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a.non-conventiona. hybrid numerica. a.proa.h with multi-dimensiona. ra.dom sa.pling for coca.ne a.use in Spa.n

Interna.iona. Journa. of Bioma.hema.ics 2018年第8期11卷 289-305页

作者： maha a. mohammed N. F. M. Noor a. I. N. Ibra.im Z. Sir Depa.tment of Ma.hema.ics Ibn-a.-Ha.tha. College of Educa.ion University of Ba.hda. 477146 Baghdad Iraq Institute of Ma.hema.ica. Sciences Faculty of Science University of Malaya 50603 Kuala Lumpur Malaysia

This pa.er introduces a.non-conventiona. a.proa.h with multi-dimensiona. ra.dom sa.pling to solve a.coca.ne a.use model with sta.istica. proba.ility. The mea. La.in hypercube finite difference (MLHFD) method is proposed for the first time via.hybrid integra.ion of the cla.sica. numerica. finite difference (FD) formula.with La.in hypercube sa.pling (LHS) technique to crea.e a.ra.dom distribution for the model pa.a.eters which a.e dependent on time t. The LHS technique gives a.va.ta.e to MLHFD method to produce fa.t va.ia.ion of the pa.a.eters' va.ues via.number of multidimensiona. simula.ions (100, 1000 a.d 5000). The genera.ed La.in hypercube sa.ple which is ra.dom or non-deterministic in na.ure is further integra.ed with the FD method to complete one cycle of LHS-FD simula.ion itera.ion. This process is repea.ed until n fina. itera.ions of LHS-FD a.e obta.ned. The mea.s of these n fina. solutions (MLHFD solutions) a.e ta.ula.ed, gra.hed a.d a.a.yzed. The numerica. simula.ion results of MLHFD for the SEIR model a.e presented side-by-side with deterministic solutions obta.ned from the cla.sica. FD scheme a.d homotopy a.a.ysis method with Pa.e a.proxima.ion (Ha.-Pa.e). The present MLHFD results a.e a.so compa.ed with the previous non-deterministic sta.istica. estima.ions from 1995 to 2015. Good a.reement between the two is perceived with sma.l errors. MLHFD method ca. be used to predict future beha.ior, ra.ge a.d prediction interva. for the epidemic model solutions. The expected profiles of the coca.ne a.use subpopula.ions a.e projected until the yea. 2045. Both the sta.istica. estima.ions a.d the deterministic results of FD a.d Ha.-Pa.e a.e found to be within the MLHFD prediction interva.s for a.l the yea.s a.d for a.l the subpopula.ions considered.

关键词： Epidemic model finite difference method La.in hypercube sa.pling ordina.ydifferentia. equa.ion prediction interva. ra.dom distribution SEIR

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On Fra.tiona. Differentia. Inclusion for a. EpidemicModel via.L-Fuzzy Fixed Point Results

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Computer Modeling in Engineering & Sciences 2023年第11期137卷 1937-1956页

作者： maha Noorwa.i mohammed Shehu Sha.a.i Depa.tment of Ma.hema.ics King Abdulaziz UniversityJeddahSaudi Arabia Depa.tment of Ma.hema.ics Faculty of Physical SciencesAhmadu Bello UniversityZariaNigeria

The rea. world is filled with uncerta.nty,va.ueness,a.d *** concepts we meet in everyda. life a.e va.ue ra.her tha. *** rea.-world situa.ions,if a.model requires tha. conclusions dra.n from it ha.e some bea.ings on rea.ity,then two ma.or problems immedia.ely a.ise,*** situa.ions a.e not usua.ly crisp a.d deterministic;complete descriptions of rea. systems often require more comprehensive da.a.tha. huma. beings could recognize simulta.eously,process a.d *** ma.hema.ica. tools which require a.l inferences to be exa.t,a.e not a.wa.s efficient to ha.dle imprecisions in a.wide va.iety of pra.tica. *** the la.ter development,a.lot of a.tention ha. been pa.d to exa.ining novel L-fuzzy a.a.ogues of conventiona. functiona. equa.ions a.d their va.ious *** this pa.er,new coincidence point results for single-va.ued ma.pings a.d a. L-fuzzy set-va.ued ma. in metric spa.es a.e *** novelty a.d genera.ity,the obta.ned inva.ia.t point notions a.e compa.ed with some well-known rela.ed concepts via.non-trivia. *** is observed tha. our principa. results subsume a.d refine some importa.t ones in the corresponding *** a. a.plica.ion,one of our results is utilized to discussmore genera. existence conditions for rea.izing the solutions of a.non-integer order inclusion model for COVID-19.

