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Effect of Ma.erna. Dia.etes on Pre- a.d Post-Na.a. Redox Sta.us of F1 Ra. Offspring

Open Journa. of Endocrine a.d Meta.olic Disea.es 2014年第5期4卷 111-127页

作者： maher a. kamel Ma.iha.H. Helmy Merva. Y. Ha.a.i Shima. a. Ma.moud Ha.a. a.o Elfetooh Depa.tment of Biochemistry Medical Research Institute University of Alexandria Alexandria Egypt

Ba.kground: The oxida.ive stress a.d disturbed redox signa.ing during gesta.ion my pla. a. importa.t role in the feta. progra.ming of a.ult dia.etes. Objective: The study a.med to investiga.e the effects of ma.erna. dia.etes on pre- a.d post-na.a. pa.crea.ic a.d periphera. tissues redox a.d oxida.ive sta.us in order to cla.ify their role in the dia.etogenic progra.ming of F1 offspring. Methods: Two groups of fema.e Wista. ra.s were used (dia.etic a.d control);dia.etes wa. neona.a.ly induced by STZ injection to 5-da. old ra.s. 10 pregna.cies of ea.h group were termina.ed a. GD 17 to obta.n pla.enta. a.d feta. pa.crea., liver, muscle a.d a.ipose tissues for prena.a. mea.urements. The rest of pregna.cies were completed to term a.d the offspring were wea.ed to control diet or high-ca.oric (HCD) diet a.d followed up for 30 weeks. Every 5 weeks 10 ma.e ra.s were sa.rificed a.d serum a.d tissues were obta.ned for a.sessment of fa.ting blood glucose, tissues content of 8-oxo-dG, TBa.S, GSH, GSSG, a.tioxida.t enzymes a.d ca.pa.e-3. Results: The results indica.ed tha., prena.a.ly redox sta.us of the foetuses of dia.etic mothers is shifted towa.d more oxidizing environment which results from eleva.ed oxida.ive stress a.d impa.red a.tioxida.ts a. indica.ed by eleva.ed feta. tissues content of 8-oxo-dG, TBa.S a.d GSSG a.d decrea.ed GSH a.d GSH/GSSG ra.io. a.l of these induce the a.optotic pa.hwa. in feta. pa.crea.. Postna.a.ly, impa.red glucose tolera.ce in the offspring of dia.etic mothers is detected a. 15th week of a.e a.d no hyperglycemia.wa. detected until a.e of 30 weeks in the offspring under CD while some of offspring under HCD a. a.e 25 weeks a.d most of them a. 30 weeks ha.e developed hyperglycemia. The pa.crea. of the offspring of dia.etic mothers suffers from oxida.ive stress from the 5th week of a.e a. indica.ed by eleva.ed levels of nuclea. a.d mitochondria. 8-oxo-dG contents a.d TBa.S. a.so, GSH level showed depletion with a.e a.d the a.tivity of gluta.hione reduc

关键词： Feta. Origin of Disea.e Dia.etes GSH Redox 8-Oxo-dG a.optosis Oxida.ive Stress

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Insulin-Like Growth Fa.tor-1 a.d Osteoca.cin a.e Correla.ed with Ma.kers of Osteoporosis in Postmenopa.sa. Women with Type-2 Dia.etes

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Open Journa. of Endocrine a.d Meta.olic Disea.es 2013年第5期3卷 245-251页

作者： maher a. kamel Ma.iha.H. Helmy a.na.N. a.ou Ra.a. Nevine Moha.na. Huda.M. N. Ha.ia Depa.tment of Biochemistry Medical Research Institute Alexandria University Alexandria Egypt Depa.tment of Interna. Medicine Faculty of Medicine Alexandria University Alexandria Egypt

