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Efficacy of Nilotinib versus Imatinib in Philadelphia Positive Patients with Chronic Myeloid Leukemia in Early Chronic Phase Who Have a Warning Molecular Response to Imatinib

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Journal of Cancer Therapy 2018年第11期9卷 883-897页

作者： Amen Hamdy zaky Aly Ahmed EL Sayed Mohammed Khalifa Esraa Abdallah Abdelkariem Gadallah Department of Medical Oncology South Egypt Cancer Institute Assuit University Assiut Egypt Department of Clinical Oncology Faculty of Medicine Sohag University Sohag Egypt Department of Medical Oncology Sohag Cancer Center Sohag Egypt

Background and Objectives: Chronic myeloid leukemia (CML) accounts for approximately 15% of newly diagnosed cases of leukemia in adults. In this study, the efficacy of nilotinib at 400 mg BID is compared with imatinib at 400 mg BID in CML patients with suboptimal molecular response after at least 12 months of daily dose 400 mg of imatinib therapy. Patients and Methods: This study included a total number of 50 patients, divided into two groups (25 patients each). The first group (Group I): Patients received imatinib at 400 mg BID, second group (Group II): Patients had a suboptimal molecular response to imatinib and received nilotinib at 400 mg BID in early chronic phase. During the two years period of data collection, the primary end included median survival. The secondary end included response rate, type of response, duration of response and progression free survival. Also side effects were recorded. Patients were followed up every month by complete and differential blood counts, liver function test, renal function test and (PCR) every three months for two year. Results: Nilotinib group had significantly higher frequency of major molecular response (MMR) where 23 (92%) patients achieved it while only 16 (64%) patients in Imatinib group achieved MMR (P = 0.01). Nilotinib had better toxicities profile than Imatinib. Conclusion: Both Nilotinib and high dose Imatinib achieved response in CML patients with suboptimal response with rapid and deeper molecular response, better survival outcomes and less side effects in nilotinib.

关键词： Nilotinib Imatinib Philadelphia Positive Chronic Myeloid Leukemia Patients Warning Molecular Response

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Determinants of Antenatal Health Care Utilization in Egypt (2000-2014) Using Binary and Count Outcomes

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Health 2019年第1期11卷 25-39页

作者： Hassan H. M. zaky Dina M. Armanious Mohamed Ali Hussein Department of Psychology School of Humanities and Social Sciences and Social Research Center of the American University in Cairo Cairo Egypt Department of Statistics Faculty of Economics and Political Science Cairo University Cairo Egypt Faculty of Commerce South Valley University Qena Egypt

Aim: This study seeks to investigate the factors determining the utilization of antenatal care services, the frequency of that use, and the timing of receiving antenatal care among Egyptian women utilizing a national representative data from Egypt Demographic and Health Surveys (EDHS) in 2000 and 2014. Methods: The paper estimates the logistic regression model, zero-inflated negative binomial model (ZINB), and negative binomial regression model (NB) to identify the most important determinants of antenatal health care utilization. Results: The findings indicate that the period 2000-2014 has experienced a significant increase in the use of antenatal health care services. The use of the public sector antenatal care services relative to that of the private sector has been decreasing over time. Moreover, wealth index, women’s education and quality of health services play significant roles in increasing accessibility of antenatal health care services. On the other hand, women’s empowerment has shown a positive effect in 2000 only. Conclusion: The study highlights the most vulnerable groups that are less likely to have access to antenatal health care services, mainly women who are less educated, poor and living in rural areas especially Upper Egypt. This certainly requires a more targeted health strategy with an equity lens.

关键词： Antenatal Health Care Services Binary and Count Data Negative Binomial Regression Determinants Egypt

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Impact of the Changes in Women’s Characteristics over Time on Antenatal Health Care Utilization in Egypt (2000-2008)

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Open Journal of Obstetrics and Gynecology 2015年第10期5卷 542-552页

作者： Hassan H. M. zaky Dina M. Armanious Mohamed Ali Hussein School of Humanities and Social Sciences the American University in Cairo Cairo Egypt Department of Statistics Faculty of Economics and Political Science Cairo University Giza Egypt Social Research Center of the American University in Cairo Cairo Egypt Faculty of Arts and Social Sciences Kingston University London UK Faculty of Commerce South Valley University Qena Egypt

Objectives: This study empirically assesses the impact of the changes in women’s characteristics, empowerment, availability and quality of health services on woman’s decision to use antenatal care (ANC) and the frequency of that use during the period 2000-2008. Study Design: The study is a cross-sectional analytical study using 2000 and 2008 Egypt Demographic and Health Surveys. Methods: The assessment of the studied impact is conducted using the Zero-inflated Negative Binomial Regression. In addition, Factor Analysis technique is used to construct some of the explanatory variables such as women’s empowerment, the availability and quality of health services indicators. Results: Utilization of antenatal health care services is greatly improved from 2000 to 2008. Availability of health services is one of the main determinants that affect the number of antenatal care visits in 2008. Wealth index and quality of health services play an important role in raising the level of antenatal care utilization in 2000 and 2008. However, the impact of the terminated pregnancy on receiving ANC increased over time. Conclusions: Further research of the determinants of antenatal health care utilization is needed, using more updated measures of women’s empowerment, availability and quality of health services. In order to improve the provision of antenatal health care services, it is important to understand barriers to antenatal health care utilization. Therefore, it is advisable to collect information from women about the reasons for not receiving antenatal care.

