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Phytochemical composition of Caesalpinia crista extract as potential source for inhibiting cholinesterase and β-amyloid aggregation: Significance to Alzheimer's disease

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Asian Pacific Journal of Tropical Biomedicine 2018年第10期8卷 500-512页

作者： Kolambe Rajappa Chethana Balappa Somappa Sasidhar mahadeva naika Rangappa Sangappa Keri Centre for Nano and Material Sciences Jain UniversityJain Global Campus Chemical Sciences and Technology Division CSIR-National Institute for InterdisciplinaryScience and Technology (CSIR-NIIST) Applied Nutrition Division Defence Food Research Laboratory

Objective: To screen plant extract fractions and elucidate the components present in Caesalpinia crista(C. crista) leaves for cholinergic and anti-amyloidogenic activities for the treatment of Alzheimer's diseases. Methods: This work has been carried out to study the action of C. crista extracts from nonpolar to polar solvents toward inhibition of oxidative stress, cholinergic and amyloidosis. The antioxidant activity was studied using DPPH total antioxidant assay; cholinergic assay by Ellman's method and anti-amyloidogenic assay by thioflavin-T fluorescence and transmission electron microscopy. Results: The quantification of polyphenols was carried out following C. crista methanolic extract(CCMeOH) HPLC fingerprinting, along with LC-MS and elucidated by MS LAMPS database. GC-MS of CCMeOH was screened for potential moieties. In vitro experimental results showed that the CCMe OH was potential extract that exhibited active inhibition of antioxidant property, cholinergic enzymes acetylcholinesterase and butyrylcholinesterase. For anti-amyloidogenic evaluations, among all the extracts, the CCMe OH was found to have the potential toward inhibiting the oligomers, fibrillation of Aβ42 with good defibrillation of amyloid cascading properties. Conclusions: These results are also supported by the presence of polyphenols as the active ingredients. Multi-potent target drug therapy is a promising option in treating the Alzheimer's diseases. Methanolic extract of C. crista shows potential activity against cholinergic enzymes, Aβ42 aggregation with antioxidant activity.

关键词： Alzheimer’s disease Caesalpinia crista Acetylcholinesterase Butyrylcholinesterase β-Amyloid

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Rauvolfia serpentina-Mediated Green Synthesis of CuO Nanoparticles and Its Multidisciplinary Studies

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Acta Metallurgica Sinica(English Letters) 2015年第9期28卷 1134-1140页

作者： K.Lingaraju H.Raja naika K.Manjunath G.Nagaraju D.Suresh H.Nagabhushana Department of Studies and Research in Environmental Science Tumkur University Centre for Nano and Material Sciences Jain University Department of Chemsitry Siddaganga Institute of Technology Department of Studies and Research in Chemistry Tumkur University Prof. C.N.R. Rao Center for Advanced Materials Tumkur University

Copper oxide nanoparticles （CuO Nps） were successfully synthesized by solution combustion method using aqueous leaf extract of Rauvolfia serpentina as a fuel. The structure and morphology of the CuO nanoparticles （Nps） were characterized by powder X-ray diffraction （PXRD）, UV-visible spectroscopy （UV-visible）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, etc. The PXRD patterns reveal the formation of monoclinic phase with crystallite structure. SEM images indicate that the particles have sponge-like structure being highly porous and agglom- erated with large surface area. The average crystallite sizes were found to be in the range of 10-20 nm by Scherrer＇s method. The CuO Nps size was further confirmed by TEM. Further, CuO Nps exhibit good photocatalytic activity for the photodegradation of trypan blue dye, indicating that it acts as a promising semiconducting material. The antibacterial properties of CuO nanoparticles were investigated against pathogenic bacterial strains, namely Gram -ve Escherichia coli （NCIM-5051） and Pseudomonas desmolyticum （NCIM-2028） and Gram ＋ve bacteria Staphylococcus aureus （NCIM- 5022） using the agar well diffusion method.

关键词： CuO Nanoparticles Rauvolfia serpentina Photocatalytic activity Antibacterial activity

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Asymptotic Comparison of Method of Moments Estimators and Maximum Likelihood Estimators of Parameters in Zero-Inflated Poisson Model

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Applied Mathematics 2012年第6期3卷 610-616页

作者： G. Nanjundan T. Raveendra naika Department of Statistics Bangalore University Bangalore India Maharani’s Science College for Women Bangalore India

This paper discusses the estimation of parameters in the zero-inflated Poisson (ZIP) model by the method of moments. The method of moments estimators (MMEs) are analytically compared with the maximum likelihood estima... 详细信息

关键词： Zero-Inflated Poisson Model Maximum Likelihood and Moment Estimators EM Algorithm Asymptotic Relative Efficiency

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