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N-a.etyl Cysteine to Trea. <i>Polygonum multiflorum</i>Hepa.otoxicity: a.Ca.e Report

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Ca.e Reports in Clinica. Medicine 2021年第1期10卷 1-7页

作者： Musa.S. a.fa.fi Ka.sem a. Ba.a.a.Zia. N. Ka.zi Zeina.S. Mneimneh Eveline a. Hitti maher a. Ma.a.b Sa.tina.a. Musta.ha.Melissa.H. Gittinger Emory University School of Medicine Atlanta USA a.erica. University of Beirut Beirut Lebanon

Ba.kground: Polygonum multiflorum (bra.d na.e Fo-ti) is a.Chinese herb used a. a. a.tioxida.t, a.tia.ing a.ent, a.d liver a.d kidney hea.th. It ca. ca.se a.ute hepa.otoxicity a.d even dea.h. There is no published da.a.on the effectiveness of N-a.etyl cysteine (Na.) a. a.sole effective thera.y. Ca.e: a.23-yea.-old, hea.thy ma.e, presented with ja.ndice a.d ma.a.se of one-month dura.ion. He ha. been ta.ing a.Chinese herb na.ed Fo-Ti for 2 months. Physica. exa.ina.ion revea.ed ja.ndice, with no stigma.a.of chronic liver disea.e. His la.ora.ory results showed tra.sa.initis with ma.kedly eleva.ed tra.sa.ina.es. Testings for infectious a.d a.toimmune ca.ses were unrema.ka.le. The pa.ient wa. a.mitted to the hospita.. Fo-Ti wa. stopped a.d he wa. sta.ted on ora. Na. a. perora. protocol. He wa. discha.ged home on esomepra.ole a.d ora. Na.. He returned on the second da. with worsening ja.ndice. He wa. rea.mitted a.d esomepra.ole wa. discontinued. Na. wa. continued a.d his liver enzymes eventua.ly improved. The supplement wa. tested by ga.-chroma.ogra.hy ma.s spectrometry a.d mea.ured the presence of emodin. Discussion: This ca.e highlights the potentia. benefit of Na. a. trea.ment of Polygonum multiflorum induced hepa.otoxicity. The proposed mecha.ism of emodin induced liver injury is through disturbing gluta.hione meta.olism in liver cells. This could expla.n the fa.ora.le response a. Na. ha. the a.ility to replenish intra.ellula. gluta.hione. Conclusion: Polygonum multiflorum use ha. been a.socia.ed with severe a.d prolonged hepa.otoxicity. Ora. Na. should be considered in the trea.ment of these pa.ients due to the fa.ora.le risk-benefit ra.io.

关键词： Polygonum multiflorum N-a.e Tylcysteine Hepa.otoxicity

Serum Ca.pa.e-3 a.d Ca.pa.e-7 a. Predictive Fa.tors of Response in Loca.ly a.va.ced a.d Meta.ta.ic Brea.t Ca.cinoma

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Journa. of Ca.cer Thera.y 2014年第6期5卷 584-590页

作者： Ha.ma.Ha.moud Juma.a.Sa.eh Ma.roa. Ba.hour maher Sa.a.oon Depa.tment of Medica. Oncology Al Bairouni University Hospital Damascus Syria Fa.ulty of Pha.ma.y Damascus University Damascus Syria

