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Electro-osmotic flow of a second-grade fluid in a porous microchannel subject to an AC electric field

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Journal of Hydrodynamics 2013年第2期25卷 309-316页

作者： misra J. C. chandra S. Department of Mathematics Institute of Technical Education and Research Siksha O Anusandhan University Department of Physics Sabang S. K. Mahavidyalaya Vidyasagar University

Studies on electro-osmotic flows of various types of fluids in microchannel are of great importance owing to their multifold applications in the transport of liquids, particularly when the ionized liquid flows with respect to a charged surface in the presence of an external electric field. In the case of viscoelastic fluids, the volumetric flow rate differs significantly from that of Newtonian fluids, even when the flow takes place under the same pressure gradient and the same electric field. With this end in view, this paper is devoted to a study concerning the flow pattern of an electro-osmotic flow in a porous microchannel, which is under the action of an alternating electric field. The influence of various rheological and electro-osmotic parameters, e.g., the Reynolds number, Debye-Huckel parameter, shape factor and fluid viscoelasticity on the kinematics of the fluid, has been investigated for a secondgrade viscoelastic fluid. The problem is first treated by using analytical methods, but the quantitative estimates are obtained numerically with the help of the software MATHEMATICA. The results presented here are applicable to the cases where the channel height is much greater than the thickness of the electrical double layer comprising the Stern and diffuse layers. The study reveals that a larger value of the Debye-Huckel parameter creates sharper profile near the wall and also that the velocity of electro-osmotic flow increases as the permeability of the porous microchannel is enhanced. The study further shows that the electro-osmotic flow dominates at lower values of Reynolds number. The results presented here will be quite useful to validate the observations of experimental investigations on the characteristics of electro-osmotic flows and also the results of complex numerical models that are necessary to deal with more realistic situations, where electro-osmotic flows come into the picture, as in blood flow in the micro-circulatory system subject to an elect

关键词： electrical double layer Debye length second-grade fluid Ionic energy

Parenteral nanosuspensions:a brief review from solubility enhancement to more novel and specific applications

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Acta Pharmaceutica Sinica B 2018年第5期8卷 733-755页

作者： Eknath Ahire Shreya Thakkar mahesh Darshanwad Manju misra Department of Pharmaceutics National Institute of Pharmaceutical Education and Research (NIPER)

Advancements in in silico techniques of lead molecule selection have resulted in the failure of around 70% of new chemical entities(NCEs). Some of these molecules are getting rejected at final developmental stage resulting in wastage of money and resources. Unfavourable physicochemical properties affect ADME profile of any efficacious and potent molecule, which may ultimately lead to killing of NCE at final stage. Numerous techniques are being explored including nanocrystals for solubility enhancement purposes. Nanocrystals are the most successful and the ones which had a shorter gap between invention and subsequent commercialization of the first marketed product. Several nanocrystal-based products are commercially available and there is a paradigm shift in using approach from simply being solubility enhancement technique to more novel and specific applications. Some other aspects in relation to parenteral nanosuspensions are concentrations of surfactant to be used, scalability and in vivo fate. At present, there exists a wide gap due to poor understanding of these critical factors,which we have tried to address in this review. This review will focus on parenteral nanosuspensions,covering varied aspects especially stabilizers used, GRAS(Generally Recognized as Safe) status of stabilizers, scalability challenges, issues of physical and chemical stability, solidification techniques to combat stability problems and in vivo fate.

关键词： Parenteral Nanosuspension Stabilizer In vivo fate Solidification Scalability

THE EFFECT OF MAGNETIC FIELDS ON LOW FREQUENCY OSCILLATING NATURAL CONVECTION WITH PRESSURE GRADIENT

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Applied Mathematics and Mechanics(English Edition) 2003年第3期24卷 274-283页

作者： G.C.Sharma Madhu Jain mahesh chandra School of Mathematical Sciences Institute of Basic ScienceSchool of Mathematical SciencesInstitute of Basic ScienceSchool of Mathematical SciencesInstitute of Basic Science KhandariAgra-282002IndiaKhandariAgra-282002IndiaKhandariAgra-282002India

The oscillating natural convection in the presence of transverse magnetic field with time depending pressure gradient is studied. The analysis of the problem is carried out by assuming that the fluid is flowing in a parallel plate configuration. The emphasis is on low frequency oscillating convective flows induced by g-jitter associated with micro gravity because of their importance to the space processing materials. A general solution for an oscillating flow in the presence of transverse magnetic field is carried out. Some special cases of the oscillating flow and its response to an applied magnetic field are performed. It was observed that the behavior of oscillating free convective flows depends on frequency, amplitude of the driving buoyancy forces, temperature gradient,magnetic field and the electric conditions of the channel walls. In the absence of magnetic field, buoyancy force plays a predominant role in driving the oscillatory flow pattern, and velocity magnitude is also affected by temperature gradients. To suppress the oscillating flow external magnetic field can be used. It is also found that the reduction of the velocity is inversely proportional to the square of the applied magnetic field with conducting wall but directly proportional to the inverse of the magnetic field with insulating wall. Detailed calculations and computational results are also carried out to depict the real situation.