Objective: The study wa. conducted to eva.ua.e the rela.ion between insulin-like growth fa.tor-1 a.d osteoca.cin a.d ma.kers of bone modula.ion (osteoprotegerin;OPG, receptor a.tiva.or nuclea. ka.pa.B;Ra.K a.d Ra.K liga.d;Ra.KL) in postmenopa.sa. Type 2 dia.etic women with a.d without osteoporosis. Methods: The study wa. conducted on 90 fema.e divided into three groups (30 ea.h). Group I included hea.thy postmenopa.sa. women a. a.control, Group II included dia.etic postmenopa.sa. women without osteoporosis Group III included dia.etic postmenopa.sa. women with osteoporosis. Fa.ting blood sa.ples were obta.ned for the determina.ion of blood glucose, Hba.c, tota. a.d ionized ca.cium, OPG, Ra.K a.d Ra.KL. a.so the levels of IGF-1 a.d osteoca.cin were a.sessed. Results: In postmenopa.sa. Type 2 dia.etic women, the osteoporosis resulted in dera.gement in OPG/sRa.KL system. The serum level of OPG wa. eleva.ed while sRa.KL declines in osteoporotic postmenopa.sa. Type 2 dia.etic women. IGF-1 level decrea.ed in dia.etic postmenopa.sa. women but those women with osteoporosis showed a.grea. decline by a.out 60%. IGF-1 level in osteoporotic dia.etic postmenopa.sa. women wa. correla.ed with BMD a.d most bone turnover ma.kers (OPG, sRa.KL, OPG/sRa.KL). Osteoca.cin declined significa.tly only in those women with osteoporosis not without osteoporosis. Conclusions: The circula.ing levels of OPG a.d sRa.KL were not useful ma.kers for bone sta.us in postmenopa.sa. women while the circula.ing levels of IGF-1 a.d osteoca.cin might give useful informa.ion a.out bone sta.us in postmenopa.sa. dia.etic women.

关键词： Osteoporosis Type 2 Dia.etes Postmenopa.se IGF-1 Osetoca.cin OPG Ra.K

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Development of new la.era.-flow immunochroma.ogra.hic strip using colloida. gold a.d mesoporous silica.na.opa.ticles for ra.id dia.nosis of a.tive schistosomia.is

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2019年第8期9卷 315-322页

作者： Ma.a. kamel Fa.en Sa.a. Zeina. Demerda.h Sa.a.maher Shima. a.ta.a.eer Ba.r a.med a.ifi Ha.a. El Ba. Immunology Depa.tment Theodor Bilharz Research InstituteKornish El Nil streetGizaEgypt Zoology Depa.tment Faculty of ScienceCairo University12613GizaEgypt

Objective: To develop a.new sa.dwich ba.ed la.era. flow immunochroma.ogra.hic strip for ra.id detection of circula.ing Schistosoma.ma.soni a.tigen in serum a.d urine sa.ples of pa.ients with a.tive schistosomia.is. Methods: This la.era. flow immunochroma.ogra.hic strip wa. prepa.ed by using a.ti-Schistosoma.ma.soni soluble egg a.tigen monoclona. a.tibody conjuga.ed gold na.opa.ticles (Ma.-a.NPs) a. a.tigen-detecting a.tibody, while crysta.line ma.eria. (MCM)-41-Ma. bioconjuga.e wa. immobilized a. the test line a. a.tigen-ca.turing a.tibody. Both a.tigen ca.turing a.d detecting a.tibodies formed sa.dwich complexes with circula.ing Schistosoma.ma.soni a.tigen in the positive sa.ples. Sa.dwich complexes immobilized a. the test line ga.e distinct red color. The a.sa. relia.ility wa. exa.ined by using urine a.d serum sa.ples of 60 Schistosoma.ma.soni infected pa.ients, 20 pa.ients infected with pa.a.ites other tha. Schistosoma. a.d 20 hea.thy individua.s a. nega.ive controls. Results were compa.ed with those obta.ned via.sa.dwich enzyme linked immunosorbent a.sa. (ELISa.. Results: The detection limit of circula.ing Schistosoma.ma.soni a.tigen by la.era. flow immunochroma.ogra.hic strip wa. lower (3 ng/mL) tha. the detection limit by ELISa.(30 ng/mL). The sensitivity a.d specificity of la.era. flow immunochroma.ogra.hic strip in urine sa.ples were 98.3% a.d 97.5%, respectively compa.ed to 93.5% a.d 90.0% by ELISa. In serum sa.ples, they were 100.0% a.d 97.5%, respectively compa.ed to 97.0% a.d 95.0% by ELISa. The strip test took a.proxima.ely 10 min to complete. Conclusions: This new la.era. flow immunochroma.ogra.hic strip offers a.sensitive, ra.id, a.d field a.plica.le technique for dia.nosis of a.tive schistosomia.is.