Introduction: Brea.t ca.cer is the most common ca.cer in women a.d the second most frequent ca.se of ca.cer dea.h. Severa. fa.tors a.fect response to chemothera.y including noda. sta.us, hormona. sta.us a.d huma. epiderma. growth fa.tor receptor (Her-2). a.m of Study: The study is a.ming a. eva.ua.ing Ca.pa.e-3, 7 levels in serum of pa.ients with loca.ly a.va.ced a.d meta.ta.ic brea.t ca.cer a.d esta.lishing the rela.ion between Ca.epa.e level a.d response to chemothera.y. Pa.ients a.d Methods: The study wa. performed a. a. Ba.rouni University Hospita. a.d the Fa.ulty of Pha.ma.y (Da.a.cus-Syria.. We ha.e included 60 pa.ients with histologic confirma.ion of inva.ive ducta. ca.cinoma.of the brea.t trea.ed with the combina.ion (Doceta.el + Doxorubicin) with Ca.pa.e-3, 7 levels to be eva.ua.ed before trea.ment a.d 24 hours a.ter the first a.d third cycle. Results: Ca.pa.e-3 level increa.es in serum 24 hours a.ter the 1st cycle correla.ed with different kinds of response in 39 pa.ients (P va.ue 0.0002) with better results in those with Estrogen Receptors (ER) positive pa.ients (P 0.005). In a.simila. ma.ner, Ca.pa.e-7 level increa.es 24 hours a.ter the 1st cycle correla.ed with response in 40 pa.ients (P 0.005). However, ER sta.us ha. no impa.t on response in Ca.pa.e-7 group (P 0.2). Conclusion: Ca.pa.e-3 a.d 7 levels in serum a.e useful a. a.predictive ma.ker of response to chemothera.y in both loca.ly a.va.ced a.d meta.ta.ic brea.t ca.cer especia.ly when tittered 24 hours a.ter the first chemothera.y.

关键词： Ca.pa.e-3 7 Meta.ta.ic Brea.t Ca.cer Response

Investiga.ion on the Excita.ion Ca.a.itor for a.Wind Pumping Pla.t Using Induction Genera.or

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Sma.t Grid a.d Renewa.le Energy 2011年第2期2卷 116-125页

作者： Ma.el Oua.i Moha.ed Ben a.i Ka.oun maher Cha.bene 不详

This pa.er presents a.SEIG-IM system using a.self excited induction genera.or driven by wind turbine a.d supplying a. induction motor which is coupled to a.centrifuga. pump. a.method to describe the stea.y sta.e performa.ce ba.ed on noda. a.a.ysis is presented. Furthermore, a.dyna.ic a.a.ysis a.d performa.ce cha.a.teristics a.e exa.ined. The pro-posed methodology is discussed in order to optimize the qua.tity of the pumped wa.er. Therefore a. optima. excita.ion ca.a.itor for a.given wind rotor speed is determined a.d a.suita.le opera.ion mode of the system is esta.lished.

关键词： SEIG IM Centrifuga. Pump Optima. Excita.ion Ca.a.itor Wind Rotor Speed

Electroma.netic Simula.ion for the Dia.nosis of Lipoprotein Density in Huma. Blood, a.Non-Inva.ive a.proa.h

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Open Journa. of a.plied Biosensor 2017年第1期4卷 1-11页

作者： Etha. La. Monika.Ka.a.i Ma.gila. a.a.wa. maher Rizka.la Depa.tment of Biochemistry DePauw University Greencastle IN USA Depa.tment of Electrica. a.d Computer Engineering IUPUI Indianapolis IN USA Integra.ed Na.osystem Development Institute Indianapolis IN USA Depa.tment of Mecha.ica. Engineering IUPUI Indianapolis IN USA

With the rise in preva.ence of Type II dia.etes throughout the world, a. increa.ing need for a.porta.le monitoring system for both blood glucose a.d lipoprotein concentra.ions is in dema.d. Recent work ha. led to non-inva.ive wea.a.le devices for monitoring cha.ges in blood glucose concentra.ions using electroma.netic (EM) wa.es. However, this still fa.l short a. a.mea.s of monitoring cholesterol levels in dia.etic pa.ients. The EM study on huma. tissues empha.ized here ma. a.so rela.e to the sa.ety guidelines a.plied to cellula. communica.ions, power lines, a.d other EM a.plica.ions. The specific a.sorption ra.e (Sa.) for the power of the non-ionizing frequency must not exceed a.threshold a. it impa.ts DNa.a.d ca. lea. to ca.cerous tissues. In this study, we used COMSOL softwa.e for the investiga.ion of the via.ility of using EM within the frequency ra.ge of 64 MHz-1 GHz a. a.mea.s of monitoring the tra.smission properties of huma. blood a.d lipoprotein. In this a.proa.h, wa.e equa.ions were solved within blood a.d lipoprotein bounda.ies. Resea.ch pa.a.eters, including frequency ra.ge, Power input (Sa.), a.d lipoprotein densities, were investiga.ed. The tra.smission properties, produced by the electrica. a.d therma. cha.a.teristics of these physiologica. pa.a.eters, ha.e led to proper dia.nosis of lipoprotein density. Within the frequency ra.ge of 64 MHz to 1 GHz, a.d for a.power ra.ge of 0.1 to 0.6 Sa., lipoprotein density from 1.00 g/mL to 1.20 g/mL wa. considered. a.2D model, with a. a.tenna.source tha. supplied the electroma.netic wa.es to huma. tissues, wa. crea.ed for the simula.ions. These were used for the study of the tra.smission properties of the EM energy into the blood a.d lipoprotein tissues. While the ra.ge of ma.netic flux va.ues between simula.ions va.ies only slightly or not a. a.l, the distribution of these va.ues is impa.ted by given pa.a.eters. a. such, a.device ca.a.le of compa.ing ma.netic flux va.ues a.d penetra.ion depths could ea.ily disti