关键词： Ha.sdorff metric L-fuzzy set L-fuzzy set-va.ued ma. Ca.uto fra.tiona. differentia. inclusion COVID-19

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Effect of Zn,Cu,Cr a.d Pb Chlorides on the Forma.ion of Trica.cium a.umina.e Trisulfa.e Hydra.e

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Journa. of Ma.eria.s Science & Technology 2008年第6期24卷 867-872页

作者： Wa.a. S.Hega.i Eisa.E.Heka. Essa. a.Kisha. maha R.mohammed Fa.ulty of Girls a.n Sha.s University CairoEgypt Fa.ulty of Science a.n Sha.s University CairoEgypt

The effect of a.dition of Zn, Cu, Pb a.d Cr chlorides a. a.mixtures on the hydra.ion rea.tion of the system 3Ca.·a.2O3-gypsum with mola. ra.io 1：3 wa. studied. Different ra.ios of ea.h sa.t were used, na.ely 0.5%, 2% a.d 4% by weight of the solid mixture. Hydra.ion rea.tion wa. ca.ried out a. 35℃ for va.ious time interva.s from 0.5 h to up to 7 d. Hydra.ion ra.e of the system 3Ca.·a.2O3-Ca.O4·2H2O in a.sence a.d presence of different sa.ts wa. studied via.the determina.ion of the combined wa.er contents. X-ra. diffra.tion a.a.ysis showed tha. the ettringite wa. the only hydra.ion product formed in the different mixes. The hydra.ion products were investiga.ed by sca.ning electron microscopy （SEM） a.d therma. gra.imetric a.a.ysis. The results indica.ed tha. the ra.e of forma.ion of ettringite a.d its microstructure depend on the a.mixture a.d its dosa.e.

关键词： Trica.cium a.umina.e Hydra.ion Ettringite forma.ion Hea.y meta.

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Nigella.sa.iva.oil a. a.trea.ment for gingivitis: a.ra.domized a.tive-control tria.

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a.ia. Pa.ific Journa. of Tropica. Medicine 2023年第3期16卷 129-138页

作者： Ishra. Ra.ma. a.ra. mohammed Ma.a. a.a.Sheddi a.a.oud a.ga.la. a.a.oud a.wa.ly Ma.a.a.Hebba. maha Ga.a. Oma. Depa.tment of Ba.ic Denta. Sciences College of DentistryPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Depa.tment of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia College of Dentistry Princess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Depa.tment of Preventa.ive Denta. Sciences College of DentistryPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia

Objective: To a.sess the clinica. a.ti-infla.ma.ory a.d a.timicrobia. effica.y of Nigella.sa.iva.oil compa.ed with chlorhexidine in pa.ients with gingivitis. Methods: a.double-blind, ra.domized clinica. tria. wa. conducted in pa.ients ha.ing chronic genera.ized gingivitis. Pa.ients were ra.domly a.signed to receive Nigella.sa.iva.oil(n=18) or chlorhexidine(n=19). The following a.sessments were ma.e on da. 0 a.d da. 15: pla.ue index, gingiva. index, gingiva. IL-6 a.d IL-18 levels were mea.ured using ELISa. pla.ue colony-forming units, a.d a.pha.hemolytic Streptococcus stra.ns. Da.a.were a.a.yzed using pa.a.etric a.d non-pa.a.etric tests a.d Fisher’s exa.t ***: Both interventions reduced pla.ue index a.d gingiva. index scores(Pa.sa.iva.oil group wa. better a. lowering IL-6(P=0.007 6) tha. the chlorhexidine group(P=0.145), a.though there wa. no cha.ge in IL-18 levels(P>0.05). The post-intervention pla.ue index a.d gingiva. index scores a.d infla.ma.ory cytokine levels between the two groups were not significa.tly different. Both interventions ca.sed a.significa.t reduction in the pla.ue colony-forming units(Pa.hogenic ba.teria. Streptococcus mitis, Streptococcus ora.is, Streptococcus sa.guinis, a.d Streptococcus pa.a.a.guinis in the chlorhexidine group(50%)(P=0.103 1), a.d the Nigella.sa.iva.oil group(20%)(P=0.739 5). Conclusions: Nigella.sa.iva.oil ha. a.ti-infla.ma.ory a.d a.tiba.teria. a.tivities, reducing biofilm forma.ion a.d disrupting the coloniza.ion of pa.hogenic ba.teria.essentia. for the progression of periodonta. disea.e. Nigella.sa.iva.oil could offer a. a.terna.ive thera.y for trea.ing gingivitis a.d ma. prevent a.socia.ed systemic disea.es a.d improve overa.l hea.th outcomes.

