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Genetic Predisposition for Type 2 Diabetes Mellitus in a Cameroonian Population: Contribution of rs4731702 (C/T) Polymorphism of Krüppel-Like factor 14 Gene

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Open Journal of Genetics 2021年第2期11卷 9-22页

作者： magellan guewo-f.keng Eugene Sobngwi Barbara Atogho-Tiedeu Eric Lontchi-Yimagou Jean-Paul Chedjou Jean-Claude Mbanya Wilfred f. Mbacham Department of Biochemistry Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon The Biotechnology Centre University of Yaoundé I Nkolbisson Yaoundé Cameroon Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Biochemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon

Introduction: Krüppel Like factor 14 (KLf14) gene has recently been identified as a master gene for multiple metabolic phenotypes. The aim of the research study was to investigate the relationship between KLf14 rs4731702 (C/T) gene polymorphism with Type 2 Diabetes Mellitus (T2DM) in a Cameroonian population. Patients and Methods: This case-control study was conducted in 85 patients with T2DM and 95 healthy normoglycemic controls. All were nonrelated, of Cameroonian origin, and were adults aged 24 years old and above. Demographic, clinical and biological data were collected, and biochemical explorations were performed using enzymatic colorimetric methods. The genotyping of KLf14 rs4731702 (CT) gene polymorphism was done by the Polymerase Chain Reaction and Restriction fragment Length Polymorphism. Results: In comparing the Cameroonian population that consisted of 85 patients with T2DM and 95 healthy controls, the minor or risk allele of the rs4731702 (C/T) polymorphism of the KLf14 gene was T (63.53% diabetic patients vs. 26.32% healthy controls, OR = 4.877 and p ferentially associated with a specific diabetes phenotype. Conclusion: This study has demonstrated for the first time the relationship between the KLf14 rs4731702 (C/T) gene polymorphism and T2DM in this Cameroonian population. This gene polymorphism could be a promising target for personalized medicine through the development of clinical genetic testing.

关键词： Genetic Krüppel-Like factor 14 Gene Type 2 Diabetes Mellitus Cameroon

On the Quaternion Ball and the Quaternion Projective Space

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Acta Mathematica Sinica,English Series 2005年第3期21卷 449-456页

作者： Qi keng LU Institute of Mathematics Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China

Since the quaternion ball was used to study the AdS/CfT problems tor spinor fields, it is worthwhile to study further the geometry （in sense of Klein） and analysis on it and on its extended space （in the sense of B... 详细信息

关键词： Discontinuous solutions Heat kernel

Heisenberg Group and Energy-Momentum Conservative Law in de-Sitter Spaces—— In Memory of the 100th Anniversary of Einstein＇s Special Relativity and the 70th Anniversary of Dirac＇s de-Sitter Spaces

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Communications in Theoretical Physics 2005年第3X期44卷 389-392页

作者： LU Qi-keng Institute of Mathematics Academy of Mathematics and System Sciences the Chinese Academy of Sciences Beijing 100080 China

In 1935 Dirac established the physical wave equations in the de-Sitter spaces but neither energy-momentum operators nor their conservative laws were given. In this article it is proved that in the de-Sitter group there is a subgroup group isomorphic to the Heisenberg group and the generators of this groups are the energy-momentum operators which obey a conservative law.

关键词： energy-momentum conservation Heisenberg grup de-Sitter space

On the Curvature Conjecture of Hua Loo-keng

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Acta Mathematica Sinica,English Series 2012年第2期28卷 295-298页

作者： Qi keng LU Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190 P.R.China

It is proved that both the holomorphic sectional and the bisectional curvatures of the conformal Bergman metric

关键词： Conformal metric curvature

Helliwell-Konkowski Conjecture and the Singularities of Cauchy Horizons in 1 + 1-Dimensional Black Holes

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Chinese Physics Letters 1996年第9期13卷 718-720页

作者： WANG Bin SU Ru-keng Department of Physics Fudan UniversityShanghai 200433

The stability conjecture of Cauchy horizons of black holes suggested by Helliwell and Konkowski is used to investigate the 1+1-dimensional(2D)black holes under perturbations of infalling null dust and of both infalling and outgoing null *** result given by this conjecture agrees with that from mass inflation scenario for 2D charged dilaton black *** 2D black holes,we show that the Cauchy horizons are unstable and the corresponding singularities exist.

关键词： Cauchy conjecture perturbations

Extended Wronskian Determinant Approach and Iterative Solutions ofOne-Dimensional Dirac Equation

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Communications in Theoretical Physics 2004年第6期41卷 859-866页

作者： XUYing LUMeng SURu-keng DepartmentofPhysics FudanUniversityShanghai200433China

An approximation method, namely, the Extended Wronskian Determinant Approach, is suggested to study the one-dimensional Dirac equation. An integral equation, which can be solved by iterative procedure to find the wave functions, is established. We employ this approach to study the one-dimensional Dirac equation with one-well potential,and give the energy levels and wave functions up to the first order iterative approximation. for double-well potential,the energy levels up to the first order approximation are given.

关键词： extended Wronskian determinant approach iteration method double-well potential

Wronskian Approach and One—Dimensional Schroedinger Equation with Double—Well Potential

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Communications in Theoretical Physics 2003年第1期39卷 21-26页

作者： QIUJian SURu－keng 等 DepartmentofPhysics FudanUniversityShanghai200433China DepartmentofPhysics FudanUniversityShanghai200433China；ChinaCenterofAdvancedScienceandTechnology（WorldLaboratory）P.O.Bo

A Wronskian Determinant approach is suggested to study the energy and the wave function for onedimensional Schroedinger *** integral equation and its corresponding Green function are *** an example,we employed this approach to study the problem of double-well potential with strong coupling,A series of expansion of ground state energy up to the second order approximation of iterative procedure is given.

关键词：薛定格方程双阱势 Wornkian方法

Properties of Strange Matter in a Model with Effective lagrangian

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Communications in Theoretical Physics 2001年第1期35卷 61-66页

作者： WANGPing SURu－keng 等 InstituteofHighEnergyPhysics TheChineseAcademyofSciencesPO.Box918（4）Beijing100039China CCAST（WorldLaboratory） P.O.Box8730Beijing100080China DepartmentofPhysics FudanUniversity

The strange hadronic matter with nucleons, -hyperons and -hyperons is studied by using an effective nuclear model in a mean-field approximation. The density and strangeness fraction dependence of the effective baryon ... 详细信息

关键词： strange hadronic matter saturation stability effective Lagrangian

Adaptive learning tracking control of robotic manipulators with uncertainties

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控制理论与应用（英文版） 2010年第2期8卷 160-165页

作者： keng Peng TEE Institute for Infocomm Research 1 Fusionopolis Way #21-01 Connexis Singapore 138632

An adaptive learning tracking control scheme is developed for robotic manipulators by a synthesis of adaptive control and learning control approaches. The proposed controller possesses both adaptive and learning properties and thereby is able to handle robotic systems with both time-varying periodic uncertainties and time invariant parameters. Theoretical proofs are established to show that proposed controllers ensure asymptotical tracking performance. The effectiveness of the proposed approaches is validated through extensive numerical simulation results.

关键词： Adaptive control Learning control Robotic dynamic systems Uncertainties