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Phosalone-induced inflammation and oxidative stress in the colon: evaluation and treatment

World Journal of Gastroenterology 2016年第21期22卷 4999-5011页

作者： Seyedeh Farnaz Ghasemi-Niri Faheem Maqbool Maryam Baeeri mahdi gholami Mohammad Abdollahi Faculty of Pharmacy and Pharmaceutical Sciences Research Center Tehran University of Medical Sciences International Campus Tehran University of Medical Sciences

AIM: To investigate the side effects of phosalone on intestinal cells and to evaluate benefits of ellagic acid(EA) as a ***: In order to conduct an in vivo study, a rat model was used. The rats were divided into ten groups based on the materials used in the experiment and their dosage. The first group was fed normally. The second group was administered EA through gavage. Next Four groups were given(1/3, 1/5, 1/10, 1/20) LD50 phosalone; an organophosphorus compound. The last four groups received(1/3, 1/5, 1/10, 1/20) LD50 phosalone and of EA. After one month, the rats were sacrificed and their colon cells were examined to evaluate the level of inflammation, proteins and oxidative stress ***: The results of this research show that phosalone elevates oxidative stress and changes the level of tumor necrosis factor-a(TNF-α), interlukin-6β(IL-6β) and nuclear factor(NF)-κB proteins. EA administration reduced phosalone toxicity and changed oxidative stress and inflammatory markers for all phosalone doses. Overall changes in reduction of TNF-α(230.47 ± 16.55 pg/mg protein vs 546.43 ± 45.24 pg/mg protein, P < 0.001), IL-6β(15.85 ± 1.03 pg/mg protein vs 21.55 ± 1.3 pg/mg protein, P < 0.05), and NF-κB(32.47 ± 4.85 pg/mg protein vs 51.41 ± 0.71 pg/mg protein, P < 0.05) manifest that the efficacy of EA is more viable for 1/3 LD50 dose of phosalone. Furthermore, EA is effective to counteract the negative outcomes of oxidative stress. When EA was used to treat 1/3 LD50 of phosalone's side effects, it improved the level of ACh E activity(48.5% ± 6% vs 25% ± 7%, P < 0.05), TTM(0.391 ± 0.008 mmol/L vs 0.249 ± 0.032 mmol/L, P < 0.05), FRAP(46.04 ± 5.005 μmol/L vs 18.22 ± 1.9 μmol/L, P < 0.01) and MPO(0.222 ± 0.019 U/mg protein vs 0.387 ± 0.04 U/mg protein, P < 0.05). CONCLUSION: This research highlights that EA is effective to alleviate the side effects of phosalone by reducing the level of oxidative stress and inflammatory proteins.

关键词： Organophosphorus Phosalone Ellagic acid Inflammation Oxidative stress Colon

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Using AdaBoost Meta-Learning Algorithm for Medical News Multi-Document Summarization

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Intelligent Information Management 2013年第6期5卷 182-190页

作者： mahdi gholami Mehr Department of Computer and Information Technology Malek-Ashtar University of Technology Tehran Iran

Automatic text summarization involves reducing a text document or a larger corpus of multiple documents to a short set of sentences or paragraphs that convey the main meaning of the text. In this paper, we discuss about multi-document summarization that differs from the single one in which the issues of compression, speed, redundancy and passage selection are critical in the formation of useful summaries. Since the number and variety of online medical news make them difficult for experts in the medical field to read all of the medical news, an automatic multi-document summarization can be useful for easy study of information on the web. Hence we propose a new approach based on machine learning meta-learner algorithm called AdaBoost that is used for summarization. We treat a document as a set of sentences, and the learning algorithm must learn to classify as positive or negative examples of sentences based on the score of the sentences. For this learning task, we apply AdaBoost meta-learning algorithm where a C4.5 decision tree has been chosen as the base learner. In our experiment, we use 450 pieces of news that are downloaded from different medical websites. Then we compare our results with some existing approaches.

