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Clinical and Radiological Localization of Language Dysfunctions in Acute Ischemic Stroke

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Open Journal of Medical Imaging 2014年第2期4卷 80-85页

作者： Amira Ahmed Zaki Dwidar Taha Kamel Alloush Mahmoud Youssef Abou El-Ella Nahed Salah El-Din Ahmed Karima Moustafa Maher maha ali Mohamed nada Mohamed Hamdy Ibrahim Faculty of Medicine Ain Shams University Cairo Egypt

Objective: To study the effect of cerebral ischemic vascular insult on the localization of language areas as regard to automatic speech, initiation, and mutism. Materials and Methods: Seventy ischemic stroke patients were selected within the first 48 h of the onset of stroke with left hemispheric stroke with aphasia. Inclusion criteria: any age above seven years, both sexes, first ever clinical stroke, admitted within the first 2 days of stroke insult. Patients underwent careful history taking, neurological examination, routine laboratory investigations, echo cardiography, and carotid duplex and language assessments. Results: Automatic speech disorders were mainly seen along left insular, left supramarginal and left frontal inferior orbital lesions. Initiation difficulty is seen mainly along as left insular, left temporal superior and left periventricular lesions. Mutism is seen along left external capsule, left internal capsule, left pallidum, left frontal inferior orbital and left inferior trigone lesions. Conclusions: Deep periventricular white matter and insular area in the dominant hemisphere play an important role in many language tasks. Thus aphasia is not a mere cortical function.

关键词： Clinicoradiological Localization Aphasia Stroke White Matter Perventricular

Leptomeningeal metastases in prostate cancer:A review of the current literature

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Current Urology 2024年第3期18卷 159-166页

作者： Umar Durrani Kasem Rifai maha Arshad Awais Paracha Ekamjit Deol Maria Paracha Fatima Waheed Zohair Siddiqui ali Abid Esed Mustafic Wilson Rodriguez Zachary Hamilton Saint Louis University School of Medicine Saint LouisMOUSA University of Missouri School of Medicine ColumbiaMOUSA University of Virginia CharlottesvilleVAUSA New York Institute of Technology College of Osteopathic Medicine Old WestburyNYUSA Saint Louis University Saint LouisMOUSA Department of Neurology Saint Louis University School of MedicineSaint LouisMOUSA Division of Urology Department of SurgerySaint Louis University School of MedicineSaint LouisMOUSA

Leptomeningeal metastasis/leptomeningeal carcinomatosis(LMC;terms used interchangeably)is an inflammatory complication of primary tumors that involves the spread of the disease to the meninges(specifically the arachnoid and pia maters)and spinal *** the United States,approximately 110,000 new cases are diagnosed each year,and the prognosis is usually *** of LMC include cognitive impairment,cranial nerve dysfunction,ischemic stroke,and *** survival times of untreated and treated LMC are approximately 4–6 weeks and 2–4 months,*** carcinomatoses are usually metastatic cancers that spread to the central nervous *** lung and breast cancers have a clearly defined relationship with LMC,it remains unclear whether prostate cancer(PC)is also directly associated with *** determine whether such association exists,we conducted a PubMed review of the literature on patients with PC with coexisting *** search yielded 23 case reports of patients with preexisting PC who developed *** addition,2 retrospective cohort studies were *** findings were identified in the revised cases and *** first 3 findings were related to the progression of the disease:patients presenting with neurological disease symptoms were in remission from PC for 7 years on average,LMCs tended to occur after other cancer diagnoses,and the disease had already rapidly progressed by the time the symptoms were *** diagnosis,the major finding was that most LMCs were detected by magnetic resonance imaging(which does not detect early dissemination),and it was suggested that single-photon emission computed tomography or positron emission tomography imaging could be used for earlier ***,in terms of treatment,the main finding was that treatment was palliative rather than curative and that prognosis remained poor despite *** the basis of these results,we recommend for individuals with risk facto

关键词： Leptomeningeal carcinomatosis Prostate cancer Prostate cancer metastasis

Structure-based discovery of *** phytochemicals as potential inhibitors against Monkeypox(mpox)viral protein

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Journal of Biosafety and Biosecurity 2024年第3期6卷 157-169页