关键词： Chlorhexidine Mouth rinse Interleukin Gingiva. index Pla.ue index

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a.compa.a.ive in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 brea.t ca.cer cells

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Oncology Resea.ch 2024年第5期32卷 817-830页

作者： SHa.ID Ka.IM a.a.OUD Na.ER a.GHa.MI maha Ja.a. HUDa.a.KREa.HY a.a. Ja.a. HIND a.a.KHa.a.I mohammed Ba.UHa.R a.Ta. a.Ma. Depa.tment of Clinica. Pha.ma.ology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Depa.tment of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Depa.tment of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Hea.th Informa.ion Technology Depa.tment The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia Pha.ma.ovigila.ce a.d Medica.ion Sa.ety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Ca.cer frequently develops resista.ce to the ma.ority of chemothera.y *** study a.med to exa.ine the synergistic cytotoxic a.d a.titumor effects of SGLT2 inhibitors,specifica.ly Ca.a.liflozin(Ca.),Da.a.liflozin(Da.),Empa.liflozin(EMP),a.d Doxorubicin(DOX),using in vitro *** precise combina.ion of Ca.+DOX ha. been found to grea.ly enha.ce the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it wa. shown tha. ca.cer cells exhibit a. increa.ed dema.d for glucose a.d a.P in order to support their ***,when these medica.ions were combined with DOX,there wa. a.considera.le inhibition of glucose consumption,a. well a. reductions in intra.ellula. a.P a.d la.ta.e ***,this effect wa. found to be dependent on the dosa.es of the *** a.dition to effectively inhibiting the cell cycle,the combina.ion of Ca.+DOX induces substa.tia. modifica.ions in both cell cycle a.d a.optotic gene *** work represents the initia. report on the beneficia. impa.t of SGLT2 inhibitor medica.ions,na.ely Ca.,Da.,a.d EMP,on the responsiveness to the a.tica.cer properties of *** underlying molecula. mecha.isms potentia.ly involve the suppression of the function of SGLT2.

关键词： SGLT2 Ca.cer Cytotoxicity a.P Cell cycle

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The Influence of Regula. Hemodia.ysis on the Highly Sensitive Troponin-I Level in Children without a.y Symptoms

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Open Journa. of Nephrology 2021年第2期11卷 183-198页

作者： Hekma. Moha.ed maha Youssef Ma.a. a.del-Sa.a. Sha.ma.a. mohammed Depa.tment of Pedia.rics Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Depa.tment of Clinica. Pa.hology Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt

Ba.kgrounds: Ca.diova.cula. disea.es a.e still the prominent ca.se of dea.h in ca.es of end-sta.e rena. disea.e, ca.dia. troponin I (cTnI) ca. be used for detecting ca.dia. involvement in a.ymptoma.ic ca.es of end-sta.e rena. disea.e on hemodia.ysis. a.m: Determine the direct ca.dia. consequence of dia.ysis trea.ments in children on hemodia.ysis by mea.uring high-sensitive troponin-I a. a.ma.ker of myoca.dia. injury. Subjects a.d Methods: This ca.e-control study included thirty children with end-sta.e rena. disea.e on regula. hemodia.ysis;the study group wa. selected from the nephrology hemodia.ysis unit of a.-Za.ra. Hospita., a.-a.ha. University. a.other group of thirty hea.thy children ma.ches a.e a.d sex with the pa.ient’s group a. a.control. Highly Sensitive cTnI (hsTnI) wa. mea.ured pre a.d post hemodia.ysis with a.sensitive a.sa.;moreover, ECG, lipid profile including cholesterol, triglyceride, low a.d high-density lipoprotein (HDL) in the sa.e line with routine investiga.ions for those pa.ients, we used bioimpeda.ce for dry weight a.sessment in the hemodia.ysis (HD) group. Results: Children on (HD) ha.e a.significa.tly higher (hsTnI) pre-dia.ysis (0.250 ± 0.069 ng/ml) compa.ed to post-dia.ysis (0.187 ± 0.004 ng/ml) with (p, 0.001). With no significa.t difference between post HD (0.187 ± 0.004 ng/ml) a.d the control group (0.189 ± 0.005) with (p, 0.090). cTnI is detected in (73.3%) of children pre-dia.ysis a.ove the cut-off va.ue compa.ed to (3.31%) ha. a.high-level post-dia.ysis. cTnI is positively correla.ed with systolic, dia.tolic blood pressure a.d hea.t ra.e with (r. 0.333, p, 0.001: r. 0.343, p, 0.001: r. 0.276, p, 0.033) respectively a.d (hsTnI) is nega.ively correla.ed with Hb a.d HDL (r. -0.333, p, 0.009: r. 0.324, p, 0.011). Mea.while (hsTnI) is positively correla.ed with serum urea. crea.inine, ph, PTH, serum ferritin a.d positively correla.ed with QT interva. a.d QTC. Conc

关键词： Highly Sensitive Troponin-I Children Hemodia.ysis

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Federa.ed Lea.ning with Blockcha.n a.sisted Ima.e Cla.sifica.ion for Clustered Ua. Networks

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Computers, Ma.eria.s & Continua 2022年第7期72卷 1195-1212页

作者： Ibra.im a.una.i maha M.a.thoba.ti Fa.d N.a.-Wesa.i a.wer Musta.a.Hila. Moha.ma. Meda.i Ma.a. a.med Ha.za.mohammed Rizwa.ulla. a.u Serwa. Za.a.i Depa.tment of Informa.ion Systems Prince Sultan UniversityRafha StreetRiyadh11586Saudi Arabia Depa.tment of Computer Science College of Computing and Information TechnologyTaif UniversityTaif21944Saudi Arabia Depa.tment of Computer Science College of Science&Art at MahayilKing Khalid UniversityMuhayel Aseer62529Saudi Arabia Fa.ulty of Computer a.d IT Sana’a UniversitySana’a61101Yemen Depa.tment of Computer a.d Self Development Prince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Depa.tment of Informa.ion Systems College of Science&Art at MahayilKing Khalid UniversityMuhayel Aseer62529Saudi Arabia

The evolving“Industry 4.0”doma.n encompa.ses a.collection of future industria. developments with cyber-physica. systems(CPS),Internet of things(IoT),big da.a.cloud computing,***,the industria. Internet of things(IIoT)directs da.a.from systems for monitoring a.d controlling the physica. world to the da.a.processing system.a.ma.or novelty of the IIoT is the unma.ned a.ria. vehicles(Ua.s),which a.e trea.ed a. a. efficient remote sensing technique to ga.her da.a.from la.ge *** a.e commonly employed in the industria. sector to solve severa. issues a.d help decision *** the strict regula.ions lea.ing to da.a.priva.y possibly hinder da.a.sha.ing a.ross a.tonomous *** lea.ning(FL)becomes a.recent a.va.cement of ma.hine lea.ning(ML)which a.ms to protect user *** this a.pect,this study designs federa.ed lea.ning with blockcha.n a.sisted ima.e cla.sifica.ion model for clustered Ua. networks(FLBIC-CUa.)on IIoT *** proposed FLBIC-CUa. technique involves three ma.or processes na.ely clustering,blockcha.n ena.led secure communica.ion a.d FL ba.ed ima.e *** Ua. cluster construction process,beetle swa.m optimiza.ion(BSO)a.gorithm with three input pa.a.eters is designed to cluster the Ua.s for effective *** a.dition,blockcha.n ena.led secure da.a.tra.smission process ta.e pla.e to tra.smit the da.a.from Ua.s to cloud ***,the cloud server uses a. FL with Residua. Network model to ca.ry out the ima.e cla.sifica.ion process.a.wide ra.ge of simula.ion a.a.yses ta.es pla.e for ensuring the betterment of the FLBIC-CUa. *** experimenta. outcomes portra.ed the betterment of the FLBIC-CUa. a.proa.h over the recent sta.e of a.t methods.

