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Revealing high-dimensional dynamical symmetry in alignment magnetic resonance

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： M.suhail Zubairy Institute for Quantum Science and Engineering (IQSE) and Department of Physics and Astronomy Texas A&M University

Symmetry permeates throughout science, underlying people's understanding on intriguing physical properties. These include conserved quantities, critical phenomena and selection rules. Dynamical symmetry, the counterpart of geometrical symmetry or static symmetry referring to the geometrical shape or structure of a physical system, is present in the motion behavior.

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Robust Machine Learning Technique to Classify COVID-19 Using Fusion of Texture and Vesselness of X-Ray Images

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1981-2004页

作者： Shaik Mahaboob Basha Victor Hugo Cde Albuquerque Samia Allaoua Chelloug Mohamed Abd Elaziz Shaik Hashmitha Mohisin suhail Parvaze Pathan Department of Electronics and Communication Engineering N.B.K.R.Institute of Science&TechnologyVidyanagarAndhra Pradesh524413India Department of Teleinformatics Engineering Federal University of CearáFortaleza60455-970Brazil Information Technology Department College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh84428Saudi Arabia Department of Mathematics Faculty of ScienceZagazig UniversityZagazig44519Egypt Faculty of Computer Science and Engineering Galala UniversitySuez435611Egypt Artificial Intelligence Research Center(AIRC) College of Engineering and Information TechnologyAjman UniversityAjmanUnited Arab Emirates Department of Electrical and Computer Engineering Lebanese American UniversityByblos13-5053Lebanon Department of Avionics Indian Institute of Space Science and TechnologyThiruvananthapuramKerala695547India Department of Veterinary Clinical Sciences University of MinnesotaSt.PaulMinnesota55108USA

Manual investigation of chest radiography(CXR)images by physicians is crucial for effective decision-making in COVID-19 ***,the high demand during the pandemic necessitates auxiliary help through image analysis and machine learning *** study presents a multi-threshold-based segmentation technique to probe high pixel intensity regions in CXR images of various pathologies,including normal *** information is extracted using gray co-occurrence matrix(GLCM)-based features,while vessel-like features are obtained using Frangi,Sato,and Meijering *** learning models employing Decision Tree(DT)and RandomForest(RF)approaches are designed to categorize CXR images into common lung infections,lung opacity(LO),COVID-19,and viral pneumonia(VP).The results demonstrate that the fusion of texture and vesselbased features provides an effective ML model for aiding *** ML model validation using performance measures,including an accuracy of approximately 91.8%with an RF-based classifier,supports the usefulness of the feature set and classifier model in categorizing the four different ***,the study investigates the importance of the devised features in identifying the underlying pathology and incorporates histogrambased *** analysis reveals varying natural pixel distributions in CXR images belonging to the normal,COVID-19,LO,and VP groups,motivating the incorporation of additional features such as mean,standard deviation,skewness,and percentile based on the filtered ***,the study achieves a considerable improvement in categorizing COVID-19 from LO,with a true positive rate of 97%,further substantiating the effectiveness of the methodology implemented.

关键词： Chest radiography(CXR)image COVID-19 classifier machine learning random forest texture analysis

Nitrosamines crisis in pharmaceuticals Insights on toxicological implications, root causes and risk assessment: A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

Recent advances in 3D printed electrode materials for electrochemical energy storage devices

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Journal of Energy Chemistry 2023年第6期81卷 272-312,I0008页

作者： suhail Mubarak Duraisami Dhamodharan Hun-Soo Byun Department of Chemical and Biomolecular Engineering Chonnam National UniversityYeosuJeonnam 59626Republic of Korea Greenlab Department of prosthodonticsSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennaiTamil Nadu 600077India

Electrochemical energy storage(EES)systems like batteries and supercapacitors are becoming the key power sources for attempts to change the energy dependency from inadequate fossil fuels to sustainable and renewable *** energy storage devices(EESDs)operate efficiently as a result of the construction and assemblage of electrodes and electrolytes with appropriate structures and effective *** manufacturing procedures have restrictions on regulating the morphology and architecture of the electrodes,which would influence the performance of the devices.3D printing(3DP)is an advanced manufacturing technology combining computer-aided design and has been recognised as an artistic method of fabricating different fragments of energy storage devices with its ability to precisely control the geometry,porosity,and morphology with improved specific energy and power *** capacity to create mathematically challenging shape or configuration designs and high-aspect-ratio 3D architectures makes 3D printing technology unique in its ***,the control settings,interactive manufacturing processes,and protracted post-treatments will affect the reproducibility of the printed *** intelligent software,sophisticated control systems,high-grade industrial equipment,and post-treatment-free methods are necessary to develop.3D printed(3DPd)EESDs necessitate dynamic printable materials and composites that are influenced by performance criteria and fundamental ***,we review the recent advances in 3DPd electrodes for EES *** emphasis is on printable material synthesis,3DP techniques,and the electrochemical performance of printed *** the fabrication of electrodes,we concentrate on major 3DP technologies such as direct ink writing(DIW),inkjet printing(IJP),fused deposition modelling(FDM),and stereolithography3DP(SLA).The benefits and drawbacks of each 3DP technology are extensively di

关键词： 3D printing 3D printed electrodes Electrochemical energy storage Lithium-ion battery Zinc-ion battery Supercapacitor