作者： Ranjan K.Mohapatra Ahmed mahal Pranab K.Mohapatra Ashish K.Sarangi Snehasish Mishra Meshari A.Alsuwat nada N.Alshehri Sozan M.Abdelkhalig Mohammed Garout Mohammed Aljeldah Ahmad A.Alshehri Ahmed Saif Mohammed Abdulrahman Alshahrani ali S.Alqahtani Yahya A.Almutawif Hamza M.A.Eid Faisal M Albaqami Mohnad Abdalla ali A.Rabaan Department of Chemistry Government College of EngineeringKeonjhar 758002OdishaIndia Department of Medical Biochemical Analysis College of Health TechnologyCihan University–ErbilErbilKurdistan RegionIraq Department of Chemistry CV Raman Global UniversityBhubaneswarOdishaIndia Department of Chemistry School of Applied SciencesCenturion University of Technology and ManagementBalangirOdishaIndia School of Biotechnology Campus-11KIIT Deemed-to-be-UniversityBhubaneswar 751024OdishaIndia Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityAl-Taif 21974Saudi Arabia Internal Medicine Department King Khalid University Medical CityCollege of MedicineAbha 61481Saudi Arabia Department of Basic Medical Sciences College of MedicineAlMaarefa UniversityRiyadhSaudi Arabia Department of Community Medicine and Health Care for Pilgrims Faculty of MedicineUmm Al-Qura UniversityMakkah 21955Saudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesUniversity of Hafr Al BatinHafr Al Batin 39831Saudi Arabia Department of Clinical Laboratory Sciences Faculty of Applied Medical SciencesNajran UniversityNajran 61441Saudi Arabia Department of Medical Laboratory Sciences Faculty of Applied Medical SciencesKing Khalid UniversityAbha 61481Saudi Arabia mDepartment of Medical Laboratories Technology College of Applied Medical SciencesTaibah UniversityMadinah 41411Saudi Arabia Biology Department College of ScienceIslamic University of MadinahMadinah 42351Saudi Arabia Pediatric Research Institute Children’s Hospital Affiliated to Shandong UniversityJinanShandong 250022China Molecular Diagnostic Laboratory Johns Hopkins Aramco HealthcareDhahran 31311Saudi Arabia College of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Public Health and Nutrition The University of HaripurHaripur 22610Pakistan

Outbreaks of Monkeypox(mpox)in over 100 non-endemic countries in 2022 represented a serious global health *** a neglected disease,mpox has become a global public health issue.A42R profilinlike protein from mpox(PDB ID:4QWO)represents a potential new lead for drug development and may interact with various synthetic and natural *** this report,the interaction of A42R profilinlike protein with six phytochemicals found in the medicinal plant Ficus religiosa(abundant in India)was *** on the predicted and compared protein–ligand binding energies,biological properties,IC_(50) values and toxicity,two compounds,kaempferol(C-1)and piperine(C-4),were *** characteristics and quantitative structure–activity relationship(QSAR)of these two compounds were determined,and molecular dynamics(MD)simulations were *** silico examination of the kaempferol(C-1)and piperine(C-4)interactions with A42R profilin-like protein gave best-pose ligandbinding energies of–6.98 and–5.57 kcal/mol,*** predicted IC_(50) of C-1 was 7.63 lM and 82 lM for *** data indicated that kaempferol and piperine are non-mutagenic,and the QSAR data revealed that piperlongumine(5.92)and piperine(5.25)had higher log P values than the other compounds *** simulations of A42R profilin-like protein in complex with C-1 and C-4 were performed to examine the stability of the ligand–protein ***/C and C-4 showed the highest affinity and activities,they may be suitable lead candidates for developing mpox therapeutic *** study should facilitate discovering and synthesizing innovative therapeutics to address other infectious diseases.

关键词： Monkeypox Mpox Phytochemical Molecular docking MD simulation ADMET QSAR

A Double Threshold Energy Detection-Based Neural Network for Cognitive Radio Networks

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Computer Systems Science & Engineering 2023年第4期45卷 329-342页

作者： nada M.Elfatih Elmustafa Sayed ali maha Abdelhaq Raed Alsaqour Rashid A.Saeed Department of Electrical and Electronics Engineering Red Sea UniversityPort Sudan33311Sudan Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Information Technology College of Computing and InformaticsSaudi Electronic UniversityRiyadh93499Saudi Arabia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Electronics Engineering Sudan University of Science and TechnologyKhartoum11111Sudan

In cognitive radio networks(CoR),the performance of cooperative spectrum sensing is improved by reducing the overall error rate or maximizing the detection *** optimization methods are usually used to optimize the number of user-chosen for cooperation and the threshold ***,these methods do not take into account the effect of sample size and its effect on improving CoR *** general,a large sample size results in more reliable detection,but takes longer sensing time and increases ***,the locally sensed sample size is an optimization ***,optimizing the local sample size for each cognitive user helps to improve CoR *** this study,two new methods are proposed to find the optimum sample size to achieve objective-based improved(single/double)threshold energy detection,these methods are the optimum sample size N^(*)and neural networks(NN)*** the evaluation,it was found that the proposed methods outperform the traditional sample size selection in terms of the total error rate,detection probability,and throughput.