关键词： Schistosomia.is Na.opa.ticles Immunochroma.ogra.hic Monoclona. a.tibodies

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Preserving Da.a.Secrecy a.d Integrity for Cloud Stora.e Using Sma.t Contra.ts a.d Cryptogra.hic Primitives

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Computers, Ma.eria.s & Continua 2024年第5期79卷 2449-2463页

作者： maher a.ha.by Cybersecurity Depa.tment College of Computer Science and EngineeringTaibah UniversityMedina42353Saudi Arabia

Cloud computing ha. emerged a. a.via.le a.terna.ive to tra.itiona. computing infra.tructures,offering va.ious ***,the a.option of cloud stora.e poses significa.t risks to da.a.secrecy a.d *** a.ticle presents a. effective mecha.ism to preserve the secrecy a.d integrity of da.a.stored on the public cloud by levera.ing blockcha.n technology,sma.t contra.ts,a.d cryptogra.hic *** proposed a.proa.h utilizes a.Solidity-ba.ed sma.t contra.t a. a. a.ditor for ma.nta.ning a.d verifying the integrity of outsourced *** preserve da.a.secrecy,symmetric encryption systems a.e employed to encrypt user da.a.before outsourcing *** extensive performa.ce a.a.ysis is conducted to illustra.e the efficiency of the proposed ***,a.rigorous a.sessment is conducted to ensure tha. the developed sma.t contra.t is free from vulnera.ilities a.d to mea.ure its a.socia.ed running *** security a.a.ysis of the proposed system confirms tha. our a.proa.h ca. securely ma.nta.n the confidentia.ity a.d integrity of cloud stora.e,even in the presence of ma.icious *** proposed mecha.ism contributes to enha.cing da.a.security in cloud computing environments a.d ca. be used a. a.founda.ion for developing more secure cloud stora.e systems.

关键词： Cloud stora.e da.a.secrecy da.a.integrity sma.t contra.ts cryptogra.hy

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a.senobeta.ne a.d thio-a.senic species in ma.ine ma.roa.ga. a.d herbivorous a.ima.s: a.cumula.ed through trophic tra.sfer or produced in situ?

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Journa. of Environmenta. Sciences 2016年第11期28卷 131-139页

作者： Simon Foster Willia. maher Ecochemistry La.ora.ory Institute for Applied Ecology University of Canberra

a.senobeta.ne（a.） a.d thio-a.senoribosides were mea.ured in common ma.roa.ga. species（8 pha.ophyta. 4 rhodophyta.a.d 2 chlorphyta., a.ong the a.stra.ia. south ea.t coa.t line. a. well, a.senic species profiles were mea.ured for two common ma.ine herbivores, the sea.urchin Centrostepha.us rodgersii a.d the fish Oda. cya.omela. tha. gra.e on these ma.roa.ga. to understa.d if trophic tra.sfer of these species would a.count for their presence in ma.ine herbivores. a. wa. found in seven of the fourteen ma.roa.ga. species investiga.ed but does not contributed significa.tly to a.y of the ma.roa.ga. a.senic content（0.01-1.2 μg/g）. a. wa. found in only two of the brown ma.roa.ga. a.d a.l the red a.d green ma.roa.ga.（with the exception of Cora.lina.officina.is）. Thio-a.senic species were found spora.ica.ly, but not in high concentra.ions in a.y of the ma.roa.ga. *** present in ma.roa.ga. is likely to be a.socia.ed with epiphytic orga.isms while thio-a.senoribosides a.e likely to be produced by deca.ing pa.ts of da.a.ed ma.roa.ga..a.la.ora.ory feeding experiment in which the herbivorous ga.tropod, a.strocochlea.constricta. wa. fed ma.roa.ga. conta.ning thio-a.senoribosides for a.24 hr period every three da.s showed tha. these a.e rea.ily a.cumula.ed over a.short period. Thio-a.senoribosides in herbivores a.e therefore proba.ly obta.ned through trophic tra.sfer. Some a. is a.so obta.ned through trophic tra.sfer; however, the presence of trimethyla.ed a.sonioribosides,a.hypothesized precursor of a. forma.ion in herbivores, suggests tha. some a. is produced within herbivores from the tra.sforma.ion of a.senoribosides a.cumula.ed from their diet.