关键词： Women’s Characteristics Antenatal Health Care Women’s Empowerment Zero-Inflated Negative Binomial Regression Egypt

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The Prognostic Significance of Pre and Post Treatment Neutrophil to Lymphocyte Ratio in Breast Cancer Patients

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Journal of Cancer Therapy 2019年第7期10卷 525-536页

作者： Nehal A. Rayan Amen H. zaky Hanan A. Eltyb Ashraf Zeidan Asmaa M. Zahran Medical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Clinical Pathology Department South Egypt Cancer Institute Assiut University Assiut Egypt

Background: The neutrophil/lymphocyte ratio (NLR) has been reported to reflect systemic inflammation and independent prognostic significance in different types of cancer. In present study, we analyzed the association between NLR and clinicopathologic features and verified the significance of NLR as a prognostic factor for patients with breast cancer. Patients and Methods: A total of 388 patients with stage I - III breast cancer were retrospectively recruited into this study. Associations with clinicopathologic factors and NLR were assessed;disease-free survival and overall survival were estimated. Results: There was no significant association between NLR and clinicopathologic factors. Patients with low pre/post-treatment NLR had longer OS. Conclusion: A high pre/postoperative NLR may be considered an important factor for predicting poor prognosis in non-metastatic breast cancer patients.

关键词： Breast Cancer NLR DFS OS

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Characteristics of Antioxidant Isolated from Some Plant Sources

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Food and Nutrition Sciences 2010年第1期1卷 5-12页

作者： A. A. El Bedawey E. H. Mansour M. S. zaky Amal A. Hassan Department of Food Science and Technology Faculty of Agriculture Menufiya University

Antioxidant characteristics of ginger roots, guava leaves, guava seeds, orange peel, sesame coat, rice bran and wheat germ as affected by ethanol, ethyl acetate, chloroform, hexane and petroleum ether were evaluated. Petroleum ether extract of ginger roots, ethanol extracts of guava leaves, guava seeds, orange peel and sesame coat and ethyl acetate extracts of rice bran and wheat germ appeared to possess higher antioxidant activity than those from other solvents. Ginger roots, orange peel and guava leaves exhibited higher antioxidant activity than that of α-tocopherol, while guava seeds, sesame coat, rice bran and wheat germ had lower antioxidant activity than that of α-tocopherol. Guava leaves extract had the highest total phenolics content among the other plant material extracts followed by ginger roots, sesame coat and orange peel extracts. However, total flavonoids content was the highest in ginger roots extract followed by guava leaves extract. Ferulic was the highest phenolic compounds in guava leaves and sesame coat extracts. However, chlorogenic acid was the highest phenolic compounds in ginger roots extract. Antioxidants in ginger roots, guava leaves and sesame coat extracts as well as α-tocopherol were heat stable with 73.1, 73.8, 66.7 and 71.6% activity, respectively, after heating at 100°C for 180 min. Induction periods of sunflower oil containing 2% guava leaves and 2% ginger roots extracts were increased by 230.6% and 226.7%, respectively. However, induction period of sunflower oil containing sesame coat was increased by 174.1%, at 0.5% concentration. Similar increment was found for the protection factor. Ginger roots, guava leaves and sesame coat might be promising sources of natural antioxidant to be used in food products.

关键词： Antioxidative Activity Ginger Roots Guava Leaves Sesame Coat Rancimat

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计算机环形局部网络的性能评价方法

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自动化学报 1988年第1期 8-16页

作者：汤毅坚 S.G.zaky 哈尔滨科技大学多伦多大学

本文应用排队论原理建立了计算机环形局部网络的统一数学模型,提出了系统评价各类环形网络通讯协议性能的方法.计算机模拟的结果表明,本文建立的数学模型与真实系统的误差是很小的.