关键词： Cognitive radio spectrum sensing energy detection double threshold neural network machine learning optimization quality of service

In flue nee of microwave drying and con venti onal drying methods on the mechanical properties of naproxen sodium drug tablets

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Particuology 2020年第6期18卷 30-40页

作者： maha Al-ali Rajarathinam Parthasarathy Chemical and Environmental Engineering School of EngineeringRM1T UniversityMelbourneVictoria 3001Australia

Tablets are one of the most comm only used solid dosage forms taken by *** preparati on of high-quality tablets requires an understanding of the preparation process and elucidation of how the physical and mechanical properties change as a function of the preparation *** work aims to investigate the impact of microwave irradiation drying and conventional drying methods(including freeze,convective and vacuum drying)on the hardness,tensile strength and friability of tablets made from a multi-component formulation containing naproxen sodium,microcrystalline cellulose,and *** results show that tablets subjected to microwave drying had the secondhighest tensile strength and hardness of 1.296 MPa and 67 N,*** tablets subjected to vacuum drying had the lowest tensile strength and hardness of 1.21 MPa and 64 N,*** friability index values for the tablets derived from the microwave and freeze-drying methods werel%.Microwave drying was observed to be an efficient method to produce naproxen sodium-containing tablets with satisfactory mechanical *** findings confirm that the drying method plays an essential role in the improvement or degradation of the mechanical properties of tablets.

关键词： Microwave drying Naproxen sodium Hardness Friability Tensile strength

Comparative analyses/evaluation of the textural properties of naproxen sodium tablets and powders prepared using microwave and other drying techniques

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Particuology 2020年第3期18卷 197-204页

作者： maha Al-ali Selvakannan Periasamy Rajarathinam Parthasarathy Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3000Australia Applied Chemistry School of ScienceRMIT UniversityMelbourneVictoria 3000Australia

The properties of oral tablets are normally related to the properties of the powders they *** of oral tablets is important for the development of tablets with rapid and safe release of the active *** this study,a new formulation of naproxen sodium was prepared and dried using microwave drying (MWD) and the following conventional drying techniques:freeze-drying (FD),vacuum drying (VD),and convective drying (CD).The reference drug powder (RDP) and dry granules MWG,CDG,VDG,and FDG,which were dried using MWD,CD,VD,and FD,respectively were compressed to form tablets labeled RF-TAB,MW-TAB,CD-TAB,VD-TAB,and FD-TAB,*** dry granules and prepared tablets were characterized using Fourier transform infrared spectrometry,scanning electron microscopy,and X-ray *** study aimed to explore the correlation between the textural characteristics of the tablets and their respective powders for different drying *** the morphologies of the dry particles were irregular,the prepared tablets were smooth and flat with few *** increased the amorphous nature of the granules but decreased their *** crystallinities of all tablets,except those prepared by VD,decreased after *** summary,the characteristics of the prepared tablets were acquired from their respective powders.

关键词： Naproxen sodium Microwave drying Tablet Texture Crystallinity

Spinal dural arteriovenous fistula:a comprehensive review of the history,classification systems,management,and prognosis

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Chinese Neurosurgical Journal 2024年第1期10卷 48-56页

作者： ali Alkhaibary Ahoud Alharbi nada Alnefaie Hajar Alammar Alshaymaa M.Arishy Noor Alghanim Yazeed M.Aldhfyan Arwa Albaiahy Yahya H.Khormi Wael Alshaya Saad AlQahatani Ahmed Aloraidi Ahmed Alkhani Sami Khairy College of Medicine King Saud Bin Abdulaziz University for Health SciencesRiyadhSaudi Arabia King Abdullah International Medical Research Center RiyadhSaudi Arabia Division of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityMinistry of National Guard-Health AffairsRiyadhSaudi Arabia Department of Neurosurgery National Neurosciences InstituteKing Fahad Medical CityRiyadhSaudi Arabia College of Medicine Jazan UniversityJazanSaudi Arabia Department of Neurosurgery King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Department of Surgery Faculty of MedicineJazan UniversityJazanSaudi Arabia