关键词： a.senobeta.ne a.senic Meta.olism Thio-a.senosuga.s Ma.roa.ga. Ga.tropods

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Bitter gourd extra.t improves glucose homeosta.is a.d lipid profile via.enha.cing insulin signa.ing in the liver a.d skeleta. muscles of dia.etic ra.s

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2021年第8期11卷 344-352页

作者： Sa.er Moha.ed Eweda.Menna.a.la. a.med a.i Ha.a.Moha.ed a.d El-Ba.y Na.ed Hussein El-Sokka.y Ma.iha.Ha.sa. Helmy maher a.del-Na.i kamel Depa.tment of Biochemistry Faculty of ScienceAlexandria UniversityAlexandriaEgypt Depa.tment of Pha.ma.ology&Thera.eutics Faculty of Pharmacy and Drug ManufacturingPharos University in AlexandriaAlexandriaEgypt Depa.tment of Biochemistry Medical Research InstituteAlexandria UniversityAlexandriaEgypt Depa.tment of Physiology Faculty of MedicineAlexandria UniversityAlexandriaEgypt Medica. La.ora.ories Technology College of Applied Medical SciencesTaibah UniversityMadinahKSA

Objective:To investiga.e the modula.ory effects of bitter gourd extra.t on the insulin signa.ing pa.hwa. in the liver a.d skeleta. muscle tissues of dia.etic ***:The etha.olic extra.t of bitter gourd wa. prepa.ed a.d its contents of tota. polyphenols a.d fla.onoids were a.sa.ed.a.neona.a. streptozotocin-induced dia.etic ra. model wa. esta.lished a.d the dia.etic ra.s were a.signed into different groups a.d were trea.ed with different doses of bitter gourd extra.t(100,200,400,or 600 mg/kg)or with glibencla.ide(0.1 mg/kg)for 30 *** blood glucose,insulin,a.d lipid profile were eva.ua.ed a.d the insulin signa.ing pa.hwa. in the liver a.d skeleta. muscle of ra.s wa. *** correla.ions between homeosta.is model a.sessment(HOMa.a.d the components of insulin signa.ing pa.hwa. were a.so ***:Different doses of bitter gourd extra.t significa.tly a.eliora.ed fa.ting blood glucose level a.d HOMa.index for insulin ***,bitter gourd extra.t increa.ed serum insulin a.d improved disrupted serum lipid *** levels of insulin receptor substra.e-1(IRS-1),p-insulin receptorβ(p-IR-β),protein kina.e C(PKC),GLUT2,a.d GLUT4 were improved by trea.ment with bitter gourd *** best results were obta.ned with 400 mg/kg dose of the extra.t,the effect of which wa. equiva.ent to tha. of *** in the bitter gourd trea.ed ra.s wa. nega.ively correla.ed with p-IR-β,IRS-1 a.d PKC in hepa.ic a.d skeleta. *** wa. a.so nega.ively correla.ed with skeleta. muscle ***:Bitter gourd extra.t improves glucose homeosta.is a.d lipid profile in dia.etic ra.s via.enha.cement of insulin secretion a.d ***,bitter gourd ca. be used a. a.potentia. pha.ma.ologica. a.ent for the trea.ment of type 2 dia.etes mellitus.

关键词： Neona.a. Streptozotocin Dia.etic Sulfonylurea Bitter gourd Phosphoryla.ed insulin receptor Protein kina.e C IRS-1 GLUT2/GLUT4 Insulin signa.ing

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Experimenta. a.d Numerica. a.a.yses of the Pull-out Response of a.Steel Post/Bovine Bone Cementless Fixa.ion

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Journa. of Bionic Engineering 2012年第4期9卷 501-507页

作者： Kha.ed Ga.moudi Moha.ed Kha.ra. maher Da.ma. Na.iona. Engineering School of Sfa. Electromechanical Systems Laboratory Soukra road km 3.5 B.P. 1173 3038 Sfax Tunisia Higher Institute of Technologica. Studies of Ga.sa University campus Sidi Ahmed Zarrouk 2112 Gafsa Tunisia Fa.ulty of Sciences of Ga.sa University campus Sidi Ahmed Zarrouk 2112 Gafsa Tunisia Prepa.a.ory Institute for Engineering Studies of Sfa. Menzel Chaker Road Km 0.5 B.P. 1172 3018 Sfax Timisia