关键词： Multi-Document Summarization Machine Learning Decision Trees AdaBoost C4.5 Medical Document Summarization

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An Expert System for Advising to Buy a FootballPlayer Using Visual Prolog

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Intelligent Information Management 2012年第4期4卷 134-137页

作者： mahdi gholami mehr Hossein Shirazi Department of Computer and Information Technology Malek-Ashtar University of Technology Tehran Iran

This work presents the design of an Expert System that aims to advice the club teams to buy a football player in the post that they needed. Suggesting different player in many posts by an expert person is based on football experience, knowledge about the player and the club that he works. For mechanization the ability of this person, we use Expert System because it can model the ability of a person in solving a problem. Visual Prolog language is used as a tool for designing our Expert System.

关键词： Artificial Intelligence Expert System Visual Prolog Football Adviser

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Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: role of α-pinene

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Journal of Traditional Chinese Medicine 2017年第1期37卷 57-63页

作者： Zahra Memariani Mohammad Sharifzadeh Mahbubeh Bozorgi Mannan Hajimahmoodi Mohammad Hosein Farzaei mahdi gholami Farideh Siavoshi Parastoo Saniee Department of Traditional Pharmacy School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Research Center of Traditional Medicine and History of Medical Sciences Babol University of Medical SciencesMazandaran ***Iran Department of Pharmacology and Toxicology Faculty of Pharmacyand Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehran ***Iran Department of Drug and Food Control Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Faculty of PharmacyKermanshah University of Medical SciencesKermanshah ***Iran Medical Biology Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Department of Microbiology School of BiologyUniversity College of SciencesUniversity of TehranTehran ***Iran

OBJECTIVE: To evaluate the efficacy of Pistacia atlantica Desf. oleoresin essential oil on peptic ulcer(PU) and its antibacterial effect on metronidazole-resistant Helicobacter pylori, as well as chemi-cal composition of the essential ***: The essential oil was standardized using gas chromatography mass spectrometry(GC/MS) analysis. Acute toxicity of the essential oil was assessed in animal model. In vitro anti-Helicobacter pylori activity was performed through disc diffusion and minimum inhibitory concentration method. For gastroprotective assay, rats received Pistacia atlantica Desf. essential oil(25, 50 and 100 mg/kg orally) 1 h before induction of ulcer by ***(ulcer index and protection rate) and microscopic examination were ***: The GC/MS analysis of the essential oil led to the identification of twenty constituents andα-pinene is predominant constituent. The essential oil was safe up to 2000 mg/kg. All Helicobacter pylori strains were susceptible to the essential oil and the MIC ranged from 275 to 1100 μg/m L. The ulcer index for treated groups was significantly reduced compared to control(P < 0.001) with EC50 value of 12.32 mg/kg. In microscopic examination, Pistacia atlantica attenuated destruction and necrosis of gastric ***: Current study exhibited protective effect of standardized Pistacia atlantica essential oil against ethanol-induced gastric ulcer and its antibacterial activity on Helicobacter pylori. α-pinene might be the responsible agent.

关键词： Peptic ulcer Pistacia Oils volatile Oleoresins Gastroprotective Helicobacter pylori Medicine traditional

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Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 101-122页

作者： M.gholami M.EFTEKHARI Department of Mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGM) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGM pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGM composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGM porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Fatigue Reliability Analysis of Fiber-Reinforced Laminated Composites by Continuum Damage Mechanics

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Acta Mechanica Solida Sinica 2023年第3期36卷 469-476页

作者： Peyman gholami Aerospace Research Institute Ministry of ScienceResearch and TechnologyTehranIran

