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Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system

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Cellular & Molecular Immunology 2021年第1期18卷 162-170页

作者： Anil K.Singh mahamudul haque Kayla O'Sullivan Mukesh Chourasia Madhu M.Ouseph Salahuddin Ahmed Department of Pharmaceutical Sciences Washington State University College of PharmacySpokaneWAUSA Center for Computational Biology and Bioinformatics Amity Institute of BiotechnologyAmity UniversityNoidaUttar PradeshIndia Department of Pathology Stanford University School of MedicineStanfordCAUSA Division of Rheumatology University of Washington School of MedicineSeattleWAUSA

Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)***,the post-translational mechanisms involved and the role of signaling proteins in this activation are *** the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 ***-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase *** the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 *** MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 *** studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase ***,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 *** of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 *** study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation.

关键词： Monosodium urate crystals Gout TAK1 Ubiquitination 5Z-7-oxozeaenol

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Job Satisfaction and Its Implications At the City Bank Limited

Job Satisfaction and Its Implications At the City Bank Limit...

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作者： mahamudul Alam 山东大学

学位级别：硕士

这项研究的动机旨在确定员工的工作满意度,以留住城市银行有限公司的员工,并为其战略提出一些建议。从该组织收集的各种书籍,期刊,文章,报告,在线资料和一些主要数据已被描述和证明是合理的。描述性研究用于进行本研究,因为它最适合实... 详细信息

这项研究的动机旨在确定员工的工作满意度,以留住城市银行有限公司的员工,并为其战略提出一些建议。从该组织收集的各种书籍,期刊,文章,报告,在线资料和一些主要数据已被描述和证明是合理的。描述性研究用于进行本研究,因为它最适合实现该项目的目标。收集了主要和次要数据以用于本研究。根据从CBL官员处收集的公司手册,HR Manuel,其他文件,报告和主要数据收集的数据,进行了三角测量分析。基于方法的研究方法是演绎的。调查是通过问卷调查来衡量员工的观点,20名受访者是在员工中随机选择的,结果非常令人满意。该审查旨在评估CBL银行官员在孟加拉国的工作履行情况。

关键词：商业银行员工管理工作满意度

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Some reproductive and biometric features of the endangered Gangetic Leaf Fish,Nandus nandus(Hamilton,1822):Implication to the baor fisheries management in Bangladesh

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Aquaculture and Fisheries 2021年第6期6卷 634-641页

作者： Md mahamudul Hasan Mredul Md Rushna Alam Antara Binta Akkas Sadia Sharmin Shib Nath Pattadar Md Lokman Ali Faculty of Fisheries Patuakhali Science and Technology UniversityDumkiPatuakhali8602Bangladesh School of Environmental and Life Sciences University of New CastleCallaghanNSW2308Australia Department of Coastal Studies and Disaster Management University of BarisalBarisal8200Bangladesh School of Environment and Natural Resources The Ohio State UniversityColumbusOH43210USA

This study reflects the biometric characters of the endangered species Nandus nandus(Hamilton,1822)including sex ratio,length-length relationships(LLRs),and length-weight relationships(LWRs)utilizing the sum of 14 linear variables,various meristic measurements,reproductive biology,and condition factor from the Borni Baor,a large wetland ecosystem of southwestern Bangladesh.A total of 579 specimens of *** have been periodically collected from the Borni Baor throughout the year(January-December,2019)using different traditional fishing *** significant LLRs(r^(2)>0.90)values indicate that length parameters are profoundly associated with one *** the LWR formula(W=aL^(b)),higher exponent b values(b>3.0)were demonstrating a positive allometric growth with a high correlation coefficient(r^(2)>0.94).Moreover,monthly gonadosomatic index and dobriyal index fluctuations suggest the primary breeding season of this fish is from March to *** revealed the breeding time was associated strongly with the rainfall and air temperature(p<0.05).The results of our study exposed a cutting-edge biometric feature of this endangered species that would be applicable for fish stock evaluation and making management strategies and conservation policy for this valuable fish resource.

