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慢性疾病与转化医学:英文版 2023年第3期9卷 258-262页

作者： Julia Feige Fritz Klausner Johannes A.R.Pfaff Eugen Trinka Slaven Pikija mahdi safdarian Department of Neurology Neurocritical Care and NeurorehabilitationCentre of Cognitive NeuroscienceChristian Doppler University HospitalParacelsus Medical UniversitySalzburgMember of EpiCARESalzburgAustria Department of Neuroradiology Christian Doppler University HospitalParacelsus Medical UniversitySalzburgAustria Neuroscience Institute Christian‐Doppler University HospitalParacelsus Medical UniversityCentre for Cognitive NeuroscienceSalzburgAustria Institute of Public Health Medical Decision‐Making and HTAUMIT‐Private University for Health SciencesMedical Informatics and TechnologyHall in TyrolAustria

1|INTRODUCTION Capecitabine is an oral prodrug of 5-fluorouracil(5-FU),which is widely used for adjuvant and neoadjuvant chemotherapy of different solid tumors,particularly breast and colorectal cancers.1 Neurotoxicity of capecitabine has been consistently reported as capecitabine-induced toxic leukoencephalopathy,which includes bilateral lesions in the corpus callosum and corticospinal tract presenting as acute or delayed central nervous system toxicity.2 This side effect requires discontinuation of chemotherapy3;however,neurological symptoms due to capecitabine are reported to be usually reversible upon drug withdrawal.

关键词： capecitabine intramyelinic edema leukoencephalopathy stroke

A superficial siderosis-related transient focal neurological episode in a patient with Marfan syndrome

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慢性疾病与转化医学:英文版 2023年第3期9卷 269-272页

作者： Slaven Pikija Eugen Trinka Pfaff Johannes Andreea Toma mahdi safdarian Department of Neurology Neurocritical Care and NeurorehabilitationCentre of Cognitive NeuroscienceChristian Doppler University HospitalParacelsus Medical UniversitySalzburgMember of EpiCARESalzburgAustria Department of Neurology Christian Doppler University HospitalCentre of Cognitive NeuroscienceNeuroscience InstituteParacelsus Medical UniversitySalzburgAustria Karl Landsteiner Institute for Neurorehabilitation and Space Neurology SalzburgAustria Department of Neuroradiology Christian Doppler University HospitalCentre of Cognitive NeuroscienceNeuroradiology InstituteParacelsus Medical UniversitySalzburgAustria

To the Editor,Marfan syndrome is an autosomal dominant disorder of connective tissue caused by mutations in the gene encoding a matrix component of microfibrils;fibrillin-1(FBN1),with an incidence of about 1-3 per 10,000 individuals.2.3 Cardinal manifestations include proximal aortic aneurysm,dislocation of the ocular lens,and long-bone overgrowth.Dural ectasia,which is defined as a ballooning or significant widening of the dural sac or neural root sleeves,is also a common finding in these patients,which is reported to present in more than 60%of cases and is considered a major criterion for the clinical diagnosis of this syndrome.

关键词： superficial Marfan balloon

Assessment of mechanism, type and severity of injury in multiple trauma patients： A cross sectional study of a trauma center in Iran

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Chinese Journal of Traumatology 2017年第2期20卷 75-80页

作者： Hamidreza Reihani Hossein Pirazghandi Ehsan Bolvardi Mohsen Ebrahimi Elham Pishbin Koorosh Ahmadi mahdi safdarian Soheil Saadat Vafa Rahimi-Movaghar Emergency Medicine Department Imam Reza Hospital Mashhad University of Medical Sciences Mashhad Iran Emergency Medicine Department Shahid Beheshti Hospital Sabzevar University of Medical Sciences Sabzevar Iran Department of Emergency Medicine Alborz University of Medical Sciences Karaj Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran

PurposeTo 精确地与在马什哈德指 Hasheminejad 大学医院的紧急情况部门的多重损伤在损伤 center.MethodsPatients 的伊朗的多重损伤病人估计损害的机制，类型和严厉，伊朗，从 2013 年 3 月进入了这生气部分研究到 2013 年 12 月。有... 详细信息

PurposeTo 精确地与在马什哈德指 Hasheminejad 大学医院的紧急情况部门的多重损伤在损伤 center.MethodsPatients 的伊朗的多重损伤病人估计损害的机制，类型和严厉，伊朗，从 2013 年 3 月进入了这生气部分研究到 2013 年 12 月。有损害严厉 20 的所有病人(ISS )> 9 在这研究被包括。数据分析被社会科学统计套装软体软件(版本 11.5 ) 和不到 0.05 被认为 differences.ResultsAmong 同样重要的 P 值执行 6306 个就医的损伤病人在这个时期期间， 148 有的 ISS > 9。男女比率是 80% 。病人的吝啬的年龄是(33.5 ??????? ‥??? ┲吗？？

关键词：事故，交通损害严厉 20 创伤和损害伊朗

Effect of Advanced Trauma Life Support program on medical interns＇ performance in simulated trauma patient management

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中华创伤杂志：英文版 2013年第3期16卷 145-148页

作者： Koorosh Ahmadi Mohammad Sedaghat mahdi safdarian Amir Masoud Hashemian Zahra Nezamdoust Mohammad Vaseie Vafa Rahimi-Movaghar Emergency Medicine Alborz University of MedicalSciences Karaj Iran Emergency Medicine Tehran University of MedicalSciences Tehran Iran 5th Year Medical Student Tehran University of MedicalSciences Tehran Iran Emergency Medicine Mashhad University of MedicalSciences Mashhad Iran Department of Ophthalmology Medical Researcher inPrivate Practice Tehran Iran General Practitioner Medical Researcher in PrivatePractice Tehran Iran Sina Trauma and Surgery Research Center Depart-ment of Neurosurgery Shariati Hospital Tehran Universityof Medical Sciences Tehran Iran Research Centre for Neural Repair University ofTehran Tehran Iran

Abstract：Since appropriate and timetable methods in trauma care have an important impact on patients' outcome,we evaluated the effect of Advanced Trauma Life Support (ATLS) program on medical interns'performance in simulated trauma patient management.Methods:A descriptive and analytical study before and after the training was conducted on 24 randomly selected undergraduate medical interns from Imam Reza Hospital in Mashhad,Iran.On the first day,we assessed interns' clinical knowledge and their practical skill performance in confronting simulated trauma patients.After 2 days of ATLS training,we performed the same study and evaluated their score again on the fourth day.The two findings,preand post-ATLS periods,were compared through SPSS version 15.0 software.P values less than 0.05 were considered statistically significant.Results:Our findings showed that interns' ability in all the three tasks improved after the training course.On the fourth day after training,there was a statistically significant increase in interns' clinical knowledge of ATLS procedures,the sequence of procedures and skill performance in trauma situations (P＜0.001,P=0.016 and P=0.01 respectively).Conclusion:ATLS course has an important role in increasing clinical knowledge and practical skill performance of trauma care in medical interns。

关键词： Advanced Trauma Life Support Care Knowledge Inservice training Wounds and injuries