This paper investigates the reliability of composite laminates with various lay-ups under fatigue *** prediction of failure probability of composite laminates subjected to different loads involves many uncertainties associated with mechanical properties,loading,and boundary *** in the composite material is truly hard to trace because there are individual faults in each ply,and we face a stochastic process due to the scatter in the mechanical *** continuum damage mechanics(CDM),as a powerful approach,is applied to model the damage of fiber,matrix,and fiber/matrix *** method defines criteria for damage detection and determines safe *** material constitutive equations are executed using a subroutine *** first-order reliability method and second-order reliability method have been applied to examine the reliability of laminated *** results are compared with those of the Monte Carlo *** composite laminates under different stress levels are considered for the failure probability *** limit state functions and random variables have been determined based on the CDM ***,the effects of the number of cycles,applied stress,and stacking sequence of the laminate on the reliability and fatigue life in fiber-reinforced laminated composites are assessed.

关键词： Composite laminate Continuum damage mechanics Fatigue damage First-order reliability method Second-order reliability method Monte Carlo simulation

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Multi-criteria prioritization of the renewable power plants in Australia using the fuzzy logic in decision-making method(FMCDM)

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Clean Energy 2022年第1期6卷 16-34页

作者： Amin Aryanfar Aslan gholami Payam Ghorbannezhad Bijan Yeganeh mahdi Pourgholi Majid Zandi Svetlana Stevanovic Faculty of Mechanical and Energy Engineering Shahid Beheshti UniversityTehranIran Faculty of New Technologies and Energy Engineering Shahid Beheshti UniversityTehranIran Faculty of Civil Water&Environmental EngineeringShahid Beheshti UniversityTehranIran Centre for Air Pollution Energy and Health ResearchGlebeNew South Wales 2037Australia Faculty of Electrical Engineering Shahid Beheshti UniversityTehranIran Faculty of Science Engineering&Built EnvironmentSchool of EngineeringDeakin UniversityGeelongVictoria 3220Australia

The presented study focused on developing an innovative decision-making framework to select the best renewable-power-plant technologies,considering comprehensive techno-economic and environmental *** to the favourable conditions,Australia was selected as the case study.A fuzzy-logic method and analytical hierarchy process were applied to prioritize different renewable-energy power *** techno-economic factors included levelized cost of energy,initial cost,simple payback time,and operation and maintenance costs along with environmental factors including carbon payback time,energy payback time and greenhouse-gas emissions were used to rank the power *** results showed that the capital cost and simple payback time had the highest priority from an economic point of *** comparison,greenhouse-gas emissions and carbon payback time were the dominant environmental *** analysis results provided economic and environmental priority tables for developing different power plants in the current state and a future scenario by *** fuzzy results and pairwise composite matrix of alternatives indicated that the onshore wind,offshore wind,single-axis tracker polycrystalline photovoltaic,single-axis tracker monocrystalline photovoltaic,fix-tilted polycrystalline photovoltaic and fix-tilted monocrystalline photovoltaic scored the highest in the current *** contrast,by 2030,the single-axis tracker photovoltaic power plants will be the best choice in the future scenario in ***,the results were used and analysed to recommend and suggest several policy implementations and future research studies.

关键词： photovoltaic wind fuzzy logic analytical hierarchy process prioritization

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Synthesis and characterization of niobium-promoted cobalt/iron catalysts supported on carbon nanotubes for the hydrogenation of carbon monoxide

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燃料化学学报 2016年第7期44卷 815-821页

作者： Zahra gholami Noor Asmawati Mohd Zabidi Fatemeh gholami Mohammadtaghi Vakili Centralized Analytical Laboratory Universiti Teknologi PETRONAS Department of Fundamental and Applied Sciences Universiti Teknologi PETRONAS Department of Mechanical Engineering Faculty of EngineeringUniversity of Malaya School of Industrial Technology Universiti Sains Malaysia