关键词： Ua. networks clustering secure communica.ion blockcha.n federa.ed lea.ning ima.e cla.sifica.ion

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Expression levels of pro-infla.ma.ory interleukin-8 a.d certa.n a.timicrobia. peptides in concurrent with ba.teria. conjunctivitis

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Interna.iona. Journa. of Ophtha.mology(English edition) 2021年第5期14卷 666-675页

作者： a.a. El-Dien Sha.ky Hosny Zeina. El-Demerda.h El-Ba.za.mohammed a.delha.im Ra.a.a. maha a.med Sha.ik Ma.moud a.med Sha.eek Ra.ia.a.delmonem Kha.ta. Microbiology a.d Immunology Depa.tment Faculty of PharmacyCairo UniversityKasr Al-Aini 11562CairoEgypt Drug Ra.ia.ion Resea.ch Depa.tment National Center for Radiation Research and TechnologyAtomic Energy AuthorityCairo 9621Egypt Ophtha.mology Depa.tment Faculty of medicineAL-Azhar UniversityCairo 11754Egypt

a.M:To detect the qua.tita.ive expression levels of the pro-infla.ma.ory interleukin-8(IL8),a.timicrobia. peptides huma. beta.defense-2(HBD2),a.d huma. beta.defense-3(HBD3)genes in ba.teria. ***:The huma. conjunctiva. epithelia. cells were obta.ned using the impression cytology technique from hea.thy controls a.d *** genes expression levels were determined utilizing a.reverse tra.scription qua.tita.ive polymera.e cha.n rea.tion(RT-q PCR).The contribution of ca.sa.ive a.ent type,the number of isola.es a.d severity of clinica. fea.ures,in the increa.e of genes expression wa. a.so ***:The RT-q PCR showed tha. IL8,HBD2,a.d HBD3 expression increa.ed in ba.teria. conjunctivitis a. compa.ed to hea.thy control(Pa.-nega.ive ba.teria. conjunctivitis,HBD2 wa. highly up-regula.ed(Pa.ed to other types of ba.teria. *** mixed ba.teria. conjunctivitis,a.direct correla.ion between HBD2 up-regula.ion a.d HBD3 up-regula.ion wa. observed(Pa. fea.ures wa. rela.ed to the up-regula.ion of IL8 a.d HBD2(Pa.d HBD3 a.e immuneeffectors in infectious ***2 is a.tive during different ba.teria. conjunctivitis but is more relea.ed with gra.-nega.ive ba.teria.compa.ed to gra.-positive ***3 is a. obvious defender in different ba.teria. conjunctivitis.

关键词： interleukin-8 huma. beta.defense-2 huma. beta.defense-3 infectious conjunctivitis rea.-time polymera.e cha.n rea.tion

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Preva.ence of Occupa.iona. Stress a.d Rela.ed Risk Fa.tors a.ong Nurses Working in a.EER Region

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Hea.th 2021年第2期13卷 110-122页

作者： maha mohammed a.ma. a.erri Fa.ma.Mosta.a.Ba.da. Sa.ha.mohammed a.ma. a.erri Nursing Educa.ion & a.ministra.ion Head of Academic Affair in ABHA Health Sector Ministry of Health Aseer Region Abha KSA Nursing a.ministra.ion a.d Educa.ion Depa.tment College of Nursing King Saud University Al Riyadh KSA Nursing a.ministra.ion Depa.tment Faculty of Nursing Alexandria University Alexandria Egypt Nursing Educa.ion & a.ministra.ion Head of Academic Affair in General Directorate of Health Affairs ABHA Ministry of Health Aseer Region Abha KSA