关键词： Sex ratio Length-length relationship Length-weight relationship GSI Baors

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股内侧带蒂皮瓣重建阴茎癌切除术后缺损龟头6例

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中华显微外科杂志 2024年第5期47卷 578-581页

作者：谢哲沙米·艾合买提 SM mahamudul Hassan Rizvi 柳辉陶圣祥武汉大学中南医院创伤与显微骨科湖北省创伤显微外科临床医学研究中心武汉430071

目的探讨股内侧带蒂皮瓣重建阴茎癌切除术后缺损龟头的临床疗效。方法回顾性研究自2021年1月至2023年8月,武汉大学中南医院创伤与显微骨科采用股内侧带蒂皮瓣治疗阴茎癌切除术后龟头缺损患者6例,年龄38~73岁,均因发现阴茎龟头肿瘤收住入... 详细信息

目的探讨股内侧带蒂皮瓣重建阴茎癌切除术后缺损龟头的临床疗效。方法回顾性研究自2021年1月至2023年8月,武汉大学中南医院创伤与显微骨科采用股内侧带蒂皮瓣治疗阴茎癌切除术后龟头缺损患者6例,年龄38~73岁,均因发现阴茎龟头肿瘤收住入院,病史1~17个月,平均7.5个月。病理结果:根据阴茎癌TNM分期标准,3例为pT1N0M0期,2例为pT_(2)N_(0)M_(0),1例为pT_(3)N_(x)M_(x)。切除后平均缩短1.2~1.4 cm,患者均取左侧股内侧皮瓣修复,面积为14.0 cm×6.0 cm~15.0 cm×8.0 cm,术后采用门诊复诊、微信联系,定期随访患者排尿及性生活情况,并进行勃起功能评分。结果术后患者皮瓣均顺利成活,皮瓣供区甲级愈合,术后随访时间6~20个月,平均10.2个月,1例患者存在尿道狭窄,排尿困难,予以尿道扩张后缓解,其余患者未见排尿困难,所有患者对阴茎外形均满意,自述术后可完成性生活,末次随访国际勃起功能指数问卷表-5(IIEF-5)评分为15~21分。1例患者出现肿瘤远处转移,局部未见异常。结论股内侧带蒂皮瓣是治疗阴茎癌切除术后龟头缺损的理想方法,可获得良好的重建效果。

关键词：阴茎癌龟头重建股内侧皮瓣显微外科技术

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Fake Profile Detection Using Machine Learning Techniques

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Journal of Computer and Communications 2022年第10期10卷 74-87页

作者： Partha Chakraborty Mahim Musharof Shazan mahamudul Nahid Md. Kaysar Ahmed Prince Chandra Talukder Department of Computer Science & Engineering Comilla University Cumilla Bangladesh

Our lives are significantly impacted by social media platforms such as Facebook, Twitter, Instagram, LinkedIn, and others. People are actively participating in it the world over. However, it also has to deal with the issue of bogus profiles. False accounts are frequently created by humans, bots, or computers. They are used to disseminate rumors and engage in illicit activities like identity theft and phishing. So, in this project, the author’ll talk about a detection model that uses a variety of machine learning techniques to distinguish between fake and real Twitter profiles based on attributes like follower and friend counts, status updates, and more. The author used the dataset of Twitter profiles, separating real accounts into TFP and E13 and false accounts into INT, TWT, and FSF. Here, the author discusses LSTM, XG Boost, Random Forest, and Neural Networks. The key characteristics are chosen to assess a social media profile’s authenticity. Hyperparameters and the architecture are also covered. Finally, results are produced after training the models. The output is therefore 0 for genuine profiles and 1 for false profiles. When a phony profile is discovered, it can be disabled or destroyed so that cyber security problems can be prevented. Python and the necessary libraries, such as Sklearn, Numpy, and Pandas, are used for implementation. At the end of this study, the author will come to the conclusion that XG Boost is the best machine learning technique for finding fake profiles.

关键词： Social Media Fake Profiles Random Forest Neural Networks XG Boost

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Antibiotic Susceptibility Pattern and Identification of Multidrug Resistant Novel Salmonella Strain in Poultry Chickens of Hathazari Region in Chattogram, Bangladesh

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Advances in Microbiology 2022年第2期12卷 53-66页

作者： Kamrun Nahar Islam Eshiika Eshaa mahamudul Hassan Tasneem Chowdhury Sifat Uz Zaman Department of Microbiology University of Chittagong Chattogram Bangladesh Infection Prevention and Control Division Medlife Healthcare Limited Dhaka Bangladesh