关键词：通讯协议计算机环网环形电网电网信息包平均等候时间寄存器报文性能评价

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Extraction and Characterization of Chitosan from Shrimp Shells

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Open Journal of Organic Polymer Materials 2018年第3期8卷 33-42页

作者： Nadia G. Kandile Howida T. zaky Mansoura I. Mohamed Abir S. Nasr Yassmin G. Ali Chemistry Department Faculty of Women Ain Shams University Cairo Egypt

Chitosan is one of the most studied polysaccharides nowadays. Because it is non-toxic, widely used in food, pharmaceutical processes, agricultural, and presents excellent biological properties such as biodegradation in the human body, and antibacterial. In the present study we reported the extraction of low cost chitosans (Cs1, Cs2, Cs3 and Cs4) from shrimp shells by extraction of chitin (Egypt: case study), then alkaline deacetylation of chitin with strong alkaline solution at different period of time. The different prepared chitosans (Cs1, Cs2, Cs3 and Cs4) were characterized by FTIR spectroscopy, thermal stability, morphology, crystallography, elemental analysis and degree of deacetylation. The data showed that the prepared chitosan Cs2 has the most thermal stability and the highest degree of deacetylation.

关键词： Chitosan Hydrogel Shrimp Shells Chitin Morphology

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用过二硫酸盐氧化电位法测定人工混合物中的铀

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国外铀金地质 1992年第3期8卷 79-81页

作者： M.zaky 李迹

本文讨论的对U(Ⅵ)的测定研究是基于:在酸性介质中,用金属锌将U(Ⅵ)还原成U(Ⅳ)后,再用已知浓度的过量S_2O_5^(2-)加以氧化.加入已知量的过量KBr还原未反应的S_2O_5^(2-),剩下的Br^-用Ag(I)电位滴定。计算Ag≡Br≡S_2O_8^(2-)≡U的等效... 详细信息

本文讨论的对U(Ⅵ)的测定研究是基于:在酸性介质中,用金属锌将U(Ⅵ)还原成U(Ⅳ)后,再用已知浓度的过量S_2O_5^(2-)加以氧化.加入已知量的过量KBr还原未反应的S_2O_5^(2-),剩下的Br^-用Ag(I)电位滴定。计算Ag≡Br≡S_2O_8^(2-)≡U的等效量.分析了人工混合物.

关键词：铀二硫酸盐氧化电位法测定

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Feasibility of Upfront Debulking Surgery versus Neoadjuvant Chemotherapy Followed by Interval Debulking Surgery for Advanced Ovarian Cancer

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Journal of Cancer Therapy 2018年第2期9卷 145-155页

作者： Amen Hamdy zaky Adel Gabr Doaa Wadie Maximous Ahmed A. S. Salem Amr Farouk Mourad Haisam Atta Marwa Ismail Medical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Surgical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Radiadiagnosis Department South Egypt Cancer Institute Assiut University Assiut Egypt Clinical Oncology Department Faculty of Medicine Assiut University Assiut Egypt

Background: Inappropriately ovarian cancer cannot be detected until an advanced stage. Radical debulking surgery is considered the cornerstone in the management of advanced ovarian cancer pointing to complete tumor resolution. Unless optimal debulking cannot be achieved, these patients gain little benefit from surgery. Neoadjuvant chemotherapy (NACT) has been recommended as a novel therapeutic modality to a diversity of malignant tumors when the disease is not willing to optimal surgical resection at the time of diagnosis or the patient who unfit for aggressive debulking surgery. The purpose of this study is to compare survival in the patient with advanced ovarian cancer (stage III/IV) underwent primary debulking surgery followed by adjuvant chemotherapy (PDS-ACTR) to those who received neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS). Results: Neoadjuvant chemotherapy (NACT-IDS) showed significant complete cytoreduction and decreased in surgical morbidity in comparison to primary debulking surgery (PDS-ACTR). NACT-IDS showed significant improvement in progression-free survival (P-value 0.002) and overall survival (P-value 0.03) in comparison to PDS-ACTR. Response to NACT and residual volume were the two independent prognostic factors for overall survival. Conclusion: NACT-IDS for advanced ovarian cancer (III/IV) resulted in higher frequency of complete resection with no residual tumor, less post-operative surgical morbidity and significant increase progression-free survival and overall survival. Both responses to NACT and residual tumor volume were the two independent prognostic factors for survival in ovarian cancer.

关键词： Advanced Ovarian Cancer Debulking Surgery Neoadjuvant Chemotherapy

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Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients

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World Journal of Gastroenterology 2013年第9期19卷 1387-1395页

作者： Walaa H Ahmed Norihiro Furusyo Saad zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi Department of Environmental Medicine and Infectious Diseases Kyushu University Hospital Fukuoka 812-8582 Japan Department of General Internal Medicine Kyushu University Hospital Fukuoka 812-8582 Japan Department of Tropical Medicine and Gastroenterology Assiut University Hospital Assuit 71515 Egypt National Center for Treatment of Chronic Hepatitis C Ministry of Health Assiut 71329 Egypt

AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) ***:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate anal

关键词： Anemia Dose reduction Hepatitis C Inosine triphosphate Ribavirin Rs1127354

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