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Climatic and anthropogenic impacts on the decrease of sediment discharge to the Mediterranean coast from the largest river of Maghreb

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International journal of Sediment Research 2021年第2期36卷 268-278页

作者： Ali Hadour Gil mahé Mohamed Meddi National High School of Hydraulics

The current study focuses on the issue of the decrease in sediment discharge to the Mediterranean Sea by the largest river in Algeria, the Wadi Cheliff(i.e. Cheliff River). This study clarifies the effect of climatic and anthropogenic factors on the changes in the sedimentary dynamics of the Cheliff River discharging to the sea. The data used(rainfall, water discharge, and sediment discharge) concern the Sidi Bel Attar gaging station on the Cheliff River, only 18 km from discharge to the Mediterranean Sea. A power-type statistical regression model was used to fill the 74.2% gap in Suspended Solids(SS) measurements in the establishment of a SS database for the period 1951 e2012. The study results show that the transport of suspended sediment discharged to the sea is about 487 t/km2/yr. Statistical tests of breaks highlight that rainfall decreased by 26% and that water and sediment input to the sea declined from 74% to 63% for the period of 1981 e2012. The correlation analysis shows a decrease in the contribution of rainfall on sediment and water input at the outlet equal to 77.9% and 77.8%, respectively, during the period of 1980 e2012, compared to the period of 1968 e1980. However, the double mass method reflects the contribution of factors other than rainfall to the decrease of sediment input to the sea. These other factors mainly include large dams, which intercepted about 71% of the total volume of sediment discharged to the sea during the period of 1968 e2010. In addition the contribution of large dams to the reduction of sedimentary input to the sea is more important than that of the decrease in rainfall. The management of large dams also contributes to the increase in the sediment deficit to the sea through the prioritization of interception of sediment at the expense of releases, for socio-economic purposes, 68.4% of the Cheliff River discharge is diverted for human use. This has led to an increase in the mean water bed level at bankfull downstream, where the

关键词： Sediment discharge Cheliff River Algeria North Africa Dams Mediterranean Sea

Thermoluminescent microparticle thermal history sensors

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Microsystems & Nanoengineering 2016年第1期2卷 116-128页

作者： joseph j.Talghader Merlin L.mah Eduardo G.Yukihara Adam C.Coleman Department of Electrical and Computer Engineering University of MinnesotaMinneapolisMN 55455USA Department of Physics Oklahoma State UniversityStillwaterOK 74078USA

While there are innumerable devices that measure temperature,the nonvolatile measurement of thermal history is far more difficult,particularly for sensors embedded in extreme environments such as fires and *** this review,an extensive analysis is given of one such technology:thermoluminescent *** are transparent dielectrics with a large distribution of trap states that can store charge carriers over very long periods of *** their simplest form,the population of these traps is dictated by an Arrhenius expression,which is highly dependent on temperature.A particle with filled traps that is exposed to high temperatures over a short period of time will preferentially lose carriers in shallow *** depopulation leaves a signature on the particle luminescence,which can be used to determine the temperature and time of the thermal *** are prepared—many months in advance of a test,if desired—by exposure to deep ultraviolet,X-ray,beta,or gamma radiation,which fills the traps with charge *** can be extracted from one or more particles regardless of whether or not they are embedded in debris or other inert *** and analysis of the method is demonstrated using laboratory experiments with microheaters and high energy explosives in the *** is shown that the thermoluminescent materials LiF:Mg,Ti,MgB_(4)O_(7):Dy,Li,and CaSO_(4):Ce,Tb,among others,provide accurate measurements of temperature in the 200 to 500℃ range in a variety of high-explosive environments.

关键词： materials microparticles sensors thermoluminescence

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锥形束计算机断层扫描中牙齿的分割精度

北京大学学报（医学版） 2010年第1期42卷 98-102页

作者：刘怡 james mah 许天民北京大学口腔医学院.口腔医院正畸科北京100081 Department of Orthodontics University of Southern California

目的:研究锥形束计算机断层扫描(cone beam computerized tomography,CBCT)影像中分割提取正常牙齿体积的精度。方法:选择10例正畸减数病例拔除的双尖牙24颗,采用排水法物理测量其体积(volume of water,Vw),其中7例(16颗牙齿)在减数前采... 详细信息