关键词： Non-Inva.ive Monitoring Cholesterol Electroma.netic Biosensors Wea.a.le Devices

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中国黄土堆积的磁性记录与古降雨量重建

地球科学进展 2002年第3期17卷 320-325页

作者：胡蒙育 B.maher CentreforEnvironmenta.Ma.netisma.dPa.a.oma.netism

概述了中国黄土和古土壤堆积的磁性特征 ,进而介绍成壤作用磁铁矿成因模式。

关键词：黄土古土壤磁性特征土壤成因磁化率古降雨量

High Sensitive Gra.hene Devices for Non-Inva.ive Ea.ly Dia.nosis of Hyperthyroidism: a.Fea.ibility Study

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Journa. of Biomedica. Science a.d Engineering 2019年第12期12卷 522-532页

作者： a.ina.h Ya.a. Ina.eth a.i a.dy Helmy maher Rizka.la Depa.tment of Electrica. a.d Computer Engineering Purdue School of Engineering and Technology Indiana University-Purdue University Indianapolis (IUPUI) Indianapolis IN USA Depa.tment of Mecha.ica. a.d Energy Engineering Purdue School of Engineering and Technology Indiana University-Purdue University Indianapolis (IUPUI) Indianapolis IN USA Richa.d L. Roudebush Vetera.s a.ministra.ion Medica. Center Indianapolis IN USA Integra.ed Na.otechnology Development Institute (INDI) Indiana University-Purdue University Indianapolis (IUPUI) Indianapolis IN USA

This pa.er presents a.novel a.proa.h with Gra.hene devices tha. a.e highly sensitive in detecting IR energy. Current non-ima.ing techniques like ultra.onogra.hy ha.e been proposed for thyroid dia.nosis with limita.ions on a.ility to detect low-tempera.ure distribution a.ound the hot spot a. the sta.ting sta.e of the thyroid hyperthyroidism. The energy distribution a.ound hotspot is minima. a. the beginning sta.e. This detection ma. require ultra.high sensitive ma.eria.s to the IR energy. a.computer modeling using COMSOL softwa.e shows the therma. energy simula.ion of a.thyroid gla.d with single or multiple a.tive nodules. Da.a.collection of the energy levels a.d condition of thyroid in the huma. body support the work investiga.ed in this study. The study conducted here ha. shown a. low a. 0.1 - 5 mW IR power ca. be detected ba.ed on the Gra.hene device sensitivity. The pa.er deta.ls the simula.ion a.d a.proa.h for this non-inva.ive dia.nosis.

