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Differentiated Thyroid Cancer with Thyroglobulin Elevation and Negative Iodine Scintigraphy (TENIS Syndrome)

International Journal of Otolaryngology and Head & Neck Surgery 2014年第4期3卷 149-153页

作者： Raja Sfar Tarek Kamoun Manel Nouira Hamza Regaieg Nouha Ammar Hela Charfi Achraf Bahloul maha ben fredj Kaouther Chatti Mohsen Guezguez Habib Essabbah Department of Nuclear Medicine Sahloul Hospital Sousse Tunisia Department of Nuclear Medicine Sahloul Hospital Sousse Tunisia Sousse University Sousse Tunisia University of Monastir Monastir Tunisia Department of Nuclear Medicine Sahloul Hospital Sousse Tunisia

Background and Objectives: Following the initial management, some patients with differentiated thyroid cancer (DTC) develop a state of high thyroglobulin (Tg) and Negative Iodine Scintigraphy. The predisposing factors and outcome of this condition are unclear. In this study, our objectives were to analyze the characteristics of patients with high Tg level and negative Iodine scintigraphy and to determine the predictive factors for development of high Tg and negative scintigraphy. Patients and Methods: Retrospective study of 34 patients undergoing treatment for DTC, followed in the Nuclear Medicine department of the University Hospital—Sahloul Sousse between 1990 and 2006 and having a high Tg and negative Iodine scintigraphy. Fourteen patients had Tg between 2 and 10 ng/ml, 16 had Tg between 11 and 100 ng/ml and 4 patients had Tg more than 100 ng/ml. Results: There were 25 women and 9 men. The mean age was 51.65 years. In 94.1% of cases, the tumor was papillary carcinoma. Follicular tumors accounted for only 5.9%. The mean nodule size was3.26 cm. Capsular invasion was seen in 47.1% cases. The locoregional invasion was found in 35.3%. The lymph node extension was found in 84.8% of patients having lymph node surgery. Lymph node involvement was observed in 92.8% of patients with papillary cancer but it was found in 7.2% of patients with follicular cancers. Lymph node invasion was unilateral in 28.6% (N1a) and bilateral, contralateral or mediastinal in 71.4% (N1b). Initial level of Tg was as follows: 7 patients had Tg between 2 and 10 ng/ml, 14 patients had Tg between 11 and 100 ng/ml and 12 had Tg more than 100 ng/ml. The mean number of radioactive Iodine cure was 11.08 for patients with Tg more than 100 ng/ml with a significant difference (P = 0.001). Conclusion: Among epidemiological, pathological and clinical characteristics, lymph node invasion is the most frequent parameter found in patients with a DTC with high Tg level and negative Iodine scintigraphy.

关键词： Differentiated Thyroid Cancer Thyroglobulin Iodine Scintigraphy TENIS Syndrome

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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq maha Abid Wissal ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of FUO.Methods:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,2023.In total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative platform.Only adult patients with confirmed infection as the cause of FUO were included in the study.The severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the study.Overall,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired infections.The most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for diagnosis.The mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not rare.Overall,38(23.8%)patients had at least one of the severity parameters.The mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)patients.Conclusions:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

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Antimicrobial activity of Tunisian Euphorbia paralias L.

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Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 629-632页

作者： Malek Besbes Hlila Kaouther Majouli Hichem ben Jannet Mahjoub Aouni maha Mastouri Boulbaba Selmi Laboratory of Transmissible Diseases and Biological Active Substances Department of Pharmaceutical Sciences Faculty of Pharmacy University of Monastir Avenue Avicenne 5000 Monastir Tunisia Laboratory of Biochemistry Research Unit:UR 12ES08'Cell Signaling and Pathologies' Department of Biology Faculty of Medicine University of Monastir Monastir Tunisia Laboratory of Heterocyclic Chemistry Natural Products and Reactivity Team:Medicinal Chemistry and Natural Products Department of Chemistry Faculty of Sciences of Monastir University of Monastir Monastir Tunisia Laboratory of Bioresources:Integrative Biology and Exploiting Higher Institute of Biotechnology of Monastir Department of Molecular Biology Cellular and Biotechnology University of Monastir Monastir Tunisia

Objective: To examine the potential antimicrobial activity of Euphorbia paralias L.(Euphorbiaeae) leaves and stems extracts.Methods: The antimicrobial activity was tested against six microbial strains: Escherichia coli ATCC 8739, Bacillus subtilis ATCC 6633, Salmonella enterica CIP 8039, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027 and Candida albicans ATCC 90028 by two different methods, the disk method and the dilution method.Results: Our results showed the important antimicrobial activity of the chloroform extract of the stems towards the majority of the strains by using both methods. Bacillus subtilis was the most sensitive strain(MIC = MBC = 15 mg/mL).Conclusion: Thus, some extracts of Euphorbia paralias can be used in the treatment of infectious diseases caused by microbes.

