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Angiogenic and FLT3 Receptors Expression in Acute Lymphoblastic Leukemia in Pediatric Age Group

Journal of Cancer Therapy 2019年第6期10卷 442-457页

作者： Mona Hilmy Alrayes Reham Hammad Mohamed Abd Alazim Hussein EL Baddiny maha saleh madbouly ibrahim Mahmoud Hammad Clinical Pathology Department Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Clinical Pathology Department National Cancer Institute Cairo University Cairo Egypt Department of Pediatric Oncology National Cancer Institute Cairo University and Children’s Cancer Hospital Egypt Cairo Egypt

Angiogenesis has an important role in pathophysiology of cancer. FMS-like tyrosine kinase 3 (FLT3) is implicated in hematopoietic malignancies. Their role in childhood acute lymphoblastic leukemia (ALL) pathogenesis needs more enlightenment. Expression of vascular endothelial growth factor receptor-1 and -2 (VEGFR-1 and -2), as well as FLT3 were assessed by flow cytometry in bone marrow (BM) blasts of 55 newly diagnosed children with ALL. Patients included B cell ALL (B-ALL) group (n = 41) and T cell ALL (T-ALL) group (n = 14). Comparison between groups revealed a significant increase in blasts percent (%) expressing FLT3 and FLT3 intensity detected in B-ALL group (p = 0.004 and p = 0.02, respectively). In B-ALL patients, a significant positive correlation was seen between blasts % expressing FLT3 and blasts percentage infiltrating BM (r = 0.405;p = 0.009), also positive correlation was seen between % of blasts expressing VEGFR-1 and VEGFR-2 (r = 0.704;p 0.001). In T-ALL group, blast % expressing FLT3 revealed significant positive correlations with blast % expressing VEGFR-1, and those expressing VEGFR-2 (r = 0.627;p = 0.016, and r = 0.654;p = 0.011, respectively). In addition, significant correlation was seen in blasts % expressing all;FLT3, VEGFR-1 and -2, with blasts % expressing stem cell marker CD34 (r = 0.826;p = 0.001, r = 0.596;p = 0.041, and r = 0.798;p = 0.002, respectively). Conclusion: Expression of VEGFR-1, VEGFR-2 and FLT3 were demonstrated and linked on leukemic blasts of ALL which highlights their role in pathogenesis. FLT3 expression plays a role in facilitating blasts proliferation in BM in B-ALL. FLT3, VEGFR-1 and -2 could be used in future profiling of CD34+ leukemic stem cell pool in T-ALL.

关键词： Childhood Leukemia Angiogenesis Vascular Endothelial Growth Factor Receptors FLT3 Acute Lymphoblastic Leukemia

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Irritable Bowel Syndrome and Dietary Habits in Northern Saudi Arabia

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Health 2019年第3期11卷 289-297页

作者： saleh Hadi Alharbi Fahad A. Alateeq Khalil ibrahim Alshammari Abdulaziz Saad Sharea Alshammri Naif Abdulmohsen Naif Alabdali Motab Ali Saud Alsulaiman Sami Mamdouh ibrahim Algothi Abdulrahman Sulaiman Altoraifi maha Qasem Almutairi Hussain Gadelkarim Ahmed Faculty of Medicine Al-Imam Mohammad Ibn Saud Islamic University Riyadh KSA College of Medicine University of Hail Hail KSA Department of Histopathology and Cytology FMLS University of Khartoum Khartoum Sudan

Background: dietary habit is one of the most universally recounted initiators of irritable bowel syndrome (IBS). The objective of the present study was to determine the role of some dietary habits in the etiology of IBS in Northern Saudi Arabia. Methodology: In this community based cross-sectional survey, data about IBS were obtained from 930 Saudi volunteers living in the city of Hail, Northern Saudi Arabia. IBS was diagnosed using Rome IV criteria. Results: The prevalence of IBS was 11% among males vs. 12.5% among females. The prevalence of IBS symptoms among males was 30% vs. 36.5% females. IBS was significantly associated with reduced water intake, the RR (95% CI) = 1.1800 (1.0146 to 1.3722), P = 0.0316. In the present study, the majority of the study population 904/929 (97.3%) didn’t accustom to vegetables/fruits intake. Conclusion: IBS is prevalent in Northern Saudi Arabia, both among males and females with relatively increasing among females. Low water intake and insufficient fibers intake (particularly, in vegetables and fruits) might be behind the growing prevalence of IBS in Saudi Arabia.

关键词： Irritable Bowel Syndrome Dietary Habits Saudi Arabia

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