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Prevalence of Occupational Stress and Related Risk Factors among Nurses Working in ASEER Region

Health 2021年第2期13卷 110-122页

作者： maha mohammed ahmad aserri Fatma Mostafa Baddar Salha mohammed ahmad aserri Nursing Education & Administration Head of Academic Affair in ABHA Health Sector Ministry of Health Aseer Region Abha KSA Nursing Administration and Education Department College of Nursing King Saud University Al Riyadh KSA Nursing Administration Department Faculty of Nursing Alexandria University Alexandria Egypt Nursing Education & Administration Head of Academic Affair in General Directorate of Health Affairs ABHA Ministry of Health Aseer Region Abha KSA

Background: Over the last century, stress as an interdisciplinary concept has become an area of great interest and has been researched extensively. Although the earliest studies on stress were mostly physiological, psychological models of stress have been developed and established a link between stressors and illness in his model of general adaptation syndrome. Objective: To investigate prevalence and factors associated with occupational stress among nurses working Asser region Hospital. The study included nurses at different age groups working at different departments with assessment of any sources of stress. Methodology: A descriptive cross-sectional study was conducted targeting nurses in the main hospitals in the Asser region, Southern Saudi Arabia. A total of the study samples of 217 nurses were required to estimate the expected average stress rate among nurses. A self-administered pre-structured questionnaire used for data collection. Results: Nurses’ ages ranged 21 to 55 years old with mean age of 30.9 ± 11.7 years old. Majority of the nurses were females 175 (80.6%). The highest mean score (more stress) was reported by nurses in relation to the following stress factors;working very hard (4.3 ± 0.9), followed by being under pressure to work long hours (4.2 ± 0.9), the opportunity given to do something is not real and enough (4.2 ± 1.0). The findings showed a significant relationship between nurses’ stress level, their personal and work-related characteristics (P = 0.001). Recommendations: Interventional programs to detect and alleviate sources and effects of occupational stress should be developed including more training regarding coping strategies, nurses’ support, and better work condition.

关键词： Stress Nurses Workload Determinants Factors Associated Psychological Effect Work Environment

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A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

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Oncology Research 2024年第5期32卷 817-830页

作者： SHAHID KARIM ALANOUD NAHER ALGHANMI maha JAMAL HUDA ALKREATHY ALAM JAMAL HIND A.ALKHATABI mohammed BAZUHAIR AFTAB ahmad Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Health Information Technology Department The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia Pharmacovigilance and Medication Safety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Cancer frequently develops resistance to the majority of chemotherapy *** study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapagliflozin(DAP),Empagliflozin(EMP),and Doxorubicin(DOX),using in vitro *** precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their ***,when these medications were combined with DOX,there was a considerable inhibition of glucose consumption,as well as reductions in intracellular ATP and lactate ***,this effect was found to be dependent on the dosages of the *** addition to effectively inhibiting the cell cycle,the combination of CAN+DOX induces substantial modifications in both cell cycle and apoptotic gene *** work represents the initial report on the beneficial impact of SGLT2 inhibitor medications,namely CAN,DAP,and EMP,on the responsiveness to the anticancer properties of *** underlying molecular mechanisms potentially involve the suppression of the function of SGLT2.

关键词： SGLT2 Cancer Cytotoxicity ATP Cell cycle

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Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 207-214页

作者： Duaa M.Bakhshwin Foziya W.Alhalabi Mohamad Omar Barasheed Ahmed M.Bakhshwin maha H.Jamal mohammed A.Bazuhair Fatemah O.Kamel Rania M.Magadmi Zoheir A Damanhouri Samar M.Alsaggaf Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Hera General Hospital MakkahSaudi Arabia Department of Pathology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:Male Wistar rats were divided into 5 groups of 5 animals each:the positive control,the negative control,the memantine-treated group,the liraglutide-treated group,and the combination group treated with memantine and ***_(3)and D-GAL were used to induce *** tests,brain beta-amyloid protein,and oxidative stress biomarkers were ***:The Morris water maze test indicated an enhanced memory in the combination ***,the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain *** inflammation and oxidative stress biomarkers were significantly reduced,and the levels of antioxidant parameters were ***:The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.