关键词：大戟属植物 paralias L. 抗菌剂活动 MIC MBC

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MIMO Spectral Efficiency over Energy Consumption Requirements: Application to WSNs

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International Journal of Communications, Network and System Sciences 2012年第2期5卷 121-129页

作者： maha ben Zid Kosai Raoof Ammar Bouallègue Departement Images et Signal (DIS) GIPSA-Lab University of Grenoble Grenoble France

This paper presents the evaluation of the “capacity to the total energy consumption per bit ratio” of multiple antennas systems with distributed fashion. We propose an adequate geometric channel modeling for the wireless communication system which operates in indoor propagation environment with scatterers. The channel model is derived in function of both the line of sight (LOS) and the non line of sight (NLOS) components. The aim of this paper is to study the limits in the gain concerning the capacity to the total energy consumption ratio when additional antennas are implemented in the communication system. To do so, we have evaluated by simulations both the capacity and the total energy consumption per bit. Then, we have determined the capacity to the total energy consumption ratio. Finally, the computational capacity to the total energy ratio is obtained for different system configurations. We have shown that the gain in capacity increases with the number of antennas but it stills be limited by the total energy consumption. The limits for increasing the number of transmit antennas are determined in function of the separation distances between the transmitter and the receiver sides of the communication system. Optimal power allocation strategy via water-filling algorithm has been carried out for evaluating the capacity to energy ratio. We find by simulation that optimal power allocation brings a gain in the addressed metric reaching a level of about 1.7 at transmit signal to noise ratio of 8 dB if comparing to the case when transmit energy is equally split among transmit antennas.

关键词： MIMO Capacity Energy Efficiency Capacity to the Total Energy Consumption Ratio Wireless Sensor Networks

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Total phenolic compounds,antioxidant potential and α-glucosidase inhibition by Tunisian Euphorbia paralias L.

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Journal of Coastal Life Medicine 2016年第8期4卷 628-633页

作者： Malek Besbes Hlila Kaouther Majouli Fethia Harzallah Skhiri Hichem ben Jannet Mahjoub Aouni maha Mastouri Boulbaba Selmi Laboratory of Transmissible Diseases and Biological Active Substances Faculty of PharmacyUniversity of MonastirAvenue Avicenne5000 MonastirTunisia Biochemistry Laboratory:Cell Signaling and Pathologies Research Unit:UR 12ES08Faculty of Medicine of MonastirTunisia Laboratory of Genetic Biodiversity and Valorisation of BioresourcesLR11ES41Higher Institute of Biotechnology of MonastirUniversity of MonastirMonastir 5000Tunisia Laboratory of Heterocyclic Chemistry Natural Products and ReactivityTeam:Medicinal Chemistry and Natural ProductsFaculty of Sciences of MonastirUniversity of MonastirMonastirTunisia Laboratory of Bioresources:Integrative Biology and exploiting Higher Institute of Biotechnology of MonastirMonastirTunisia

Objective:To examine the potential antioxidant and anti-α-glucosidase inhibitory activities of Tunisian Euphorbia paralias L.leaves and stems extracts and their composition of total polyphenol and flavonoids.Methods:The different samples were tested for their antiradical activities by using 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)and 1,1-diphenyl-2-picrylhydrazyl(DPPH)assays.Inα-glucosidase activity,α-glucosidase(0.3 IU/mL)and substrate,2500μmol/L p-nitrophenylα-D-glucopyranoside were used;absorbance was registered at 405 nm.Results:The leaves acetonic extract exhibited the strongestα-glucosidase inhibition[IC_(50)=(0.0035±0.001)μg/mL],which was 20-fold more active than the standard product(acarbose)[IC_(50)=(0.07±0.01)μg/mL].Acetonic extract of the leaves exhibited the highest quantity of total phenolic[(95.54±0.04)μg gallic acid equivalent/mg]and flavonoid[(55.16±0.25)μg quercetin equivalent/mg].The obtained findings presented also that this extract was detected with best antioxidant capacity[IC_(50)=(0.015±0.01)μg/mL]against DPPH and a value of IC_(50)equal to(0.02±0.01)μg/mL against ABTS.Positive relationship between polyphenolic content of the tested Euphorbia paralias L.leaves and stems extracts and its antioxidant activity(DPPH and ABTS)was detected.Elevated positive linear correlation was got between ABTS and total phenolic(R^(2)=0.751).Conclusions:The findings clearly demonstrate that the use of a polar solvent enables extraction of significant quantities of phenol compounds and flavonoids.

关键词： Euphorbia paralias L. Polyphenolic compounds Antioxidant activity Anti-α-glucosidase activity

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