Poultry chickens are potential source of transmission of zoonotic Salmonella, into human food chain, causing food-borne illness and also hindering development of poultry industry in Bangladesh. The non-judicious uses of antibiotics in poultry farm have increased the multidrug resistant bacteria. So, this study reports the occurrence of Salmonella in poultry samples (meat, egg, liver and cloacal swab) and the antimicrobial resistance pattern of the isolates. This study was carried out throughout the period of May 2019-March 2020, at the bacteriological laboratory in the Department of Microbiology, University of Chittagong. Isolates were identified on the basis of cultural and biochemical tests from a total of 25 broiler samples (meat, liver, eggshell and cloacal swab). Antibiotic susceptibility pattern was observed using Kirby-Bauer disk diffusion method. The overall detection rate of Salmonella was 48% (12/25) and the highest occurrence was noticed in raw meat 62.5% and the lowest in liver (37.5%). The antimicrobial resistance tests revealed that all the isolates (n = 12) exhibited 100% resistance to vancomycin and cephalexin, followed by ampicillin (75%), nalidixic acid (58.33%), chloramphenicol (41.66%), doxycycline (50%), and neomycin (50%). On the other hand, ciprofloxacin showed 83.33%, ceftazidime and amoxicillin showed 91.6% sensitivity respectively. A considerably high proportion of isolates (11/12, 91.67%) was resistant to three or more antibiotics and 6 multidrug profiles were observed. The ampicillin-chloramphenicol-nalidixic acid-neomycin-cephalexin-doxycycline-vancomycin (4/12) was more frequently observed phenotype in multidrug profiles. Finally, two multidrug-resistant strains of Salmonella were identified and classified based on their 16S ribosomal RNA gene sequences as Salmonella enterica subsp. enterica strain Eshaa2 and Salmonella enterica subsp. enterica strain Eshiika3 at NCBI GenBank with Accession no. MT163513 and MT164531 respectively. So, mo

关键词： Antimicrobial Resistance Chicken Meat Multidrug-Resistant Salmonella Salmonellosis

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Holistic Approach to Safety and Operational Stability: Analyzing VVER-1200 Reactor Dynamics in SGTR and AC Power Loss

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Journal of Power and Energy Engineering 2024年第9期12卷 102-130页

作者： Shaon Md Tariqur Rahman Md. Sadman Anjum Joarder Antor mahamudul Hashan Sharon Md Mahabubur Rahman Redar Hameed Ali Institute of New Materials and Technologies Ural Federal University Yekaterinburg Russia Department of Mechanical Engineering Rajshahi University of Engineering & Technology Rajshahi Bangladesh Institute of Fundamental Education Department of Intelligent Information Technologies Ural Federal University Yekaterinburg Russia Department of Textile Engineering Khulna University of Engineering and Technology Khulna Bangladesh Institute of Economic and Management Ural Federal University Yekatringburg Russsia

VVER-1200 (Water-Water Energetic Reactor) represents a significant advancement in nuclear power generation, emphasizing the continuous analysis and enhancement of safety systems for reliable operation. The proposed study focuses on simulating combined scenarios involving steam generator tube rupture (SGTR) and AC power loss using core algorithms and models within personal computer transient analyzer (PCTRAN). Reactor kinetic equations, thermal-hydraulic balance, and safety system models are discussed to elucidate their role in simulating SGTR and AC power loss. Safety criteria, boundaries and initial conditions are outlined to provide a comprehensive understanding of the simulation framework. The analysis delves into dynamic behavior of VVER-1200, placing emphasis on thermal-hydraulic implications, essential reactor parameters, and radiation monitoring to facilitate impact evaluation. Continuous monitoring and maintenance of safety systems are underscored to ensure stable core cooling, particularly during proposed transient conditions. Through meticulous analysis and comparison with established benchmarks, this study contributes to bolstering the safety and reliability of VVER-1200 reactors by identifying vulnerabilities, assessing mitigation strategies, and refining emergency response protocols. Practical implications of this study offer a crucial understanding of reactor behavior, safety system performance, and emergency response strategies, thereby improving safety, optimizing operational practices, and reducing risks in nuclear reactor accidents.

关键词： VVER-1200 Nuclear Technology Safety Systems Operational Efficiency Transient Events

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精索内静脉-腹壁下静脉双flow-through超引流技术治疗精索静脉曲张应用解剖

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中华实验外科杂志 2024年第4期41卷 840-842页

作者： S M mahamudul Hassan Rizvi 王莉沙米·艾合买提柳辉陈熹张之涵汪迎晖陶圣祥武汉大学中南医院创伤与显微骨科武汉430062 武汉市第六医院综合科武汉430014 武汉大学中南医院综合超声医学科武汉430062

目的观察成人腹壁下血管穿过腹股沟区域时的直径、血流速度、血管位置、血管长度,为精索静脉曲张双flow-through超引流技术提供解剖依据。方法2023年7月至2023年11月在武汉大学中南医院对30例年龄在20~30岁之间的成年男性进行B超检查,... 详细信息