关键词： Alzheimer’s disease Cognitive function Glucagonlike peptide-1 Liraglutide Memantine

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On Fractional Differential Inclusion for an EpidemicModel via L-Fuzzy Fixed Point Results

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Computer Modeling in Engineering & Sciences 2023年第11期137卷 1937-1956页

作者： maha Noorwali mohammed Shehu Shagari Department of Mathematics King Abdulaziz UniversityJeddahSaudi Arabia Department of Mathematics Faculty of Physical SciencesAhmadu Bello UniversityZariaNigeria

The real world is filled with uncertainty,vagueness,and *** concepts we meet in everyday life are vague rather than *** real-world situations,if a model requires that conclusions drawn from it have some bearings on reality,then two major problems immediately arise,*** situations are not usually crisp and deterministic;complete descriptions of real systems often require more comprehensive data than human beings could recognize simultaneously,process and *** mathematical tools which require all inferences to be exact,are not always efficient to handle imprecisions in a wide variety of practical *** the latter development,a lot of attention has been paid to examining novel L-fuzzy analogues of conventional functional equations and their various *** this paper,new coincidence point results for single-valued mappings and an L-fuzzy set-valued map in metric spaces are *** novelty and generality,the obtained invariant point notions are compared with some well-known related concepts via non-trivial *** is observed that our principal results subsume and refine some important ones in the corresponding *** an application,one of our results is utilized to discussmore general existence conditions for realizing the solutions of a non-integer order inclusion model for COVID-19.

关键词： Hausdorff metric L-fuzzy set L-fuzzy set-valued map Caputo fractional differential inclusion COVID-19

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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

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Effect of Zn,Cu,Cr and Pb Chlorides on the Formation of Tricalcium Aluminate Trisulfate Hydrate

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Journal of Materials Science & Technology 2008年第6期24卷 867-872页

作者： Wafaa S.Hegazi Eisa E.Hekal Essam A.Kishar maha R.mohammed Faculty of Girls Ain Shams University CairoEgypt Faculty of Science Ain Shams University CairoEgypt

The effect of addition of Zn, Cu, Pb and Cr chlorides as admixtures on the hydration reaction of the system 3CaO·Al2O3-gypsum with molar ratio 1：3 was studied. Different ratios of each salt were used, namely 0.5%, 2% and 4% by weight of the solid mixture. Hydration reaction was carried out at 35℃ for various time intervals from 0.5 h to up to 7 d. Hydration rate of the system 3CaO·Al2O3-CaSO4·2H2O in absence and presence of different salts was studied via the determination of the combined water contents. X-ray diffraction analysis showed that the ettringite was the only hydration product formed in the different mixes. The hydration products were investigated by scanning electron microscopy （SEM） and thermal gravimetric analysis. The results indicated that the rate of formation of ettringite and its microstructure depend on the admixture and its dosage.

关键词： Tricalcium aluminate Hydration Ettringite formation Heavy metal

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Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages

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World Journal of Gastroenterology 2014年第48期20卷 18390-18396页

作者： Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh ahmad M Zubaidi Mansoor-Ali Vaali-mohammed Robin Boushey James H Mckerrow maha-Hamadien Abdulla Colorectal Research Center Department of Surgery King Saud University Riyadh 11472 Saudi Arabia Department of Pathology King Saud University Riyadh 11472 Saudi Arabia Division of General Surgery Ottawa Hospital University of Ottawa Ontario K1H 8L6 Canada Center for Discovery and Innovation in Parasitic Diseases University of California San Francisco San Francisco CA 94158-2330 United States

AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of ***:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University *** demographic information,including age and gender,tumor sites,and histological type of CRC,was *** measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal *** transcription and reverse transcription polymerase chain reaction were *** tissue microarrays were constructed to investigate the protein expression of TNF-a by ***:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal *** TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were *** showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of ***:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC.

关键词： Tumor necrosis factor-a Colorectal cancer Real time polymerase chain reaction Immunohistochemistry m RNA

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Nigella sativa oil as a treatment for gingivitis: A randomized active-control trial

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亚太热带医药杂志：英文版 2023年第3期16卷 129-138页

作者： Ishrat Rahman Afrah mohammed Manal A.AlSheddi Alanoud Algazlan Alanoud Alwably Mamata Hebbal maha Galal Omar Department of Basic Dental Sciences College of DentistryPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia College of Dentistry Princess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Preventative Dental Sciences College of DentistryPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia

Objective: To assess the clinical anti-inflammatory and antimicrobial efficacy of Nigella sativa oil compared with chlorhexidine in patients with gingivitis. Methods: A double-blind, randomized clinical trial was conducted in patients having chronic generalized gingivitis. Patients were randomly assigned to receive Nigella sativa oil(n=18) or chlorhexidine(n=19). The following assessments were made on day 0 and day 15: plaque index, gingival index, gingival IL-6 and IL-18 levels were measured using ELISA, plaque colony-forming units, and alpha-hemolytic Streptococcus strains. Data were analyzed using parametric and non-parametric tests and Fisher’s exact ***: Both interventions reduced plaque index and gingival index scores(P0.05). The post-intervention plaque index and gingival index scores and inflammatory cytokine levels between the two groups were not significantly different. Both interventions caused a significant reduction in the plaque colony-forming units(P<0.000 1), reducing pathogenic bacteria: Streptococcus mitis, Streptococcus oralis, Streptococcus sanguinis, and Streptococcus parasanguinis in the chlorhexidine group(50%)(P=0.103 1), and the Nigella sativa oil group(20%)(P=0.739 5). Conclusions: Nigella sativa oil had anti-inflammatory and antibacterial activities, reducing biofilm formation and disrupting the colonization of pathogenic bacteria essential for the progression of periodontal disease. Nigella sativa oil could offer an alternative therapy for treating gingivitis and may prevent associated systemic diseases and improve overall health outcomes.