目的:研究锥形束计算机断层扫描(cone beam computerized tomography,CBCT)影像中分割提取正常牙齿体积的精度。方法:选择10例正畸减数病例拔除的双尖牙24颗,采用排水法物理测量其体积(volume of water,Vw),其中7例(16颗牙齿)在减数前采用i-CAT进行三维扫描,3例(8颗牙齿)使用CB MercuRay。使用Amira4.0软件在CBCT影像中分割提取减数双尖牙并测量其体积(volume in amira,Va)。所有的测量均由两名操作者测量两次。采用配对t检验对Vw与Va进行统计学分析,用Pearson相关分析及组内相关系数确定组内及组间的相关性。结果:样本总体平均Vw为(0.553±0.082)cm3,平均Va为(0.548±0.079)cm3[操作者1为(0.529±0.078)cm3,操作者2为(0.567±0.085)cm3],Va与Vw之间差异有统计意义(P<0.05),Va的测量在两个操作者之间差异也有统计学意义(P<0.05),组内与组间相关系数高。Amira软件中表面光滑处理的过程可以损失3%～12%的体积。结论:利用CBCT分割提取双尖牙根是可行的,但分割提取的体积与正常相比有小范围的差异(本研究为-4%～7%),表面处理功能中虽然能美化视觉效果,但有体积的丢失。

关键词：锥形束CT 图像处理计算机辅助牙根正畸学

The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin

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Bone Research 2021年第1期9卷 109-125页

作者： Pawanrat Tangseefa Sally K.Martin Peck Yin Chin james Breen Chui Yan mah Paul A.Baldock Gary A.Wittert Amanda j.Page Christopher G.Proud Stephen Fitter Andrew C.W.Zannettino Adelaide Medical School Faculty of Health and Medical ScienceUniversity of AdelaideAdelaide5005 SAAustralia Cancer Program Precision Medicine ThemeSouth Australian Health and Medical Research InstituteAdelaide5000 SAAustralia Research Centre for Reproductive Health School of Paediatrics and Reproductive HealthUniversity of AdelaideAdelaide5005 SAAustralia Computational&Systems Biology program Precision Medicine ThemeSouth Australian Health and Medical Research InstituteAdelaide5000 SAAustralia Robinson Research Institute University of AdelaideAdelaideSA 5005Australia Bioinformatics Hub University of AdelaideAdelaideSA 5005Australia Freemasons Foundation Centre for Men’s Health University of AdelaideAdelaide5005 SAAustralia Skeletal Metabolism Group Garvan Institute of Medical ResearchSydney2010 NSWAustralia Nutrition Diabetes&Metabolism ProgramLifelong Health ThemeSouth Australian Health and Medical Research InstituteAdelaide5000 SAAustralia School of Biological Sciences University of AdelaideAdelaide5005 SAAustralia Central Adelaide Local Health Network AdelaideSAAustralia

Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin *** osteoblasts(OBs),insulin signaling plays a crucial role in the control of systemic glucose *** utilized mice with conditional deletion of Rptor to investigate how the loss of mTORC1 function in OB affects glucose metabolism under normal and overnutrition dietary *** to the controls,chow-fed Rptorob−/−mice had substantially less fat mass and exhibited adipocyte ***,upon feeding with high-fat diet,mice with pre-and post-natal deletion of Rptor in OBs were protected from diet-induced obesity and exhibited improved glucose metabolism with lower fasting glucose and insulin levels,increased glucose tolerance and insulin *** leanness and resistance to weight gain was not attributable to changes in food intake,physical activity or lipid absorption but instead was due to increased energy expenditure and greater whole-body substrate ***-seq revealed an increase in glycolysis and skeletal insulin signaling pathways,which correlated with the potentiation of insulin signaling and increased insulin-dependent glucose uptake in Rptorknockout ***,these findings point to a critical role for the mTORC1 complex in the skeletal regulation of wholebody glucose metabolism and the skeletal development of insulin resistance.

关键词： metabolism mTORC1 homeostasis

Lipogenic effects of androgen signaling in normal and malignant prostate

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Asian journal of Urology 2020年第3期7卷 258-270页

作者： Chui Yan mah Zeyad D.Nassar johannes V.Swinnen Lisa M.Butler Adelaide Medical School and Freemasons Foundation Centre for Men’s Health University of AdelaideAdelaideAustralia South Australian Health and Medical Research Institute AdelaideAustralia KU Leuven-University of Leuven LKI-Leuven Cancer InstituteDepartment of OncologyLaboratory of Lipid Metabolism and CancerLeuvenBelgium