目的观察成人腹壁下血管穿过腹股沟区域时的直径、血流速度、血管位置、血管长度,为精索静脉曲张双flow-through超引流技术提供解剖依据。方法2023年7月至2023年11月在武汉大学中南医院对30例年龄在20~30岁之间的成年男性进行B超检查,测量腹壁下静脉,腹壁浅静脉直径、血流速度,计量资料以均数±标准差(±s)表示,并进行文献查阅,查出腹壁下血管在腹股沟区域的走行及精索静脉曲张时的静脉管径及流速。并且在两具人体标本上进行精索内静脉-腹壁下静脉双flow-through超引流模拟手术,总结经验,得出较好的手术方法。组间比较采用t检验。结果通过B超测得的腹壁下动脉直径[(2.3±0.2)mm]大于腹壁浅动脉[(1.4±0.2)mm,t=10.312,P0.05],腹壁下静脉流速[(1.77±0.23)cm/s]小于腹壁浅静脉流速[(3.03±0.58)cm/s,t=-6.017,P<0.01]。结论精索静脉曲张腹壁下静脉双flow-through超引流技术临床应用价值较高。

关键词：精索静脉曲张静脉分流术显微外科腹股沟血管

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负载蛋白聚糖4的温度敏感性聚己内酯-聚乙二醇-聚己内酯可注射水凝胶对软骨修复的影响

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中华实验外科杂志 2023年第12期40卷 2520-2524页

作者：陶圣祥张之涵柳辉陈熹沙米·艾合买提瑞之曾忠华武汉大学中南医院创伤与显微骨科武汉430062 武汉大学中南医院骨科中心武汉430062

目的探讨负载蛋白聚糖4(PRG4)的温度敏感性聚己内酯-聚乙二醇-聚己内酯共聚物(PCEC)可注射水凝胶材料表征及修复新西兰兔软骨缺损的效果。方法2022年3月至2023年6月,利用PCEC温敏性水凝胶负载了PRG4效应因子(PRG4@PCEC),使用扫描电子显... 详细信息

目的探讨负载蛋白聚糖4(PRG4)的温度敏感性聚己内酯-聚乙二醇-聚己内酯共聚物(PCEC)可注射水凝胶材料表征及修复新西兰兔软骨缺损的效果。方法2022年3月至2023年6月,利用PCEC温敏性水凝胶负载了PRG4效应因子(PRG4@PCEC),使用扫描电子显微镜观察冷冻干燥的PRG4@PCEC水凝胶的形貌,测量PCEC和PRG4@PCEC水凝胶的最低共溶温度;使用活/死细胞染色技术评估水凝胶的生物安全性;采用雄性新西兰大白兔18只,36个膝关节缺损样本,随机分为3组,其中12个缺损组用PRG4@PCEC水凝胶修复,12个缺损组用PCEC水凝胶修复,12个缺损组为空白对照组,观察水凝胶的软骨修复能力;通过微型计算机断层扫描(Micro-CT)分析软骨下骨再生,标本组织切片苏木精-伊红(HE)、马松(Masson)染色及荧光定量聚合酶链反应(PCR)评估水凝胶对软骨缺损的修复作用。组间比较采用t检验。结果水凝胶具有明显的多孔微观结构,PCEC和PRG4@PCEC水凝胶分别在35℃和38℃表现出最低共溶温度;激光共聚焦观察活/死细胞染色结果证明PRG4@PCEC水凝胶对于兔软骨细胞具有良好的生物相容性;载有PRG4的水凝胶组在8周时,缺损已经完全被高含量的新生软骨组织填充,表明软骨缺损修复最佳;Micro-CT显示在8周时PCEC组[(37.33±0.39)mm^(3)]和PRG4@PCEC组[(25.33±0.21)mm^(3)]软骨下骨缺损体积均小于对照组[(51.57±0.49)mm^(3),t=32.19、69.56,P<0.01];切片染色显示PRG4@PCEC水凝胶组软骨下骨有效形成;荧光定量PCR结果显示在4周和8周PCEC组(2.79±0.07、2.18±0.10)与PRG4@PCEC组白细胞介素-1β(IL-1β)表达水平(1.54±0.07、0.80±0.10)均低于对照组(3.21±0.08、2.54±0.07,t=0.68、4.97、27.63、24.43,P<0.01),同时PCEC组(0.95±0.24、1.45±0.34)和PRG4@PCEC组Ⅱ型胶原蛋白(COL2)基因表达水平(1.19±0.45、1.53±0.26)高于对照组(0.64±0.07、1.01±0.14,t=7.47、0.08、10.70、3.12,P<0.05)。结论负载PRG4的温度敏感性PCEC可注射水凝胶具有良好的温度敏感性和生物安全性,对关节软骨缺损有明显修复作用。

关键词：软骨缺损负载蛋白聚糖4 聚己内酯-聚乙二醇-聚己内酯可注射水凝胶新西兰兔膝关节软骨缺损模型

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