关键词： Chlorhexidine Mouth rinse Interleukin Gingival index Plaque index

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A non-conventional hybrid numerical approach with multi-dimensional random sampling for cocaine abuse in Spain

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International Journal of Biomathematics 2018年第8期11卷 289-305页

作者： maha A. mohammed N. F. M. Noor A. I. N. Ibrahim Z. Sir Department of Mathematics Ibn-Al-Haitham College of Education University of Baghdad 477146 Baghdad Iraq Institute of Mathematical Sciences Faculty of Science University of Malaya 50603 Kuala Lumpur Malaysia

This paper introduces a non-conventional approach with multi-dimensional random sampling to solve a cocaine abuse model with statistical probability. The mean Latin hypercube finite difference (MLHFD) method is proposed for the first time via hybrid integration of the classical numerical finite difference (FD) formula with Latin hypercube sampling (LHS) technique to create a random distribution for the model parameters which are dependent on time t. The LHS technique gives advantage to MLHFD method to produce fast variation of the parameters' values via number of multidimensional simulations (100, 1000 and 5000). The generated Latin hypercube sample which is random or non-deterministic in nature is further integrated with the FD method to complete one cycle of LHS-FD simulation iteration. This process is repeated until n final iterations of LHS-FD are obtained. The means of these n final solutions (MLHFD solutions) are tabulated, graphed and analyzed. The numerical simulation results of MLHFD for the SEIR model are presented side-by-side with deterministic solutions obtained from the classical FD scheme and homotopy analysis method with Pade approximation (HAM-Pade). The present MLHFD results are also compared with the previous non-deterministic statistical estimations from 1995 to 2015. Good agreement between the two is perceived with small errors. MLHFD method can be used to predict future behavior, range and prediction interval for the epidemic model solutions. The expected profiles of the cocaine abuse subpopulations are projected until the year 2045. Both the statistical estimations and the deterministic results of FD and HAM-Pade are found to be within the MLHFD prediction intervals for all the years and for all the subpopulations considered.

关键词： Epidemic model finite difference method Latin hypercube sampling ordinarydifferential equation prediction interval random distribution SEIR

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Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression

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World Journal of Gastroenterology 2005年第42期11卷 6624-6630页

作者： Abdel-Rahman N Zekri mohammed S El-Din Ashour Ahmed Hassan Hanaa M Alam El-Din Amal MR El-Shehaby maha A Abu-Shady Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Egypt Microbiology Department Faculty of Pharmacy Azhar University Egypt Microbiology and Immunology Department Sohag Faculty of Medicine South Valley University Egypt Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Egypt Biochemistry Department El-Kaser El-Aini School of Medicine Cairo University Egypt

AIM： To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression. METHODS： We measured the cytokine levels of Thl （IL-2 and IL-2R）, Th2 （IL-10） and the pro-inflammatory cytokines （IL-6 and IL-6R and TNF and TNF-RI and II） by the ELISA technique in the sera of 33 hepatocellular carcinoma （HCC） patients and 20 chronic liver disease （CLD） patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus（HCV） markers served as controls. RESULTS： Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases. On the other hand, HCV viremia was detected using RT- PCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases. Also bilharziaI-Ab was positive in 55% of HCC cases, 65% of CLD cases and in 70% of asymptomatic carriers （ASC）. HCC patients had significantly higher values of IL- 2R, TNF-RII （P〈0.001）, and TNF-RI （P〉0.05）, but lower TNFα （P〈0.001） and IL-6 （P = 0.032） in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RI and TNF-RII, but lower TNF-α （P〈0.001）. CLD patients had higher IL-2R, TNF-RI, and TNF-RII （P〈0.001） than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RI and TNF-RII, but lower TNF-α （P〈0.001）. IL-10 was higher （though not significantly） in HCC and CLD patients than in symptomatic carriers and non-cancer controls. CONCLUSION： Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R, TNF-RI, and TNF-RII could be used as potential markers.

关键词： Cytokine HCV Genotype-4 Liver disease

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