Prostate cancer is an androgen-dependent cancer with unique metabolic features compared to many other solid tumors,and typically does not exhibit the“Warburg effect”.During malignant transformation,an early metabolic switch diverts the dependence of normal prostate cells on aerobic glycolysis for the synthesis of and secretion of citrate towards a more energetically favorable metabolic phenotype,whereby citrate is actively oxidised for energy and biosynthetic processes(*** novo lipogenesis).It is now clear that lipid metabolism is one of the key androgen-regulated processes in prostate cells and alterations in lipid metabolism are a hallmark of prostate cancer,whereby increased de novo lipogenesis accompanied by overexpression of lipid metabolic genes are characteristic of primary and advanced *** recent advances in our understanding of altered lipid metabolism in prostate tumorigenesis and cancer progression,the intermediary metabolism of the normal prostate and its relationship to androgen signaling remains poorly *** this review,we discuss the fundamental metabolic relationships that are distinctive in normal versus malignant prostate tissues,and the role of androgens in the regulation of lipid metabolism at different stages of prostate tumorigenesis.

关键词： Androgen receptor Fatty acids Metabolism Phospholipids Prostate gland

Flexible polymeric patch based nanotherapeutics against non-cancer therapy

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Bioactive Materials 2022年第12期7卷 471-491页

作者： Houjuan Zhu justin mah jian Qiang Chen Gang Wang Chui Yu Chan Qiang Zhu Enyi Ye Zibiao Li Xian jun Loh Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore138634Singapore Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore Institute of Sustainability for Chemicals Energy and Environment(ISCE2)A*STAR(Agency for ScienceTechnology and Research)1 Pesek RoadJurong IslandSingapore627833Singapore

Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance,superior biocompatibility and biodegradation,as well as high loading capability and permeability of *** polymeric patches are classified into microneedles(MNs),hydrogel,microcapsule,microsphere and fiber depending on the formed *** combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity,promoting on-demand and regulated drug administration,thus providing the great potential to their clinic *** this review,the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further *** applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed,including diabetes therapy,wound healing,dermatological disease therapy,bone regeneration,cardiac repair,hair repair,obesity therapy and some immune disease ***,the limitations,latest challenges and future perspectives of such biomedical therapeutic devices are addressed.

关键词： Flexible polymeric patches Microneedle Hydrogel Nanomaterials Non-cancer therapy Biomedical scaffolds

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促进出口与经济发展——以韩国为例

软科学 2007年第6期21卷 34-38页

作者： jai S.mah 高华邵丹韩国Ewha女子大学研究生院华中科技大学法学院武汉430074

分析了韩国促进出口措施的贡献和存在的问题,阐述了韩国从过去注重直接出口补贴向现在的间接出口激励措施转变,促进经济发展的经验。

关键词：出口税收奖励财政扶持 GATT/WTO 韩国

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肉鸡呼吸系统疾病的控制

中国家禽 2006年第18期28卷 5-8页

作者： Gray D Butcher Choew Kong mah 吕玲（编译）美国佛罗里达州大学兽医学院印第安那州Elanco动物健康公司不详

现代的商品肉鸡具有生长快速的遗传潜力,42日龄的体重达到2.3千克是非常普遍的现象,这要归功于高强度的基因选择。然而,肌肉组织的增加与身体其它系统的生长并不成比例,尽管现代肉鸡生长得更快了,它们的体质则更加脆弱,并且它们的呼吸/... 详细信息

现代的商品肉鸡具有生长快速的遗传潜力,42日龄的体重达到2.3千克是非常普遍的现象,这要归功于高强度的基因选择。然而,肌肉组织的增加与身体其它系统的生长并不成比例,尽管现代肉鸡生长得更快了,它们的体质则更加脆弱,并且它们的呼吸/循环系统对应激因素更加敏感。其中,由于腹水症、心脏病、热应激和呼吸综合征导致的死亡率给养禽业造成了极大的损失。如果肉鸡要达到最佳生产性能,呼吸系统功能就必须完善。但是,现代肉鸡比它们的祖先更易遭受呼吸系统疾病的威胁,需要借助疫苗免疫来维护呼吸系统的正常功能以实现快速生长的目的。有效的呼吸系统管理计划有助于获得最佳的生长性能。

关键词：呼吸系统疾病商品肉鸡快速生长控制现代肉鸡呼吸综合征遗传潜力基因选择

200MHZ SUPERCONDUCTING NB-CU CAVITIES FOR MUON ACCELERATION

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200MHZ SUPERCONDUCTING NB-CU CAVITIES FOR MUON ACCELERATION