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c-Met enforces proinflammatory and migratory features of human activated CD4^(+)T cells

Cellular & Molecular Immunology 2021年第8期18卷 2051-2053页

作者： mahdia benkhoucha Ngoc Lan Tran Gautier Breville Isis Senoner Camilla Jandus Patrice Lalive Department of Pathology and Immunology Faculty of MedicineUniversity of GenevaGenevaSwitzerland Department of Neurosciences Division of NeurologyUniversity Hospital of GenevaGenevaSwitzerland Ludwig Institute for Cancer Research Lausanne BranchLausanneSwitzerland

The receptor tyrosine kinase c-Met is essential for embryonic development and tissue regeneration,as it promotes cell survival,proliferation,migration,and angiogenesis[1,2].The HGF/c-Met axis modulates several inflammatory-mediated diseases by acting on a wide variety of cells[3].Nevertheless,studies on the role of c-Met in peripheral T cell functions are very limited,partly because we and others have reported negligible c-Met expression in naive T cells[2,4].

关键词： inflammatory diseases negligible

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Co-optimization of carbon dioxide storage and enhanced oil recovery in oil reservoirs using a multi-objective genetic algorithm(NSGA-Ⅱ)

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Petroleum Science 2014年第3期11卷 460-468页

作者： SAFARZADEH Mohammad Amin MOTAHHARI Seyyed mahdia Research Institute of Petroleum Industry

Climate researchers have observed that the carbon dioxide （CO2） concentration in the atmosphere have been growing significantly over the past century. CO2 from energy represents about 75% of the greenhouse gas （GHG） emissions for Annex B （Developed） countries, and over 60% of global emissions. Because of impermeable cap rocks hydrocarbon reservoirs are able to sequester CO〉 In addition, due to high-demand for oil worldwide, injection of CO2 is a useful way to enhance oil production. Hence, applying an efficient method to co-optimize CO2 storage and oil production is vital. Lack of suitable optimization techniques in the past led most multi-objective optimization problems to be tackled in the same way as a single objective optimization issue. However, there are some basic differences between the multi and single objective optimization methods. In this study, by using a non- dominated sorting genetic algorithm （NSGA-II） for an oil reservoir, some appropriate scenarios are proposed based on simultaneous gas storage and enhanced oil recovery optimization. The advantages of this method allow us to amend production scenarios after implementing the optimization process, by regarding the variation of economic parameters such as oil price and CO2 tax. This leads to reduced risks and time duration of making new decisions based on upcoming situations.

关键词： Greenhouse gas emission carbon dioxide enhanced oil recovery multi-objective optimization decision making

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未开发远景区页岩气的综合评价方法--以伊朗卢雷斯坦页岩气区为例

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石油勘探与开发 2022年第3期49卷 522-529页

作者： ABDOLLAHI Reza MOTAHHARI Seyed mahdia ASKARI Amir Abbas HEMATPUR Hamed ZAMANI Ziba TIRTASHI Rahim Bagheri DARYABANDEH Manouchehr 陈浩伊朗德黑兰石油工业研究所EOR研究部德黑兰***伊朗伊朗德黑兰石油工业研究所地球科学部德黑兰***伊朗伊朗国家石油公司勘探局地球化学部德黑兰***伊朗中国石油大学(北京)安全与海洋工程学院北京102249

页岩气评价方法及关键参数研究表明,仅靠技术指标来寻找地质甜点并不能实现页岩气的商业经济开发。通过将总有机碳含量、镜质体反射率等技术指标与内部收益率、投资回收期等经济指标相结合,提出一套经济指标和技术指标相结合的研究方法... 详细信息

页岩气评价方法及关键参数研究表明,仅靠技术指标来寻找地质甜点并不能实现页岩气的商业经济开发。通过将总有机碳含量、镜质体反射率等技术指标与内部收益率、投资回收期等经济指标相结合,提出一套经济指标和技术指标相结合的研究方法,用以筛选页岩气未开发区的最佳技术经济开发甜点。采用该方法通过总有机碳含量、镜质体反射率、有效储集层厚度和含气量等参数筛选21个地质甜点。再基于类比研究法,以压力梯度、黏土矿物含量、埋藏深度等参数为类比依据,选择Eagle Ford页岩为类比对象,提取采收率和生产曲线两项指标,估算研究区的技术可采储量。在此基础上,结合内部收益率、投资回收期等经济指标评价地质甜点的经济性。应用这套多参数综合评价方法,对伊朗卢雷斯坦地区白垩系页岩气储集层S_(1)层和S_(2)层进行评估,确定该区域的最佳技术经济开发甜点。结果表明,在净现值取其P_(10)值(累计概率10%时对应的参数值)的情况下,技术可采储量和经济可采储量总量分别为7875×10^(8)m^(3)和4306×10^(8)m^(3),有11个地质甜点具有商业开发价值,其中1号甜点价值最高,净现值为35×10^(8)美元。