关键词： convection g- jitter acceleration buoyancy force magnetic field pressure gradient

Flow of a micropolar fluid in a micro-channel under the action of an alternating electric field: Estimates of flow in bio-fluidic devices

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Journal of Hydrodynamics 2015年第3期27卷 350-358页

作者： misra J.C. chandra S. HERWIG H. Centre for Healthcare Science and Technology Indian Institute of Engineering Science and Technology Department of Physics Sabang S. K. Mahavidyalaya Vidyasagar University Institute of Thermo-Fluid Dynamics Technische Universitat Hamburg-Harburg

The paper is devoted to a study of the electro-osmotic flow of a micropolar bio-fluid, when the flow takes place between two plates that are in a state of periodic vibrations. Considering blood as a micropolar fluid, it is found that the amplitude of oscillation of the microparticles of blood increases when the micropolar effect is pronounced more and more and that a rise in DebyeHtickel parameter enhances both the velocity and microrotation gradient. The results provide guidelines for the improvement of design of bio-sensing and micro-fluidic devices. The study leads to the conclusion that electrical double layers formed in the vicinity of the wall can significantly alter the flow dynamics of physiological fluids in micro-bio-fluidic devices.

关键词： microrotation Electro-osmotic flow Debye-Hiickel parameter micropolar fluid

Electroosmotic oscillatory flow of micropolar fluid in microchannels:application to dynamics of blood flow in microfluidic devices

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Applied Mathematics and Mechanics(English Edition) 2014年第6期35卷 749-766页

作者： J.C.misra S.chandra G.C.SHIT P.K.KUNDU Department of Mathematics Institute of Technical Education and ResearchSiksha O Anusandhan University Department of Mathematics Jadavpur University

The electroosmotic flow of a micropolar fluid in a microchannel bounded by two parallel porous plates undergoing periodic vibration is studied. The equations for conservation of linear and angular momentums and Gauss＇s law of charge distribution are solved within the framework of the Debye-Hückel approximation. The fluid velocity and microrotation are assumed to depend linearly on the Reynolds number. The study shows that the amplitude of microrotation is highly sensitive to the changes in the magnitude of the suction velocity and the width of the microchannel. An increase in the micropolar parameter gives rise to a decrease in the amplitude of microrotation. Numerical estimates reveal that the microrotation of the suspended microelements in blood also plays an important role in controlling the electro-osmotically actuated flow dynamics in microbio-fluidic devices.

关键词： blood flow electrohydrodynamic effect microfluidics channel flow

Recent advances on pathogenesis,diagnosis,prevention,immunological aspects,and vectors of dengue:A review

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Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 325-338页

作者： mahesh chandra Sahu Rakesh Kumar Samantaray Aditi Pal Sanghamitra Pati Division of Medical Entomology ICMR-Regional Medical Research CentreChandrasekharpurBhubaneswar-751023OdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023OdishaIndia

Dengue is a vector-borne disease caused by the dengue virus(DENV)of family *** fever is common in both developed and developing ***,approximately 400 million cases of dengue fever are reported annually,resulting in approximately 22000 *** cases in India have progressively increased in the last *** recent years,substantial progress has been made in understanding various aspects of dengue,including its pathogenesis,diagnosis,prevention strategies,immunological responses,and the role of vectors in its *** transmission of a positive RNA virus occurs through Aedes mosquitoes,specifically Aedes aegypti and Aedes *** virus is associated with a wide spectrum of symptoms,ranging from mild undifferentiated fever to severe hemorrhagic fever and shock,posing a potential threat to human *** are 4 types of antigenically distinct dengue serotypes(DENV-1 to DENV-4)and among them,DENV-2 is more lethal and extremely *** overcome the severity of dengue,Dengvaxia is administered to children 9 to 16 years old with evidence of previous dengue *** diagnosis of dengue is carried out by ELISA-based non-structural protein(NS1)and immunoglobulin ***,there are no specific biomarkers to identify severe disease *** factors and temperature play an important role in complex interaction among host,vector,and virus to manifest the severity of *** is a need for the refinement of climate-based disease forecasting models in India to effectively control the spread of *** mosquito repellent should be used periodically to kill or repel the Aedes mosquito to prevent the spread of dengue in humans.