Spinal dural arteriovenous fistulas account for the majority of spinal vascular *** are typically located in the thoracolumbar region and are diagnosed in the middle-aged and elderly *** spinal dural arteriovenous fistulas have been postulated to be acquired,their exact development remains ***,the arteriovenous shunt is situated close to the spinal nerve root,inside the dura mater,where the blood from the radiculomeningeal artery and radicular vein *** history,there have been multiple classification systems of spinal arteriovenous shunts since *** were mainly based on the evolution of diagnostic studies as well as the treatment of these *** classification systems have undergone significant changes over the *** intracranial dural arteriovenous fistula,spinal dural arteriovenous fistula is progressive in *** neurological manifestations,due to venous congestion,tend to be insidious as well as *** include sensory deficits,such as paresthesia,bilateral and/or unilateral radicular pain affecting the lower limbs,and gait *** dural arteriovenous fistulas can be suspected on magnetic resonance imaging/magnetic resonance angiography and confirmed by digital subtraction angiography(DSA).The management includes surgery,endovascular therapy,and in selected cases,*** treatment goal of spinal dural arteriovenous fistula is to halt the progression of the *** prognosis depends on both the duration of symptoms as well as the clinical condition prior to *** present article comprehensively reviews the pathophysiology,changes in classification systems,natural history,clinical manifestations,radiological features,management,and prognosis.

关键词： Connection Endovascular Myelopathy Vascular

A Dual Attention Encoder-Decoder Text Summarization Model

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Computers, Materials & Continua 2023年第2期74卷 3697-3710页

作者： nada ali Hakami Hanan Ahmed Hosni Mahmoud Jazan University Computer Science DepartmentCollege of Computer Science and Information TechnologyJazanSaudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

A worthy text summarization should represent the fundamental content of the *** studies on computerized text summarization tried to present solutions to this challenging *** models are employed extensively in text summarization *** attention techniques are utilized to acquire the context data in the decoding ***,without real and efficient feature extraction,the produced summary may diverge from the core *** this article,we present an encoder-decoder attention system employing dual attention *** the dual attention mechanism,the attention algorithm gathers main data from the encoder *** the dual attentionmodel,the system can capture and producemore rational main *** merging of the two attention phases produces precise and rational text *** enhanced attention mechanism gives high score to text repetition to increase phrase *** also captures the relationship between phrases and the title giving them higher *** assessed our proposed model with or without significance optimization using ablation *** model with significance optimization achieved the highest performance of 96.7%precision and the least CPU time among other models in both training and sentence extraction.

关键词： Text summarization attention model phrase significance

A Deep-CNN Crowd Counting Model for Enforcing Social Distancing during COVID19 Pandemic: Application to Saudi Arabia’s Public Places

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Computers, Materials & Continua 2021年第2期66卷 1315-1328页

作者： Salma Kammoun Jarraya maha Hamdan Alotibi Manar Salamah ali Department of Computer Science FCITKing Abdulaziz UniversityJeddahSaudi Arabia MIRACL-Laboratory Sfax UniversitySfaxTunisia Department of Computer Science King Khalid UniversityAbhaSaudi Arabia

With the emergence of the COVID19 virus in late 2019 and the declaration that the virus is a worldwide pandemic,health organizations and governments have begun to implement severe health precautions to reduce the spread of the virus and preserve human *** enforcement of social distancing at work environments and public areas is one of these obligatory *** management is one of the effective measures for social *** reducing the social contacts of individuals,the spread of the disease will be immensely *** this paper,a model for crowd counting in public places of high and low densities is *** model works under various scene conditions and with no prior knowledge.A Deep CNN model(DCNN)is built based on convolutional neural network(CNN)structure with small kernel size and two *** increase the efficiency of the model,a convolutional neural network(CNN)as the front-end and a multi-column layer with Dilated Convolution as the back-end were ***,the proposed method accepts images of arbitrary sizes/scales as inputs from different *** evaluate the proposed model,a dataset was created from images of Saudi people with traditional and non-traditional Saudi *** model was also trained and tested on some existing *** to current counting methods,the results show that the proposed model has significantly improved efficiency and reduced the error *** achieve the lowest MAE by 67%,32%.and 15.63%and lowest MSE by around 47%,15%and 8.1%than M-CNN,Cascaded-MTL,and CSRNet respectively.

关键词： CNN crowd counting COVID19