Ba.kground: Over the la.t century, stress a. a. interdisciplina.y concept ha. become a. a.ea.of grea. interest a.d ha. been resea.ched extensively. a.though the ea.liest studies on stress were mostly physiologica., psychologica. models of stress ha.e been developed a.d esta.lished a.link between stressors a.d illness in his model of genera. a.a.ta.ion syndrome. Objective: To investiga.e preva.ence a.d fa.tors a.socia.ed with occupa.iona. stress a.ong nurses working a.ser region Hospita.. The study included nurses a. different a.e groups working a. different depa.tments with a.sessment of a.y sources of stress. Methodology: a.descriptive cross-sectiona. study wa. conducted ta.geting nurses in the ma.n hospita.s in the a.ser region, Southern Sa.di a.a.ia. a.tota. of the study sa.ples of 217 nurses were required to estima.e the expected a.era.e stress ra.e a.ong nurses. a.self-a.ministered pre-structured questionna.re used for da.a.collection. Results: Nurses’ a.es ra.ged 21 to 55 yea.s old with mea. a.e of 30.9 ± 11.7 yea.s old. Ma.ority of the nurses were fema.es 175 (80.6%). The highest mea. score (more stress) wa. reported by nurses in rela.ion to the following stress fa.tors;working very ha.d (4.3 ± 0.9), followed by being under pressure to work long hours (4.2 ± 0.9), the opportunity given to do something is not rea. a.d enough (4.2 ± 1.0). The findings showed a.significa.t rela.ionship between nurses’ stress level, their persona. a.d work-rela.ed cha.a.teristics (P = 0.001). Recommenda.ions: Interventiona. progra.s to detect a.d a.levia.e sources a.d effects of occupa.iona. stress should be developed including more tra.ning rega.ding coping stra.egies, nurses’ support, a.d better work condition.

关键词： Stress Nurses Workloa. Determina.ts Fa.tors a.socia.ed Psychologica. Effect Work Environment

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Increa.ed expression of tumor necrosis fa.tor-a.is a.socia.ed with a.va.ced colorecta. ca.cer sta.es

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World Journa. of Ga.troenterology 2014年第48期20卷 18390-18396页

作者： Oma. a.a. Obeed Kha.a. a.a.kha.a. a.dulma.ik a. Sheikh a.ma. M Zuba.di Ma.soor-a.i Va.li-mohammed Robin Boushey Ja.es H Mckerrow maha-Ha.a.ien a.dulla Colorecta. Resea.ch Center Department of Surgery King Saud University Riyadh 11472 Saudi Arabia Depa.tment of Pa.hology King Saud University Riyadh 11472 Saudi Arabia Division of Genera. Surgery Ottawa Hospital University of Ottawa Ontario K1H 8L6 Canada Center for Discovery a.d Innova.ion in Pa.a.itic Disea.es University of California San Francisco San Francisco CA 94158-2330 United States

a.M:To detect the expression of tumor necrosis fa.tor-a.TNF-a.in colorecta. ca.cer(CRC)cells a.ong Sa.di pa.ients,a.d correla.e its expression with clinica. sta.es of ***:a.chiva. tissue specimens were collected from 30 pa.ients with CRC who ha. undergone surgica. intervention a. King Kha.id University *** demogra.hic informa.ion,including a.e a.d gender,tumor sites,a.d histologica. type of CRC,wa. *** mea.ure TNF-a.m RNa.expression in CRC,tota. RNa.wa. extra.ted from tumor forma.in-fixed,pa.a.finembedded,a.d a.ja.ent norma. *** tra.scription a.d reverse tra.scription polymera.e cha.n rea.tion were *** tissue microa.ra.s were constructed to investiga.e the protein expression of TNF-a.by ***:The rela.ive expression of TNF-a.m RNa.in colorecta. ca.cer wa. significa.tly higher tha. tha. seen in a.ja.ent norma. colorecta. *** TNF-a.gene expression wa. a.socia.ed with Sta.eⅢa.dⅣneopla.ms when compa.ed with ea.lier tumor sta.es(P=0.004).Eighty-three percent of pa.ients(25/30)showed strong TNF-a.positive sta.ning,while only 10%(n=3/30)of pa.ients showed wea. sta.ning,a.d 7%(n=2/30)were *** showed the presence of eleva.ed TNF-a.gene expression in ca.cer cells,which strongly correla.ed with a.va.ced sta.es of ***:High levels of TNF-a.expression could be a. independent dia.nostic indica.or of colorecta. ca.cer,a.d ta.geting TNF-a.might be a.promising prognostic tool by a.sessment of the clinica. sta.es of CRC.

关键词： Tumor necrosis fa.tor-a Colorecta. ca.cer Rea. time polymera.e cha.n rea.tion Immunohistochemistry m RNA

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