关键词： Dengue Aedes mosquitoes Insecticide NS1 Immunoglobulin

A chemical-reaction-optimization-based neuro-fuzzy hybrid network for stock closing price prediction

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Financial Innovation 2019年第1期5卷 645-678页

作者： Sarat chandra Nayak Bijan Bihari misra Department of Computer Science and Engineering CMR College of Engineering&TechnologyHyderabad 501401India Department of Information Technology Silicon Institute of TechnologyBhubaneswar 751024India

Accurate prediction of stock market behavior is a challenging issue for financial *** neural networks,such as multilayer perceptron have been established as better approximation and classification models for this *** study proposes a chemical reaction optimization(CRO)based neuro-fuzzy network model for prediction of stock *** input vectors to the model are fuzzified by applying a Gaussian membership function,and each input is associated with a degree of membership to different classes.A multilayer perceptron with one hidden layer is used as the base model and CRO is used to the optimal weights and biases of this *** was chosen because it requires fewer control parameters and has a faster convergence *** statistical parameters are used to evaluate the performance of the model,and the model is validated by forecasting the daily closing indices for five major stock *** performance of the proposed model is compared with four state-of-art models that are trained similarly and was found to be *** conducted the Deibold-Mariano test to check the statistical significance of the proposed model,and it was found to be *** model can be used as a promising tool for financial forecasting.

关键词： Artificial neural network Neuro-fuzzy network Multilayer perceptron Chemical reaction optimization Stock market forecasting Financial time series forecasting

Estimating stock closing indices using a GA-weighted condensed polynomial neural network

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Financial Innovation 2018年第1期4卷 311-332页

作者： Sarat chandra Nayak Bijan Bihari misra Department of Computer Science and Engineering CMR College of Engineering&Technology(Autonomous)501401HyderabadIndia Department of Information Technology Silicon Institute of Technology751024BhubaneswarIndia.

Accurate forecasting of changes in stock market indices can provide financial managers and individual investors with strategically valuable ***,predicting the closing prices of stock indices remains a challenging task because stock price movements are characterized by high volatility and *** paper proposes a novel condensed polynomial neural network(CPNN)for the task of forecasting stock closing price *** developed a model that uses partial descriptions(PDs)and is limited to only two layers for the PNN *** outputs of these PDs along with the original features are fed to a single output neuron,and the synaptic weight values and biases of the CPNN are optimized by a genetic *** proposed model was evaluated by predicting the next day’s closing price of five fast-growing stock indices:the BSE,DJIA,NASDAQ,FTSE,and *** comparative testing,the proposed model proved its ability to provide closing price predictions with superior ***,the Deibold-Mariano test justified the statistical significance of the model,establishing that this approach can be adopted as a competent financial forecasting tool.

关键词： Stock market forecasting Polynomial neural network Partial description Genetic algorithm Multilayer perceptron

Extreme learning with chemical reaction optimization for stock volatility prediction

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Financial Innovation 2020年第1期6卷 290-312页

Extreme learning machine(ELM)allows for fast learning and better generalization performance than conventional gradient-based ***,the possible inclusion of non-optimal weight and bias due to random selection and the need for more hidden neurons adversely influence network ***,choosing the optimal number of hidden nodes for a network usually requires intensive human intervention,which may lead to an ill-conditioned *** this context,chemical reaction optimization(CRO)is a meta-heuristic paradigm with increased success in a large number of application *** is characterized by faster convergence capability and requires fewer tunable *** study develops a learning framework combining the advantages of ELM and CRO,called extreme learning with chemical reaction optimization(ELCRO).ELCRO simultaneously optimizes the weight and bias vector and number of hidden neurons of a single layer feed-forward neural network without compromising prediction *** evaluate its performance by predicting the daily volatility and closing prices of BSE ***,its performance is compared with three other similarly developed models—ELM based on particle swarm optimization,genetic algorithm,and gradient descent—and find the performance of the proposed algorithm *** signed-rank and Diebold–Mariano tests are then conducted to verify the statistical significance of the proposed ***,this model can be used as a promising tool for financial forecasting.

关键词： Extreme learning machine Single layer feed-forward network Artificial chemical reaction optimization Stock volatility prediction Financial time series forecasting Artificial neural network Genetic algorithm Particle swarm optimization