro-optic tuning in composite silicon photonics based on ferroionic 2D materials

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Light(Science & Applications) 2024年第5期13卷 852-864页

作者： Ghada Dushaq Solomon Serunjogi Srinivasa R.Tamalampudi mahmoud Rasras Department of Electrical and Computer Engineering New York University Abu DhabiP.O.Box 129188Abu DhabiUnited Arab Emirates NYU Tandon School of Engineering New York UniversityNew YorkNYUSA

Tunable optical materials are indispensable elements in modern optoelectronics,especially in integrated photonics circuits where precise control over the effective refractive index is essential for diverse ***-dimensional materials like transition metal dichalcogenides(TMDs)and graphene exhibit remarkable optical responses to external ***,achieving distinctive modulation across short-wave infrared(SWIR)regions while enabling precise phase control at low signal loss within a compact footprint remains an ongoing *** this work,we unveil the robust electro-refractive response of multilayer ferroionic two-dimensional CuCrP2S6(CCPS)in the near-infrared wavelength *** integrating CCPS into silicon photonics(SiPh)microring resonators(MRR),we enhance lightmatter interaction and measurement sensitivity to minute phase and absorption *** show that electrically driven Cu ions can tune the effective refractive index on the order of 2.8×10−3 RIU(refractive index unit)while preserving extinction ratios and resonance ***,these devices exhibit low optical losses and excellent modulation efficiency of 0.25 *** with a consistent blue shift in the resonance wavelengths among all devices for either polarity of the applied *** results outperform earlier findings on phase shifters based on ***,our study demonstrates distinct variations in electro-optic tuning sensitivity when comparing transverse electric(TE)and transverse magnetic(TM)modes,revealing a polarization-dependent response that paves the way for diverse applications in light *** combined optoelectronic and ionotronic capabilities of two-terminal CCPS devices present extensive opportunities across several *** potential applications range from phased arrays and optical switching to their use in environmental sensing and metrology,optical imaging systems,and neuromorphic systems in light-sensitive artificial synapses.

关键词： tuning polarization refractive

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Microstructure and impact behavior of Mg-4Al-5RE-xGd cast magnesium alloys

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Journal of Magnesium and Alloys 2024年第5期12卷 1799-1814页

作者： Jie Wei Qudong Wang Huisheng Cai mahmoud Ebrahimi Chuan Lei National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This work investigated the microstructure and impact behavior of Mg-4Al-5RE-xGd(RE represents La-Ce mischmetal;x=0,0.2,0.7 wt.%)alloys cast by high-pressure die casting(HPDC),permanent mold casting(PMC),and sand casting(SC)*** results indicated that with increasing Gd content,the grain sizes of the HPDC alloy had a slight change,but the grains of the PMC and SC alloys were significantly ***,the acicular Al_(11)RE_(3)phase was modified into the short-rod shape under the three casting *** impact toughness of the studied alloy was mainly dominated by the absorbed energy during the crack *** increasing Gd content,the impact toughness of the studied alloy monotonically increased due to the lower tendency of the modified second phase toward crack *** impact stress was higher than the tensile stress,exhibiting a strain rate sensitivity for the mechanical response;however,the HPDC alloy had an inconsistent strain rate sensitivity during the impact event due to the transformation of the deformation mechanism from twinning to slip with increasing *** dimples covered the fracture surface of the fine-grained HPDC alloys,indicating a typical ductile ***,due to the deficient{1012}twinning activity and the suppressed grain boundary sliding during the impact event,the HPDC alloys showed insufficient plastic deformation capacity.

关键词： Mg-Al-RE alloy Gadolinium Microstructure Impact behavior

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Numerical Analysis of Bacterial Meningitis Stochastic Delayed Epidemic Model through Computational Methods

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 311-329页

作者： Umar Shafique Mohamed Mahyoub Al-Shamiri Ali Raza emad Fadhal Muhammad Rafiq Nauman Ahmed Department of Mathematics National College of Business Administration and EconomicsLahore54660Pakistan Department of Mathematics Applied CollegeMahayl AssirKing Khalid UniversityAbha62529Saudi Arabia Department of Physical Sciences The University of ChenabGujrat50700Pakistan Department of Mathematics&Statistics College of ScienceKing Faisal UniversityP.O.Box 400Al-Ahsa31982Saudi Arabia Department of Computer Science and Mathematics Lebanese American UniversityBeirut1102-2801Lebanon Department of Mathematics Faculty of Science and TechnologyUniversity of Central PunjabLahore54000Pakistan Department of Mathematics and Statistics University of LahoreLahore54000Pakistan

Based on theWorld Health Organization(WHO),Meningitis is a severe infection of the meninges,the membranes covering the brain and spinal *** is a devastating disease and remains a significant public health *** study investigates a bacterial meningitis model through deterministic and stochastic ***-compartment population dynamics explain the concept,particularly the susceptible population,carrier,infected,and *** model predicts the nonnegative equilibrium points and reproduction number,i.e.,the Meningitis-Free Equilibrium(MFE),and Meningitis-Existing Equilibrium(MEE).For the stochastic version of the existing deterministicmodel,the twomethodologies studied are transition probabilities and non-parametric ***,positivity,boundedness,extinction,and disease persistence are studiedrigorouslywiththe helpofwell-known *** and nonstandard techniques such as EulerMaruyama,stochastic Euler,stochastic Runge Kutta,and stochastic nonstandard finite difference in the sense of delay have been presented for computational analysis of the stochastic ***,standard methods fail to restore the biological properties of the model,so the stochastic nonstandard finite difference approximation is offered as an efficient,low-cost,and independent of time step *** addition,the convergence,local,and global stability around the equilibria of the nonstandard computational method is studied by assuming the perturbation effect is *** simulations and comparison of the methods are presented to support the theoretical results and for the best visualization of results.

关键词： BacterialMeningitis disease stochastic delayed model stability analysis extinction and persistence computational methods

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Planning Target Volume Margin in Linac-Based Stereotactic Radiosurgery for Brain Metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany S. Attallah Radwa M. Hamed Khaled M. EL-Shahat Aliaa mahmoud mahmoud Abdallah Ibraheem Haggag emad Moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of Medical Physics Al Azhar University Cairo Egypt Department of Medical Physics International Medical Center (IMC) Cairo Egypt Department of Medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. Material and Methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： SRS Brain Metastases PTV

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