关键词：页岩气地质甜点技术经济开发甜点页岩气经济评价伊朗卢雷斯坦地区白垩系

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High Sensitivity of Porous Cu-Doped SnO₂ Thin Films to Methanol

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Advances in Nanoparticles 2016年第2期5卷 140-148页

作者： Sara Benzitouni Mourad Zaabat Aicha Khial Djamil Rechem Ahlem Benaboud Dhikra Bouras Abdelhakim Mahdjoub mahdia Toubane Raphael Coste Laboratoire des Composants Actifs et Matériaux (LCAM) Université Larbi Ben M’hidi Oum El Bouaghi Algérie Laboratoire des Matériaux et Structure des Systèmes Electromécaniques et leur Fiabilité (LMSSEF) Université Larbi Ben M’hidi Oum El Bouaghi Algérie Unité de Recherche Matériaux Procédés et Environnement (URMPE) Université M’hamed Bougara Boumerdes Algérie Laboratoire de Recherche en Nanoscience (LRN) UFR Sciences Université de Reims Reims France

Porous Cu-doped SnO2 thin films were synthesized by the sol-gel dip-coating method for enhancing methanol sensing performance. The effect of Cu doping concentration on the SnO2 sensibility was investigated. XRD data confirm that the fabricated SnO2 films are polycrystalline with tetragonal rutile crystal structure. AFM and SEM micrographs confirmed the roughness and the porosity of SnO2 surface, respectively. UV-Vis spectrum shows that SnO2 thin films exhibit high transmittance in the visible region ~95%. The band gap (3.80 - 3.92 eV) and the optical thickness (893 - 131 nm) of prepared films were calculated from transmittance data. The sensing results demonstrate that SnO2 films have a high sensitivity and a fast response to methanol. In particular, 3% Cu-SnO2 films have a higher sensitivity (98%), faster response (10-2 s) and shorter recovery time (18 s) than other films.

关键词： SnO2 Cu-Doped Sensitivity Porosity Response Time Band Gap Thin Films

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Transgenic Date Palm Containing Endotoxin Cry3Aa Gene

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Journal of Agricultural Science and Technology(A) 2017年第4期7卷 246-257页

作者： Awatef Mahmoud Badr-Elden Ibrahim Abd El-Maksoud Ibrahim Hamdy Ahmed Emaral mahdia Farid Gabr Ahmed Abbas Nower Tamer Mahfouz Abd Elaziem Department of Plant Biotechnology Genetic Engineering and Biotechnology Research Institute (GEBRI) University of Sadat CitySadat City 32897 Egypt Department of Plant Genetic Resources Desert Research Center Cairo 11753 Egypt

Date palm, like all other crops, is very sensitive to the injury by many insect pests, which may lead to the death of the affected plant and causes decrease in yield. In the present study, an efficient Agrobacterium for genetic transformation was successfully achieved for well known date palm （Phoenix dactylifera L.） cv. Medjool and Khalas using callus as explant. Embryogenic callus were recorded 100% mortality when cultured on MS medium containing 100 mg/L kanamycin with different cultivars, thus it was chosen for the selection of transformed explants. Embryogenic callus of Medjool and Khalas were incubated with Agrobacterium tumefaciens strain LBA 4404 for 0.5, 1, 2, 4 and 24 h on LB medium. After the incubation periods, embryogenic callus was transferred to MS medium with 0.1 mg/L NAA, 0.05 mg/L BA, 250 mg/L carbenicillin and 100 mg/L kanamycin for detection of transgenic embryogenic callus. Polymerase chain reaction （PCR） was used for the rapid screening of Cry3Aa gene. For screening, total genomic DNA was isolated from transformants. Using primer specific to Cry3Aa gene （forward and reverse）, a PCR product with a size of about 2,000 bp was amplified when all nucleic acid from the transformants were utilized as templates. PCR analysis confirmed the appearance of the transgene of 2,000 bp in one individual plantlet. Presence and integration of foreign Cry3Aa gene in regenerated kanamycin resistant embryogenic callus was also confirmed by Southern blot hybridization. It was found that one transgenic embryogenic callus for both Medjool and Khalas showed a single copy of gene integration. These results signify the successful transfer of Cry3Aa gene into date palm plant.

关键词： Date palm Agrobacterium tumefaciens Cry3Aa gene Southern blot analysis transformation.

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