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Tolerance protocol of living kidney transplant for developing countries through basic strategy of lymphocyte depletion

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World Journal of Transplantation 2022年第6期12卷 112-119页

作者： Sufi M suhail Department of Renal Medicine Singapore General HospitalSingapore 169856Singapore Department of Clinical Research Duke-NUS Graduate Medical SchoolSingapore 169856Singapore

End-stage kidney failure(ESKD)is a global issue where kidney replacement therapy imposes enormous economic burden to people of developing countries,in addition to the severe limitations to the availability of hemodialysis and peritoneal dialysis *** best option of kidney transplantation also requires lifelong combination immunosuppressive medicines,the cost of which is equally comparable to lifelong dialysis.A strategy of achieving transplant tolerance that requires minimum immunosuppressive medicines,although in experimental stage,also requires state-of-art technology with costly medicines and *** is evidently beyond the reach of ESKD patients of developing ***,globally in developing countries,a need for an innovative but cost-effective tolerance protocol is a burning need for a successful transplant *** brief,transplant tolerance is defined as a state of donorspecific unresponsiveness to the allograft antigens without the need for ongoing pharmacologic immunosuppression or with a minimal *** state-of-art techniques involves:(1)A state of hematological chimera,for complete tolerance;(2)Prope or partial tolerance where immune-reactive T-lymphocytes are inhibited using monoclonal antibodies;and(3)Chimeric antigen receptor for T-regulatory(T-reg)cell therapy using genetically engineered T-reg cells targeting specific Tlymphocyte receptors for inducing *** our real-world experience in transplant management in post-transplant lympho-proliferative disorders(PTLD),we noticed frequently a drastic reduction in the need of immunosuppressive medicines following lympho-ablative therapy for *** recently published a case study on a real-world experience transplant case where we explained a partial or prope tolerance that developed after lymphocyte ablation therapy,following which the allograft was maintained with low dose dual standard immunosuppressive *** on this publication,we propose here an innovat

关键词： Renal allograft B and T lymphocytes depletion Tolerance protocol Immunosuppressive medicines Living renal transplant

Evidence-based approach to management of hepatic encephalopathy in adults

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World Journal of Hepatology 2022年第4期14卷 670-681页

作者： Gilles Jadd Hoilat Fathima Keshia suhail Talal Adhami Savio John Department of Medicine SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Gastroenterology Cleveland Clinic FoundationClevelandOH 44195United States Department of Gastroenterology SUNY Upstate Medical UniversitySyracuseNY 13210United States

Hepatic encephalopathy(HE)is a reversible syndrome of impaired brain function and represents one of the many complications of portal hypertension and decompensated liver *** ammonia is clearly implicated in the pathogenesis of HE,the pathogenesis of HE is multifactorial with numerous mechanisms that results in functional impairment of neuronal *** initial management of HE focuses on supportive care and stabilization which includes providing appropriate nutritional ***,focus should be on identifying and treating the precipitating *** are many therapeutic agents available for the management of HE,most of which are directed towards lowering the gut nitrogen load and thus the serum ammonia *** review aims to provide an update on the conventional and emerging treatment options for HE.

关键词： Hepatic encephalopathy Lactulose Rifaximin Fecal microbiota transplant Zinc L-ornithine L-aspartate

General Formalism for the BRST Symmetry

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Communications in Theoretical Physics 2013年第4期59卷 439-442页

作者： suhail Ahmad Departmet of Physics Jamia Millia Islamia University

In this paper we will discuss Faddeev-Popov method for gauge theories with a general form of gauge symmetry in an abstract way. We will then develope a general formalism for dealing with the BRST symmetry. This formal... 详细信息

关键词： BRST symmetry Faddeev-Popov method

Biochemical association between the prevalence of genetic polymorphism and myocardial infarction

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BIOCELL 2023年第3期47卷 473-484页

作者： MOMINA SHAHID KANWAL REHMAN MUHAMMAD SAJID HAMID AKASH SHALEEM suhail SUMBAL RASHEED MUHAMMAD IMRAN MOHAMMED AASSIRI Department of Pharmaceutical Chemistry Government College UniversityFaisalabad38000Pakistan Department of Pharmacy The Women UniversityMultan60000Pakistan Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha62413Saudi Arabia Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha62413Saudi Arabia

Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction(MI).Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state.A single gene can exhibit genetic polymorphism at more than one position giving rise to different *** polymorphism of angiotensinogen(AGT)M235T,AGT T174M,and angiotensin-1-converting enzyme(ACE)I/D,endothelial nitric oxide synthase(eNOS),and methylenetetrahydrofolate reductase(MTHFR)can be a risk factor for ***,it is important to study the prevalence of genetic polymorphisms of these genes among different *** is influenced by genetic polymorphism of various genes,including AGT,ACE,eNOS,MTHFR,***,the association of genetic polymorphism of these genes varies among different populations,but different ethnic groups could show contradictory *** genes have shown a positive association with risks of MI in some populations,whereas the results have not been consistent with every ethnic *** this article,we have summarized the genetic variations in the aforementioned genes and their association with MI.

关键词： Endothelial nitric oxide synthase Methylenetetrahydrofolate reductase AGT M235T AGT T174M