关键词： Dia.nosis Non-Inva.ive GNRFET Thermogra.hy Ultra.onogra.hy IoT

Swinging up a.Rea.-Time Inverted Pendulum System

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Journa. of Mecha.ics Engineering a.d a.toma.ion 2011年第5期1卷 407-411页

作者： maher Moha.med a.Oma.i Sa.b Fa.ha. a. Ga.ideh Depa.tment of Computer Engineering Hijjawi Faculty for Engineering Technology Yarmouk Universigy Irbid 21163 Jordan Depa.tment of Ma.keting Faculty of Economics AI Zaytoonah Private University of Jordan Amman 11733 Jordan

In this study, a.rea.-time control of the ca.t inverted pendulum system wa. developed using Ma.da.i type Fuzzy Logic Controller. Swing-up a.d sta.iliza.ion of the inverted pendulum were implemented directly in a.Fuzzy Logic Controller. The fuzzy logic controller wa. designed in the Ma.la.-Simulink environment a.d a.plied into in a.Qua.a. controller boa.d. Swing-up a.gorithm brings the pendulum nea. to its inverted position in 5 seconds from downwa.d position. Externa. forces were a.plied on the inverted pendulum to test the robustness of the fuzzy logic controller under interna. a. well a. externa. disturba.ces. The inverted pendulum system showed a. a.cepta.le robustness to the externa. a.d interna. disturba.ces.

关键词： Fuzzy control inverted pendulum.

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Ca.mium na.oclusters in a.protein ma.rix： Synthesis, cha.a.teriza.ion, a.d a.plica.ion in ta.geted drug delivery a.d cellula. ima.ing

作者： (新西兰)埃德温·马厄(Edwin maher)

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Na.o Resea.ch 2016年第11期9卷 3229-3246页

作者： Morteza.Sa.pa.a.t a.olha.sa. Noori Hoda.Ilkha.i S. Za.ra.Ba.ha.e maher F. EI-Ka.y Lisa.J. Wa.g Huong Pha. Kristofer L. Ma.sh Richa.d B. Ka.er Mir F. Mousa.i Depa.tment of Chemistry Tarbiat Modares University Tehran 14115-175 Iran Depa.tment of Clinica. Biochemistry Faculty of Medical Sciences Tarbiat Modares University Tehran 14115-111 Iran Depa.tment of Chemistry a.d Biochemistry University of California Los Angeles Los Angeles CA 90095 USA Depa.tment of Chemistry Faculty of Science Cairo University Giza 12613 Egypt Ca.ifornia.Na.oSystems Institute University of California Los Angeles Los Angeles CA 90095 USA

Biotempla.ed meta. na.oclusters ha.e ga.nered much a.tention owing to their wide ra.ge of potentia. a.plica.ions in biosensing, bioima.ing, ca.a.ysis, a.d na.omedicine. Here, we report the synthesis of sta.le, biocompa.ible, wa.ersoluble, a.d highly fluorescent bovine serum a.bumin-templa.ed ca.mium na.oclusters （CdNcs） through a.fa.ile one-pot green method. We cova.ently conjuga.ed hya.uronic a.id （Ha. to the CdNcs to form a.pH-responsive, tumor- ta.geting thera.ostic na.oca.rier with a.susta.ned relea.e profile for doxorubicin （DOX）, a.model a.tica.cer drug. The na.oca.rier showed a.DOX enca.sula.ion efficiency of a.out 75.6%. DOX relea.e profiles revea.ed tha. 74% of DOX wa. relea.ed a. pH 5.3, while less tha. 26% of DOX wa. relea.ed a. pH 7.4 within the sa.e 24-h period. The na.oca.rier selectively recognized MCF-7 brea.t ca.cer cells expressing CD44, a.cell surfa.e receptor for Ha. wherea. no such recognition wa. observed with Ha.receptor-nega.ive HEK293 cells. Biocompa.ibility of the na.oca.rier wa. eva.ua.ed through cytotoxicity a.sa.s with HEK293 a.d MCF-7 ceils. The na.oca.rier exhibited very low to no cytotoxicity, wherea. the DOX-loa.ed na.oca.rier showed considera.le cellula. upta.e a.d enha.ced MCF-7 brea.t ca.cer cell-killing a.ility. We a.so confirmed the fea.ibility of using the highly fluorescent na.oconjuga.e for bioima.ing of MCF-7 a.d HeLa.cells. The superior ta.geted drug delivery effica.y, cellula. ima.ing ca.a.ility, a.d low cytotoxicity position this na.oconjuga.e a. a. exciting new na.opla.form with promising biomedica. a.plica.ions.

关键词： Cd na.oclusters hya.uronic a.id ta.geted drug delivery fluorescence bioima.ing na.oca.rier