Effect of initia. interference fit on pull-out strength in cementless fixa.ion between bovine tibia.a.d smooth sta.nless steel post wa. investiga.ed in this study. Compressive beha.ior of bovine spongious bone wa. studied using mecha.ica. testing in order to eva.ua.e the ela.tic-pla.tic properties in different regions of the proxima. tibia. Friction tests were ca.ried out in the a.m to eva.ua.e the friction beha.ior of the conta.t between bovine spongious bone a.d sta.nless steel. a.cylindrica. sta.nless steel post inserted in a.pre-drilled bovine tibia.with a. initia. interference fit wa. ta.en a. a. in vitro model to a.sess the contribution of post fixa.ion to the initia. sta.ility of the Tota. Knee a.thropla.ty （TKa. tibia. component. Pull-out experiments were ca.ried out for different initia. interference fits. Finite Element Models （FEM） using loca. ela.tic-pla.tic properties of the bovine bone were developed for the a.a.ysis of the experimenta. ultima.e pull-out force results. a. the post/bone interfa.e, Coulomb friction wa. considered in the FEM ca.cula.ions with pressure-dependent friction coefficient. It wa. found tha. the FEM results of the ultima.e force a.e in good a.reement with the experimenta. results. The a.a.ysis of the FEM interfa.ia. stresses indica.es tha. the micro-slip initia.ion depends on the loca. bone properties.

关键词： tota. knee a.thropla.ty bovine bone/steel post fixa.ion interference fit puU-out strength FEM

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BROWDER a.D SEMI-BROWDER OPERa.ORS

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a.ta.Ma.hema.ica.Scientia 2012年第3期32卷 942-954页

作者： Fa.ma.Fa.hfa.h maher Mnif D'epa.tement de Ma.h'ema.iques Universit'e de SfaxFacult'e des Sciences de SfaxRoute de SoukraKm 3.5B.P.11713000 SfaxTunisie

In this a.ticle, we study cha.a.teriza.ion, sta.ility, a.d spectra. ma.ping the- orem for Browder＇s essentia. spectrum, Browder＇s essentia. defect spectrum a.d Browder＇s essentia. a.proxima.e point spectrum of clos... 详细信息

关键词： Browder a.d semi-Browder opera.ors Browder's essentia. spectrum Browder's essentia. defect spectrum Browder's essentia. a.proxima.e point spectrum

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Ra.io Frequency Induction Pla.ma.Spra.ing of Molybdenum

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Pla.ma.Science a.d Technology 2003年第4期5卷 1895-1900页

作者：蒋显亮 maher Boulos Institute of Surfa.e a.d Coa.ings Technology Central South UniversityChangsha 410083China Pla.ma.Technology Resea.ch Center University of SherbrookeSherbrooke J1K 2R1Canada

Ra.io frequency (RF) induction pla.ma.wa. used to ma.e free-sta.ding deposition of molybdenum (Mo). The phenomena.of pa.ticle melting, fla.tening, a.d sta.king were investiga.ed. The effect of process pa.a.eters such a. pla.ma.power, cha.ber pressure, a.d spra. dista.ce on the phenomena.mentioned a.ove wa. studied. Sca.ning electron microscopy (SEM) wa. used to a.a.yze the pla.ma.processed powder, spla.s formed, a.d deposits obta.ned. Experimenta. results show tha. less Mo pa.ticles a.e spheroidized when compa.ed to the number of spheroidized tungsten (W) pa.ticles a. the sa.e powder feed ra.e under the sa.e pla.ma.spra. condition. Molten Mo pa.ticles ca. be sufficiently fla.tened on substra.e. The influence of the process pa.a.eters on the fla.tening beha.ior is not significa.t. Mo deposit is not a. dense a. W deposit, due to the spla.h a.d low impa.t of molten Mo pa.ticles. Oxida.ion of the Mo powder with a.la.ge pa.ticle size is not evident under the low pressure pla.ma.spra..

关键词： induction pla.ma molybdenum spheroidi/a.ion fla.tening deposition density

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ESSENTIa. a.PROXIMa.E POINT SPECTRa.FOR UPPER TRIa.GULa. Ma.RIX OF LINEa. RELa.IONS

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a.ta.Ma.hema.ica.Scientia 2013年第4期33卷 1187-1201页

作者： Souhir ELLEUCH maher MNIF Dépa.tement de Ma.héma.iques Université de Sfax Faculté des Sciences de SfaxLaboratoire de Physiques Mathématiques

When a.E ∈LR（H） a.d B E ∈LR（K） a.e given, for C E∈LR（K, H） we denoteby Mc the linea. rela.ion a.ting on the infinite dimensiona. sepa.a.le Hilbert spa.e H Kof the formIn this pa.er, we give the necessa.y a.d sufficient conditionson a.a.d B for wh{ch Mc is upper semi-Fredholm with nega.ive index or Weyl for some C C ∈LR（K, H）.

关键词： linea. rela.ion Fredholm a.d semi-Fredholm rela.ion essentia. a.proxima.epoint spectra.for linea. rela.ion

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