Bimetallic Co /Fe catalysts supported on carbon nanotubes( CNTs) were prepared,and niobium( Nb) was added as promoter to the 70 Co ∶30Fe /CNT catalyst. The physicochemical properties of the catalysts were characterized,and the catalytic performances were analyzed at the same operation conditions( H_2 ∶CO( volume ratio) = 2 ∶1,p = 1 MPa,and t = 260 ℃) in a tubular fixed-bed microreactor system. The addition of Nb to the bimetallic catalyst decreases the average size of the oxide nanoparticles and improves the reducibility of the bimetallic catalyst. Evaluation of the catalyst performance in a Fischer-Tropsch reaction shows that the catalyst results in high selectivity to methane,and the selectivity to C_(5+) increased slightly in the bimetallic catalyst unlike that in the monometallic catalysts. The addition of 1% Nb to the bimetallic catalyst increases CO conversion and selectivity to C_(5+). Meanwhile,a decrease in methane selectivity is observed.

关键词： Fischer-Tropsch synthesis bimetallic catalyst niobium promoter carbon nanotubes

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Edge Coloring of Graphs with Applications in Coding Theory

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China Communications 2021年第1期18卷 181-195页

作者： Ghaffar Raeisi Mohammad gholami Department of Mathematical Sciences Shahrekord UniversityShahrekordP.O.Box 115Iran

In this paper,a new type of edge coloring of graphs together with an algorithm for such an edge coloring is presented to construct some columnweight three low-density parity-check(LDPC)codes whose Tanner graphs are free of *** kind of edge coloring is applied on some well-known classes of graphs such as complete graphs and complete bipartite graphs to generate some column-weight 3 LDPC codes having flexibility in terms of code length and ***,the constructed(3;k)-regular codes with regularities k=4;5;:::;22 have lengths n=12;20;26,35;48;57;70;88;104;117;140;155;176;204;228;247;280;301;330;having minimum block length compared to the best known similar codes in the *** addition to linear complexity of generating such parity-check matrices,they can be considered as the base matrices of some quasi-cyclic(QC)LDPC codes with maximum achievable girth 18,which inherit the low-complexity encoder implementations of QC-LDPC *** results show that the QC-LDPC codes with large girth lifted from the constructed base matrices have good performances and outperform random codes,progressive edge growth LDPC codes,some finite fields and group rings based QC-LDPC codes and also have a close competition to the standard IEEE 802.16e(WiMAX)code.

关键词： low-density parity-check code edge coloring Quasi-cyclic LDPC code girth AWGN channel

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Some Explicit Constructions of Type-Ⅱ,Ⅲ,Ⅳ,Ⅴ QC-LDPC Codes with Girth 6

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China Communications 2020年第5期17卷 89-109页

作者： Farzaneh Abedi Mohammad gholami Department of Mathematics Shahrekord UniversityP.O.Box 88186-34141ShahrekordIran School of Computer Sciences Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5746TehranIran

Multi-type quasi-cyclic(QC) low-density parity-check(LDPC) codes can be considered as multiple-edge protograph QC-LDPC codes having some advantages in the minimum Hamming distance bound over single-edge protograph codes or type-Ⅰ QC-LDPC codes when the base matrices have the same size. In this paper, we investigate a class of multi-type QC-LDPC codes whose parity-check matrices contain just one blockrow of circulants and we obtain the generator matrix of such codes in general form. Using the permutation arrays and defining injection arrays, we present a new approach to construct a class of high-rate type-Ⅰ QC-LDPC codes with girth 6 from the constructed 4-cycle free multi-type QC-LDPC codes. In continue, for 2 ≤ w≤6, some type-w QC-LDPC codes with girth 6 are constructed explicitly such that the constructed codes are flexible in terms of rate and length. To the best of our knowledge, for w = 5,6, this is the first paper which deals with the explicit construction of type-w QC-LDPC codes with girth 6 and high rates. Moreover, for w = 3, 4, the constructed type-w QC-LDPC codes have better(6,8)-cycle multiplicities than the codes with minimum achievable length recently constructed by cyclic difference families(CDFs). Simulation results show that the binary and non-binary constructed codes outperform the constituent underlying QC-LDPC codes.

关键词： QC-LDPC codes permutation arrays girth explicit constructions

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